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Hang Hubert Yin

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentChemistry & Biochemistry
Phone303/492-6786
ORCID ORCID Icon0000-0002-9762-4818 Additional info

    Collapse Research 
    Collapse research activities and funding
    R21CA138373     (MARTIN, JENNIFER M)Apr 10, 2009 - Mar 31, 2012
    NIH/NCI
    Probing EBV-LMP-1's Transmembrane Activation Domain with Synthetic Peptide Antago
    Role: Co-Principal Investigator

    R03DA025740     (YIN, HANG HUBERT)May 15, 2009 - Apr 30, 2011
    NIH/NIDA
    Transforming Clinical Pain Control by Targeting a Novel Non-Neuronal Receptor
    Role: Principal Investigator

    R21DA026950     (YIN, HANG HUBERT)Jul 1, 2009 - Jun 30, 2012
    NIH/NIDA
    Optimizing the Clinical Efficacy of Opioids by TLR4 Blockade
    Role: Principal Investigator

    R03DA027977     (YIN, HANG HUBERT)Sep 1, 2009 - Aug 31, 2011
    NIH/NIDA
    Probing Opioid-Induced Glial Activation with Peptide Antagonists
    Role: Principal Investigator

    R21NS067425     (YIN, HANG HUBERT)Sep 30, 2009 - Aug 31, 2012
    NIH/NINDS
    Developing Small-Molecule Probes for Opioid-Induced Glial Activation
    Role: Principal Investigator

    R01GM101279     (YIN, HANG HUBERT)Dec 5, 2012 - Nov 30, 2017
    NIH/NIGMS
    Exogenous Chemical Probes of TLR-Mediated Neuroinflammation
    Role: Principal Investigator

    R01GM103843     (YIN, HANG HUBERT)Sep 1, 2013 - Apr 30, 2017
    NIH/NIGMS
    Dissecting Cell Signaling Mediated by Protein-Protein Interactions in Membranes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang L, Dewan V, Yin H. Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities. J Med Chem. 2017 Jun 06. PMID: 28537730.
      View in: PubMed
    2. Smith CE, Soti S, Jones TA, Nakagawa A, Xue D, Yin H. Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol. 2017 Mar 16; 24(3):281-292. PMID: 28238723.
      View in: PubMed
    3. de Jesus AJ, Yin H. Computational Design of Membrane Curvature-Sensing Peptides. Methods Mol Biol. 2017; 1529:417-437. PMID: 27914065.
      View in: PubMed
    4. Das N, Dewan V, Grace PM, Gunn RJ, Tamura R, Tzarum N, Watkins LR, Wilson IA, Yin H. HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia. Cell Rep. 2016 Oct 18; 17(4):1128-1140. PMID: 27760316.
      View in: PubMed
    5. Grace PM, Strand KA, Galer EL, Urban DJ, Wang X, Baratta MV, Fabisiak TJ, Anderson ND, Cheng K, Greene LI, Berkelhammer D, Zhang Y, Ellis AL, Yin HH, Campeau S, Rice KC, Roth BL, Maier SF, Watkins LR. Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proc Natl Acad Sci U S A. 2016 06 14; 113(24):E3441-50. PMID: 27247388; PMCID: PMC4914184 [Available on 12/14/16].
    6. de Jesus AJ, White OR, Flynn AD, Yin H. Determinants of Curvature-Sensing Behavior for MARCKS-Fragment Peptides. Biophys J. 2016 May 10; 110(9):1980-92. PMID: 27166806; PMCID: PMC4939528 [Available on 05/10/17].
    7. Flynn AD, Yin H. Lipid-Targeting Peptide Probes for Extracellular Vesicles. J Cell Physiol. 2016 Nov; 231(11):2327-32. PMID: 26909741.
      View in: PubMed
    8. Yang H, Chen YZ, Zhang Y, Wang X, Zhao X, Godfroy JI, Liang Q, Zhang M, Zhang T, Yuan Q, Ann Royal M, Driscoll M, Xia NS, Yin H, Xue D. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nat Commun. 2015 Jan 07; 6:5717. PMID: 25564762; PMCID: PMC4306451.
    9. Smith C, Wang X, Yin H. Caspases come together over LPS. Trends Immunol. 2015 Feb; 36(2):59-61. PMID: 25573609; PMCID: PMC4323722.
    10. Beninson LA, Brown PN, Loughridge AB, Saludes JP, Maslanik T, Hills AK, Woodworth T, Craig W, Yin H, Fleshner M. Acute stressor exposure modifies plasma exosome-associated heat shock protein 72 (Hsp72) and microRNA (miR-142-5p and miR-203). PLoS One. 2014; 9(9):e108748. PMID: 25259839; PMCID: PMC4178201.
    11. Morton LA, Tamura R, de Jesus AJ, Espinoza A, Yin H. Biophysical investigations with MARCKS-ED: dissecting the molecular mechanism of its curvature sensing behaviors. Biochim Biophys Acta. 2014 Dec; 1838(12):3137-44. PMID: 25195712; PMCID: PMC4194239.
    12. Csakai A, Smith C, Davis E, Martinko A, Coulup S, Yin H. Saccharin derivatives as inhibitors of interferon-mediated inflammation. J Med Chem. 2014 Jun 26; 57(12):5348-55. PMID: 24897296; PMCID: PMC4079330.
    13. Kastelowitz N, Yin H. Exosomes and microvesicles: identification and targeting by particle size and lipid chemical probes. Chembiochem. 2014 May 05; 15(7):923-8. PMID: 24740901; PMCID: PMC4098878.
    14. de Jesus AJ, Kastelowitz N, Yin H. Changes in lipid density induce membrane curvature. RSC Adv. 2013 Sep 07; 3(33):13622-13625. PMID: 23930220.
      View in: PubMed
    15. Wang X, Smith C, Yin H. Targeting Toll-like receptors with small molecule agents. Chem Soc Rev. 2013 Jun 21; 42(12):4859-66. PMID: 23503527; PMCID: PMC3665707.
    16. Saludes JP, Morton LA, Coulup SK, Fiorini Z, Cook BM, Beninson L, Chapman ER, Fleshner M, Yin H. Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles. Mol Biosyst. 2013 Aug; 9(8):2005-9. PMID: 23715428; PMCID: PMC3764994.
    17. Wang X, Grace PM, Pham MN, Cheng K, Strand KA, Smith C, Li J, Watkins LR, Yin H. Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain. FASEB J. 2013 Jul; 27(7):2713-22. PMID: 23568774; PMCID: PMC3688759.
    18. Li J, Wang X, Zhang F, Yin H. Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases. Pharmacol Ther. 2013 Jun; 138(3):441-51. PMID: 23531543; PMCID: PMC3686650.
    19. Lee J, Sammond DW, Fiorini Z, Saludes JP, Resch MG, Hao B, Wang W, Yin H, Liu X. Computationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4). Chembiochem. 2013 Mar 04; 14(4):445-51. PMID: 23401343; PMCID: PMC4028150.
    20. Lluis MW, Yin H. Engineering and utilization of reporter cell lines for cell-based assays of transmembrane receptors. Methods Mol Biol. 2013; 1063:211-25. PMID: 23975780.
      View in: PubMed
    21. Godfroy JI, Roostan M, Moroz YS, Korendovych IV, Yin H. Isolated Toll-like receptor transmembrane domains are capable of oligomerization. PLoS One. 2012; 7(11):e48875. PMID: 23155421; PMCID: PMC3498381.
    22. Brown PN, Yin H. PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells. Chem Commun (Camb). 2013 May 14; 49(39):4415-7. PMID: 23111503; PMCID: PMC3593954.
    23. Morton LA, Yang H, Saludes JP, Fiorini Z, Beninson L, Chapman ER, Fleshner M, Xue D, Yin H. MARCKS-ED peptide as a curvature and lipid sensor. ACS Chem Biol. 2013 Jan 18; 8(1):218-25. PMID: 23075500; PMCID: PMC3548944.
    24. Wang X, Fiorini Z, Smith C, Zhang Y, Li J, Watkins LR, Yin H. Repositioning antimicrobial agent pentamidine as a disruptor of the lateral interactions of transmembrane domain 5 of EBV latent membrane protein 1. PLoS One. 2012; 7(10):e47703. PMID: 23094078; PMCID: PMC3477141.
    25. Yin H. Constrained peptides as miniature protein structures. ISRN Biochem. 2012; 2012:692190. PMID: 25969758; PMCID: PMC4392992.
    26. Cheng K, Wang X, Zhang S, Yin H. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem Int Ed Engl. 2012 Dec 03; 51(49):12246-9. PMID: 22969053; PMCID: PMC3510333.
    27. Zhang S, Cheng K, Wang X, Yin H. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem. 2012 Oct 15; 20(20):6073-9. PMID: 22985959; PMCID: PMC3517184.
    28. Saludes JP, Morton LA, Ghosh N, Beninson LA, Chapman ER, Fleshner M, Yin H. Detection of highly curved membrane surfaces using a cyclic peptide derived from synaptotagmin-I. ACS Chem Biol. 2012 Oct 19; 7(10):1629-35. PMID: 22769435; PMCID: PMC3477269.
    29. Morton LA, Saludes JP, Yin H. Constant pressure-controlled extrusion method for the preparation of Nano-sized lipid vesicles. J Vis Exp. 2012 Jun 22; (64). PMID: 22760481; PMCID: PMC3471306.
    30. Wang X, Saludes JP, Zhao TX, Csakai A, Fiorini Z, Chavez SA, Li J, Lee GI, Varga K, Yin H. Targeting the lateral interactions of transmembrane domain 5 of Epstein-Barr virus latent membrane protein 1. Biochim Biophys Acta. 2012 Sep; 1818(9):2282-9. PMID: 22609737; PMCID: PMC3378808.
    31. Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas J, Cheng K, Reddy A, Somogyi AA, Hutchinson MR, Watkins LR, Yin H. Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6325-30. PMID: 22474354; PMCID: PMC3341002.
    32. Joce C, Wiener AA, Yin H. Multi-Tox: application of the ToxR-transcriptional reporter assay to the study of multi-pass protein transmembrane domain oligomerization. Biochim Biophys Acta. 2011 Dec; 1808(12):2948-53. PMID: 21791200; PMCID: PMC3195870.
    33. Liu L, Ghosh N, Slivka PF, Fiorini Z, Hutchinson MR, Watkins LR, Yin H. An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo. Chembiochem. 2011 Aug 16; 12(12):1827-31. PMID: 21678541; PMCID: PMC3374877.
    34. Chavez SA, Martinko AJ, Lau C, Pham MN, Cheng K, Bevan DE, Mollnes TE, Yin H. Development of ß-amino alcohol derivatives that inhibit Toll-like receptor 4 mediated inflammatory response as potential antiseptics. J Med Chem. 2011 Jul 14; 54(13):4659-69. PMID: 21591694; PMCID: PMC3131463.
    35. Joce C, Wiener A, Yin H. Transmembrane domain oligomerization propensity determined by ToxR assay. J Vis Exp. 2011 May 26; (51). PMID: 21654625; PMCID: PMC3197428.
    36. Sammond DW, Joce C, Takeshita R, McQuate SE, Ghosh N, Martin JM, Yin H. Transmembrane peptides used to investigate the homo-oligomeric interface and binding hotspot of latent membrane protein 1. Biopolymers. 2011 Nov; 95(11):772-84. PMID: 21560118; PMCID: PMC3192311.
    37. Cheng K, Wang X, Yin H. Small-molecule inhibitors of the TLR3/dsRNA complex. J Am Chem Soc. 2011 Mar 23; 133(11):3764-7. PMID: 21355588; PMCID: PMC3068529.
    38. Joce C, Stahl JA, Shridhar M, Hutchinson MR, Watkins LR, Fedichev PO, Yin H. Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions. Bioorg Med Chem Lett. 2010 Sep 15; 20(18):5411-3. PMID: 20709548; PMCID: PMC2930491.
    39. Bevan DE, Martinko AJ, Loram LC, Stahl JA, Taylor FR, Joshee S, Watkins LR, Yin H. Selection, Preparation, and Evaluation of Small- Molecule Inhibitors of Toll-Like Receptor 4. ACS Med Chem Lett. 2010 Apr 12; 1(5):194-198. PMID: 20824192.
      View in: PubMed
    40. Buchanan MM, Hutchinson M, Watkins LR, Yin H. Toll-like receptor 4 in CNS pathologies. J Neurochem. 2010 Jul; 114(1):13-27. PMID: 20402965; PMCID: PMC2909662.
    41. Zhao TX, Martinko AJ, Le VH, Zhao J, Yin H. Development of agents that modulate protein-protein interactions in membranes. Curr Pharm Des. 2010; 16(9):1055-62. PMID: 20030619.
      View in: PubMed
    42. Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, Falke JJ, Leinwand LA, Maier SF, Yin H, Rice KC, Watkins LR. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun. 2010 Jan; 24(1):83-95. PMID: 19679181; PMCID: PMC2788078.
    43. Slivka PF, Shridhar M, Lee GI, Sammond DW, Hutchinson MR, Martinko AJ, Buchanan MM, Sholar PW, Kearney JJ, Harrison JA, Watkins LR, Yin H. A peptide antagonist of the TLR4-MD2 interaction. Chembiochem. 2009 Mar 02; 10(4):645-9. PMID: 19184989; PMCID: PMC2982775.
    44. Li Y, Chase AR, Slivka PF, Baggett CT, Zhao TX, Yin H. Design, synthesis, and evaluation of biotinylated opioid derivatives as novel probes to study opioid pharmacology. Bioconjug Chem. 2008 Dec; 19(12):2585-9. PMID: 19090701; PMCID: PMC2636689.
    45. Caputo GA, Litvinov RI, Li W, Bennett JS, Degrado WF, Yin H. Computationally designed peptide inhibitors of protein-protein interactions in membranes. Biochemistry. 2008 Aug 19; 47(33):8600-6. PMID: 18642886; PMCID: PMC2719017.
    46. Slivka PF, Wong J, Caputo GA, Yin H. Peptide probes for protein transmembrane domains. ACS Chem Biol. 2008 Jul 18; 3(7):402-11. PMID: 18533658.
      View in: PubMed
    47. Yin H. Exogenous agents that target transmembrane domains of proteins. Angew Chem Int Ed Engl. 2008; 47(15):2744-52. PMID: 18318029.
      View in: PubMed
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