Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Contact Us
If you have any questions or feedback please contact us.

Stephanie R. Wesolowski

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-3293

    Collapse Biography 
    Collapse education and training
    Michigan State University, East Lansing, MIBS05/2000Animal Science
    University of Nebraska, Lincoln, NEMS08/2002Genomics
    Cornell University, Ithaca, NYPhD05/2007Metabolism, Endocrinology
    University of Colorado, Aurora, COPostdoctoral Fellow07/2009Fetal Physiology, Molecular Metabolism

    Collapse Overview 
    Collapse overview
    My long-term goal is to understand how altered nutrient supply programs fetal metabolism and how these changes may persist after birth and increase susceptibility to adult metabolic disease. My primary research is aimed to understand the effects of intrauterine growth restriction (IUGR) using integrative approaches in physiology and metabolism combined with novel molecular techniques in cell biology, epigenetics, and metabolomics. Current studies in our research program are focused on understanding the mechanisms for the early activation of fetal hepatic glucose production and development of hepatic insulin resistance, specifically the role of reduced glucose versus oxygen supply to the fetus, both key features of placental insufficiency and resulting IUGR. This is important in understanding why IUGR offspring have increased susceptibility to diabetes across their lifespan. I am also involved in projects investigating the effects of maternal high fat diet and obesity on offspring metabolism, specifically the early development of non-alcoholic fatty liver disease (NAFLD) and immune cell reprogramming.

    Current Projects in the lab with cellular metabolism, molecular biology, metabolic flux, and in vivo fetal physiology include:

    • Molecular mechanisms for early development of fetal hepatic insulin resistance on suppression of glucose production in fetuses with IUGR
    • Coordination of carbon and energy substrates (metabolic flux) within the liver and from other fetal organs and the placenta to support early activation of hepatic glucose production in IUGR fetus
    • Role of hypoxia versus hypoglycemia in the early activation of fetal hepatic glucose production
    • Effect of intrauterine exposures on fetal hepatic immune cell programming and function
    • Mechanisms for early development of steatosis and NAFLD risk following exposure to maternal obesity
    • Intrauterine intervention strategies to prevent later life metabolic disease risk

    Collapse Research 
    Collapse research activities and funding
    F32DK082207     (THORN, STEPHANIE R)Jul 1, 2008 - May 31, 2010
    NIH/NIDDK
    Mechanisms for Fetal Hepatic Programming during Intrauterine Growth Restriction
    Role: PI

    R24DK090964     (Friedman, Jacob E)Aug 1, 2010 - Jul 31, 2020
    NIH/NIDDK
    Interrupting the viscous cycle of obesity and metabolic syndrome
    Role: Co-Investigator

    K01DK090199     (THORN, STEPHANIE R)Sep 30, 2010 - Aug 31, 2015
    NIH/NIDDK
    TISSUE SPECIFIC REGULATION OF GLUCOSE METABOLISM AND INSULIN ACTION IN IUGR FETUS
    Role: Principal Investigator

    R03DK102972     (THORN, STEPHANIE R)Jul 1, 2014 - Jun 30, 2016
    NIH/NIDDK
    Effect of hypoxia on glucose metabolism in IUGR fetal liver
    Role: Principal Investigator

    R01DK108910     (WESOLOWSKI, STEPHANIE R)Jan 17, 2017 - Dec 31, 2021
    NIH/NIDDK
    Nutrient and Insulin Metabolic Actions in IUGR Fetal Liver
    Role: Principal Investigator

    F32DK120070     (Jones, Amanda K)Feb 1, 2019 - Jan 31, 2021
    NIH/NIDDK
    Glucose metabolism in the fetal liver during hypoxia
    Role: Sponsor

    R13HD098851     (WESOLOWSKI, STEPHANIE R)Apr 1, 2019 - Mar 31, 2020
    NIH/NICHD
    2019 Aspen/Snowmass Perinatal Biology Conference
    Role: Principal Investigator

    R24DK090964     (FRIEDMAN, JACOB E)Aug 1, 2019 - Jun 30, 2015
    NIH/NIDDK
    Interrupting the Vicious Cycle of Obesity and Metabolic Syndrome
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Boehmer BH, Baker PR, Brown LD, Wesolowski SR, Rozance PJ. Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep. J Endocrinol. 2020 Oct; 247(1):115-126. PMID: 32756000.
      View in: PubMed
    2. Rozance PJ, Jones AK, Bourque SL, D'Alessandro A, Hay WW, Brown LD, Wesolowski SR. Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver. Am J Physiol Endocrinol Metab. 2020 Oct 01; 319(4):E721-E733. PMID: 32830555.
      View in: PubMed
    3. Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ß Cells in Late-Gestation Sheep. J Nutr. 2020 Aug 01; 150(8):2061-2069. PMID: 32470982.
      View in: PubMed
    4. Zarate MA, Wesolowski SR, Nguyen LM, De Dios RK, Wilkening RB, Rozance PJ, Wright CJ. In utero inflammatory challenge induces an early activation of the hepatic innate immune response in late gestation fetal sheep. Innate Immun. 2020 Oct; 26(7):549-564. PMID: 32538259.
      View in: PubMed
    5. Campodonico-Burnett W, Hetrick B, Wesolowski SR, Schenk S, Takahashi DL, Dean TA, Sullivan EL, Kievit P, Gannon M, Aagaard K, Friedman JE, McCurdy CE. Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates. Diabetes. 2020 Jul; 69(7):1389-1400. PMID: 32354857.
      View in: PubMed
    6. Chang EI, Rozance PJ, Wesolowski SR, Nguyen LM, Shaw SC, Sclafani RA, Bjorkman KK, Peter AK, Hay W, Brown LD. Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep. J Endocrinol. 2019 12 19; 244(2):339-352. PMID: 31751294.
      View in: PubMed
    7. Chang EI, Wesolowski SR, Gilje EA, Baker PR, Reisz JA, D'Alessandro A, Hay WW, Rozance PJ, Brown LD. Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb. . 2019 11 01; 317(5):R615-R629. PMID: 31483682.
      View in: PubMed
    8. Jones AK, Rozance PJ, Brown LD, Goldstrohm DA, Hay WW, Limesand SW, Wesolowski SR. Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus. Am J Physiol Endocrinol Metab. 2019 07 01; 317(1):E1-E10. PMID: 30964701.
      View in: PubMed
    9. Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW, Friedman JE, Wesolowski SR. Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver. . 2019 05 01; 316(5):R427-R440. PMID: 30758974.
      View in: PubMed
    10. Paulsen ME, Rosario FJ, Wesolowski SR, Powell TL, Jansson T. Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring. FASEB J. 2019 02; 33(2):2899-2909. PMID: 30346829.
      View in: PubMed
    11. Wesolowski SR, Mulligan CM, Janssen RC, Baker PR, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 12; 18:25-41. PMID: 30337225.
      View in: PubMed
    12. Wai SG, Rozance PJ, Wesolowski SR, Hay WW, Brown LD. Prolonged amino acid infusion into intrauterine growth-restricted fetal sheep increases leucine oxidation rates. Am J Physiol Endocrinol Metab. 2018 12 01; 315(6):E1143-E1153. PMID: 30205012.
      View in: PubMed
    13. Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. Pulsatile hyperglycemia increases insulin secretion but not pancreatic ß-cell mass in intrauterine growth-restricted fetal sheep. J Dev Orig Health Dis. 2018 10; 9(5):492-499. PMID: 29973299.
      View in: PubMed
    14. Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 01 01; 596(1):67-82. PMID: 28940557.
      View in: PubMed
    15. Brown LD, Kohn JR, Rozance PJ, Hay WW, Wesolowski SR. Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. . 2017 05 01; 312(5):R654-R663. PMID: 28179229.
      View in: PubMed
    16. Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. . 2017 04 01; 312(4):R492-R500. PMID: 28100476.
      View in: PubMed
    17. Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 03; 232(3):475-491. PMID: 28053000.
      View in: PubMed
    18. Harris RA, Alcott CE, Sullivan EL, Takahashi D, McCurdy CE, Comstock S, Baquero K, Blundell P, Frias AE, Kahr M, Suter M, Wesolowski S, Friedman JE, Grove KL, Aagaard KM. Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model. Sci Rep. 2016 11 04; 6:36123. PMID: 27811965.
      View in: PubMed
    19. Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE. Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol. 2017 02; 14(2):81-96. PMID: 27780972.
      View in: PubMed
    20. Brown LD, Davis M, Wai S, Wesolowski SR, Hay WW, Limesand SW, Rozance PJ. Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep. Endocrinology. 2016 Oct; 157(10):3788-3799. PMID: 27501184.
      View in: PubMed
    21. Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep. . 2016 07 01; 311(1):R200-8. PMID: 27170658.
      View in: PubMed
    22. Hay WW, Brown LD, Rozance PJ, Wesolowski SR, Limesand SW. Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep. Acta Paediatr. 2016 Aug; 105(8):881-9. PMID: 27028695.
      View in: PubMed
    23. Brown LD, Wesolowski SR, Kailey J, Bourque S, Wilson A, Andrews SE, Hay WW, Rozance PJ. Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle. Endocrinology. 2016 06; 157(6):2447-60. PMID: 27049667.
      View in: PubMed
    24. Ehrhardt RA, Foskolos A, Giesy SL, Wesolowski SR, Krumm CS, Butler WR, Quirk SM, Waldron MR, Boisclair YR. Increased plasma leptin attenuates adaptive metabolism in early lactating dairy cows. J Endocrinol. 2016 05; 229(2):145-57. PMID: 26957637.
      View in: PubMed
    25. Wesolowski SR, Hay WW. Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production. Mol Cell Endocrinol. 2016 11 05; 435:61-68. PMID: 26723529.
      View in: PubMed
    26. Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW, Wesolowski SR. Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction. . 2015 Oct 15; 309(8):R920-8. PMID: 26224688.
      View in: PubMed
    27. Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan; 156(1):367-76. PMID: 25343274.
      View in: PubMed
    28. Houin SS, Rozance PJ, Brown LD, Hay WW, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2015 Feb 15; 308(4):E306-14. PMID: 25516551.
      View in: PubMed
    29. Harvatine KJ, Robblee MM, Thorn SR, Boisclair YR, Bauman DE. Trans-10, cis-12 CLA dose-dependently inhibits milk fat synthesis without disruption of lactation in C57BL/6J mice. J Nutr. 2014 Dec; 144(12):1928-34. PMID: 25320189.
      View in: PubMed
    30. Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ. A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia. Physiol Rep. 2014 Jun 18; 2(6). PMID: 24944291.
      View in: PubMed
    31. Leamy LJ, Elo K, Nielsen MK, Thorn SR, Valdar W, Pomp D. Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss. PeerJ. 2014; 2:e392. PMID: 24918027.
      View in: PubMed
    32. Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ. Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep. J Anim Sci Biotechnol. 2014; 5(1):28. PMID: 24917928.
      View in: PubMed
    33. Thorn SR, Baquero KC, Newsom SA, El Kasmi KC, Bergman BC, Shulman GI, Grove KL, Friedman JE. Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. Diabetes. 2014 Aug; 63(8):2702-13. PMID: 24705404.
      View in: PubMed
    34. Roberts VH, Pound LD, Thorn SR, Gillingham MB, Thornburg KL, Friedman JE, Frias AE, Grove KL. Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J. 2014 Jun; 28(6):2466-77. PMID: 24563374.
      View in: PubMed
    35. Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW, Brown LD, Rozance PJ. Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ß-cell mass in fetal sheep. Am J Physiol Endocrinol Metab. 2013 Feb 15; 304(4):E352-62. PMID: 23211516.
      View in: PubMed
    36. Lavezzi JR, Thorn SR, O'Meara MC, LoTurco D, Brown LD, Hay WW, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. . 2013 Jan 01; 304(1):R50-8. PMID: 23135788.
      View in: PubMed
    37. Grant WF, Nicol LE, Thorn SR, Grove KL, Friedman JE, Marks DL. Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques. PLoS One. 2012; 7(10):e48119. PMID: 23118937.
      View in: PubMed
    38. Thorn SR, Sekar SM, Lavezzi JR, O'Meara MC, Brown LD, Hay WW, Rozance PJ. A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia. . 2012 Oct 15; 303(8):R861-9. PMID: 22933022.
      View in: PubMed
    39. Thorn SR, Brown LD, Rozance PJ, Hay WW, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan; 62(1):65-73. PMID: 22933111.
      View in: PubMed
    40. Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E352-64. PMID: 22649066.
      View in: PubMed
    41. Maliszewski AM, Gadhia MM, O'Meara MC, Thorn SR, Rozance PJ, Brown LD. Prolonged infusion of amino acids increases leucine oxidation in fetal sheep. Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1483-92. PMID: 22454287.
      View in: PubMed
    42. Thorn SR, Rozance PJ, Brown LD, Hay WW. The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin Reprod Med. 2011 May; 29(3):225-36. PMID: 21710398.
      View in: PubMed
    43. Thorn SR, Giesy SL, Myers MG, Boisclair YR. Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3 signaling. Endocrinology. 2010 Aug; 151(8):3985-95. PMID: 20501669.
      View in: PubMed
    44. Thorn SR, Regnault TR, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW, Friedman JE. Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle. Endocrinology. 2009 Jul; 150(7):3021-30. PMID: 19342452.
      View in: PubMed
    45. Thorn SR, Ehrhardt RA, Butler WR, Quirk SM, Boisclair YR. Insulin regulates hepatic leptin receptor expression in early lactating dairy cows. . 2008 Nov; 295(5):R1455-62. PMID: 18815207.
      View in: PubMed
    46. Thorn SR, Purup S, Vestergaard M, Sejrsen K, Meyer MJ, Van Amburgh ME, Boisclair YR. Regulation of mammary parenchymal growth by the fat pad in prepubertal dairy heifers: role of inflammation-related proteins. J Endocrinol. 2008 Mar; 196(3):539-46. PMID: 18310449.
      View in: PubMed
    47. Rozance PJ, Limesand SW, Barry JS, Brown LD, Thorn SR, LoTurco D, Regnault TR, Friedman JE, Hay WW. Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep. Am J Physiol Endocrinol Metab. 2008 Feb; 294(2):E365-70. PMID: 18056789.
      View in: PubMed
    48. Thorn SR, Meyer MJ, Van Amburgh ME, Boisclair YR. Effect of estrogen on leptin and expression of leptin receptor transcripts in prepubertal dairy heifers. J Dairy Sci. 2007 Aug; 90(8):3742-50. PMID: 17638985.
      View in: PubMed
    49. Thorn SR, Purup S, Cohick WS, Vestergaard M, Sejrsen K, Boisclair YR. Leptin does not act directly on mammary epithelial cells in prepubertal dairy heifers. J Dairy Sci. 2006 May; 89(5):1467-77. PMID: 16606717.
      View in: PubMed
    50. Wesolowski SR, Raney NE, Ernst CW. Developmental changes in the fetal pig transcriptome. Physiol Genomics. 2004 Jan 15; 16(2):268-74. PMID: 14726603.
      View in: PubMed
    51. Pomp D, Allan MF, Wesolowski SR. Quantitative genomics: exploring the genetic architecture of complex trait predisposition. J Anim Sci. 2004; 82 E-Suppl:E300-312. PMID: 15471811.
      View in: PubMed
    52. Wesolowski SR, Allan MF, Nielsen MK, Pomp D. Evaluation of hypothalamic gene expression in mice divergently selected for heat loss. Physiol Genomics. 2003 Apr 16; 13(2):129-37. PMID: 12618490.
      View in: PubMed
    Wesolowski's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description

    Copyright © 2020 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)