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Colm Collins

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Overview 
    Collapse overview
    The goal of my research is to drive the development of novel therapeutic strategies to target both symptoms and underlying etiology of inflammatory bowel disease (IBD) an incurable disease which affects 1.4 million people in the US. While focused primarily on IBD, our research also has broader implications for a range of inflammatory conditions including arthritis, multiple sclerosis and diabetes.

    Collapse Research 
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    K01DK099403     (COLLINS, COLM)Aug 1, 2013 - May 31, 2018
    Selective MicoRNA modification to enhance regulatory T cell function in IBD
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF. C/EBPß Deletion Promotes Expansion of Functionally Poor Intestinal Regulatory T Cells. J Crohns Colitis. 2019 Jan 09. PMID: 30624617.
      View in: PubMed
    2. Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF. C/EBPß Deletion Promotes Expansion of Poorly Functional Intestinal Regulatory T Cells. J Crohns Colitis. 2018 Nov 28; 12(12):1475-1485. PMID: 30085016.
      View in: PubMed
    3. Aherne CM, Collins CB, Rapp CR, Olli KE, Perrenoud L, Jedlicka P, Bowser JL, Mills TW, Karmouty-Quintana H, Blackburn MR, Eltzschig HK. Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation. JCI Insight. 2018 Oct 18; 3(20). PMID: 30333323.
      View in: PubMed
    4. Sanctuary MR, Huang RH, Jones AA, Luck ME, Aherne CM, Jedlicka P, de Zoeten EF, Collins CB. miR-106a deficiency attenuates inflammation in murine IBD models. Mucosal Immunol. 2019 Jan; 12(1):200-211. PMID: 30327532.
      View in: PubMed
    5. Leinwand KL, Jones AA, Huang RH, Jedlicka P, Kao DJ, de Zoeten EF, Ghosh S, Moaddel R, Wehkamp J, Ostaff MJ, Bader J, Aherne CM, Collins CB. Cannabinoid Receptor-2 Ameliorates Inflammation in Murine Model of Crohn's Disease. J Crohns Colitis. 2017 Oct 27; 11(11):1369-1380. PMID: 28981653.
      View in: PubMed
    6. MacManus CF, Collins CB, Nguyen TT, Alfano RW, Jedlicka P, de Zoeten EF. VEN-120, a Recombinant Human Lactoferrin, Promotes a Regulatory T Cell [Treg] Phenotype and Drives Resolution of Inflammation in Distinct Murine Models of Inflammatory Bowel Disease. J Crohns Colitis. 2017 Sep 01; 11(9):1101-1112. PMID: 28472424.
      View in: PubMed
    7. Leinwand KL, Gerich ME, Hoffenberg EJ, Collins CB. Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review. Inflamm Bowel Dis. 2017 02; 23(2):192-199. PMID: 28079617.
      View in: PubMed
    8. Hoffenberg EJ, Newman H, Collins C, Tarbell S, Leinwand K. Cannabis and Pediatric Inflammatory Bowel Disease: Change Blossoms a Mile High. J Pediatr Gastroenterol Nutr. 2017 02; 64(2):265-271. PMID: 27579692.
      View in: PubMed
    9. Neff CP, Rhodes ME, Arnolds KL, Collins CB, Donnelly J, Nusbacher N, Jedlicka P, Schneider JM, McCarter MD, Shaffer M, Mazmanian SK, Palmer BE, Lozupone CA. Diverse Intestinal Bacteria Contain Putative Zwitterionic Capsular Polysaccharides with Anti-inflammatory Properties. Cell Host Microbe. 2016 Oct 12; 20(4):535-547. PMID: 27693306.
      View in: PubMed
    10. Wehrmann F, Lavelle JC, Collins CB, Tinega AN, Thurman JM, Burnham EL, Simonian PL. ?d T cells protect against LPS-induced lung injury. J Leukoc Biol. 2016 Feb; 99(2):373-86. PMID: 26428678; PMCID: PMC4718194 [Available on 02/01/17].
    11. Isfort RW, Collins CB, Gerich ME. Response to Utomo et al. Am J Gastroenterol. 2015 Aug; 110(8):1245-6. PMID: 26263368.
      View in: PubMed
    12. Luck ME, Muljo SA, Collins CB. Prospects for Therapeutic Targeting of MicroRNAs in Human Immunological Diseases. J Immunol. 2015 Jun 01; 194(11):5047-52. PMID: 25980029.
      View in: PubMed
    13. McNamee EN, Masterson JC, Veny M, Collins CB, Jedlicka P, Byrne FR, Ng GY, Rivera-Nieves J. Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohn's-like murine ileitis. J Leukoc Biol. 2015 Jun; 97(6):1011-22. PMID: 25637591; PMCID: PMC4438744.
    14. Collins CB, Strassheim D, Aherne CM, Yeckes AR, Jedlicka P, de Zoeten EF. Targeted inhibition of heat shock protein 90 suppresses tumor necrosis factor-a and ameliorates murine intestinal inflammation. Inflamm Bowel Dis. 2014 Apr; 20(4):685-94. PMID: 24552830.
      View in: PubMed
    15. Collins CB, Rivera-Nieves J. Broadening the paradigm of mucosal dendritic cell-mediated induction of gut-homing on T cells. Gastroenterology. 2014 Mar; 146(3):854-5. PMID: 24468172.
      View in: PubMed
    16. Kominsky DJ, Campbell EL, Ehrentraut SF, Wilson KE, Kelly CJ, Glover LE, Collins CB, Bayless AJ, Saeedi B, Dobrinskikh E, Bowers BE, MacManus CF, Müller W, Colgan SP, Bruder D. IFN-?-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia. J Immunol. 2014 Feb 01; 192(3):1267-76. PMID: 24367025; PMCID: PMC4042245.
    17. Collins CB, Aherne CM, Ehrentraut SF, Gerich ME, McNamee EN, McManus MC, Lebsack MD, Jedlicka P, Azam T, de Zoeten EF, Dinarello CA, Rivera-Nieves J. Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis. Inflamm Bowel Dis. 2013 Aug; 19(9):1964-73. PMID: 23835442.
      View in: PubMed
    18. Aherne CM, Collins CB, Eltzschig HK. Netrin-1 guides inflammatory cell migration to control mucosal immune responses during intestinal inflammation. Tissue Barriers. 2013 Apr 01; 1(2):e24957. PMID: 24665394; PMCID: PMC3879190.
    19. McNamee EN, Masterson JC, Jedlicka P, Collins CB, Williams IR, Rivera-Nieves J. Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis. Gut. 2013 Jan; 62(1):53-62. PMID: 22267601; PMCID: PMC3726216.
    20. Collins CB, Aherne CM, McNamee EN, Lebsack MD, Eltzschig H, Jedlicka P, Rivera-Nieves J. Flt3 ligand expands CD103? dendritic cells and FoxP3? T regulatory cells, and attenuates Crohn's-like murine ileitis. Gut. 2012 Aug; 61(8):1154-62. PMID: 22068168; PMCID: PMC3684390.
    21. Collins CB, Aherne CM, Kominsky D, McNamee EN, Lebsack MD, Eltzschig H, Jedlicka P, Rivera-Nieves J. Retinoic acid attenuates ileitis by restoring the balance between T-helper 17 and T regulatory cells. Gastroenterology. 2011 Nov; 141(5):1821-31. PMID: 22027263; PMCID: PMC3684415.
    22. McNamee EN, Masterson JC, Jedlicka P, McManus M, Grenz A, Collins CB, Nold MF, Nold-Petry C, Bufler P, Dinarello CA, Rivera-Nieves J. Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16711-6. PMID: 21873195; PMCID: PMC3189085.
    23. Aherne CM, Collins CB, Masterson JC, Tizzano M, Boyle TA, Westrich JA, Parnes JA, Furuta GT, Rivera-Nieves J, Eltzschig HK. Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis. Gut. 2012 May; 61(5):695-705. PMID: 21813473; PMCID: PMC3322588.
    24. Kominsky DJ, Keely S, MacManus CF, Glover LE, Scully M, Collins CB, Bowers BE, Campbell EL, Colgan SP. An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. J Immunol. 2011 Jun 01; 186(11):6505-14. PMID: 21515785; PMCID: PMC3383860.
    25. McNamee EN, Wermers JD, Masterson JC, Collins CB, Lebsack MD, Fillon S, Robinson ZD, Grenawalt J, Lee JJ, Jedlicka P, Furuta GT, Rivera-Nieves J. Novel model of TH2-polarized chronic ileitis: the SAMP1 mouse. Inflamm Bowel Dis. 2010 May; 16(5):743-52. PMID: 19856411.
      View in: PubMed
    26. McNamee EN, Collins CB, Lebsack MD, Rivera-Nieves J. Cell-specific inhibition of p38alpha as a therapeutic strategy for inflammatory bowel disease. Gastroenterology. 2010 Apr; 138(4):1237-9. PMID: 20184972; PMCID: PMC4414012.
    27. Collins CB, McNamee EN, Wermers JD, Lebsack MD, Rivera-Nieves J. Chemokine decoy receptor D6 in inflammatory bowel disease (IBD) and IBD-associated colon cancer. Gut. 2010 Feb; 59(2):151-2. PMID: 20176637; PMCID: PMC4418614.
    28. Fanning RA, Campion DP, Collins CB, Keely S, Briggs LP, O'Connor JJ, Carey MF. A comparison of the inhibitory effects of bupivacaine and levobupivacaine on isolated human pregnant myometrium contractility. Anesth Analg. 2008 Oct; 107(4):1303-7. PMID: 18806044.
      View in: PubMed
    29. Collins CB, Ho J, Wilson TE, Wermers JD, Tlaxca JL, Lawrence MB, Solga M, Lannigan J, Rivera-Nieves J. CD44 deficiency attenuates chronic murine ileitis. Gastroenterology. 2008 Dec; 135(6):1993-2002. PMID: 18854186; PMCID: PMC4418802.
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