Karen Moulton
Title | Associate Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-MED |
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Phone | 303/724-5443 |
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Research R21HL108177 (MOULTON, KAREN SIMPSON)Jun 1, 2011 - Sep 30, 2013 NIH Molecular Targeting of Plaque Angiogenesis in Diabetes Role: Principal Investigator |
| RC4DK090852 (MOULTON, KAREN SIMPSON)Sep 30, 2010 - Sep 29, 2012 NIH Urinary MMP activity biomarkers for early diabetic renal dysfunction Role: Principal Investigator |
| R01HL067255 (MOULTON, KAREN SIMPSON)Aug 1, 2001 - Jul 31, 2005 NIH Endogenous Regulators of Plaque Angiogenesis Role: Principal Investigator |
| K11HL002563 (MOULTON, KAREN SIMPSON)Jan 1, 1991 - Feb 28, 1998 NIH REGULATION OF MACROPHAGE DEVELOPMENT Role: Principal Investigator |
Bibliographic
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Lu S, Jolly AJ, Dubner AM, Strand KA, Mutryn MF, Hinthorn T, Noble T, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MC. KLF4 in smooth muscle cell-derived progenitor cells is essential for angiotensin II-induced cardiac inflammation and fibrosis. bioRxiv. 2024 Jun 06. PMID: 38895472.
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Dubner AM, Lu S, Jolly AJ, Strand KA, Mutryn MF, Hinthorn T, Noble T, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MC. Smooth muscle-derived adventitial progenitor cells direct atherosclerotic plaque composition complexity in a Klf4-dependent manner. JCI Insight. 2023 11 22; 8(22). PMID: 37991018.
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Dubner AM, Lu S, Jolly AJ, Noble T, Hinthorn T, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MCM. Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research-Brief Report. Arterioscler Thromb Vasc Biol. 2023 11; 43(11):2223-2230. PMID: 37706321.
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Dubner AM, Lu S, Jolly AJ, Strand KA, Mutryn MF, Hinthorn T, Noble T, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MC. Smooth muscle-derived adventitial progenitor cells promote key cell type transitions controlling plaque stability in atherosclerosis in a Klf4-dependent manner. bioRxiv. 2023 Jul 19. PMID: 37503181.
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Jolly AJ, Lu S, Dubner AM, Strand KA, Mutryn MF, Pilotti-Riley A, Danis EP, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MC. Redistribution of the chromatin remodeler Brg1 directs smooth muscle-derived adventitial progenitor-to-myofibroblast differentiation and vascular fibrosis. JCI Insight. 2023 05 08; 8(9). PMID: 36976650.
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Walker CJ, Batan D, Bishop CT, Ramirez D, Aguado BA, Schroeder ME, Crocini C, Schwisow J, Moulton K, Macdougall L, Weiss RM, Allen MA, Dowell R, Leinwand LA, Anseth KS. Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling. Bioeng Transl Med. 2022 Sep; 7(3):e10394. PMID: 36176599.
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Jolly AJ, Lu S, Strand KA, Dubner AM, Mutryn MF, Nemenoff RA, Majesky MW, Moulton KS, Weiser-Evans MCM. Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodelling. Cardiovasc Res. 2022 05 06; 118(6):1452-1465. PMID: 33989378.
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Ambardekar AV, Stratton MS, Weiser-Evans MCM, Moulton KS, McKinsey TA. Reply: Aortic Valve Remodeling in?CF-LVAD: Beyond the Arterial Wall. J Am Coll Cardiol. 2022 03 29; 79(12):e223. PMID: 35331421.
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Aguado BA, Walker CJ, Grim JC, Schroeder ME, Batan D, Vogt BJ, Rodriguez AG, Schwisow JA, Moulton KS, Weiss RM, Heistad DD, Leinwand LA, Anseth KS. Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts. Circulation. 2022 02 15; 145(7):513-530. PMID: 35000411.
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Ambardekar AV, Stratton MS, Dobrinskikh E, Hunter KS, Tatman PD, Lemieux ME, Cleveland JC, Tuder RM, Weiser-Evans MCM, Moulton KS, McKinsey TA. Matrix-Degrading Enzyme Expression and Aortic Fibrosis During Continuous-Flow Left Ventricular Mechanical Support. J Am Coll Cardiol. 2021 11 02; 78(18):1782-1795. PMID: 34711337.
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Lu S, Jolly AJ, Strand KA, Dubner AM, Mutryn MF, Moulton KS, Nemenoff RA, Majesky MW, Weiser-Evans MC. Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis. JCI Insight. 2020 12 03; 5(23). PMID: 33119549.
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Strand KA, Lu S, Mutryn MF, Li L, Zhou Q, Enyart BT, Jolly AJ, Dubner AM, Moulton KS, Nemenoff RA, Koch KA, LaBarbera DV, Weiser-Evans MCM. High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2020 08; 40(8):1854-1869. PMID: 32580634.
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Lu S, Strand KA, Mutryn MF, Tucker RM, Jolly AJ, Furgeson SB, Moulton KS, Nemenoff RA, Weiser-Evans MCM. PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report. Arterioscler Thromb Vasc Biol. 2020 02; 40(2):394-403. PMID: 31852223.
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Ambardekar AV, Weiser-Evans MCM, Li M, Purohit SN, Aftab M, Reece TB, Moulton KS. Coronary Artery Remodeling and Fibrosis With Continuous-Flow Left Ventricular Assist Device Support. Circ Heart Fail. 2018 05; 11(5):e004491. PMID: 29724722.
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Moulton KS, Li M, Strand K, Burgett S, McClatchey P, Tucker R, Furgeson SB, Lu S, Kirkpatrick B, Cleveland JC, Nemenoff RA, Ambardekar AV, Weiser-Evans MC. PTEN deficiency promotes pathological vascular remodeling of human coronary arteries. JCI Insight. 2018 02 22; 3(4). PMID: 29467331.
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Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA, Weiser-Evans MC. Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Nat Commun. 2016 Mar 04; 7:10830. PMID: 26940659.
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Vuorio T, Nurmi H, Moulton K, Kurkipuro J, Robciuc MR, Ohman M, Heinonen SE, Samaranayake H, Heikura T, Alitalo K, Yl?-Herttuala S. Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis. Arterioscler Thromb Vasc Biol. 2014 Jun; 34(6):1162-70. PMID: 24723556.
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McKittrick IB, Bogaert Y, Nadeau K, Snell-Bergeon J, Hull A, Jiang T, Wang X, Levi M, Moulton KS. Urinary matrix metalloproteinase activities: biomarkers for plaque angiogenesis and nephropathy in diabetes. Am J Physiol Renal Physiol. 2011 Dec; 301(6):F1326-33. PMID: 21921021.
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Zhang Y, Naggar JC, Welzig CM, Beasley D, Moulton KS, Park HJ, Galper JB. Simvastatin inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice: possible role of ERK. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1764-71. PMID: 19729613.
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Romeo GR, Moulton KS, Kazlauskas A. Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse. Circ Res. 2007 Aug 17; 101(4):357-67. PMID: 17615372.
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Moulton KS, Olsen BR, Sonn S, Fukai N, Zurakowski D, Zeng X. Loss of collagen XVIII enhances neovascularization and vascular permeability in atherosclerosis. Circulation. 2004 Sep 07; 110(10):1330-6. PMID: 15313955.
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Yu Y, Moulton KS, Khan MK, Vineberg S, Boye E, Davis VM, O'Donnell PE, Bischoff J, Milstone DS. E-selectin is required for the antiangiogenic activity of endostatin. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8005-10. PMID: 15148373.
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Moulton KS, Vakili K, Zurakowski D, Soliman M, Butterfield C, Sylvin E, Lo KM, Gillies S, Javaherian K, Folkman J. Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4736-41. PMID: 12682294.
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Moulton KS, Heller E, Konerding MA, Flynn E, Palinski W, Folkman J. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation. 1999 Apr 06; 99(13):1726-32. PMID: 10190883.
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Horvai A, Palinski W, Wu H, Moulton KS, Kalla K, Glass CK. Scavenger receptor A gene regulatory elements target gene expression to macrophages and to foam cells of atherosclerotic lesions. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5391-5. PMID: 7777517.
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Jackman WM, Wang XZ, Friday KJ, Fitzgerald DM, Roman C, Moulton K, Margolis PD, Bowman AJ, Kuck KH, Naccarelli GV, et al. Catheter ablation of atrioventricular junction using radiofrequency current in 17 patients. Comparison of standard and large-tip catheter electrodes. Circulation. 1991 May; 83(5):1562-76. PMID: 2022016.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1995 | 1 | 1999 | 1 | 2003 | 1 | 2004 | 2 | 2007 | 1 | 2009 | 1 | 2011 | 1 | 2014 | 1 | 2016 | 1 | 2018 | 2 | 2019 | 1 | 2020 | 2 | 2021 | 1 | 2022 | 4 | 2023 | 4 | 2024 | 1 |
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