Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Jonathan Mark Petrash

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Ophthalmology
Phone303/724-0681

    Collapse Research 
    Collapse research activities and funding
    P30EY002687     (BASSNETT, STEVEN)Dec 1, 1978 - Aug 31, 2020
    NIH/NEI
    Core Grant for Vision Research
    Role: Co-Principal Investigator

    R23EY005856     (PETRASH, JONATHAN MARK)Dec 1, 1984 - May 31, 1988
    NIH/NEI
    MOLECULAR STUDIES OF ALDOSE REDUCTASE AND CATARACT
    Role: Principal Investigator

    R01EY005856     (PETRASH, JONATHAN MARK)Dec 1, 1984 - Mar 31, 2015
    NIH/NEI
    Aldose Reductase and Diabetic Eye Disease
    Role: Principal Investigator

    R55EY005856     (PETRASH, JONATHAN MARK)Jul 16, 1988 - Mar 31, 1992
    NIH/NEI
    MOLECULAR BIOLOGY OF ALDOSE REDUCTASE AND CATARACT
    Role: Principal Investigator

    R01EY013897     (PETRASH, JONATHAN MARK)May 1, 2002 - Apr 30, 2008
    NIH/NEI
    Molecular Interactions of Crystallins in the Eye
    Role: Principal Investigator

    RC1EY020361     (PETRASH, JONATHAN MARK)Sep 30, 2009 - Sep 29, 2011
    NIH/NEI
    Development of Small Heat Shock Proteins as Therapeutic Agents in the Eye
    Role: Principal Investigator

    T35EY021455     (PETRASH, JONATHAN MARK)Jan 1, 2011 - Dec 31, 2015
    NIH/NEI
    Vision Research Training Program
    Role: Principal Investigator

    R01EY021498     (PETRASH, JONATHAN MARK)Sep 30, 2011 - Aug 31, 2016
    NIH/NEI
    Novel Therapeutics Against Diabetic Eye Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chang KC, Shieh B, Petrash JM. Influence of aldose reductase on epithelial-to-mesenchymal transition signaling in lens epithelial cells. Chem Biol Interact. 2017 Jan 27. PMID: 28137510.
      View in: PubMed
    2. Diego JL, Bidikov L, Pedler MG, Kennedy JB, Quiroz-Mercado H, Gregory DG, Petrash JM, McCourt EA. Effect of human milk as a treatment for dry eye syndrome in a mouse model. Mol Vis. 2016; 22:1095-1102. PMID: 27667918.
      View in: PubMed
    3. Chang KC, Li L, Sanborn TM, Shieh B, Lenhart P, Ammar D, LaBarbera DV, Petrash JM. Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract. J Nat Prod. 2016 May 27; 79(5):1439-44. PMID: 27140653.
      View in: PubMed
    4. Tewari-Singh N, Croutch CR, Tuttle R, Goswami DG, Kant R, Peters E, Culley T, Ammar DA, Enzenauer RW, Petrash JM, Casillas RP, Agarwal R. Clinical progression of ocular injury following arsenical vesicant lewisite exposure. Cutan Ocul Toxicol. 2016 Dec; 35(4):319-28. PMID: 27002633.
      View in: PubMed
    5. Goswami DG, Tewari-Singh N, Dhar D, Kumar D, Agarwal C, Ammar DA, Kant R, Enzenauer RW, Petrash JM, Agarwal R. Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization. Cornea. 2016 Feb; 35(2):257-66. PMID: 26555588.
      View in: PubMed
    6. Mueller NH, Fogueri U, Pedler MG, Montana K, Petrash JM, Ammar DA. Impact of Subunit Composition on the Uptake of a-Crystallin by Lens and Retina. PLoS One. 2015; 10(9):e0137659. PMID: 26355842.
      View in: PubMed
    7. Chang KC, Petrash JM. Aldose Reductase Mediates Transforming Growth Factor ß2 (TGF-ß2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4198-210. PMID: 26132779.
      View in: PubMed
    8. Nagaraj RH, Nahomi RB, Mueller NH, Raghavan CT, Ammar DA, Petrash JM. Therapeutic potential of a-crystallin. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):252-7. PMID: 25840354.
      View in: PubMed
    9. Snow A, Shieh B, Chang KC, Pal A, Lenhart P, Ammar D, Ruzycki P, Palla S, Reddy GB, Petrash JM. Aldose reductase expression as a risk factor for cataract. Chem Biol Interact. 2015 Jun 05; 234:247-53. PMID: 25541468.
      View in: PubMed
    10. Chang KC, Snow A, LaBarbera DV, Petrash JM. Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells. Chem Biol Interact. 2015 Jun 05; 234:254-60. PMID: 25451566.
      View in: PubMed
    11. Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ. Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy. J Am Soc Nephrol. 2014 Nov; 25(11):2526-38. PMID: 24876114.
      View in: PubMed
    12. Lee CA, Li G, Patel MD, Petrash JM, Benetz BA, Veenstra A, Amengual J, von Lintig J, Burant CJ, Tang J, Kern TS. Diabetes-induced impairment in visual function in mice: contributions of p38 MAPK, rage, leukocytes, and aldose reductase. Invest Ophthalmol Vis Sci. 2014 May 02; 55(5):2904-10. PMID: 23920367.
      View in: PubMed
    13. Chang KC, Ponder J, Labarbera DV, Petrash JM. Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia. Invest Ophthalmol Vis Sci. 2014 May 02; 55(5):2853-61. PMID: 24677107.
      View in: PubMed
    14. Li L, Chang KC, Zhou Y, Shieh B, Ponder J, Abraham AD, Ali H, Snow A, Petrash JM, LaBarbera DV. Design of an amide N-glycoside derivative of ß-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem. 2014 Jan 09; 57(1):71-7. PMID: 24341381.
      View in: PubMed
    15. Petrash JM. Aging and age-related diseases of the ocular lens and vitreous body. Invest Ophthalmol Vis Sci. 2013 Dec 13; 54(14):ORSF54-9. PMID: 24335070.
      View in: PubMed
    16. Christopher KL, Pedler MG, Shieh B, Ammar DA, Petrash JM, Mueller NH. Alpha-crystallin-mediated protection of lens cells against heat and oxidative stress-induced cell death. Biochim Biophys Acta. 2014 Feb; 1843(2):309-15. PMID: 24275510.
      View in: PubMed
    17. Yandrapu SK, Upadhyay AK, Petrash JM, Kompella UB. Nanoparticles in porous microparticles prepared by supercritical infusion and pressure quench technology for sustained delivery of bevacizumab. Mol Pharm. 2013 Dec 02; 10(12):4676-86. PMID: 24131101.
      View in: PubMed
    18. Tang J, Du Y, Petrash JM, Sheibani N, Kern TS. Deletion of aldose reductase from mice inhibits diabetes-induced retinal capillary degeneration and superoxide generation. PLoS One. 2013; 8(4):e62081. PMID: 23614016.
      View in: PubMed
    19. Énzsöly A, Markó K, Tábi T, Szöko É, Zelkó R, Tóth M, Petrash JM, Mátyus P, Németh J. Lack of association between VAP-1/SSAO activity and corneal neovascularization in a rabbit model. J Neural Transm (Vienna). 2013 Jun; 120(6):969-75. PMID: 23397320.
      View in: PubMed
    20. Mueller NH, Ammar DA, Petrash JM. Cell penetration peptides for enhanced entry of aB-crystallin into lens cells. Invest Ophthalmol Vis Sci. 2013 Jan 02; 54(1):2-8. PMID: 23150610.
      View in: PubMed
    21. Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Ruzicky P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013; 4:2434. PMID: 24022321.
      View in: PubMed
    22. Chang KC, Laffin B, Ponder J, Enzsöly A, Németh J, LaBarbera DV, Petrash JM. Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues. Chem Biol Interact. 2013 Feb 25; 202(1-3):283-7. PMID: 23247009.
      View in: PubMed
    23. Samuels IS, Lee CA, Petrash JM, Peachey NS, Kern TS. Exclusion of aldose reductase as a mediator of ERG deficits in a mouse model of diabetic eye disease. Vis Neurosci. 2012 Nov; 29(6):267-74. PMID: 23101909.
      View in: PubMed
    24. Rao VR, Muthenna P, Shankaraiah G, Akileshwari C, Babu KH, Suresh G, Babu KS, Chandra Kumar RS, Prasad KR, Yadav PA, Petrash JM, Reddy GB, Rao JM. Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs). Eur J Med Chem. 2012 Nov; 57:344-61. PMID: 23124161.
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    25. Tewari-Singh N, Jain AK, Inturi S, Ammar DA, Agarwal C, Tyagi P, Kompella UB, Enzenauer RW, Petrash JM, Agarwal R. Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries. Toxicol Appl Pharmacol. 2012 Oct 01; 264(1):23-31. PMID: 22841772.
      View in: PubMed
    26. Akileshwari C, Muthenna P, Nastasijevic B, Joksic G, Petrash JM, Reddy GB. Inhibition of aldose reductase by Gentiana lutea extracts. Exp Diabetes Res. 2012; 2012:147965. PMID: 22844269.
      View in: PubMed
    27. Laffin B, Petrash JM. Expression of the Aldo-Ketoreductases AKR1B1 and AKR1B10 in Human Cancers. Front Pharmacol. 2012; 3:104. PMID: 22685431.
      View in: PubMed
    28. Puppala M, Ponder J, Suryanarayana P, Reddy GB, Petrash JM, LaBarbera DV. The isolation and characterization of ß-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis. PLoS One. 2012; 7(4):e31399. PMID: 22485126.
      View in: PubMed
    29. Validandi V, Reddy VS, Srinivas PN, Mueller NH, Bhagyalaxmi SG, Padma T, Petrash JM, Reddy GB. Temperature-dependent structural and functional properties of a mutant (F71L) aA-crystallin: molecular basis for early onset of age-related cataract. FEBS Lett. 2011 Dec 15; 585(24):3884-9. PMID: 22085609.
      View in: PubMed
    30. Petrash JM, Ruzycki PA, Zablocki GJ. Guest editorial: visionary genomics. Hum Genomics. 2011 Oct; 5(6):519-21. PMID: 22155600.
      View in: PubMed
    31. Zablocki GJ, Ruzycki PA, Overturf MA, Palla S, Reddy GB, Petrash JM. Aldose reductase-mediated induction of epithelium-to-mesenchymal transition (EMT) in lens. Chem Biol Interact. 2011 May 30; 191(1-3):351-6. PMID: 21329682.
      View in: PubMed
    32. Ruiz FX, Moro A, Gallego O, Ardèvol A, Rovira C, Petrash JM, Parés X, Farrés J. Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde. Chem Biol Interact. 2011 May 30; 191(1-3):199-205. PMID: 21329680.
      View in: PubMed
    33. Salabei JK, Li XP, Petrash JM, Bhatnagar A, Barski OA. Functional expression of novel human and murine AKR1B genes. Chem Biol Interact. 2011 May 30; 191(1-3):177-84. PMID: 21276782.
      View in: PubMed
    34. Hegde KR, Kowluru RA, Mohr S, Nagaraj RH, Petrash JM. New horizons in research on diabetic complications of the eye: special emphasis on diabetic cataracts and retinopathy. J Ophthalmol. 2010; 2010:979040. PMID: 21049002.
      View in: PubMed
    35. Srinivas P, Narahari A, Petrash JM, Swamy MJ, Reddy GB. Importance of eye lens a-crystallin heteropolymer with 3:1 aA to aB ratio: stability, aggregation, and modifications. IUBMB Life. 2010 Sep; 62(9):693-702. PMID: 20836128.
      View in: PubMed
    36. Huang SP, Palla S, Ruzycki P, Varma RA, Harter T, Reddy GB, Petrash JM. Aldo-keto reductases in the eye. J Ophthalmol. 2010; 2010:521204. PMID: 20628518.
      View in: PubMed
    37. Kahook MY, Liu L, Ruzycki P, Mandava N, Carpenter JF, Petrash JM, Ammar DA. High-molecular-weight aggregates in repackaged bevacizumab. Retina. 2010 Jun; 30(6):887-92. PMID: 20458261.
      View in: PubMed
    38. Muthenna P, Suryanarayana P, Gunda SK, Petrash JM, Reddy GB. Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance. FEBS Lett. 2009 Nov 19; 583(22):3637-42. PMID: 19850041.
      View in: PubMed
    39. Srivastava S, Vladykovskaya E, Barski OA, Spite M, Kaiserova K, Petrash JM, Chung SS, Hunt G, Dawn B, Bhatnagar A. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009 Oct 09; 105(8):793-802. PMID: 19729598.
      View in: PubMed
    40. Bhagyalaxmi SG, Srinivas P, Barton KA, Kumar KR, Vidyavathi M, Petrash JM, Bhanuprakash Reddy G, Padma T. A novel mutation (F71L) in alphaA-crystallin with defective chaperone-like function associated with age-related cataract. Biochim Biophys Acta. 2009 Oct; 1792(10):974-81. PMID: 19595763.
      View in: PubMed
    41. Barton KA, Hsu CD, Petrash JM. Interactions between small heat shock protein alpha-crystallin and galectin-related interfiber protein (GRIFIN) in the ocular lens. Biochemistry. 2009 May 12; 48(18):3956-66. PMID: 19296714.
      View in: PubMed
    42. Shi Y, Barton K, De Maria A, Petrash JM, Shiels A, Bassnett S. The stratified syncytium of the vertebrate lens. J Cell Sci. 2009 May 15; 122(Pt 10):1607-15. PMID: 19401333.
      View in: PubMed
    43. Tammali R, Reddy AB, Ramana KV, Petrash JM, Srivastava SK. Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation. Carcinogenesis. 2009 May; 30(5):799-807. PMID: 19028703.
      View in: PubMed
    44. Reddy GB, Satyanarayana A, Balakrishna N, Ayyagari R, Padma M, Viswanath K, Petrash JM. Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy. Mol Vis. 2008 Mar 24; 14:593-601. PMID: 18385795.
      View in: PubMed
    45. Saraswat M, Muthenna P, Suryanarayana P, Petrash JM, Reddy GB. Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications. Asia Pac J Clin Nutr. 2008; 17(4):558-65. PMID: 19114390.
      View in: PubMed
    46. Chang Q, Petrash JM. Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae. Biochim Biophys Acta. 2008 Feb; 1783(2):237-45. PMID: 17919749.
      View in: PubMed
    47. Suryanarayana P, Saraswat M, Petrash JM, Reddy GB. Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats. Mol Vis. 2007 Jul 24; 13:1291-7. PMID: 17679931.
      View in: PubMed
    48. Spite M, Baba SP, Ahmed Y, Barski OA, Nijhawan K, Petrash JM, Bhatnagar A, Srivastava S. Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes. Biochem J. 2007 Jul 01; 405(1):95-105. PMID: 17381426.
      View in: PubMed
    49. Barton KA, Shui YB, Petrash JM, Beebe DC. Comment on: the Stokes-Einstein equation and the physiological effects of vitreous surgery. Acta Ophthalmol Scand. 2007 May; 85(3):339-40. PMID: 17362364.
      View in: PubMed
    50. Estey T, Cantore M, Weston PA, Carpenter JF, Petrash JM, Vasiliou V. Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1. J Biol Chem. 2007 Feb 16; 282(7):4382-92. PMID: 17158879.
      View in: PubMed
    51. Chang Q, Griest TA, Harter TM, Petrash JM. Functional studies of aldo-keto reductases in Saccharomyces cerevisiae. Biochim Biophys Acta. 2007 Mar; 1773(3):321-9. PMID: 17140678.
      View in: PubMed
    52. Singh R, White MA, Ramana KV, Petrash JM, Watowich SJ, Bhatnagar A, Srivastava SK. Structure of a glutathione conjugate bound to the active site of aldose reductase. Proteins. 2006 Jul 01; 64(1):101-10. PMID: 16639747.
      View in: PubMed
    53. Hsu CD, Kymes S, Petrash JM. A transgenic mouse model for human autosomal dominant cataract. Invest Ophthalmol Vis Sci. 2006 May; 47(5):2036-44. PMID: 16639013.
      View in: PubMed
    54. Petrash JM. All in the family: aldose reductase and closely related aldo-keto reductases. Cell Mol Life Sci. 2004 Apr; 61(7-8):737-49. PMID: 15094999.
      View in: PubMed
    55. Suryanarayana P, Kumar PA, Saraswat M, Petrash JM, Reddy GB. Inhibition of aldose reductase by tannoid principles of Emblica officinalis: implications for the prevention of sugar cataract. Mol Vis. 2004 Mar 12; 10:148-54. PMID: 15031705.
      View in: PubMed
    56. Chang Q, Harter TM, Rikimaru LT, Petrash JM. Aldo-keto reductases as modulators of stress response. Chem Biol Interact. 2003 Feb 01; 143-144:325-32. PMID: 12604219.
      View in: PubMed
    57. Cecconi I, Scaloni A, Rastelli G, Moroni M, Vilardo PG, Costantino L, Cappiello M, Garland D, Carper D, Petrash JM, Del Corso A, Mura U. Oxidative modification of aldose reductase induced by copper ion. Definition of the metal-protein interaction mechanism. J Biol Chem. 2002 Nov 01; 277(44):42017-27. PMID: 12183464.
      View in: PubMed
    58. Rastelli G, Costantino L, Gamberini MC, Del Corso A, Mura U, Petrash JM, Ferrari AM, Pacchioni S. Binding of 1-benzopyran-4-one derivatives to aldose reductase: a free energy perturbation study. Bioorg Med Chem. 2002 May; 10(5):1427-36. PMID: 11886805.
      View in: PubMed
    59. Wu X, Chen SG, Petrash JM, Monnier VM. Alteration of substrate selectivity through mutation of two arginine residues in the binding site of amadoriase II from Aspergillus sp. Biochemistry. 2002 Apr 02; 41(13):4453-8. PMID: 11914093.
      View in: PubMed
    60. Cobb BA, Petrash JM. Factors influencing alpha-crystallin association with phospholipid vesicles. Mol Vis. 2002 Mar 22; 8:85-93. PMID: 11951084.
      View in: PubMed
    61. Cobb BA, Petrash JM. alpha-Crystallin chaperone-like activity and membrane binding in age-related cataracts. Biochemistry. 2002 Jan 15; 41(2):483-90. PMID: 11781086.
      View in: PubMed
    62. Costantino L, Del Corso A, Rastelli G, Petrash JM, Mura U. 7-Hydroxy-2-substituted-4-H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR study. Eur J Med Chem. 2001 Sep; 36(9):697-703. PMID: 11672879.
      View in: PubMed
    63. Srivastava S, Dixit BL, Ramana KV, Chandra A, Chandra D, Zacarias A, Petrash JM, Bhatnagar A, Srivastava SK. Structural and kinetic modifications of aldose reductase by S-nitrosothiols. Biochem J. 2001 Aug 15; 358(Pt 1):111-8. PMID: 11485558.
      View in: PubMed
    64. Ramana KV, Dixit BL, Srivastava S, Bhatnagar A, Balendiran GK, Watowich SJ, Petrash JM, Srivastava SK. Characterization of the glutathione binding site of aldose reductase. Chem Biol Interact. 2001 Jan 30; 130-132(1-3):537-48. PMID: 11306073.
      View in: PubMed
    65. Petrash JM, Murthy BS, Young M, Morris K, Rikimaru L, Griest TA, Harter T. Functional genomic studies of aldo-keto reductases. Chem Biol Interact. 2001 Jan 30; 130-132(1-3):673-83. PMID: 11306085.
      View in: PubMed
    66. Cobb BA, Petrash JM. Structural and functional changes in the alpha A-crystallin R116C mutant in hereditary cataracts. Biochemistry. 2000 Dec 26; 39(51):15791-8. PMID: 11123904.
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    67. Dixit BL, Balendiran GK, Watowich SJ, Srivastava S, Ramana KV, Petrash JM, Bhatnagar A, Srivastava SK. Kinetic and structural characterization of the glutathione-binding site of aldose reductase. J Biol Chem. 2000 Jul 14; 275(28):21587-95. PMID: 10764810.
      View in: PubMed
    68. Cobb BA, Petrash JM. Characterization of alpha-crystallin-plasma membrane binding. J Biol Chem. 2000 Mar 03; 275(9):6664-72. PMID: 10692476.
      View in: PubMed
    69. Reddy GB, Das KP, Petrash JM, Surewicz WK. Temperature-dependent chaperone activity and structural properties of human alphaA- and alphaB-crystallins. J Biol Chem. 2000 Feb 18; 275(7):4565-70. PMID: 10671481.
      View in: PubMed
    70. Das KP, Choo-Smith LP, Petrash JM, Surewicz WK. Insight into the secondary structure of non-native proteins bound to a molecular chaperone alpha-crystallin. An isotope-edited infrared spectroscopic study. J Biol Chem. 1999 Nov 19; 274(47):33209-12. PMID: 10559193.
      View in: PubMed
    71. Srivastava S, Watowich SJ, Petrash JM, Srivastava SK, Bhatnagar A. Structural and kinetic determinants of aldehyde reduction by aldose reductase. Biochemistry. 1999 Jan 05; 38(1):42-54. PMID: 9890881.
      View in: PubMed
    72. Petrash JM, Harter TM, Srivastava S, Chandra A, Bhatnagar A, Srivastava SK. Structure-function studies of FR-1. A growth factor-inducible aldo-keto reductase. Adv Exp Med Biol. 1999; 463:435-43. PMID: 10352716.
      View in: PubMed
    73. Srivastava SK, Chandra A, Srivastava S, Petrash JM, Bhatnagar A. Regulation of aldose reductase by aldehydes and nitric oxide. Adv Exp Med Biol. 1999; 463:501-7. PMID: 10352725.
      View in: PubMed
    74. Cecconi I, Moroni M, Vilardo PG, Dal Monte M, Borella P, Rastelli G, Costantino L, Garland D, Carper D, Petrash JM, Del Corso A, Mura U. Oxidative modification of aldose reductase induced by copper ion. Factors and conditions affecting the process. Biochemistry. 1998 Oct 06; 37(40):14167-74. PMID: 9760253.
      View in: PubMed
    75. Srivastava S, Harter TM, Chandra A, Bhatnagar A, Srivastava SK, Petrash JM. Kinetic studies of FR-1, a growth factor-inducible aldo-keto reductase. Biochemistry. 1998 Sep 15; 37(37):12909-17. PMID: 9737870.
      View in: PubMed
    76. Chandra A, Srivastava S, Petrash JM, Bhatnagar A, Srivastava SK. Modification of aldose reductase by S-nitrosoglutathione. Biochemistry. 1997 Dec 16; 36(50):15801-9. PMID: 9398310.
      View in: PubMed
    77. Chandra A, Srivastava S, Petrash JM, Bhatnagar A, Srivastava SK. Active site modification of aldose reductase by nitric oxide donors. Biochim Biophys Acta. 1997 Sep 05; 1341(2):217-22. PMID: 9357961.
      View in: PubMed
    78. Petrash JM, Harter TM, Murdock GL. A potential role for aldose reductase in steroid metabolism. Adv Exp Med Biol. 1997; 414:465-73. PMID: 9059652.
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    79. Wilson DK, Nakano T, Petrash JM, Quiocho FA. Structural studies of aldo-keto reductase inhibition. Adv Exp Med Biol. 1997; 414:435-42. PMID: 9059648.
      View in: PubMed
    80. Cappiello M, Voltarelli M, Cecconi I, Vilardo PG, Dal Monte M, Marini I, Del Corso A, Wilson DK, Quiocho FA, Petrash JM, Mura U. Specifically targeted modification of human aldose reductase by physiological disulfides. J Biol Chem. 1996 Dec 27; 271(52):33539-44. PMID: 8969219.
      View in: PubMed
    81. Andley UP, Mathur S, Griest TA, Petrash JM. Cloning, expression, and chaperone-like activity of human alphaA-crystallin. J Biol Chem. 1996 Dec 13; 271(50):31973-80. PMID: 8943244.
      View in: PubMed
    82. Nakano T, Petrash JM. Kinetic and spectroscopic evidence for active site inhibition of human aldose reductase. Biochemistry. 1996 Aug 27; 35(34):11196-202. PMID: 8780524.
      View in: PubMed
    83. Das KP, Petrash JM, Surewicz WK. Conformational properties of substrate proteins bound to a molecular chaperone alpha-crystallin. J Biol Chem. 1996 May 03; 271(18):10449-52. PMID: 8631839.
      View in: PubMed
    84. Wilson DK, Nakano T, Petrash JM, Quiocho FA. 1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor. Biochemistry. 1995 Nov 07; 34(44):14323-30. PMID: 7578036.
      View in: PubMed
    85. Cook PN, Ward WH, Petrash JM, Mirrlees DJ, Sennitt CM, Carey F, Preston J, Brittain DR, Tuffin DP, Howe R. Kinetic characteristics of ZENECA ZD5522, a potent inhibitor of human and bovine lens aldose reductase. Biochem Pharmacol. 1995 Apr 18; 49(8):1043-9. PMID: 7748183.
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    86. Petrash JM, Tarle I, Wilson DK, Quiocho FA. Aldose reductase catalysis and crystallography. Insights from recent advances in enzyme structure and function. Diabetes. 1994 Aug; 43(8):955-9. PMID: 8039602.
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    87. Hay RE, Andley UP, Petrash JM. Expression of recombinant bovine gamma B-, gamma C- and gamma D-crystallins and correlation with native proteins. Exp Eye Res. 1994 May; 58(5):573-84. PMID: 7925695.
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    88. Tarle I, Borhani DW, Wilson DK, Quiocho FA, Petrash JM. Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110. J Biol Chem. 1993 Dec 05; 268(34):25687-93. PMID: 8245005.
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    89. Wilson DK, Tarle I, Petrash JM, Quiocho FA. Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):9847-51. PMID: 8234324.
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    90. Tilton RG, Chang K, Hasan KS, Smith SR, Petrash JM, Misko TP, Moore WM, Currie MG, Corbett JA, McDaniel ML, et al. Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. Diabetes. 1993 Feb; 42(2):221-32. PMID: 7678825.
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    91. Petrash JM, Harter T, Tarle I, Borhani D. Kinetic alteration of human aldose reductase by mutagenesis of cysteine residues. Adv Exp Med Biol. 1993; 328:289-300. PMID: 8493906.
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    92. Borhani DW, Harter TM, Petrash JM. The crystal structure of the aldose reductase.NADPH binary complex. J Biol Chem. 1992 Dec 05; 267(34):24841-7. PMID: 1447221.
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    93. Petrash JM, Harter TM, Devine CS, Olins PO, Bhatnagar A, Liu S, Srivastava SK. Involvement of cysteine residues in catalysis and inhibition of human aldose reductase. Site-directed mutagenesis of Cys-80, -298, and -303. J Biol Chem. 1992 Dec 05; 267(34):24833-40. PMID: 1332968.
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    94. Bhatnagar A, Liu SQ, Petrash JM, Srivastava SK. Mechanism of inhibition of aldose reductase by menadione (vitamin K3). Mol Pharmacol. 1992 Nov; 42(5):917-21. PMID: 1435755.
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    95. Abghari SZ, Stulting RD, Petrash JM. Detection of herpes simplex virus type 1 latency-associated transcripts in corneal cells of inbred mice by in situ hybridization. Cornea. 1992 Sep; 11(5):433-8. PMID: 1330438.
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    96. Petrash JM, Flath M, Sens D, Bylander J. Effects of osmotic stress and hyperglycemia on aldose reductase gene expression in human renal proximal tubule cells. Biochem Biophys Res Commun. 1992 Aug 31; 187(1):201-8. PMID: 1520300.
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    97. Petrash JM. Applications of molecular biological techniques to the understanding of visual system disorders. Am J Ophthalmol. 1992 May 15; 113(5):573-82. PMID: 1575233.
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    98. el-Kabbani O, Narayana SV, Babu YS, Moore KM, Flynn TG, Petrash JM, Westbrook EM, DeLucas LJ, Bugg CE. Purification, crystallization and preliminary crystallographic analysis of porcine aldose reductase. J Mol Biol. 1991 Apr 20; 218(4):695-8. PMID: 1902521.
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    99. Petrash JM, DeLucas LJ, Bowling E, Egen N. Resolving isoforms of aldose reductase by preparative isoelectric focusing in the Rotofor. Electrophoresis. 1991 Jan; 12(1):84-90. PMID: 1904814.
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    100. Kaye NW, Lalley PA, Petrash JM, Church RL. Regional assignment of the mouse alpha A2-crystallin gene (Crya-1) to chromosome 17A3----B by in situ hybridization. Cytogenet Cell Genet. 1990; 53(2-3):95-6. PMID: 2369847.
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    101. Petrash JM, Favello AD. Isolation and characterization of cDNA clones encoding aldose reductase. Curr Eye Res. 1989 Oct; 8(10):1021-7. PMID: 2515032.
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    102. Hay RE, Petrash JM. Nucleotide sequence of a bovine lens alpha A-crystallin cDNA. Biochem Biophys Res Commun. 1987 Oct 14; 148(1):31-7. PMID: 3675580.
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    103. Hay RE, Woods WD, Church RL, Petrash JM. cDNA clones encoding bovine gamma-crystallins. Biochem Biophys Res Commun. 1987 Jul 15; 146(1):332-8. PMID: 3606621.
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    104. Kaye NW, Church RL, Piatigorsky J, Petrash JM, Lalley PA. Assignment of the mouse alpha A-crystallin structural gene to chromosome 17. Curr Eye Res. 1985 Dec; 4(12):1263-8. PMID: 4085253.
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    105. Srivastava SK, Das B, Hair GA, Gracy RW, Awasthi S, Ansari NH, Petrash JM. Interrelationships among human aldo-keto reductases: immunochemical, kinetic and structural properties. Biochim Biophys Acta. 1985 Jul 05; 840(3):334-43. PMID: 3924115.
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    106. Petrash JM, Srivastava SK. Purification and properties of human liver aldehyde reductases. Biochim Biophys Acta. 1982 Sep 22; 707(1):105-14. PMID: 6753936.
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    107. Srivastava SK, Ansari NH, Brown JH, Petrash JM. Formation of sorbitol 6-phosphate by bovine and human lens aldose reductase, sorbitol dehydrogenase and sorbitol kinase. Biochim Biophys Acta. 1982 Aug 06; 717(2):210-4. PMID: 6288113.
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    108. Srivastava SK, Petrash JM, Sadana IJ, Ansari NH, Partridge CA. Susceptibility of aldehyde and aldose reductases of human tissues to aldose reductase inhibitors. Curr Eye Res. 1982-1983; 2(6):407-10. PMID: 6820339.
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