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Anne-laure Perraud

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology
Phone303 2702078

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gally F, Rao DM, Schmitz C, Colvin KL, Yeager ME, Perraud AL. The TRPM2 ion channel contributes to cytokine hyperproduction in a mouse model of Down Syndrome. Biochim Biophys Acta. 2018 Jan; 1864(1):126-132. PMID: 28970008.
      View in: PubMed
    2. Rao D, Perraud AL, Schmitz C, Gally F. Cigarette smoke inhibits LPS-induced FABP5 expression by preventing c-Jun binding to the FABP5 promoter. PLoS One. 2017; 12(5):e0178021. PMID: 28542209.
      View in: PubMed
    3. Haladyna JN, Pastuer T, Riedel SS, Perraud AL, Bernt KM. Transient potential receptor melastatin-2 (Trpm2) does not influence murine MLL-AF9-driven AML leukemogenesis or in vitro response to chemotherapy. Exp Hematol. 2016 Jul; 44(7):596-602.e3. PMID: 27033163; PMCID: PMC4914470 [Available on 07/01/17].
    4. Davenport B, Li Y, Heizer JW, Schmitz C, Perraud AL. Signature Channels of Excitability no More: L-Type Channels in Immune Cells. Front Immunol. 2015; 6:375. PMID: 26257741; PMCID: PMC4512153.
    5. Brandao K, Deason-Towne F, Zhao X, Perraud AL, Schmitz C. TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions. Cell Mol Life Sci. 2014 Dec; 71(24):4853-67. PMID: 24858416; PMCID: PMC4234683.
    6. Schmitz C, Brandao K, Perraud AL. The channel-kinase TRPM7, revealing the untold story of Mg(2+) in cellular signaling. Magnes Res. 2014 Jan-Mar; 27(1):9-15. PMID: 24752033.
      View in: PubMed
    7. Yogi A, Callera GE, O'Connor S, Antunes TT, Valinsky W, Miquel P, Montezano AC, Perraud AL, Schmitz C, Shrier A, Touyz RM. Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its a-kinase domain. Cell Signal. 2013 Nov; 25(11):2163-75. PMID: 23838006; PMCID: PMC4293696.
    8. Shimizu T, Macey TA, Quillinan N, Klawitter J, Perraud AL, Traystman RJ, Herson PS. Androgen and PARP-1 regulation of TRPM2 channels after ischemic injury. J Cereb Blood Flow Metab. 2013 Oct; 33(10):1549-55. PMID: 23801245; PMCID: PMC3790922.
    9. Brandao K, Deason-Towne F, Perraud AL, Schmitz C. The role of Mg2+ in immune cells. Immunol Res. 2013 Mar; 55(1-3):261-9. PMID: 22990458.
      View in: PubMed
    10. Knowles H, Li Y, Perraud AL. The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation. Immunol Res. 2013 Mar; 55(1-3):241-8. PMID: 22975787.
      View in: PubMed
    11. Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. J Immunol. 2013 Mar 15; 190(6):2835-43. PMID: 23378430; PMCID: PMC3593745.
    12. Deason-Towne F, Perraud AL, Schmitz C. Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C ?2 (PLC?2) using TRPM7-kinase. Cell Signal. 2012 Nov; 24(11):2070-5. PMID: 22759789; PMCID: PMC4049354.
    13. Knowles H, Heizer JW, Li Y, Chapman K, Ogden CA, Andreasen K, Shapland E, Kucera G, Mogan J, Humann J, Lenz LL, Morrison AD, Perraud AL. Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11578-83. PMID: 21709234; PMCID: PMC3136283.
    14. Deason-Towne F, Perraud AL, Schmitz C. The Mg2+ transporter MagT1 partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7. FEBS Lett. 2011 Jul 21; 585(14):2275-8. PMID: 21627970; PMCID: PMC3139019.
    15. Perraud AL, Zhao X, Ryazanov AG, Schmitz C. The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k. Cell Signal. 2011 Mar; 23(3):586-93. PMID: 21112387; PMCID: PMC3038675.
    16. Mace KE, Lussier MP, Boulay G, Terry-Powers JL, Parfrey H, Perraud AL, Riches DW. TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling. J Cell Physiol. 2010 Nov; 225(2):444-53. PMID: 20458742; PMCID: PMC4447216.
    17. Ahmad S, Ahmad A, Dremina ES, Sharov VS, Guo X, Jones TN, Loader JE, Tatreau JR, Perraud AL, Schöneich C, Randell SH, White CW. Bcl-2 suppresses sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression in cystic fibrosis airways: role in oxidant-mediated cell death. Am J Respir Crit Care Med. 2009 May 01; 179(9):816-26. PMID: 19201925; PMCID: PMC2675566.
    18. Hermosura MC, Cui AM, Go RC, Davenport B, Shetler CM, Heizer JW, Schmitz C, Mocz G, Garruto RM, Perraud AL. Altered functional properties of a TRPM2 variant in Guamanian ALS and PD. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):18029-34. PMID: 19004782; PMCID: PMC2584682.
    19. Gally F, Hartney JM, Janssen WJ, Perraud AL. CD38 plays a dual role in allergen-induced airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2009 Apr; 40(4):433-42. PMID: 18931329; PMCID: PMC2720120.
    20. Song Y, Buelow B, Perraud AL, Scharenberg AM. Development and validation of a cell-based high-throughput screening assay for TRPM2 channel modulators. J Biomol Screen. 2008 Jan; 13(1):54-61. PMID: 18057180.
      View in: PubMed
    21. Schmitz C, Deason F, Perraud AL. Molecular components of vertebrate Mg2+-homeostasis regulation. Magnes Res. 2007 Mar; 20(1):6-18. PMID: 17536484.
      View in: PubMed
    22. Grubisha O, Rafty LA, Takanishi CL, Xu X, Tong L, Perraud AL, Scharenberg AM, Denu JM. Metabolite of SIR2 reaction modulates TRPM2 ion channel. J Biol Chem. 2006 May 19; 281(20):14057-65. PMID: 16565078.
      View in: PubMed
    23. Perraud AL, Schmitz C, Scharenberg AM. Analysis of cellular Mg2+ in DT40 cells. Subcell Biochem. 2006; 40:373-8. PMID: 17623923.
      View in: PubMed
    24. Perraud AL, Schmitz C, Scharenberg AM. Calcium signaling, ion channels and more. The DT40 system as a model of vertebrate ion homeostasis and cell physiology. Subcell Biochem. 2006; 40:257-70. PMID: 17623910; PMCID: PMC3628819.
    25. Schmitz C, Dorovkov MV, Zhao X, Davenport BJ, Ryazanov AG, Perraud AL. The channel kinases TRPM6 and TRPM7 are functionally nonredundant. J Biol Chem. 2005 Nov 11; 280(45):37763-71. PMID: 16150690.
      View in: PubMed
    26. Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem. 2005 Feb 18; 280(7):6138-48. PMID: 15561722.
      View in: PubMed
    27. Schmitz C, Perraud AL, Fleig A, Scharenberg AM. Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms. Pediatr Res. 2004 May; 55(5):734-7. PMID: 14764909.
      View in: PubMed
    28. Shen BW, Perraud AL, Scharenberg A, Stoddard BL. The crystal structure and mutational analysis of human NUDT9. J Mol Biol. 2003 Sep 12; 332(2):385-98. PMID: 12948489.
      View in: PubMed
    29. Schmitz C, Perraud AL, Johnson CO, Inabe K, Smith MK, Penner R, Kurosaki T, Fleig A, Scharenberg AM. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell. 2003 Jul 25; 114(2):191-200. PMID: 12887921.
      View in: PubMed
    30. Perraud AL, Schmitz C, Scharenberg AM. TRPM2 Ca2+ permeable cation channels: from gene to biological function. Cell Calcium. 2003 May-Jun; 33(5-6):519-31. PMID: 12765697.
      View in: PubMed
    31. McHugh D, Flemming R, Xu SZ, Perraud AL, Beech DJ. Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem. 2003 Mar 28; 278(13):11002-6. PMID: 12529379.
      View in: PubMed
    32. Perraud AL, Shen B, Dunn CA, Rippe K, Smith MK, Bessman MJ, Stoddard BL, Scharenberg AM. NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. J Biol Chem. 2003 Jan 17; 278(3):1794-801. PMID: 12427752.
      View in: PubMed
    33. Rafty LA, Schmidt MT, Perraud AL, Scharenberg AM, Denu JM. Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases. J Biol Chem. 2002 Dec 06; 277(49):47114-22. PMID: 12370179.
      View in: PubMed
    34. Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP. TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell. 2002 May 03; 109(3):397-407. PMID: 12015988.
      View in: PubMed
    35. König J, Bock A, Perraud AL, Fuchs TM, Beier D, Gross R. Regulatory factors of Bordetella pertussis affecting virulence gene expression. J Mol Microbiol Biotechnol. 2002 May; 4(3):197-203. PMID: 11931547.
      View in: PubMed
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