Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Erwin Gelfand

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

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    P01HL036577     (GELFAND, ERWIN WILLIAM)Jul 1, 1986 - Apr 30, 2013
    NIH/NHLBI
    Inflammation, Airways Reactivity and Asthma
    Role: Principal Investigator

    R01AI026490     (GELFAND, ERWIN WILLIAM)Jul 1, 1989 - Jun 30, 1992
    NIH/NIAID
    IONIC,BIOCHEMICAL,GENETIC BASIS FOR CYCLOSPORIN ACTIVITY
    Role: Principal Investigator

    R01AI029704     (GELFAND, ERWIN WILLIAM)Jul 1, 1990 - Jun 30, 1993
    NIH/NIAID
    ACTIVATION &TRANSFORMATION OF HUMAN B CELLS BY EB VIRUS
    Role: Principal Investigator

    T32AI050248     (GELFAND, ERWIN WILLIAM)Sep 1, 1990 - Aug 31, 2006
    NIH/NIAID
    TRAINING PROGRAM IN PEDIATRIC IMMUMOLOGY
    Role: Principal Investigator

    R03AI041022     (GELFAND, ERWIN WILLIAM)Aug 1, 1996 - Jan 31, 1999
    NIH/NIAID
    MECHANISMS OF STEROID REDUCTION IN IVIG TREATED ASTHMA
    Role: Principal Investigator

    R01AI042246     (GELFAND, ERWIN WILLIAM)Jul 1, 1998 - Jun 30, 2003
    NIH/NIAID
    REGULATION OF MAST CELL CYTOKINE PRODUCTION
    Role: Principal Investigator

    R21AI042246     (GELFAND, ERWIN WILLIAM)Jul 1, 1998 - Aug 31, 2004
    NIH/NIAID
    MEKK2 Regulation of Mast Cell/T Cell Cytokine Production
    Role: Principal Investigator

    R01HL061005     (GELFAND, ERWIN WILLIAM)Sep 1, 1999 - Apr 30, 2010
    NIH/NHLBI
    Age-Dependent Increases in Airway Responsiveness by RSV
    Role: Principal Investigator

    R56AI077609     (GELFAND, ERWIN WILLIAM)Sep 17, 2008 - Aug 31, 2009
    NIH/NIAID
    Naturally occurring T regulatory cells control airway hyperresponsiveness
    Role: Principal Investigator

    R01AI077609     (GELFAND, ERWIN WILLIAM)Aug 15, 2009 - Jul 31, 2014
    NIH/NIAID
    Naturally Occurring T Regulatory Cells Control Airway Hyperresponsiveness
    Role: Principal Investigator

    RC1HD063508     (GELFAND, ERWIN WILLIAM)Sep 30, 2009 - Aug 31, 2012
    NIH/NICHD
    Antenatal Dietary Supplementation is a Risk Factor for Infant Atopy Through Epige
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Abbott JK, Huoh YS, Reynolds PR, Yu L, Rewers M, Reddy M, Anderson MS, Hur S, Gelfand EW. Dominant-negative loss of function arises from a second, more frequent variant within the SAND domain of autoimmune regulator (AIRE). J Autoimmun. 2017 Nov 09. PMID: 29129473.
      View in: PubMed
    2. Ma CA, Stinson JR, Zhang Y, Abbott JK, Weinreich MA, Hauk PJ, Reynolds PR, Lyons JJ, Nelson CG, Ruffo E, Dorjbal B, Glauzy S, Yamakawa N, Arjunaraja S, Voss K, Stoddard J, Niemela J, Zhang Y, Rosenzweig SD, McElwee JJ, DiMaggio T, Matthews HF, Jones N, Stone KD, Palma A, Oleastro M, Prieto E, Bernasconi AR, Dubra G, Danielian S, Zaiat J, Marti MA, Kim B, Cooper MA, Romberg ND, Meffre E, Gelfand EW, Snow AL, Milner JD. Corrigendum: Germline hypomorphic CARD11 mutations in severe atopic disease. Nat Genet. 2017 Oct 27; 49(11):1661. PMID: 29074947.
      View in: PubMed
    3. Gelfand EW. Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma. Semin Immunol. 2017 Oct; 33:44-51. PMID: 29042028.
      View in: PubMed
    4. Miot C, Imai K, Imai C, Mancini AJ, Kucuk ZY, Kawai T, Nishikomori R, Ito E, Pellier I, Dupuis Girod S, Rosain J, Sasaki S, Chandrakasan S, Pachlopnik Schmid J, Okano T, Colin E, Olaya-Vargas A, Yamazaki-Nakashimada M, Qasim W, Espinosa Padilla S, Jones A, Krol A, Cole N, Jolles S, Bleesing J, Vraetz T, Gennery AR, Abinun M, Güngör T, Costa-Carvalho B, Condino-Neto A, Veys P, Holland SM, Uzel G, Moshous D, Neven B, Blanche S, Ehl S, Döffinger R, Patel SY, Puel A, Bustamante J, Gelfand EW, Casanova JL, Orange JS, Picard C. Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG/NEMO mutations. Blood. 2017 Sep 21; 130(12):1456-1467. PMID: 28679735.
      View in: PubMed
    5. Gelfand EW, Joetham A, Wang M, Takeda K, Schedel M. Spectrum of T-lymphocyte activities regulating allergic lung inflammation. Immunol Rev. 2017 Jul; 278(1):63-86. PMID: 28658551.
      View in: PubMed
    6. Ma CA, Stinson JR, Zhang Y, Abbott JK, Weinreich MA, Hauk PJ, Reynolds PR, Lyons JJ, Nelson CG, Ruffo E, Dorjbal B, Glauzy S, Yamakawa N, Arjunaraja S, Voss K, Stoddard J, Niemela J, Zhang Y, Rosenzweig SD, McElwee JJ, DiMaggio T, Matthews HF, Jones N, Stone KD, Palma A, Oleastro M, Prieto E, Bernasconi AR, Dubra G, Danielian S, Zaiat J, Marti MA, Kim B, Cooper MA, Romberg N, Meffre E, Gelfand EW, Snow AL, Milner JD. Germline hypomorphic CARD11 mutations in severe atopic disease. Nat Genet. 2017 Aug; 49(8):1192-1201. PMID: 28628108.
      View in: PubMed
    7. Petersheim D, Massaad MJ, Lee S, Scarselli A, Cancrini C, Moriya K, Sasahara Y, Lankester AC, Dorsey M, Di Giovanni D, Bezrodnik L, Ohnishi H, Nishikomori R, Tanita K, Kanegane H, Morio T, Gelfand EW, Jain A, Secord E, Picard C, Casanova JL, Albert MH, Torgerson TR, Geha RS. Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency. J Allergy Clin Immunol. 2017 Jun 17. PMID: 28629746.
      View in: PubMed
    8. Lamborn IT, Jing H, Zhang Y, Drutman SB, Abbott JK, Munir S, Bade S, Murdock HM, Santos CP, Brock LG, Masutani E, Fordjour EY, McElwee JJ, Hughes JD, Nichols DP, Belkadi A, Oler AJ, Happel CS, Matthews HF, Abel L, Collins PL, Subbarao K, Gelfand EW, Ciancanelli MJ, Casanova JL, Su HC. Recurrent rhinovirus infections in a child with inherited MDA5 deficiency. J Exp Med. 2017 Jul 03; 214(7):1949-1972. PMID: 28606988.
      View in: PubMed
    9. Wang M, Yang IV, Davidson EJ, Joetham A, Takeda K, O'Connor BP, Gelfand EW. Forkhead box protein 3 demethylation is associated with tolerance induction in peanut-induced intestinal allergy. J Allergy Clin Immunol. 2017 May 04. PMID: 28479331.
      View in: PubMed
    10. Khorasanizadeh M, Eskian M, Gelfand EW, Rezaei N. Mitogen-activated protein kinases as therapeutic targets for asthma. Pharmacol Ther. 2017 Jun; 174:112-126. PMID: 28223227.
      View in: PubMed
    11. Fujii U, Miyahara N, Taniguchi A, Waseda K, Morichika D, Kurimoto E, Koga H, Kataoka M, Gelfand EW, Cua DJ, Yoshimura A, Tanimoto M, Kanehiro A. IL-23 Is Essential for the Development of Elastase-Induced Pulmonary Inflammation and Emphysema. Am J Respir Cell Mol Biol. 2016 Nov; 55(5):697-707. PMID: 27351934.
      View in: PubMed
    12. Takeda K, Miyahara N, Matsubara S, Taube C, Kitamura K, Hirano A, Tanimoto M, Gelfand EW. Immunomodulatory Effects of Ambroxol on Airway Hyperresponsiveness and Inflammation. Immune Netw. 2016 Jun; 16(3):165-75. PMID: 27340385; PMCID: PMC4917400.
    13. Schedel M, Jia Y, Michel S, Takeda K, Domenico J, Joetham A, Ning F, Strand M, Han J, Wang M, Lucas JJ, Vogelberg C, Kabesch M, O'Connor BP, Gelfand EW. 1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter. Nat Commun. 2016 Jan 11; 7:10213. PMID: 26750596; PMCID: PMC4712703.
    14. Dakhama A, Gelfand EW. In Vivo Assessment of Airway Function in the Mouse Model. Methods Mol Biol. 2016; 1442:219-30. PMID: 27464698.
      View in: PubMed
    15. Dutmer CM, Asturias EJ, Smith C, Dishop MK, Schmid DS, Bellini WJ, Tirosh I, Lee YN, Notarangelo LD, Gelfand EW. Late Onset Hypomorphic RAG2 Deficiency Presentation with Fatal Vaccine-Strain VZV Infection. J Clin Immunol. 2015 Nov; 35(8):754-60. PMID: 26515615; PMCID: PMC4662621 [Available on 11/01/16].
    16. Chan SK, Gelfand EW. Primary Immunodeficiency Masquerading as Allergic Disease. Immunol Allergy Clin North Am. 2015 Nov; 35(4):767-78. PMID: 26454318.
      View in: PubMed
    17. Abbott JK, Gelfand EW. Common Variable Immunodeficiency: Diagnosis, Management, and Treatment. Immunol Allergy Clin North Am. 2015 Nov; 35(4):637-58. PMID: 26454311.
      View in: PubMed
    18. Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fujii U, Tanimoto Y, Kataoka M, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A. Contrasting roles for the receptor for advanced glycation end-products on structural cells in allergic airway inflammation vs. airway hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15; 309(8):L789-800. PMID: 26472810.
      View in: PubMed
    19. Smith C, Dutmer C, Schmid DS, Dishop MK, Bellini WJ, Gelfand EW, Asturias EJ. A Toddler With Rash, Encephalopathy, and Hemolytic Anemia. J Pediatric Infect Dis Soc. 2015 Dec; 4(4):376-80. PMID: 26407265.
      View in: PubMed
    20. Meltzer LJ, Faino A, Szefler SJ, Strand M, Gelfand EW, Beebe DW. Experimentally manipulated sleep duration in adolescents with asthma: Feasibility and preliminary findings. Pediatr Pulmonol. 2015 Dec; 50(12):1360-7. PMID: 25872769; PMCID: PMC4785884 [Available on 12/01/16].
    21. Waseda K, Miyahara N, Taniguchi A, Kurimoto E, Ikeda G, Koga H, Fujii U, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A. Emphysema requires the receptor for advanced glycation end-products triggering on structural cells. Am J Respir Cell Mol Biol. 2015 Apr; 52(4):482-91. PMID: 25188021.
      View in: PubMed
    22. Gelfand EW, Alam R. The other side of asthma: Steroid-refractory disease in the absence of TH2-mediated inflammation. J Allergy Clin Immunol. 2015 May; 135(5):1196-8. PMID: 25772592.
      View in: PubMed
    23. Takeda K, Shiraishi Y, Ashino S, Han J, Jia Y, Wang M, Lee NA, Lee JJ, Gelfand EW. Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge. J Allergy Clin Immunol. 2015 Feb; 135(2):451-60. PMID: 25312762; PMCID: PMC4587899.
    24. Kwan A, Abraham RS, Currier R, Brower A, Andruszewski K, Abbott JK, Baker M, Ballow M, Bartoshesky LE, Bonilla FA, Brokopp C, Brooks E, Caggana M, Celestin J, Church JA, Comeau AM, Connelly JA, Cowan MJ, Cunningham-Rundles C, Dasu T, Dave N, De La Morena MT, Duffner U, Fong CT, Forbes L, Freedenberg D, Gelfand EW, Hale JE, Hanson IC, Hay BN, Hu D, Infante A, Johnson D, Kapoor N, Kay DM, Kohn DB, Lee R, Lehman H, Lin Z, Lorey F, Abdel-Mageed A, Manning A, McGhee S, Moore TB, Naides SJ, Notarangelo LD, Orange JS, Pai SY, Porteus M, Rodriguez R, Romberg N, Routes J, Ruehle M, Rubenstein A, Saavedra-Matiz CA, Scott G, Scott PM, Secord E, Seroogy C, Shearer WT, Siegel S, Silvers SK, Stiehm ER, Sugerman RW, Sullivan JL, Tanksley S, Tierce ML, Verbsky J, Vogel B, Walker R, Walkovich K, Walter JE, Wasserman RL, Watson MS, Weinberg GA, Weiner LB, Wood H, Yates AB, Puck JM, Bonagura VR. Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States. JAMA. 2014 Aug 20; 312(7):729-38. PMID: 25138334; PMCID: PMC4492158.
    25. Joetham A, Schedel M, Takeda K, Jia Y, Ashino S, Dakhama A, Lluis A, Okamoto M, Gelfand EW. JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses. J Immunol. 2014 Sep 01; 193(5):2238-47. PMID: 25070841; PMCID: PMC4135003.
    26. Han J, Takeda K, Wang M, Zeng W, Jia Y, Shiraishi Y, Okamoto M, Dakhama A, Gelfand EW. Effects of anti-g and anti-f antibodies on airway function after respiratory syncytial virus infection. Am J Respir Cell Mol Biol. 2014 Jul; 51(1):143-54. PMID: 24521403; PMCID: PMC4091856.
    27. Jia Y, Domenico J, Swasey C, Wang M, Gelfand EW, Lucas JJ. Modulated expression of genes encoding estrogen metabolizing enzymes by G1-phase cyclin-dependent kinases 6 and 4 in human breast cancer cells. PLoS One. 2014; 9(5):e97448. PMID: 24848372; PMCID: PMC4029737.
    28. Jing H, Zhang Q, Zhang Y, Hill BJ, Dove CG, Gelfand EW, Atkinson TP, Uzel G, Matthews HF, Mustillo PJ, Lewis DB, Kavadas FD, Hanson IC, Kumar AR, Geha RS, Douek DC, Holland SM, Freeman AF, Su HC. Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype. J Allergy Clin Immunol. 2014 Jun; 133(6):1667-75. PMID: 24797421; PMCID: PMC4132167.
    29. Kim SH, Sutherland ER, Gelfand EW. Is there a link between obesity and asthma? Allergy Asthma Immunol Res. 2014 May; 6(3):189-95. PMID: 24843792; PMCID: PMC4021235.
    30. Shearer WT, Fleisher TA, Buckley RH, Ballas Z, Ballow M, Blaese RM, Bonilla FA, Conley ME, Cunningham-Rundles C, Filipovich AH, Fuleihan R, Gelfand EW, Hernandez-Trujillo V, Holland SM, Hong R, Lederman HM, Malech HL, Miles S, Notarangelo LD, Ochs HD, Orange JS, Puck JM, Routes JM, Stiehm ER, Sullivan K, Torgerson T, Winkelstein J. Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts. J Allergy Clin Immunol. 2014 Apr; 133(4):961-6. PMID: 24582311; PMCID: PMC4009347.
    31. Chung EH, Jia Y, Ohnishi H, Takeda K, Leung DY, Sutherland ER, Dakhama A, Martin RJ, Gelfand EW. Leukotriene B4 receptor 1 is differentially expressed on peripheral T cells of steroid-sensitive and -resistant asthmatics. Ann Allergy Asthma Immunol. 2014 Mar; 112(3):211-216.e1. PMID: 24428972; PMCID: PMC3951978.
    32. Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine PR, Gelfand EW. Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses. J Allergy Clin Immunol. 2014 Apr; 133(4):1162-74. PMID: 24365136; PMCID: PMC3972277.
    33. Wang M, Gelfand EW. Targeting Pim1 kinase in the treatment of peanut allergy. Expert Opin Ther Targets. 2014 Feb; 18(2):177-83. PMID: 24266874.
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    34. Goleva E, Jackson LP, Harris JK, Robertson CE, Sutherland ER, Hall CF, Good JT, Gelfand EW, Martin RJ, Leung DY. The effects of airway microbiome on corticosteroid responsiveness in asthma. Am J Respir Crit Care Med. 2013 Nov 15; 188(10):1193-201. PMID: 24024497; PMCID: PMC3863730.
    35. Abbott JK, Ochs HD, Gelfand EW. Coding-region alterations in BTK do not universally cause X-linked agammaglobulinemia. J Allergy Clin Immunol. 2013 Nov; 132(5):1246-8. PMID: 24001798.
      View in: PubMed
    36. Wang M, Ramirez J, Han J, Jia Y, Domenico J, Seibold MA, Hagman JR, Gelfand EW. The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis. J Allergy Clin Immunol. 2013 Nov; 132(5):1174-1183.e8. PMID: 23870673; PMCID: PMC3864874.
    37. Mohiuddin MS, Abbott JK, Hubbard N, Torgerson TR, Ochs HD, Gelfand EW. Diagnosis and evaluation of primary panhypogammaglobulinemia: a molecular and genetic challenge. J Allergy Clin Immunol. 2013 Jun; 131(6):1717-8. PMID: 23726535.
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    38. Jia Y, Domenico J, Takeda K, Han J, Wang M, Armstrong M, Reisdorph N, O'Connor BP, Lucas JJ, Gelfand EW. Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8152-7. PMID: 23630275; PMCID: PMC3657775.
    39. Gelfand EW, Ochs HD, Shearer WT. Controversies in IgG replacement therapy in patients with antibody deficiency diseases. J Allergy Clin Immunol. 2013 Apr; 131(4):1001-5. PMID: 23540617.
      View in: PubMed
    40. Jia Y, Takeda K, Han J, Joetham A, Marcus RA, Lucas JJ, O'Connor BP, Gelfand EW. Stepwise epigenetic and phenotypic alterations poise CD8+ T cells to mediate airway hyperresponsiveness and inflammation. J Immunol. 2013 Apr 15; 190(8):4056-65. PMID: 23509358; PMCID: PMC3622148.
    41. Gelfand EW. Intravenous immune globulin in autoimmune and inflammatory diseases. N Engl J Med. 2013 Feb 21; 368(8):777. PMID: 23425181.
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    42. Koga H, Miyahara N, Fuchimoto Y, Ikeda G, Waseda K, Ono K, Tanimoto Y, Kataoka M, Gelfand EW, Tanimoto M, Kanehiro A. Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses. Respir Res. 2013 Jan 24; 14:8. PMID: 23347423; PMCID: PMC3570429.
    43. Kurimoto E, Miyahara N, Kanehiro A, Waseda K, Taniguchi A, Ikeda G, Koga H, Nishimori H, Tanimoto Y, Kataoka M, Iwakura Y, Gelfand EW, Tanimoto M. IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice. Respir Res. 2013 Jan 20; 14:5. PMID: 23331548; PMCID: PMC3564829.
    44. Shiraishi Y, Jia Y, Domenico J, Joetham A, Karasuyama H, Takeda K, Gelfand EW. Sequential engagement of FceRI on Mast Cells and Basophil Histamine H(4) Receptor and FceRI in Allergic Rhinitis. J Immunol. 2013 Jan 15; 190(2):539-48. PMID: 23241885; PMCID: PMC3538893.
    45. Gelfand EW. Intravenous immune globulin in autoimmune and inflammatory diseases. N Engl J Med. 2012 Nov 22; 367(21):2015-25. PMID: 23171098.
      View in: PubMed
    46. Han J, Dakhama A, Jia Y, Wang M, Zeng W, Takeda K, Shiraishi Y, Okamoto M, Ziegler SF, Gelfand EW. Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand. J Allergy Clin Immunol. 2012 Nov; 130(5):1175-1186.e9. PMID: 23036746; PMCID: PMC3593657.
    47. Gelfand EW. Development of asthma is determined by the age-dependent host response to respiratory virus infection: therapeutic implications. Curr Opin Immunol. 2012 Dec; 24(6):713-9. PMID: 22981683; PMCID: PMC3508171.
    48. Wang M, Okamoto M, Domenico J, Han J, Ashino S, Shin YS, Gelfand EW. Inhibition of Pim1 kinase prevents peanut allergy by enhancing Runx3 expression and suppressing T(H)2 and T(H)17 T-cell differentiation. J Allergy Clin Immunol. 2012 Oct; 130(4):932-44.e12. PMID: 22944483; PMCID: PMC3652680.
    49. Shin YS, Takeda K, Shiraishi Y, Jeong YY, Domenico J, Jia Y, Han J, Spallek R, Singh M, Lucas JJ, Gelfand EW. Microbial heat shock protein 65 attenuates airway hyperresponsiveness and inflammation by modulating the function of dendritic cells. J Immunol. 2012 Oct 01; 189(7):3404-10. PMID: 22933632; PMCID: PMC3448847.
    50. Schroeder S, Fleischer DM, Masterson JC, Gelfand E, Furuta GT, Atkins D. Successful treatment of eosinophilic esophagitis with ciclesonide. J Allergy Clin Immunol. 2012 May; 129(5):1419-21. PMID: 22480537; PMCID: PMC3816103.
    51. Joetham A, Ohnishi H, Okamoto M, Takeda K, Schedel M, Domenico J, Dakhama A, Gelfand EW. Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation. J Biol Chem. 2012 May 18; 287(21):17100-8. PMID: 22461627; PMCID: PMC3366833.
    52. Yamabayashi C, Koya T, Kagamu H, Kawakami H, Kimura Y, Furukawa T, Sakagami T, Hasegawa T, Sakai Y, Matsumoto K, Nakayama M, Gelfand EW, Suzuki E, Narita I. A novel prostacyclin agonist protects against airway hyperresponsiveness and remodeling in mice. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):170-7. PMID: 22403804.
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    53. Domenico J, Lucas JJ, Fujita M, Gelfand EW. Susceptibility to vaccinia virus infection and spread in mice is determined by age at infection, allergen sensitization and mast cell status. Int Arch Allergy Immunol. 2012; 158(2):196-205. PMID: 22286752; PMCID: PMC3291886.
    54. Goplen N, Karim Z, Guo L, Zhuang Y, Huang H, Gorska MM, Gelfand E, Pagés G, Pouysségur J, Alam R. ERK1 is important for Th2 differentiation and development of experimental asthma. FASEB J. 2012 May; 26(5):1934-45. PMID: 22262639; PMCID: PMC3336776.
    55. Takeda K, Thurman JM, Tomlinson S, Okamoto M, Shiraishi Y, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Gelfand EW. The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation. J Immunol. 2012 Jan 15; 188(2):661-7. PMID: 22174452; PMCID: PMC3253223.
    56. Shin YS, Takeda K, Shiraishi Y, Jia Y, Wang M, Jackson L, Wright AD, Carter L, Robinson J, Hicken E, Gelfand EW. Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol. 2012 Apr; 46(4):488-97. PMID: 22074702; PMCID: PMC3359953.
    57. Okamoto M, Takeda K, Lucas JJ, Joetham A, Yasutomo K, Gelfand EW. Low-dose lipopolysaccharide affects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic cells. Int Arch Allergy Immunol. 2012; 157(1):65-72. PMID: 21912175; PMCID: PMC3180653.
    58. Rabinovitch N, Silveira L, Gelfand EW, Strand M. The response of children with asthma to ambient particulate is modified by tobacco smoke exposure. Am J Respir Crit Care Med. 2011 Dec 15; 184(12):1350-7. PMID: 21868505; PMCID: PMC3262032.
    59. Rabinovitch N, Reisdorph N, Silveira L, Gelfand EW. Urinary leukotriene E4 levels identify children with tobacco smoke exposure at risk for asthma exacerbation. J Allergy Clin Immunol. 2011 Aug; 128(2):323-7. PMID: 21807251; PMCID: PMC3150462.
    60. Fuchimoto Y, Kanehiro A, Miyahara N, Koga H, Ikeda G, Waseda K, Tanimoto Y, Ueha S, Kataoka M, Gelfand EW, Tanimoto M. Requirement for chemokine receptor 5 in the development of allergen-induced airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1248-55. PMID: 21757680; PMCID: PMC3262662.
    61. Han J, Takeda K, Gelfand EW. The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse Model. Pulm Med. 2011; 2011:748038. PMID: 21766019; PMCID: PMC3135221.
    62. Shin YS, Takeda K, Ohnishi H, Jia Y, Shiraishi Y, Cox ML, Fine JS, Rosenblum S, Lundel D, Jenh CH, Manfra DJ, Gelfand EW. Targeting CXCR3 reduces ligand-induced T-cell activation but not development of lung allergic responses. Ann Allergy Asthma Immunol. 2011 Aug; 107(2):145-53. PMID: 21802023.
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    63. Waseda K, Miyahara N, Kanehiro A, Ikeda G, Koga H, Fuchimoto Y, Kurimoto E, Tanimoto Y, Kataoka M, Tanimoto M, Gelfand EW. Blocking the leukotriene B4 receptor 1 inhibits late-phase airway responses in established disease. Am J Respir Cell Mol Biol. 2011 Oct; 45(4):851-7. PMID: 21421908; PMCID: PMC3208610.
    64. Peterson LK, Shaw LA, Joetham A, Sakaguchi S, Gelfand EW, Dragone LL. SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice. J Immunol. 2011 Feb 15; 186(4):2273-81. PMID: 21248251; PMCID: PMC3135266.
    65. Joetham A, Okamoto M, Takeda K, Schedel M, Ohnishi H, Dakhama A, Gelfand EW. CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease. J Immunol. 2011 Jan 01; 186(1):113-20. PMID: 21115736; PMCID: PMC3127584.
    66. Wang M, Takeda K, Shiraishi Y, Okamoto M, Dakhama A, Joetham A, Gelfand EW. Peanut-induced intestinal allergy is mediated through a mast cell-IgE-FcepsilonRI-IL-13 pathway. J Allergy Clin Immunol. 2010 Aug; 126(2):306-16, 316.e1-12. PMID: 20624645; PMCID: PMC2917491.
    67. Matsuda H, Takeda K, Koya T, Okamoto M, Shiraishi Y, Miyahara N, Dakhama A, Matsuda JL, Gapin L, Gelfand EW. Plasticity of invariant NKT cell regulation of allergic airway disease is dependent on IFN-gamma production. J Immunol. 2010 Jul 01; 185(1):253-62. PMID: 20525882.
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    68. Beebe A, Gelfand EW, Bender B. A randomized trial to test the effectiveness of art therapy for children with asthma. J Allergy Clin Immunol. 2010 Aug; 126(2):263-6, 266.e1. PMID: 20462632.
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    76. Takeda K, Dow SW, Miyahara N, Kodama T, Koya T, Taube C, Joetham A, Park JW, Dakhama A, Kedl RM, Gelfand EW. Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation. J Immunol. 2009 Jul 01; 183(1):181-90. PMID: 19542429.
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    78. Gelfand EW. Pediatric asthma: a different disease. Proc Am Thorac Soc. 2009 May 01; 6(3):278-82. PMID: 19387030; PMCID: PMC2677403.
    79. Nelson HS, Gallegos CM, Silveira LJ, Newell JD, Gelfand EW. Effect of the inhaled corticosteroid mometasone on small airway patency in patients with asthma. Allergy Asthma Proc. 2009 May-Jun; 30(3):284-92. PMID: 19549430.
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    82. Ohnishi H, Takeda K, Domenico J, Lucas JJ, Miyahara N, Swasey CH, Dakhama A, Gelfand EW. Mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2-dependent pathways are essential for CD8+ T cell-mediated airway hyperresponsiveness and inflammation. J Allergy Clin Immunol. 2009 Jan; 123(1):249-57. PMID: 19130938.
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    84. Ohnishi H, Miyahara N, Gelfand EW. The role of leukotriene B(4) in allergic diseases. Allergol Int. 2008 Dec; 57(4):291-8. PMID: 18797182.
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    86. Carel K, Bratton DL, Miyazawa N, Gyorkos E, Kelsay K, Bender B, Strand M, Atkins D, Gelfand EW, Klinnert MD. The Atopic Dermatitis Quickscore (ADQ): validation of a new parent-administered atopic dermatitis scoring tool. Ann Allergy Asthma Immunol. 2008 Nov; 101(5):500-7. PMID: 19055204.
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    91. Lopez-Granados E, Keenan JE, Kinney MC, Leo H, Jain N, Ma CA, Quinones R, Gelfand EW, Jain A. A novel mutation in NFKBIA/IKBA results in a degradation-resistant N-truncated protein and is associated with ectodermal dysplasia with immunodeficiency. Hum Mutat. 2008 Jun; 29(6):861-8. PMID: 18412279; PMCID: PMC3179847.
    92. Rabinovitch N, Strand M, Stuhlman K, Gelfand EW. Exposure to tobacco smoke increases leukotriene E4-related albuterol usage and response to montelukast. J Allergy Clin Immunol. 2008 Jun; 121(6):1365-71. PMID: 18439662.
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    93. Okamoto M, Takeda K, Joetham A, Ohnishi H, Matsuda H, Swasey CH, Swanson BJ, Yasutomo K, Dakhama A, Gelfand EW. Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation. J Exp Med. 2008 May 12; 205(5):1087-97. PMID: 18426985; PMCID: PMC2373841.
    94. Ohnishi H, Miyahara N, Dakhama A, Takeda K, Mathis S, Haribabu B, Gelfand EW. Corticosteroids enhance CD8+ T cell-mediated airway hyperresponsiveness and allergic inflammation by upregulating leukotriene B4 receptor 1. J Allergy Clin Immunol. 2008 Apr; 121(4):864-71.e4. PMID: 18395551.
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    96. Salt BH, Niemela JE, Pandey R, Hanson EP, Deering RP, Quinones R, Jain A, Orange JS, Gelfand EW. IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function. J Allergy Clin Immunol. 2008 Apr; 121(4):976-82. PMID: 18179816; PMCID: PMC3050055.
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    100. Matsubara S, Swasey CH, Loader JE, Dakhama A, Joetham A, Ohnishi H, Balhorn A, Miyahara N, Takeda K, Gelfand EW. Estrogen determines sex differences in airway responsiveness after allergen exposure. Am J Respir Cell Mol Biol. 2008 May; 38(5):501-8. PMID: 18063836; PMCID: PMC2335333.
    101. Ito W, Tanimoto M, Ono K, Mizuno S, Yoshida A, Koga H, Fuchimoto Y, Kondo N, Tanimoto Y, Kiura K, Matsumoto K, Kataoka M, Nakamura T, Gelfand EW, Kanehiro A. Growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice. Int Arch Allergy Immunol. 2008; 145(4):324-39. PMID: 18004075.
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    103. Lee YM, Miyahara N, Takeda K, Prpich J, Oh A, Balhorn A, Joetham A, Gelfand EW, Dakhama A. IFN-gamma production during initial infection determines the outcome of reinfection with respiratory syncytial virus. Am J Respir Crit Care Med. 2008 Jan 15; 177(2):208-18. PMID: 17962634; PMCID: PMC2204078.
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    105. Joetham A, Takeda K, Miyahara N, Matsubara S, Ohnishi H, Koya T, Dakhama A, Gelfand EW. Activation of naturally occurring lung CD4(+)CD25(+) regulatory T cells requires CD8 and MHC I interaction. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15057-62. PMID: 17855564; PMCID: PMC1986612.
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    110. Mjaanes CM, Hendershot RW, Quinones RR, Gelfand EW. A novel mutation of intron 22 in Janus kinase 3-deficient severe combined immunodeficiency. J Allergy Clin Immunol. 2007 Jun; 119(6):1542-5. PMID: 17433830.
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    114. Prins C, Gelfand EW, French LE. Intravenous immunoglobulin: properties, mode of action and practical use in dermatology. Acta Derm Venereol. 2007; 87(3):206-18. PMID: 17533485.
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    146. Dreyfus DH, Nagasawa M, Gelfand EW, Ghoda LY. Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors. BMC Immunol. 2005 Jun 21; 6:12. PMID: 15969767; PMCID: PMC1184076.
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    150. Paull K, Covar R, Jain N, Gelfand EW, Spahn JD. Do NHLBI lung function criteria apply to children? A cross-sectional evaluation of childhood asthma at National Jewish Medical and Research Center, 1999-2002. Pediatr Pulmonol. 2005 Apr; 39(4):311-7. PMID: 15678505.
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    153. Durandy A, Wahn V, Petteway S, Gelfand EW. Immunoglobulin replacement therapy in primary antibody deficiency diseases--maximizing success. Int Arch Allergy Immunol. 2005 Mar; 136(3):217-29. PMID: 15713984.
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    154. Ito W, Kanehiro A, Matsumoto K, Hirano A, Ono K, Maruyama H, Kataoka M, Nakamura T, Gelfand EW, Tanimoto M. Hepatocyte growth factor attenuates airway hyperresponsiveness, inflammation, and remodeling. Am J Respir Cell Mol Biol. 2005 Apr; 32(4):268-80. PMID: 15626778.
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    155. Dakhama A, Park JW, Taube C, El Gazzar M, Kodama T, Miyahara N, Takeda K, Kanehiro A, Balhorn A, Joetham A, Loader JE, Larsen GL, Gelfand EW. Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L761-70. PMID: 15608150.
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    156. Rabinovitch N, Zhang L, Murphy JR, Vedal S, Dutton SJ, Gelfand EW. Effects of wintertime ambient air pollutants on asthma exacerbations in urban minority children with moderate to severe disease. J Allergy Clin Immunol. 2004 Nov; 114(5):1131-7. PMID: 15536421.
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    157. Gelfand EW. Inflammatory mediators in allergic rhinitis. J Allergy Clin Immunol. 2004 Nov; 114(5 Suppl):S135-8. PMID: 15536444.
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    158. Duez C, Dakhama A, Tomkinson A, Marquillies P, Balhorn A, Tonnel AB, Bratton DL, Gelfand EW. Migration and accumulation of eosinophils toward regional lymph nodes after airway allergen challenge. J Allergy Clin Immunol. 2004 Oct; 114(4):820-5. PMID: 15480321.
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    159. Taube C, Dakhama A, Gelfand EW. Insights into the pathogenesis of asthma utilizing murine models. Int Arch Allergy Immunol. 2004 Oct; 135(2):173-86. PMID: 15375327.
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    160. Pulfer MK, Taube C, Gelfand E, Murphy RC. Ozone exposure in vivo and formation of biologically active oxysterols in the lung. J Pharmacol Exp Ther. 2005 Jan; 312(1):256-64. PMID: 15316091.
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    161. Li G, Domenico J, Lucas JJ, Gelfand EW. Identification of multiple cell cycle regulatory functions of p57Kip2 in human T lymphocytes. J Immunol. 2004 Aug 15; 173(4):2383-91. PMID: 15294951.
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    162. Dakhama A, Park JW, Taube C, Chayama K, Balhorn A, Joetham A, Wei XD, Fan RH, Swasey C, Miyahara N, Kodama T, Alvarez A, Takeda K, Gelfand EW. The role of virus-specific immunoglobulin E in airway hyperresponsiveness. Am J Respir Crit Care Med. 2004 Nov 01; 170(9):952-9. PMID: 15306536.
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    163. Miyahara N, Swanson BJ, Takeda K, Taube C, Miyahara S, Kodama T, Dakhama A, Ott VL, Gelfand EW. Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nat Med. 2004 Aug; 10(8):865-9. PMID: 15258576.
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    164. Gelfand EW, Joetham A, Cui ZH, Balhorn A, Takeda K, Taube C, Dakhama A. Induction and maintenance of airway responsiveness to allergen challenge are determined at the age of initial sensitization. J Immunol. 2004 Jul 15; 173(2):1298-306. PMID: 15240723.
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    165. Anderson ME, Freas MR, Wallace AS, Kempe A, Gelfand EW, Liu AH. Successful school-based intervention for inner-city children with persistent asthma. J Asthma. 2004 Jun; 41(4):445-53. PMID: 15281330.
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    166. Dakhama A, Larsen GL, Gelfand EW. Calcitonin gene-related peptide: role in airway homeostasis. Curr Opin Pharmacol. 2004 Jun; 4(3):215-20. PMID: 15140411.
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    167. Taube C, Wei X, Swasey CH, Joetham A, Zarini S, Lively T, Takeda K, Loader J, Miyahara N, Kodama T, Shultz LD, Donaldson DD, Hamelmann EH, Dakhama A, Gelfand EW. Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant. J Immunol. 2004 May 15; 172(10):6398-406. PMID: 15128831.
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    168. Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser LJ, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, Drazen J, Weiss ST. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet. 2004 Jul 01; 13(13):1353-9. PMID: 15128701.
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    169. Lahn M, Kanehiro A, Hahn YS, Wands JM, Aydintug MK, O'Brien RL, Gelfand EW, Born WK. Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity. Int Arch Allergy Immunol. 2004 May; 134(1):49-55. PMID: 15051940.
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    170. Hahn YS, Taube C, Jin N, Sharp L, Wands JM, Aydintug MK, Lahn M, Huber SA, O'Brien RL, Gelfand EW, Born WK. Different potentials of gamma delta T cell subsets in regulating airway responsiveness: V gamma 1+ cells, but not V gamma 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation. J Immunol. 2004 Mar 01; 172(5):2894-902. PMID: 14978091.
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    171. Rabinovitch N, Gelfand EW. Expression of functional activating and inhibitory Fcgamma receptors on human B cells. Int Arch Allergy Immunol. 2004 Mar; 133(3):285-94. PMID: 14976398.
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    172. Miyahara N, Takeda K, Kodama T, Joetham A, Taube C, Park JW, Miyahara S, Balhorn A, Dakhama A, Gelfand EW. Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13. J Immunol. 2004 Feb 15; 172(4):2549-58. PMID: 14764728.
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    173. Lucas JJ, Domenico J, Gelfand EW. Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells. Mol Cancer Res. 2004 Feb; 2(2):105-14. PMID: 14985467.
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    174. Spahn JD, Cherniack R, Paull K, Gelfand EW. Is forced expiratory volume in one second the best measure of severity in childhood asthma? Am J Respir Crit Care Med. 2004 Apr 01; 169(7):784-6. PMID: 14754761.
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    175. Park JW, Taube C, Swasey C, Kodama T, Joetham A, Balhorn A, Takeda K, Miyahara N, Allen CB, Dakhama A, Kim SH, Dinarello CA, Gelfand EW. Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone. Am J Respir Cell Mol Biol. 2004 Jun; 30(6):830-6. PMID: 14754758.
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    176. Taube C, Nick JA, Siegmund B, Duez C, Takeda K, Rha YH, Park JW, Joetham A, Poch K, Dakhama A, Dinarello CA, Gelfand EW. Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2004 Jun; 30(6):837-43. PMID: 14742296.
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    177. Gelfand EW. Use of IGIV in the treatment of immune-mediated dermatologic disorders. J Investig Dermatol Symp Proc. 2004 Jan; 9(1):92-6. PMID: 14870993.
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    178. Gelfand EW, Appajosyula S, Meeves S. Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research. Curr Med Res Opin. 2004 Jan; 20(1):73-81. PMID: 14741075.
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    179. Park JW, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Shultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW. Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. Am J Respir Crit Care Med. 2004 Mar 15; 169(6):726-32. PMID: 14701711.
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    180. Park JW, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Donaldson DD, Gelfand EW. Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen. J Allergy Clin Immunol. 2003 Dec; 112(6):1078-87. PMID: 14657862.
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    181. Cui ZH, Joetham A, Aydintug MK, Hahn YS, Born WK, Gelfand EW. Reversal of allergic airway hyperreactivity after long-term allergen challenge depends on gammadelta T cells. Am J Respir Crit Care Med. 2003 Dec 01; 168(11):1324-32. PMID: 14644924.
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    182. Mäkelä MJ, Tripp R, Dakhama A, Park JW, Ikemura T, Joetham A, Waris M, Anderson LJ, Gelfand EW. Prior airway exposure to allergen increases virus-induced airway hyperresponsiveness. J Allergy Clin Immunol. 2003 Nov; 112(5):861-9. PMID: 14610471.
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    183. Wei X, Sun W, Fan R, Hahn J, Joetham A, Li G, Webb S, Garrington T, Dakhama A, Lucas J, Johnson GL, Gelfand EW. MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells. Eur J Immunol. 2003 Oct; 33(10):2903-9. PMID: 14515274.
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    184. Gelfand EW, Cui ZH, Takeda K, Kanehiro A, Joetham A. Effects of fexofenadine on T-cell function in a murine model of allergen-induced airway inflammation and hyperresponsiveness. J Allergy Clin Immunol. 2003 Oct; 112(4 Suppl):S89-95. PMID: 14530794.
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    185. Jenkins HA, Cherniack R, Szefler SJ, Covar R, Gelfand EW, Spahn JD. A comparison of the clinical characteristics of children and adults with severe asthma. Chest. 2003 Oct; 124(4):1318-24. PMID: 14555561.
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    186. Gelfand EW. Introduction to anti-allergic properties of antihistamines. J Allergy Clin Immunol. 2003 Oct; 112(4 Suppl):S41. PMID: 14530787.
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    187. Taube C, Rha YH, Takeda K, Park JW, Joetham A, Balhorn A, Dakhama A, Giclas PC, Holers VM, Gelfand EW. Inhibition of complement activation decreases airway inflammation and hyperresponsiveness. Am J Respir Crit Care Med. 2003 Dec 01; 168(11):1333-41. PMID: 14500265.
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    188. Hahn YS, Taube C, Jin N, Takeda K, Park JW, Wands JM, Aydintug MK, Roark CL, Lahn M, O'Brien RL, Gelfand EW, Born WK. V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice. J Immunol. 2003 Sep 15; 171(6):3170-8. PMID: 12960345.
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    189. Zhang F, Pao W, Umphress SM, Jakowlew SB, Meyer AM, Dwyer-Nield LD, Nielsen LD, Takeda K, Gelfand EW, Fisher JH, Zhang L, Malkinson AM, Mason RJ. Serum levels of surfactant protein D are increased in mice with lung tumors. Cancer Res. 2003 Sep 15; 63(18):5889-94. PMID: 14522914.
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    190. Takeda K, Miyahara N, Rha YH, Taube C, Yang ES, Joetham A, Kodama T, Balhorn AM, Dakhama A, Duez C, Evans AJ, Voelker DR, Gelfand EW. Surfactant protein D regulates airway function and allergic inflammation through modulation of macrophage function. Am J Respir Crit Care Med. 2003 Oct 01; 168(7):783-9. PMID: 12882759.
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    191. Jenkins HA, Cool C, Szefler SJ, Covar R, Brugman S, Gelfand EW, Spahn JD. Histopathology of severe childhood asthma: a case series. Chest. 2003 Jul; 124(1):32-41. PMID: 12853499.
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    192. Tripp RA, Dakhama A, Jones LP, Barskey A, Gelfand EW, Anderson LJ. The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P. J Virol. 2003 Jun; 77(11):6580-4. PMID: 12743318; PMCID: PMC155004.
    193. Casale TB, Blaiss MS, Gelfand E, Gilmore T, Harvey PD, Hindmarch I, Simons FE, Spangler DL, Szefler SJ, Terndrup TE, Waldman SA, Weiler J, Wong DF. First do no harm: managing antihistamine impairment in patients with allergic rhinitis. J Allergy Clin Immunol. 2003 May; 111(5):S835-42. PMID: 12743547.
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    194. Dakhama A, Kraft M, Martin RJ, Gelfand EW. Induction of regulated upon activation, normal T cells expressed and secreted (RANTES) and transforming growth factor-beta 1 in airway epithelial cells by Mycoplasma pneumoniae. Am J Respir Cell Mol Biol. 2003 Sep; 29(3 Pt 1):344-51. PMID: 12714377.
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    195. Taube C, Dakhama A, Rha YH, Takeda K, Joetham A, Park JW, Balhorn A, Takai T, Poch KR, Nick JA, Gelfand EW. Transient neutrophil infiltration after allergen challenge is dependent on specific antibodies and Fc gamma III receptors. J Immunol. 2003 Apr 15; 170(8):4301-9. PMID: 12682266.
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    196. Sun W, Wei X, Kesavan K, Garrington TP, Fan R, Mei J, Anderson SM, Gelfand EW, Johnson GL. MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src. Mol Cell Biol. 2003 Apr; 23(7):2298-308. PMID: 12640115; PMCID: PMC150715.
    197. Taube C, Dakhama A, Takeda K, Nick JA, Gelfand EW. Allergen-specific early neutrophil infiltration after allergen challenge in a murine model. Chest. 2003 Mar; 123(3 Suppl):410S-1S. PMID: 12629005.
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    198. Gelfand EW. Role of histamine in the pathophysiology of asthma: immunomodulatory and anti-inflammatory activities of H1-receptor antagonists. Am J Med. 2002 Dec 16; 113 Suppl 9A:2S-7S. PMID: 12517576.
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    199. Gelfand EW, Winkelstein J. Are all IGIVs the same? J Allergy Clin Immunol. 2002 Dec; 110(6):938. PMID: 12464965.
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    200. Taube C, Duez C, Cui ZH, Takeda K, Rha YH, Park JW, Balhorn A, Donaldson DD, Dakhama A, Gelfand EW. The role of IL-13 in established allergic airway disease. J Immunol. 2002 Dec 01; 169(11):6482-9. PMID: 12444158.
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    201. Rha YH, Taube C, Haczku A, Joetham A, Takeda K, Duez C, Siegel M, Aydintug MK, Born WK, Dakhama A, Gelfand EW. Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness. J Immunol. 2002 Nov 01; 169(9):5300-7. PMID: 12391250.
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    202. Kanehiro A, Lahn M, Mäkelä MJ, Dakhama A, Joetham A, Rha YH, Born W, Gelfand EW. Requirement for the p75 TNF-alpha receptor 2 in the regulation of airway hyperresponsiveness by gamma delta T cells. J Immunol. 2002 Oct 15; 169(8):4190-7. PMID: 12370348.
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    203. Gelfand EW. Pro: mice are a good model of human airway disease. Am J Respir Crit Care Med. 2002 Jul 01; 166(1):5-6; discussion 7-8. PMID: 12091160.
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    204. Gelfand EW, Cui ZH, Takeda K, Kanehiro A, Joetham A. Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness. J Allergy Clin Immunol. 2002 Jul; 110(1):85-95. PMID: 12110826.
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    205. Lahn M, Kanehiro A, Takeda K, Terry J, Hahn YS, Aydintug MK, Konowal A, Ikuta K, O'Brien RL, Gelfand EW, Born WK. MHC class I-dependent Vgamma4+ pulmonary T cells regulate alpha beta T cell-independent airway responsiveness. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8850-5. PMID: 12070351; PMCID: PMC124387.
    206. Tomkinson A, Duez C, Lahn M, Gelfand EW. Adoptive transfer of T cells induces airway hyperresponsiveness independently of airway eosinophilia but in a signal transducer and activator of transcription 6-dependent manner. J Allergy Clin Immunol. 2002 May; 109(5):810-6. PMID: 11994705.
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    207. Dakhama A, Kanehiro A, Mäkelä MJ, Loader JE, Larsen GL, Gelfand EW. Regulation of airway hyperresponsiveness by calcitonin gene-related peptide in allergen sensitized and challenged mice. Am J Respir Crit Care Med. 2002 Apr 15; 165(8):1137-44. PMID: 11956058.
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    208. Mäkelä MJ, Kanehiro A, Dakhama A, Borish L, Joetham A, Tripp R, Anderson L, Gelfand EW. The failure of interleukin-10-deficient mice to develop airway hyperresponsiveness is overcome by respiratory syncytial virus infection in allergen-sensitized/challenged mice. Am J Respir Crit Care Med. 2002 Mar 15; 165(6):824-31. PMID: 11897651.
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    209. Kronfeld I, Kazimirsky G, Gelfand EW, Brodie C. NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta. Eur J Immunol. 2002 Jan; 32(1):136-43. PMID: 11754354.
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