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Stephanie R. Wesolowski

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
    Collapse research activities and funding
    F32DK082207     (THORN, STEPHANIE R)Jul 1, 2008 - Jun 30, 2010
    Mechanisms for Fetal Hepatic Programming during Intrauterine Growth Restriction
    Role: Co-Principal Investigator

    K01DK090199     (THORN, STEPHANIE R)Sep 30, 2010 - Aug 31, 2015
    Role: Co-Principal Investigator

    R03DK102972     (THORN, STEPHANIE R)Jul 1, 2014 - Jun 30, 2016
    Effect of hypoxia on glucose metabolism in IUGR fetal liver
    Role: Co-Principal Investigator

    R01DK108910     (WESOLOWSKI, STEPHANIE R)Jan 17, 2017 - Dec 31, 2021
    Nutrient and Insulin Metabolic Actions in IUGR Fetal Liver
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wai SG, Rozance PJ, Wesolowski SR, Hay WW, Brown LD. Prolonged amino acid infusion into intrauterine growth restricted fetal sheep increases leucine oxidation rates. Am J Physiol Endocrinol Metab. 2018 Sep 11. PMID: 30205012.
      View in: PubMed
    2. Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. Pulsatile hyperglycemia increases insulin secretion but not pancreatic ß-cell mass in intrauterine growth-restricted fetal sheep. J Dev Orig Health Dis. 2018 Oct; 9(5):492-499. PMID: 29973299.
      View in: PubMed
    3. Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 Jan 01; 596(1):67-82. PMID: 28940557.
      View in: PubMed
    4. Brown LD, Kohn JR, Rozance PJ, Hay WW, Wesolowski SR. Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 05 01; 312(5):R654-R663. PMID: 28179229.
      View in: PubMed
    5. Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 04 01; 312(4):R492-R500. PMID: 28100476.
      View in: PubMed
    6. Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 03; 232(3):475-491. PMID: 28053000.
      View in: PubMed
    7. Harris RA, Alcott CE, Sullivan EL, Takahashi D, McCurdy CE, Comstock S, Baquero K, Blundell P, Frias AE, Kahr M, Suter M, Wesolowski S, Friedman JE, Grove KL, Aagaard KM. Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model. Sci Rep. 2016 11 04; 6:36123. PMID: 27811965.
      View in: PubMed
    8. Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE. Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol. 2017 02; 14(2):81-96. PMID: 27780972.
      View in: PubMed
    9. Brown LD, Davis M, Wai S, Wesolowski SR, Hay WW, Limesand SW, Rozance PJ. Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep. Endocrinology. 2016 Oct; 157(10):3788-3799. PMID: 27501184.
      View in: PubMed
    10. Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2016 07 01; 311(1):R200-8. PMID: 27170658.
      View in: PubMed
    11. Hay WW, Brown LD, Rozance PJ, Wesolowski SR, Limesand SW. Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep. Acta Paediatr. 2016 Aug; 105(8):881-9. PMID: 27028695.
      View in: PubMed
    12. Brown LD, Wesolowski SR, Kailey J, Bourque S, Wilson A, Andrews SE, Hay WW, Rozance PJ. Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle. Endocrinology. 2016 06; 157(6):2447-60. PMID: 27049667; PMCID: PMC4891788 [Available on 06/01/17].
    13. Ehrhardt RA, Foskolos A, Giesy SL, Wesolowski SR, Krumm CS, Butler WR, Quirk SM, Waldron MR, Boisclair YR. Increased plasma leptin attenuates adaptive metabolism in early lactating dairy cows. J Endocrinol. 2016 05; 229(2):145-57. PMID: 26957637.
      View in: PubMed
    14. Wesolowski SR, Hay WW. Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production. Mol Cell Endocrinol. 2016 11 05; 435:61-68. PMID: 26723529.
      View in: PubMed
    15. Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW, Wesolowski SR. Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15; 309(8):R920-8. PMID: 26224688; PMCID: PMC4666949 [Available on 10/15/16].
    16. Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan; 156(1):367-76. PMID: 25343274; PMCID: PMC4272391.
    17. Houin SS, Rozance PJ, Brown LD, Hay WW, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2015 Feb 15; 308(4):E306-14. PMID: 25516551; PMCID: PMC4329495.
    18. Harvatine KJ, Robblee MM, Thorn SR, Boisclair YR, Bauman DE. Trans-10, cis-12 CLA dose-dependently inhibits milk fat synthesis without disruption of lactation in C57BL/6J mice. J Nutr. 2014 Dec; 144(12):1928-34. PMID: 25320189.
      View in: PubMed
    19. Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ. A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia. Physiol Rep. 2014 Jun 18; 2(6). PMID: 24944291; PMCID: PMC4208658.
    20. Leamy LJ, Elo K, Nielsen MK, Thorn SR, Valdar W, Pomp D. Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss. PeerJ. 2014; 2:e392. PMID: 24918027; PMCID: PMC4045330.
    21. Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ. Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep. J Anim Sci Biotechnol. 2014; 5(1):28. PMID: 24917928; PMCID: PMC4051387.
    22. Thorn SR, Baquero KC, Newsom SA, El Kasmi KC, Bergman BC, Shulman GI, Grove KL, Friedman JE. Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. Diabetes. 2014 Aug; 63(8):2702-13. PMID: 24705404; PMCID: PMC4113070.
    23. Roberts VH, Pound LD, Thorn SR, Gillingham MB, Thornburg KL, Friedman JE, Frias AE, Grove KL. Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J. 2014 Jun; 28(6):2466-77. PMID: 24563374; PMCID: PMC4021444.
    24. Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW, Brown LD, Rozance PJ. Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ß-cell mass in fetal sheep. Am J Physiol Endocrinol Metab. 2013 Feb 15; 304(4):E352-62. PMID: 23211516; PMCID: PMC3566506.
    25. Lavezzi JR, Thorn SR, O'Meara MC, LoTurco D, Brown LD, Hay WW, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 01; 304(1):R50-8. PMID: 23135788; PMCID: PMC3543651.
    26. Grant WF, Nicol LE, Thorn SR, Grove KL, Friedman JE, Marks DL. Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques. PLoS One. 2012; 7(10):e48119. PMID: 23118937; PMCID: PMC3484148.
    27. Thorn SR, Sekar SM, Lavezzi JR, O'Meara MC, Brown LD, Hay WW, Rozance PJ. A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15; 303(8):R861-9. PMID: 22933022; PMCID: PMC3469666.
    28. Thorn SR, Brown LD, Rozance PJ, Hay WW, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan; 62(1):65-73. PMID: 22933111; PMCID: PMC3526037.
    29. Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E352-64. PMID: 22649066; PMCID: PMC3423121.
    30. Maliszewski AM, Gadhia MM, O'Meara MC, Thorn SR, Rozance PJ, Brown LD. Prolonged infusion of amino acids increases leucine oxidation in fetal sheep. Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1483-92. PMID: 22454287; PMCID: PMC3378157.
    31. Thorn SR, Rozance PJ, Brown LD, Hay WW. The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin Reprod Med. 2011 May; 29(3):225-36. PMID: 21710398; PMCID: PMC3216466.
    32. Thorn SR, Giesy SL, Myers MG, Boisclair YR. Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3 signaling. Endocrinology. 2010 Aug; 151(8):3985-95. PMID: 20501669; PMCID: PMC3208358.
    33. Thorn SR, Regnault TR, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW, Friedman JE. Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle. Endocrinology. 2009 Jul; 150(7):3021-30. PMID: 19342452; PMCID: PMC2703533.
    34. Thorn SR, Ehrhardt RA, Butler WR, Quirk SM, Boisclair YR. Insulin regulates hepatic leptin receptor expression in early lactating dairy cows. Am J Physiol Regul Integr Comp Physiol. 2008 Nov; 295(5):R1455-62. PMID: 18815207.
      View in: PubMed
    35. Thorn SR, Purup S, Vestergaard M, Sejrsen K, Meyer MJ, Van Amburgh ME, Boisclair YR. Regulation of mammary parenchymal growth by the fat pad in prepubertal dairy heifers: role of inflammation-related proteins. J Endocrinol. 2008 Mar; 196(3):539-46. PMID: 18310449.
      View in: PubMed
    36. Rozance PJ, Limesand SW, Barry JS, Brown LD, Thorn SR, LoTurco D, Regnault TR, Friedman JE, Hay WW. Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep. Am J Physiol Endocrinol Metab. 2008 Feb; 294(2):E365-70. PMID: 18056789; PMCID: PMC3857025.
    37. Thorn SR, Meyer MJ, Van Amburgh ME, Boisclair YR. Effect of estrogen on leptin and expression of leptin receptor transcripts in prepubertal dairy heifers. J Dairy Sci. 2007 Aug; 90(8):3742-50. PMID: 17638985.
      View in: PubMed
    38. Thorn SR, Purup S, Cohick WS, Vestergaard M, Sejrsen K, Boisclair YR. Leptin does not act directly on mammary epithelial cells in prepubertal dairy heifers. J Dairy Sci. 2006 May; 89(5):1467-77. PMID: 16606717.
      View in: PubMed
    39. Wesolowski SR, Raney NE, Ernst CW. Developmental changes in the fetal pig transcriptome. Physiol Genomics. 2004 Jan 15; 16(2):268-74. PMID: 14726603.
      View in: PubMed
    40. Pomp D, Allan MF, Wesolowski SR. Quantitative genomics: exploring the genetic architecture of complex trait predisposition. J Anim Sci. 2004; 82 E-Suppl:E300-312. PMID: 15471811.
      View in: PubMed
    41. Wesolowski SR, Allan MF, Nielsen MK, Pomp D. Evaluation of hypothalamic gene expression in mice divergently selected for heat loss. Physiol Genomics. 2003 Apr 16; 13(2):129-37. PMID: 12618490.
      View in: PubMed
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