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Tomas Majtan

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Address2RC1N
Research North Tower
12800 E 19th Ave, Bldg. RC1 North Room P18-9103
Aurora CO 80010
Phone303/724-3813

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Thorson MK, Van Wagoner RM, Harper MK, Ireland CM, Majtan T, Kraus JP, Barrios AM. Marine natural products as inhibitors of cystathionine beta-synthase activity. Bioorg Med Chem Lett. 2015 Mar 1; 25(5):1070-2.
      View in: PubMed
    2. Ereño-Orbea J, Majtan T, Oyenarte I, Kraus JP, Martínez-Cruz LA. Structural insight into the molecular mechanism of allosteric activation of human cystathionine ß-synthase by S-adenosylmethionine. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):E3845-52.
      View in: PubMed
    3. Majtan T, Pey AL, Fernández R, Fernández JA, Martínez-Cruz LA, Kraus JP. Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases. PLoS One. 2014; 9(8):e105290.
      View in: PubMed
    4. Pey AL, Majtan T, Kraus JP. The role of surface electrostatics on the stability, function and regulation of human cystathionine ß-synthase, a complex multidomain and oligomeric protein. Biochim Biophys Acta. 2014 Sep; 1844(9):1453-62.
      View in: PubMed
    5. Ereño-Orbea J, Majtan T, Oyenarte I, Kraus JP, Martínez-Cruz LA. Purification, crystallization and preliminary crystallographic analysis of the catalytic core of cystathionine ß-synthase from Saccharomyces cerevisiae. Acta Crystallogr F Struct Biol Commun. 2014 Mar; 70(Pt 3):320-5.
      View in: PubMed
    6. Ereño-Orbea J, Majtan T, Oyenarte I, Kraus JP, Martínez-Cruz LA. Structural basis of regulation and oligomerization of human cystathionine ß-synthase, the central enzyme of transsulfuration. Proc Natl Acad Sci U S A. 2013 Oct 1; 110(40):E3790-9.
      View in: PubMed
    7. Majtan J, Bohova J, Garcia-Villalba R, Tomas-Barberan FA, Madakova Z, Majtan T, Majtan V, Klaudiny J. Fir honeydew honey flavonoids inhibit TNF-a-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing. Arch Dermatol Res. 2013 Sep; 305(7):619-27.
      View in: PubMed
    8. Thorson MK, Majtan T, Kraus JP, Barrios AM. Identification of cystathionine ß-synthase inhibitors using a hydrogen sulfide selective probe. Angew Chem Int Ed Engl. 2013 Apr 22; 52(17):4641-4.
      View in: PubMed
    9. Su Y, Majtan T, Freeman KM, Linck R, Ponter S, Kraus JP, Burstyn JN. Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine ß-synthases. Biochemistry. 2013 Jan 29; 52(4):741-51.
      View in: PubMed
    10. Pey AL, Majtan T, Sanchez-Ruiz JM, Kraus JP. Human cystathionine ß-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM. Biochem J. 2013 Jan 1; 449(1):109-21.
      View in: PubMed
    11. Oyenarte I, Majtan T, Ereño J, Corral-Rodríguez MA, Klaudiny J, Majtan J, Kraus JP, Martínez-Cruz LA. Purification, crystallization and preliminary crystallographic analysis of the full-length cystathionine ß-synthase from Apis mellifera. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1; 68(Pt 11):1323-8.
      View in: PubMed
    12. Oyenarte I, Majtan T, Ereño J, Corral-Rodríguez MA, Kraus JP, Martínez-Cruz LA. Purification, crystallization and preliminary crystallographic analysis of human cystathionine ß-synthase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1; 68(Pt 11):1318-22.
      View in: PubMed
    13. Smith AT, Su Y, Stevens DJ, Majtan T, Kraus JP, Burstyn JN. Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine ß-synthase. Biochemistry. 2012 Aug 14; 51(32):6360-70.
      View in: PubMed
    14. Hnízda A, Majtan T, Liu L, Pey AL, Carpenter JF, Kodícek M, Kožich V, Kraus JP. Conformational properties of nine purified cystathionine ß-synthase mutants. Biochemistry. 2012 Jun 12; 51(23):4755-63.
      View in: PubMed
    15. Majtan T, Kraus JP. Folding and activity of mutant cystathionine ß-synthase depends on the position and nature of the purification tag: characterization of the R266K CBS mutant. Protein Expr Purif. 2012 Apr; 82(2):317-24.
      View in: PubMed
    16. Swanson MA, Kathirvelu V, Majtan T, Frerman FE, Eaton GR, Eaton SS. Electron transfer flavoprotein domain II orientation monitored using double electron-electron resonance between an enzymatically reduced, native FAD cofactor, and spin labels. Protein Sci. 2011 Mar; 20(3):610-20.
      View in: PubMed
    17. Majtan T, Freeman KM, Smith AT, Burstyn JN, Kraus JP. Purification and characterization of cystathionine ß-synthase bearing a cobalt protoporphyrin. Arch Biochem Biophys. 2011 Apr 1; 508(1):25-30.
      View in: PubMed
    18. Majtan T, Frerman FE, Kraus JP. Effect of cobalt on Escherichia coli metabolism and metalloporphyrin formation. Biometals. 2011 Apr; 24(2):335-47.
      View in: PubMed
    19. Majtan J, Kumar P, Majtan T, Walls AF, Klaudiny J. Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes. Exp Dermatol. 2010 Aug; 19(8):e73-9.
      View in: PubMed
    20. Majtan T, Liu L, Carpenter JF, Kraus JP. Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes. J Biol Chem. 2010 May 21; 285(21):15866-73.
      View in: PubMed
    21. Swanson MA, Kathirvelu V, Majtan T, Frerman FE, Eaton GR, Eaton SS. DEER distance measurement between a spin label and a native FAD semiquinone in electron transfer flavoprotein. J Am Chem Soc. 2009 Nov 11; 131(44):15978-9.
      View in: PubMed
    22. Majtan T, Singh LR, Wang L, Kruger WD, Kraus JP. Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone. J Biol Chem. 2008 Dec 12; 283(50):34588-95.
      View in: PubMed
    23. Buckley DH, Baumgartner LK, Visscher PT. Vertical distribution of methane metabolism in microbial mats of the Great Sippewissett Salt Marsh. Environ Microbiol. 2008 Apr; 10(4):967-77.
      View in: PubMed
    24. Majtan T, Majtanova L, Timko J, Majtan V. Oligonucleotide microarray for molecular characterization and genotyping of Salmonella spp. strains. J Antimicrob Chemother. 2007 Nov; 60(5):937-46.
      View in: PubMed
    25. Majtan T, Halgasova N, Bukovska G, Timko J. Transcriptional profiling of bacteriophage BFK20: coexpression interrogated by "guilt-by-association" algorithm. Virology. 2007 Mar 1; 359(1):55-65.
      View in: PubMed
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