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Tomas Majtan

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Majtan T, Bublil EM, Park I, Arning E, Bottiglieri T, Glavin F, Kraus JP. Pharmacokinetics and pharmacodynamics of PEGylated truncated human cystathionine beta-synthase for treatment of homocystinuria. Life Sci. 2018 May 01; 200:15-25. PMID: 29526799.
      View in: PubMed
    2. Collard R, Majtan T, Park I, Kraus JP. Import of TAT-Conjugated Propionyl Coenzyme A Carboxylase Using Models of Propionic Acidemia. Mol Cell Biol. 2018 Mar 15; 38(6). PMID: 29378828.
      View in: PubMed
    3. Majtan T, Pey AL, Gimenez-Mascarell P, Martínez-Cruz LA, Szabo C, Kožich V, Kraus JP. Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria. Handb Exp Pharmacol. 2018; 245:345-383. PMID: 29119254.
      View in: PubMed
    4. Giménez-Mascarell P, Majtan T, Oyenarte I, Ereño-Orbea J, Majtan J, Klaudiny J, Kraus JP, Martínez-Cruz LA. Crystal structure of cystathionine ß-synthase from honeybee Apis mellifera. J Struct Biol. 2018 Apr; 202(1):82-93. PMID: 29275181.
      View in: PubMed
    5. Majtan T, Jones W, Krijt J, Park I, Kruger WD, Kožich V, Bassnett S, Bublil EM, Kraus JP. Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther. 2018 Mar 07; 26(3):834-844. PMID: 29398487.
      View in: PubMed
    6. Majtan T, Park I, Bublil EM, Kraus JP. Enzyme replacement therapy prevents loss of bone and fat mass in murine homocystinuria. Hum Mutat. 2018 02; 39(2):210-218. PMID: 29044829.
      View in: PubMed
    7. Majtan T, Krijt J, Sokolová J, Krížková M, Ralat MA, Kent J, Gregory JF, Kožich V, Kraus JP. Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase. Antioxid Redox Signal. 2018 02 01; 28(4):311-323. PMID: 28874062.
      View in: PubMed
    8. Majtan T, Hulková H, Park I, Krijt J, Kožich V, Bublil EM, Kraus JP. Enzyme replacement prevents neonatal death, liver damage, and osteoporosis in murine homocystinuria. FASEB J. 2017 12; 31(12):5495-5506. PMID: 28821635.
      View in: PubMed
    9. Majtan T, Park I, Carrillo RS, Bublil EM, Kraus JP. Engineering and Characterization of an Enzyme Replacement Therapy for Classical Homocystinuria. Biomacromolecules. 2017 Jun 12; 18(6):1747-1761. PMID: 28431470.
      View in: PubMed
    10. Pey AL, Martínez-Cruz LA, Kraus JP, Majtan T. Oligomeric status of human cystathionine beta-synthase modulates AdoMet binding. FEBS Lett. 2016 Dec; 590(24):4461-4471. PMID: 27861796.
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    11. Bublil EM, Majtan T, Park I, Carrillo RS, Hulková H, Krijt J, Kožich V, Kraus JP. Enzyme replacement with PEGylated cystathionine ß-synthase ameliorates homocystinuria in murine model. J Clin Invest. 2016 06 01; 126(6):2372-84. PMID: 27183385.
      View in: PubMed
    12. Majtan T, Pey AL, Kraus JP. Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuria. Biochimie. 2016 Jul; 126:6-13. PMID: 26805382.
      View in: PubMed
    13. Majtan T, Pey AL, Ereño-Orbea J, Martínez-Cruz LA, Kraus JP. Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions. Curr Drug Targets. 2016; 17(13):1455-70. PMID: 26931358.
      View in: PubMed
    14. Thorson MK, Van Wagoner RM, Harper MK, Ireland CM, Majtan T, Kraus JP, Barrios AM. Marine natural products as inhibitors of cystathionine beta-synthase activity. Bioorg Med Chem Lett. 2015 Mar 01; 25(5):1064-6. PMID: 25666819.
      View in: PubMed
    15. Ereño-Orbea J, Majtan T, Oyenarte I, Kraus JP, Martínez-Cruz LA. Structural insight into the molecular mechanism of allosteric activation of human cystathionine ß-synthase by S-adenosylmethionine. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):E3845-52. PMID: 25197074; PMCID: PMC4169959.
    16. Majtan T, Pey AL, Fernández R, Fernández JA, Martínez-Cruz LA, Kraus JP. Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases. PLoS One. 2014; 9(8):e105290. PMID: 25122507; PMCID: PMC4133348.
    17. Pey AL, Majtan T, Kraus JP. The role of surface electrostatics on the stability, function and regulation of human cystathionine ß-synthase, a complex multidomain and oligomeric protein. Biochim Biophys Acta. 2014 Sep; 1844(9):1453-62. PMID: 24780582; PMCID: PMC4112162.
    18. Ereño-Orbea J, Majtan T, Oyenarte I, Kraus JP, Martínez-Cruz LA. Purification, crystallization and preliminary crystallographic analysis of the catalytic core of cystathionine ß-synthase from Saccharomyces cerevisiae. Acta Crystallogr F Struct Biol Commun. 2014 Mar; 70(Pt 3):320-5. PMID: 24598918; PMCID: PMC3944693.
    19. Ereño-Orbea J, Majtan T, Oyenarte I, Kraus JP, Martínez-Cruz LA. Structural basis of regulation and oligomerization of human cystathionine ß-synthase, the central enzyme of transsulfuration. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):E3790-9. PMID: 24043838; PMCID: PMC3791738.
    20. Majtan J, Bohova J, Garcia-Villalba R, Tomas-Barberan FA, Madakova Z, Majtan T, Majtan V, Klaudiny J. Fir honeydew honey flavonoids inhibit TNF-a-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing. Arch Dermatol Res. 2013 Sep; 305(7):619-27. PMID: 23812412.
      View in: PubMed
    21. Thorson MK, Majtan T, Kraus JP, Barrios AM. Identification of cystathionine ß-synthase inhibitors using a hydrogen sulfide selective probe. Angew Chem Int Ed Engl. 2013 Apr 22; 52(17):4641-4. PMID: 23512751.
      View in: PubMed
    22. Su Y, Majtan T, Freeman KM, Linck R, Ponter S, Kraus JP, Burstyn JN. Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine ß-synthases. Biochemistry. 2013 Jan 29; 52(4):741-51. PMID: 23002992; PMCID: PMC3751582.
    23. Pey AL, Majtan T, Sanchez-Ruiz JM, Kraus JP. Human cystathionine ß-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM. Biochem J. 2013 Jan 01; 449(1):109-21. PMID: 22985361.
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    24. Oyenarte I, Majtan T, Ereño J, Corral-Rodríguez MA, Klaudiny J, Majtan J, Kraus JP, Martínez-Cruz LA. Purification, crystallization and preliminary crystallographic analysis of the full-length cystathionine ß-synthase from Apis mellifera. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 01; 68(Pt 11):1323-8. PMID: 23143241; PMCID: PMC3515373.
    25. Oyenarte I, Majtan T, Ereño J, Corral-Rodríguez MA, Kraus JP, Martínez-Cruz LA. Purification, crystallization and preliminary crystallographic analysis of human cystathionine ß-synthase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 01; 68(Pt 11):1318-22. PMID: 23143240; PMCID: PMC3515372.
    26. Smith AT, Su Y, Stevens DJ, Majtan T, Kraus JP, Burstyn JN. Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine ß-synthase. Biochemistry. 2012 Aug 14; 51(32):6360-70. PMID: 22738154; PMCID: PMC3569099.
    27. Hni´zda A, Majtan T, Liu L, Pey AL, Carpenter JF, Kodi´cek M, Kožich V, Kraus JP. Correction to Conformational Properties of Nine Purified Cystathionine ß-Synthase Mutants. Biochemistry. 2012 Jul 10; 51(27):5540. PMID: 22734603.
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    28. Hnízda A, Majtan T, Liu L, Pey AL, Carpenter JF, Kodícek M, Kožich V, Kraus JP. Conformational properties of nine purified cystathionine ß-synthase mutants. Biochemistry. 2012 Jun 12; 51(23):4755-63. PMID: 22612060; PMCID: PMC3384745.
    29. Majtan T, Kraus JP. Folding and activity of mutant cystathionine ß-synthase depends on the position and nature of the purification tag: characterization of the R266K CBS mutant. Protein Expr Purif. 2012 Apr; 82(2):317-24. PMID: 22333527; PMCID: PMC3319291.
    30. Smith AT, Majtan T, Freeman KM, Su Y, Kraus JP, Burstyn JN. Cobalt cystathionine ß-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif. Inorg Chem. 2011 May 16; 50(10):4417-27. PMID: 21480614; PMCID: PMC3350334.
    31. Swanson MA, Kathirvelu V, Majtan T, Frerman FE, Eaton GR, Eaton SS. Electron transfer flavoprotein domain II orientation monitored using double electron-electron resonance between an enzymatically reduced, native FAD cofactor, and spin labels. Protein Sci. 2011 Mar; 20(3):610-20. PMID: 21308847; PMCID: PMC3064839.
    32. Majtan T, Freeman KM, Smith AT, Burstyn JN, Kraus JP. Purification and characterization of cystathionine ß-synthase bearing a cobalt protoporphyrin. Arch Biochem Biophys. 2011 Apr 01; 508(1):25-30. PMID: 21262193; PMCID: PMC3063419.
    33. Majtan T, Frerman FE, Kraus JP. Effect of cobalt on Escherichia coli metabolism and metalloporphyrin formation. Biometals. 2011 Apr; 24(2):335-47. PMID: 21184140; PMCID: PMC3071258.
    34. Majtan J, Kumar P, Majtan T, Walls AF, Klaudiny J. Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes. Exp Dermatol. 2010 Aug; 19(8):e73-9. PMID: 19845754.
      View in: PubMed
    35. Majtan T, Liu L, Carpenter JF, Kraus JP. Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes. J Biol Chem. 2010 May 21; 285(21):15866-73. PMID: 20308073; PMCID: PMC2871454.
    36. Swanson MA, Kathirvelu V, Majtan T, Frerman FE, Eaton GR, Eaton SS. DEER distance measurement between a spin label and a native FAD semiquinone in electron transfer flavoprotein. J Am Chem Soc. 2009 Nov 11; 131(44):15978-9. PMID: 19886689; PMCID: PMC2782885.
    37. Majtan T, Singh LR, Wang L, Kruger WD, Kraus JP. Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone. J Biol Chem. 2008 Dec 12; 283(50):34588-95. PMID: 18849566; PMCID: PMC2596375.
    38. Majtan T, Majtanova L, Timko J, Majtan V. Oligonucleotide microarray for molecular characterization and genotyping of Salmonella spp. strains. J Antimicrob Chemother. 2007 Nov; 60(5):937-46. PMID: 17897936.
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    39. Majtan T, Halgasova N, Bukovska G, Timko J. Transcriptional profiling of bacteriophage BFK20: coexpression interrogated by "guilt-by-association" algorithm. Virology. 2007 Mar 01; 359(1):55-65. PMID: 17052739.
      View in: PubMed
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