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Jorge A DiPaola

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
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    K23HL004460     (DIPAOLA, JORGE A)Sep 20, 2001 - Jul 31, 2006
    NIH/NHLBI
    Role of Platelet Integrin a2b1 in von Willebrand Disease
    Role: Principal Investigator

    R01HL084086     (DIPAOLA, JORGE A)Feb 1, 2007 - Jan 31, 2014
    NIH/NHLBI
    Genetic Modifiers of von Willebrand Disease
    Role: Principal Investigator

    RC1HL100333     (DIPAOLA, JORGE A)Sep 30, 2009 - Aug 31, 2011
    NIH/NHLBI
    Use of microfluidics in determining hemostatic phenotypes
    Role: Principal Investigator

    T35HL112930     (ABMAN, STEVEN HERBERT)Apr 1, 2012 - Mar 31, 2016
    NIH/NHLBI
    Pediatric Pulmonology and Hematology Research Training for Medical Students
    Role: Co-Principal Investigator

    R01HL120728     (NEEVES, KEITH B)Sep 1, 2014 - May 31, 2019
    NIH/NHLBI
    A Systems Biology Approach to Predicting Bleeding in Hemophilia
    Role: Co-Principal Investigator

    R13HL132417     (MORRISSEY, JAMES H.)May 1, 2016 - Apr 30, 2017
    NIH/NHLBI
    2016 Hemostasis Gordon Research Conference and Gordon Research Seminar
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Guglielmone HA, Smith N, Minoldo S, Jarchum GD, White-Adams T, Di Paola J. Platelet abnormalities in a family with von Willebrand disease type 2B (V1316M) and association with bleeding score. Haemophilia. 2016 Sep; 22(5):e455-8. PMID: 27385556.
      View in: PubMed
    2. Tomberg K, Khoriaty R, Westrick RJ, Fairfield HE, Reinholdt LG, Brodsky GL, Davizon-Castillo P, Ginsburg D, Di Paola J. Spontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in Mice. PLoS One. 2016; 11(3):e0150852. PMID: 26950939.
      View in: PubMed
    3. Othman M, Kaur H, Favaloro EJ, Lillicrap D, Di Paola J, Harrison P, Gresele P. Platelet type von Willebrand disease and registry report: communication from the SSC of the ISTH. J Thromb Haemost. 2016 Feb; 14(2):411-4. PMID: 26882161.
      View in: PubMed
    4. Di Paola J. Paris-Trousseau: evidence keeps pointing to FLI1. Blood. 2015 Oct 22; 126(17):1973-4. PMID: 26494917.
      View in: PubMed
    5. Kirkpatrick G, Noetzli L, Di Paola J, Porter CC. ETV6 mutations define a new cancer predisposition syndrome. Oncotarget. 2015 Jul 10; 6(19):16830-1. PMID: 26219557.
      View in: PubMed
    6. Chen J, Hinckley JD, Haberichter S, Jacobi P, Montgomery R, Flood VH, Wong R, Interlandi G, Chung DW, López JA, Di Paola J. Variable content of von Willebrand factor mutant monomer drives the phenotypic variability in a family with von Willebrand disease. Blood. 2015 Jul 09; 126(2):262-9. PMID: 26019279.
      View in: PubMed
    7. Branchford BR, Ng CJ, Neeves KB, Di Paola J. Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis. Thromb Res. 2015 Jul; 136(1):13-9. PMID: 26014643.
      View in: PubMed
    8. Bodó I, Eikenboom J, Montgomery R, Patzke J, Schneppenheim R, Di Paola J. Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH. J Thromb Haemost. 2015 Jul; 13(7):1345-50. PMID: 25858564.
      View in: PubMed
    9. Noetzli L, Lo RW, Lee-Sherick AB, Callaghan M, Noris P, Savoia A, Rajpurkar M, Jones K, Gowan K, Balduini CL, Pecci A, Gnan C, De Rocco D, Doubek M, Li L, Lu L, Leung R, Landolt-Marticorena C, Hunger S, Heller P, Gutierrez-Hartmann A, Xiayuan L, Pluthero FG, Rowley JW, Weyrich AS, Kahr WH, Porter CC, Di Paola J. Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia. Nat Genet. 2015 May; 47(5):535-8. PMID: 25807284.
      View in: PubMed
    10. Ng C, Motto DG, Di Paola J. Diagnostic approach to von Willebrand disease. Blood. 2015 Mar 26; 125(13):2029-37. PMID: 25712990.
      View in: PubMed
    11. Hinckley J, Di Paola J. Genetic basis of congenital platelet disorders. Hematology Am Soc Hematol Educ Program. 2014 Dec 05; 2014(1):337-42. PMID: 25696876.
      View in: PubMed
    12. Gonzalez-Alegre P, Di Paola J, Wang K, Fabbro S, Yu HC, Shaikh TH, Darbro BW, Bassuk AG. Evaluating Familial Essential Tremor with Novel Genetic Approaches: Is it a Genotyping or Phenotyping Issue? Tremor Other Hyperkinet Mov (N Y). 2014; 4:258. PMID: 25374765.
      View in: PubMed
    13. Di Paola J. Understanding congenital platelet disorders. Clin Adv Hematol Oncol. 2014 Jul; 12(7):461-3. PMID: 25322327.
      View in: PubMed
    14. Aleman MM, Byrnes JR, Wang JG, Tran R, Lam WA, Di Paola J, Mackman N, Degen JL, Flick MJ, Wolberg AS. Factor XIII activity mediates red blood cell retention in venous thrombi. J Clin Invest. 2014 Aug; 124(8):3590-600. PMID: 24983320.
      View in: PubMed
    15. Boulden Warren B, Di Paola JA. Platelets join the world of "Omics". Blood. 2014 Apr 17; 123(16):2446-7. PMID: 24744250.
      View in: PubMed
    16. Branchford BR, Ruegg K, Villalobos-Menuey E, Jacobson LJ, Di Paola JA, Manco-Johnson M. FVIII/VWF ratio is not a reliable predictor of VWD in children. Pediatr Blood Cancer. 2014 May; 61(5):936-9. PMID: 24281894.
      View in: PubMed
    17. Zhang W, McIver AL, Stashko MA, DeRyckere D, Branchford BR, Hunter D, Kireev D, Miley MJ, Norris-Drouin J, Stewart WM, Lee M, Sather S, Zhou Y, Di Paola JA, Machius M, Janzen WP, Earp HS, Graham DK, Frye SV, Wang X. Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem. 2013 Dec 12; 56(23):9693-700. PMID: 24219778.
      View in: PubMed
    18. Onasoga-Jarvis AA, Leiderman K, Fogelson AL, Wang M, Manco-Johnson MJ, Di Paola JA, Neeves KB. The effect of factor VIII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational models. PLoS One. 2013; 8(11):e78732. PMID: 24236042.
      View in: PubMed
    19. Noetzli L, Sanz PG, Brodsky GL, Hinckley JD, Giugni JC, Giannaula RJ, Gonzalez-Alegre P, Di Paola J. A novel mutation in PLP1 causes severe hereditary spastic paraplegia type 2. Gene. 2014 Jan 01; 533(1):447-50. PMID: 24103481.
      View in: PubMed
    20. Hinckley JD, Abbott D, Burns TL, Heiman M, Shapiro AD, Wang K, Di Paola J. Quantitative trait locus linkage analysis in a large Amish pedigree identifies novel candidate loci for erythrocyte traits. Mol Genet Genomic Med. 2013 Sep 01; 1(3):131-141. PMID: 24058921.
      View in: PubMed
    21. Kahr WH, Lo RW, Li L, Pluthero FG, Christensen H, Ni R, Vaezzadeh N, Hawkins CE, Weyrich AS, Di Paola J, Landolt-Marticorena C, Gross PL. Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice. Blood. 2013 Nov 07; 122(19):3349-58. PMID: 23861251.
      View in: PubMed
    22. Di Paola J. SHPing in different directions in platelet production. Blood. 2013 May 16; 121(20):4018-9. PMID: 23682031.
      View in: PubMed
    23. Mannuccio Mannucci P, Kyrle PA, Schulman S, Di Paola J, Schneppenheim R, Cox Gill J. Prophylactic efficacy and pharmacokinetically guided dosing of a von Willebrand factor/factor VIII concentrate in adults and children with von Willebrand's disease undergoing elective surgery: a pooled and comparative analysis of data from USA and European Union clinical trials. Blood Transfus. 2013 Oct; 11(4):533-40. PMID: 23736911.
      View in: PubMed
    24. Flood VH, Friedman KD, Gill JC, Haberichter SL, Christopherson PA, Branchford BR, Hoffmann RG, Abshire TC, Dunn AL, Di Paola JA, Hoots WK, Brown DL, Leissinger C, Lusher JM, Ragni MV, Shapiro AD, Montgomery RR. No increase in bleeding identified in type 1 VWD subjects with D1472H sequence variation. Blood. 2013 May 02; 121(18):3742-4. PMID: 23520336.
      View in: PubMed
    25. Branchford BR, Monahan PE, Di Paola J. New developments in the treatment of pediatric hemophilia and bleeding disorders. Curr Opin Pediatr. 2013 Feb; 25(1):23-30. PMID: 23274430.
      View in: PubMed
    26. Neeves KB, Onasoga AA, Hansen RR, Lilly JJ, Venckunaite D, Sumner MB, Irish AT, Brodsky G, Manco-Johnson MJ, Di Paola JA. Sources of variability in platelet accumulation on type 1 fibrillar collagen in microfluidic flow assays. PLoS One. 2013; 8(1):e54680. PMID: 23355889.
      View in: PubMed
    27. Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, Di Paola J, Reynolds SD, White CW. Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):94-104. PMID: 23065128.
      View in: PubMed
    28. Marchi R, Walton BL, McGary CS, Lin FC, Ma AD, Pawlinski R, Mackman N, Campbell RA, Di Paola J, Wolberg AS. Dysregulated coagulation associated with hypofibrinogenaemia and plasma hypercoagulability: implications for identifying coagulopathic mechanisms in humans. Thromb Haemost. 2012 Sep; 108(3):516-26. PMID: 22836883.
      View in: PubMed
    29. Branchford BR, Di Paola J. Making a diagnosis of VWD. Hematology Am Soc Hematol Educ Program. 2012; 2012:161-7. PMID: 23233576.
      View in: PubMed
    30. Di Paola J, Johnson J. Thrombocytopenias due to gray platelet syndrome or THC2 mutations. Semin Thromb Hemost. 2011 Sep; 37(6):690-7. PMID: 22102272.
      View in: PubMed
    31. Hansen RR, Tipnis AA, White-Adams TC, Di Paola JA, Neeves KB. Characterization of collagen thin films for von Willebrand factor binding and platelet adhesion. Langmuir. 2011 Nov 15; 27(22):13648-58. PMID: 21967679.
      View in: PubMed
    32. Kahr WH, Hinckley J, Li L, Schwertz H, Christensen H, Rowley JW, Pluthero FG, Urban D, Fabbro S, Nixon B, Gadzinski R, Storck M, Wang K, Ryu GY, Jobe SM, Schutte BC, Moseley J, Loughran NB, Parkinson J, Weyrich AS, Di Paola J. Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. Nat Genet. 2011 Jul 17; 43(8):738-40. PMID: 21765413.
      View in: PubMed
    33. Di Paola J, Lethagen S, Gill J, Mannucci P, Manco-Johnson M, Bernstein J, Nichols WL, Bergman GE. Presurgical pharmacokinetic analysis of a von Willebrand factor/factor VIII (VWF/FVIII) concentrate in patients with von Willebrand's disease (VWD) has limited value in dosing for surgery. Haemophilia. 2011 Sep; 17(5):752-8. PMID: 21689209.
      View in: PubMed
    34. Fabbro S, Kahr WH, Hinckley J, Wang K, Moseley J, Ryu GY, Nixon B, White JG, Bair T, Schutte B, Di Paola J. Homozygosity mapping with SNP arrays confirms 3p21 as a recessive locus for gray platelet syndrome and narrows the interval significantly. Blood. 2011 Mar 24; 117(12):3430-4. PMID: 21263149.
      View in: PubMed
    35. DiPaola J, Lillicrap D. Challenges and innovations in the treatment of bleeding disorders. Thromb Res. 2011 Jan; 127 Suppl 1:S1-2. PMID: 21056903.
      View in: PubMed
    36. Monahan PE, Di Paola J. Recombinant factor IX for clinical and research use. Semin Thromb Hemost. 2010 Jul; 36(5):498-509. PMID: 20632248.
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    37. James P, Di Paola J. The application of genetics to inherited bleeding disorders. Haemophilia. 2010 Jul; 16 Suppl 5:35-9. PMID: 20590854.
      View in: PubMed
    38. Flood VH, Gill JC, Morateck PA, Christopherson PA, Friedman KD, Haberichter SL, Branchford BR, Hoffmann RG, Abshire TC, Di Paola JA, Hoots WK, Leissinger C, Lusher JM, Ragni MV, Shapiro AD, Montgomery RR. Common VWF exon 28 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor. Blood. 2010 Jul 15; 116(2):280-6. PMID: 20231421.
      View in: PubMed
    39. Valentino LA, Recht M, Dipaola J, Shapiro AD, Pipe SW, Ewing N, Urgo J, Bullock T, Simmons M, Deguzman C. Experience with a third generation recombinant factor VIII concentrate (Advate) for immune tolerance induction in patients with haemophilia A. Haemophilia. 2009 May; 15(3):718-26. PMID: 19298383.
      View in: PubMed
    40. Young G, Ebbesen LS, Viuff D, Di Paola J, Konkle BA, Negrier C, Pasi J, Ingerslev J. Evaluation of thromboelastography for monitoring recombinant activated factor VII ex vivo in haemophilia A and B patients with inhibitors: a multicentre trial. Blood Coagul Fibrinolysis. 2008 Jun; 19(4):276-82. PMID: 18469548.
      View in: PubMed
    41. Abbott D, Di Paola J. VWD type 1: a calculated diagnosis. Blood. 2008 Apr 15; 111(8):3919-20. PMID: 18434968.
      View in: PubMed
    42. Sharthkumar A, Greist A, Di Paola J, Winay J, Roberson C, Heiman M, Herbert S, Parameswaran R, Shapiro A. Biologic response to subcutaneous and intranasal therapy with desmopressin in a large Amish kindred with Type 2M von Willebrand disease. Haemophilia. 2008 May; 14(3):539-48. PMID: 18312368.
      View in: PubMed
    43. Jobe SM, Wilson KM, Leo L, Raimondi A, Molkentin JD, Lentz SR, Di Paola J. Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis. Blood. 2008 Feb 01; 111(3):1257-65. PMID: 17989312.
      View in: PubMed
    44. Di Paola J, Smith MP, Klamroth R, Mannucci PM, Kollmer C, Feingold J, Kessler C, Pollmann H, Morfini M, Udata C, Rothschild C, Hermans C, Janco R. ReFacto and Advate: a single-dose, randomized, two-period crossover pharmacokinetics study in subjects with haemophilia A. Haemophilia. 2007 Mar; 13(2):124-30. PMID: 17286764.
      View in: PubMed
    45. Di Paola J, Aledort L, Britton H, Carcao M, Grabowski E, Hutter J, Journeycake J, Kempton C, Leissinger C. Application of current knowledge to the management of bleeding events during immune tolerance induction. Haemophilia. 2006 Nov; 12(6):591-7. PMID: 17083508.
      View in: PubMed
    46. Shafagh H, Soltani MA, Douvoyiannis M, Widness J, Di Paola J, Yadav N, Jatzlau A, Pohl J, Weir M. Index of suspicion. Pediatr Rev. 2005 Dec; 26(12):461-6. PMID: 16327027.
      View in: PubMed
    47. Di Paola J. Determinants of bleeding severity in von Willebrand disease. Curr Hematol Rep. 2005 Sep; 4(5):345-9. PMID: 16131434.
      View in: PubMed
    48. Jobe SM, Leo L, Eastvold JS, Dickneite G, Ratliff TL, Lentz SR, Di Paola J. Role of FcRgamma and factor XIIIA in coated platelet formation. Blood. 2005 Dec 15; 106(13):4146-51. PMID: 16105983.
      View in: PubMed
    49. Di Paola J, Jugessur A, Goldman T, Reiland J, Tallman D, Sayago C, Murray JC. Platelet glycoprotein I(b)alpha and integrin alpha2 beta1 polymorphisms: gene frequencies and linkage disequilibrium in a population diversity panel. J Thromb Haemost. 2005 Jul; 3(7):1511-21. PMID: 15978109.
      View in: PubMed
    50. Shapiro AD, Di Paola J, Cohen A, Pasi KJ, Heisel MA, Blanchette VS, Abshire TC, Hoots WK, Lusher JM, Negrier C, Rothschild C, Roth DA. The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B. Blood. 2005 Jan 15; 105(2):518-25. PMID: 15383463.
      View in: PubMed
    51. Di Paola J. Product selection issues in the management of hemophilia B. Blood Coagul Fibrinolysis. 2004 Jun; 15 Suppl 2:S17-8. PMID: 15322454.
      View in: PubMed
    52. Jobe S, Donohoue P, Di Paola J. Deep venous thrombosis and Turner syndrome. J Pediatr Hematol Oncol. 2004 Apr; 26(4):272. PMID: 15087960.
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    53. Di Paola J, Goldman T, Qian Q, Patil SR, Schutte BC, Schute BC. Breakpoint of a balanced translocation (X:14) (q27.1;q32.3) in a girl with severe hemophilia B maps proximal to the factor IX gene. J Thromb Haemost. 2004 Mar; 2(3):437-40. PMID: 15009460.
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    54. Leo L, Di Paola J, Judd BA, Koretzky GA, Lentz SR. Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen. Blood. 2002 Oct 15; 100(8):2839-44. PMID: 12351393.
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    55. Di Paola JA, Buchanan GR. Immune thrombocytopenic purpura. Pediatr Clin North Am. 2002 Oct; 49(5):911-28. PMID: 12430619.
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    56. Di Paola J, Nugent D, Young G. Current therapy for rare factor deficiencies. Haemophilia. 2001 Jan; 7 Suppl 1:16-22. PMID: 11240614.
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    57. Di Paola J, Federici AB, Mannucci PM, Canciani MT, Kritzik M, Kunicki TJ, Nugent D. Low platelet alpha2beta1 levels in type I von Willebrand disease correlate with impaired platelet function in a high shear stress system. Blood. 1999 Jun 01; 93(11):3578-82. PMID: 10339461.
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    58. Doncel GF, Di Paola JA, Lustig L. Sequential study of the histopathology and cellular and humoral immune response during the development of an autoimmune orchitis in Wistar rats. Am J Reprod Immunol. 1989 Jun; 20(2):44-51. PMID: 2803528.
      View in: PubMed
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