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Amy R Brooks-Kayal

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    K08NS001936     (BROOKS-KAYAL, AMY R.)Jan 1, 1997 - Dec 31, 2002
    NIH/NINDS
    DEVELOPMENTAL REGULATION OF GABAA RECEPTOR EXPRESSION
    Role: Principal Investigator

    R01NS038595     (BROOKS-KAYAL, AMY R.)Apr 1, 1999 - Nov 30, 2010
    NIH/NINDS
    GABA (A) Receptors in Developmental Epileptogenesis
    Role: Principal Investigator

    R01NS051710     (BROOKS-KAYAL, AMY R.)Apr 1, 2005 - Jun 30, 2019
    NIH/NINDS
    GABA(A) Receptor Subunit Regulation in Epileptogenesis
    Role: Principal Investigator

    R21NS083057     (BROOKS-KAYAL, AMY R.)Jan 1, 2014 - Dec 31, 2015
    NIH/NINDS
    Development of novel JAK/STAT inhibitors for Epilepsy prevention and treatment
    Role: Principal Investigator

    K12NS089417     (BENKE, TIMOTHY A)Jul 1, 2015 - Jun 30, 2020
    NIH/NINDS
    Colorado Neurological Sciences Academic Development Award (NSADA)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ravizza T, Onat FY, Brooks-Kayal AR, Depaulis A, Galanopoulou AS, Mazarati A, Numis AL, Sankar R, Friedman A. WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities. Epilepsia. 2017 Mar; 58(3):331-342. PMID: 28035782.
      View in: PubMed
    2. Thomas AX, Cruz Del Angel Y, Gonzalez MI, Carrel AJ, Carlsen J, Lam PM, Hempstead BL, Russek SJ, Brooks-Kayal AR. Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery. eNeuro. 2016 Jan-Feb; 3(1). PMID: 27057559; PMCID: PMC4814566.
    3. Raible DJ, Frey LC, Del Angel YC, Carlsen J, Hund D, Russek SJ, Smith B, Brooks-Kayal AR. JAK/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI. Exp Neurol. 2015 Sep; 271:445-56. PMID: 26172316.
      View in: PubMed
    4. González MI, Grabenstatter HL, Cea-Del Rio CA, Cruz Del Angel Y, Carlsen J, Laoprasert RP, White AM, Huntsman MM, Brooks-Kayal A. Seizure-related regulation of GABAA receptors in spontaneously epileptic rats. Neurobiol Dis. 2015 May; 77:246-56. PMID: 25769812; PMCID: PMC4415851.
    5. Grabenstatter HL, Cogswell M, Cruz Del Angel Y, Carlsen J, Gonzalez MI, Raol YH, Russek SJ, Brooks-Kayal AR. Effect of spontaneous seizures on GABAA receptor a4 subunit expression in an animal model of temporal lobe epilepsy. Epilepsia. 2014 Nov; 55(11):1826-33. PMID: 25223733; PMCID: PMC4596257.
    6. Simonato M, Brooks-Kayal AR, Engel J, Galanopoulou AS, Jensen FE, Moshé SL, O'Brien TJ, Pitkanen A, Wilcox KS, French JA. The challenge and promise of anti-epileptic therapy development in animal models. Lancet Neurol. 2014 Sep; 13(9):949-60. PMID: 25127174; PMCID: PMC5003536.
    7. Raible DJ, Frey LC, Brooks-Kayal AR. Effects of JAK2-STAT3 signaling after cerebral insults. JAKSTAT. 2014; 3:e29510. PMID: 25105066; PMCID: PMC4124058.
    8. Pearl PL, McConnell ER, Fernandez R, Brooks-Kayal A. Survey of the professors of child neurology: neurology versus pediatrics home for child neurology. Pediatr Neurol. 2014 Sep; 51(3):344-7. PMID: 24993248.
      View in: PubMed
    9. Grabenstatter HL, Carlsen J, Raol YH, Yang T, Hund D, Cruz Del Angel Y, White AM, Gonzalez MI, Longo FM, Russek SJ, Brooks-Kayal AR. Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. J Neurosci Res. 2014 Oct; 92(10):1307-18. PMID: 24801281; PMCID: PMC4134742.
    10. Scharfman HE, Brooks-Kayal AR. Is plasticity of GABAergic mechanisms relevant to epileptogenesis? Adv Exp Med Biol. 2014; 813:133-50. PMID: 25012373; PMCID: PMC4370216.
    11. Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. Authors' response to letter by A. Mazarati. Epilepsia. 2013 Dec; 54(12):2229-30. PMID: 24304440.
      View in: PubMed
    12. Grabenstatter HL, Del Angel YC, Carlsen J, Wempe MF, White AM, Cogswell M, Russek SJ, Brooks-Kayal AR. The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Neurobiol Dis. 2014 Feb; 62:73-85. PMID: 24051278; PMCID: PMC3908775.
    13. Arndt DH, Lerner JT, Matsumoto JH, Madikians A, Yudovin S, Valino H, McArthur DL, Wu JY, Leung M, Buxey F, Szeliga C, Van Hirtum-Das M, Sankar R, Brooks-Kayal A, Giza CC. Subclinical early posttraumatic seizures detected by continuous EEG monitoring in a consecutive pediatric cohort. Epilepsia. 2013 Oct; 54(10):1780-8. PMID: 24032982; PMCID: PMC4439105.
    14. Pitkänen A, Nehlig A, Brooks-Kayal AR, Dudek FE, Friedman D, Galanopoulou AS, Jensen FE, Kaminski RM, Kapur J, Klitgaard H, Löscher W, Mody I, Schmidt D. Issues related to development of antiepileptogenic therapies. Epilepsia. 2013 Aug; 54 Suppl 4:35-43. PMID: 23909852; PMCID: PMC3740390.
    15. Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia. 2013 Aug; 54 Suppl 4:44-60. PMID: 23909853; PMCID: PMC3924317.
    16. González MI, Cruz Del Angel Y, Brooks-Kayal A. Down-regulation of gephyrin and GABAA receptor subunits during epileptogenesis in the CA1 region of hippocampus. Epilepsia. 2013 Apr; 54(4):616-24. PMID: 23294024; PMCID: PMC3618570.
    17. Grabenstatter HL, Russek SJ, Brooks-Kayal AR. Molecular pathways controlling inhibitory receptor expression. Epilepsia. 2012 Dec; 53 Suppl 9:71-8. PMID: 23216580; PMCID: PMC3776022.
    18. Raible DJ, Frey LC, Cruz Del Angel Y, Russek SJ, Brooks-Kayal AR. GABA(A) receptor regulation after experimental traumatic brain injury. J Neurotrauma. 2012 Nov 01; 29(16):2548-54. PMID: 22827467; PMCID: PMC3495117.
    19. Chapman KE, Raol YH, Brooks-Kayal A. Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette. Eur J Neurosci. 2012 Jun; 35(12):1857-65. PMID: 22708596; PMCID: PMC3383637.
    20. Raol YH, Brooks-Kayal AR. Experimental models of seizures and epilepsies. Prog Mol Biol Transl Sci. 2012; 105:57-82. PMID: 22137429.
      View in: PubMed
    21. Kim JH, Roberts DS, Hu Y, Lau GC, Brooks-Kayal AR, Farb DH, Russek SJ. Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons. J Neurochem. 2012 Jan; 120(2):210-9. PMID: 22035109.
      View in: PubMed
    22. González MI, Brooks-Kayal A. Altered GABA(A) receptor expression during epileptogenesis. Neurosci Lett. 2011 Jun 27; 497(3):218-22. PMID: 21376781; PMCID: PMC3134403.
    23. Brooks-Kayal A. Molecular mechanisms of cognitive and behavioral comorbidities of epilepsy in children. Epilepsia. 2011 Jan; 52 Suppl 1:13-20. PMID: 21214535; PMCID: PMC3058310.
    24. Baram TZ, Jensen FE, Brooks-Kayal A. Does acquired epileptogenesis in the immature brain require neuronal death. Epilepsy Curr. 2011 Jan; 11(1):21-6. PMID: 21461261; PMCID: PMC3063568.
    25. Lemos JC, Zhang G, Walsh T, Kirby LG, Akanwa A, Brooks-Kayal A, Beck SG. Stress-hyperresponsive WKY rats demonstrate depressed dorsal raphe neuronal excitability and dysregulated CRF-mediated responses. Neuropsychopharmacology. 2011 Mar; 36(4):721-34. PMID: 21160465; PMCID: PMC3055727.
    26. Kedia S, Stroud B, Parsons J, Schreiner T, Curtis DJ, Bagdure D, Brooks-Kayal AR, Glode MP, Dominguez SR. Pediatric neurological complications of 2009 pandemic influenza A (H1N1). Arch Neurol. 2011 Apr; 68(4):455-62. PMID: 21149805; PMCID: PMC3096015.
    27. Brooks-Kayal A. Epilepsy and autism spectrum disorders: are there common developmental mechanisms? Brain Dev. 2010 Oct; 32(9):731-8. PMID: 20570072.
      View in: PubMed
    28. McRae PA, Baranov E, Sarode S, Brooks-Kayal AR, Porter BE. Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure. Neurobiol Dis. 2010 Sep; 39(3):439-48. PMID: 20493259; PMCID: PMC2935142.
    29. Marsh E, Fulp C, Gomez E, Nasrallah I, Minarcik J, Sudi J, Christian SL, Mancini G, Labosky P, Dobyns W, Brooks-Kayal A, Golden JA. Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females. Brain. 2009 Jun; 132(Pt 6):1563-76. PMID: 19439424; PMCID: PMC2685924.
    30. Brooks-Kayal AR, Raol YH, Russek SJ. Alteration of epileptogenesis genes. Neurotherapeutics. 2009 Apr; 6(2):312-8. PMID: 19332325; PMCID: PMC2700027.
    31. Raol YH, Lapides DA, Keating JG, Brooks-Kayal AR, Cooper EC. A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol. 2009 Mar; 65(3):326-36. PMID: 19334075; PMCID: PMC2666110.
    32. Jacobs MP, Leblanc GG, Brooks-Kayal A, Jensen FE, Lowenstein DH, Noebels JL, Spencer DD, Swann JW. Curing epilepsy: progress and future directions. Epilepsy Behav. 2009 Mar; 14(3):438-45. PMID: 19341977; PMCID: PMC2822433.
    33. Lund IV, Hu Y, Raol YH, Benham RS, Faris R, Russek SJ, Brooks-Kayal AR. BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway. Sci Signal. 2008 Oct 14; 1(41):ra9. PMID: 18922788; PMCID: PMC2651003.
    34. Marsh ED, Minarcik J, Campbell K, Brooks-Kayal AR, Golden JA. FACS-array gene expression analysis during early development of mouse telencephalic interneurons. Dev Neurobiol. 2008 Mar; 68(4):434-45. PMID: 18172891.
      View in: PubMed
    35. Hu Y, Lund IV, Gravielle MC, Farb DH, Brooks-Kayal AR, Russek SJ. Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor. J Biol Chem. 2008 Apr 04; 283(14):9328-40. PMID: 18180303; PMCID: PMC2431045.
    36. Marsh ED, Brooks-Kayal AR, Porter BE. Seizures and antiepileptic drugs: does exposure alter normal brain development? Epilepsia. 2006 Dec; 47(12):1999-2010. PMID: 17201696.
      View in: PubMed
    37. Raol YH, Lund IV, Bandyopadhyay S, Zhang G, Roberts DS, Wolfe JH, Russek SJ, Brooks-Kayal AR. Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. J Neurosci. 2006 Nov 01; 26(44):11342-6. PMID: 17079662.
      View in: PubMed
    38. Raol YH, Zhang G, Lund IV, Porter BE, Maronski MA, Brooks-Kayal AR. Increased GABA(A)-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticus. Epilepsia. 2006 Oct; 47(10):1665-73. PMID: 17054689.
      View in: PubMed
    39. Roberts DS, Hu Y, Lund IV, Brooks-Kayal AR, Russek SJ. Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons. J Biol Chem. 2006 Oct 06; 281(40):29431-5. PMID: 16901909.
      View in: PubMed
    40. Porter BE, Cui XN, Brooks-Kayal AR. Status epilepticus differentially alters AMPA and kainate receptor subunit expression in mature and immature dentate granule neurons. Eur J Neurosci. 2006 Jun; 23(11):2857-63. PMID: 16819974.
      View in: PubMed
    41. Frye CA, Rhodes ME, Raol YH, Brooks-Kayal AR. Early postnatal stimulation alters pregnane neurosteroids in the hippocampus. Psychopharmacology (Berl). 2006 Jun; 186(3):343-50. PMID: 16491430; PMCID: PMC3608213.
    42. Roberts DS, Raol YH, Bandyopadhyay S, Lund IV, Budreck EC, Passini MA, Passini MJ, Wolfe JH, Brooks-Kayal AR, Russek SJ. Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11894-9. PMID: 16091474; PMCID: PMC1187961.
    43. Porter BE, Zhang G, Celix J, Hsu FC, Raol YH, Telfeian A, Gallagher PR, Coulter DA, Brooks-Kayal AR. Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients. Neurobiol Dis. 2005 Apr; 18(3):484-91. PMID: 15755675.
      View in: PubMed
    44. Raizen DM, Brooks-Kayal A, Steinkrauss L, Tennekoon GI, Stanley CA, Kelly A. Central nervous system hyperexcitability associated with glutamate dehydrogenase gain of function mutations. J Pediatr. 2005 Mar; 146(3):388-94. PMID: 15756227.
      View in: PubMed
    45. Raol YH, Zhang G, Budreck EC, Brooks-Kayal AR. Long-term effects of diazepam and phenobarbital treatment during development on GABA receptors, transporters and glutamic acid decarboxylase. Neuroscience. 2005; 132(2):399-407. PMID: 15802192.
      View in: PubMed
    46. Brooks-Kayal AR. Rearranging receptors. Epilepsia. 2005; 46 Suppl 7:29-38. PMID: 16201993.
      View in: PubMed
    47. Kao A, Mariani J, McDonald-McGinn DM, Maisenbacher MK, Brooks-Kayal AR, Zackai EH, Lynch DR. Increased prevalence of unprovoked seizures in patients with a 22q11.2 deletion. Am J Med Genet A. 2004 Aug 15; 129A(1):29-34. PMID: 15266612.
      View in: PubMed
    48. Porter BE, Maronski M, Brooks-Kayal AR. Fate of newborn dentate granule cells after early life status epilepticus. Epilepsia. 2004 Jan; 45(1):13-9. PMID: 14692902.
      View in: PubMed
    49. Zhang G, Raol YH, Hsu FC, Coulter DA, Brooks-Kayal AR. Effects of status epilepticus on hippocampal GABAA receptors are age-dependent. Neuroscience. 2004; 125(2):299-303. PMID: 15062973; PMCID: PMC2441871.
    50. Zhang G, Raol YS, Hsu FC, Brooks-Kayal AR. Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility. J Neurochem. 2004 Jan; 88(1):91-101. PMID: 14675153.
      View in: PubMed
    51. Hsu FC, Zhang GJ, Raol YS, Valentino RJ, Coulter DA, Brooks-Kayal AR. Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12213-8. PMID: 14530409; PMCID: PMC218738.
    52. Raol YS, Budreck EC, Brooks-Kayal AR. Epilepsy after early-life seizures can be independent of hippocampal injury. Ann Neurol. 2003 Apr; 53(4):503-11. PMID: 12666118.
      View in: PubMed
    53. Porter BE, Brooks-Kayal A, Golden JA. Disorders of cortical development and epilepsy. Arch Neurol. 2002 Mar; 59(3):361-5. PMID: 11890838.
      View in: PubMed
    54. Crino PB, Jin H, Shumate MD, Robinson MB, Coulter DA, Brooks-Kayal AR. Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy. Epilepsia. 2002 Mar; 43(3):211-8. PMID: 11906504; PMCID: PMC2441873.
    55. Brooks-Kayal AR, Shumate MD, Jin H, Rikhter TY, Kelly ME, Coulter DA. gamma-Aminobutyric acid(A) receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal development. J Neurochem. 2001 Jun; 77(5):1266-78. PMID: 11389177.
      View in: PubMed
    56. Raol YH, Lynch DR, Brooks-Kayal AR. Role of excitatory amino acids in developmental epilepsies. Ment Retard Dev Disabil Res Rev. 2001; 7(4):254-60. PMID: 11754519.
      View in: PubMed
    57. Bergqvist AG, Chee CM, Lutchka LM, Brooks-Kayal AR. Treatment of acquired epileptic aphasia with the ketogenic diet. J Child Neurol. 1999 Nov; 14(11):696-701. PMID: 10593544.
      View in: PubMed
    58. Brooks-Kayal AR, Shumate MD, Jin H, Lin DD, Rikhter TY, Holloway KL, Coulter DA. Human neuronal gamma-aminobutyric acid(A) receptors: coordinated subunit mRNA expression and functional correlates in individual dentate granule cells. J Neurosci. 1999 Oct 01; 19(19):8312-8. PMID: 10493732.
      View in: PubMed
    59. Strober JB, Zuppa A, Brooks-Kayal AR. A 15-year-old with back pain, fever, and leg numbness. Semin Pediatr Neurol. 1999 Sep; 6(3):190-4; discussion 194-5. PMID: 10522338.
      View in: PubMed
    60. Dlugos DJ, Brooks-Kayal AR. A 4-year-old with pica, progressive incoordination, and decreased responsiveness. Semin Pediatr Neurol. 1999 Sep; 6(3):164-7. PMID: 10522333.
      View in: PubMed
    61. Dlugos DJ, Moss EM, Duhaime AC, Brooks-Kayal AR. Language-related cognitive declines after left temporal lobectomy in children. Pediatr Neurol. 1999 Jul; 21(1):444-9. PMID: 10428428.
      View in: PubMed
    62. Brooks-Kayal AR, Shumate MD, Jin H, Rikhter TY, Coulter DA. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat Med. 1998 Oct; 4(10):1166-72. PMID: 9771750.
      View in: PubMed
    63. Brooks-Kayal AR, Munir M, Jin H, Robinson MB. The glutamate transporter, GLT-1, is expressed in cultured hippocampal neurons. Neurochem Int. 1998 Aug; 33(2):95-100. PMID: 9761452.
      View in: PubMed
    64. Brooks-Kayal AR, Jin H, Price M, Dichter MA. Developmental expression of GABA(A) receptor subunit mRNAs in individual hippocampal neurons in vitro and in vivo. J Neurochem. 1998 Mar; 70(3):1017-28. PMID: 9489721.
      View in: PubMed
    65. Amin J, Brooks-Kayal A, Weiss DS. Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors. Mol Pharmacol. 1997 May; 51(5):833-41. PMID: 9145922.
      View in: PubMed
    66. Brooks-Kayal AR, Liu GT, Menacker SJ, Heher KL, Katowitz JA, Bilaniuk LT. Tonic pupil and orbital glial-neural hamartoma in infancy. Am J Ophthalmol. 1995 Jun; 119(6):809-11. PMID: 7785705.
      View in: PubMed
    67. Brooks-Kayal AR, Pritchett DB. Developmental changes in human gamma-aminobutyric acidA receptor subunit composition. Ann Neurol. 1993 Nov; 34(5):687-93. PMID: 7694542.
      View in: PubMed
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