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Lori Walker

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-5420

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Keller AC, Knaub LA, McClatchey PM, Connon CA, Bouchard R, Miller MW, Geary KE, Walker LA, Klemm DJ, Reusch JE. Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model. Oxid Med Cell Longev. 2016; 2016:8524267.
      View in: PubMed
    2. Bruns DR, Buttrick PM, Walker LA. Genetic ablation of interleukin-18 does not attenuate hypobaric hypoxia-induced right ventricular hypertrophy. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15; 310(6):L542-50.
      View in: PubMed
    3. Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O'Rourke R, Jones KL, Jeong MY, Walker LA, Buttrick PM, McKinsey TA, Song K. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015 Sep 10; 6:8243.
      View in: PubMed
    4. Seo SW, Koeppen M, Bonney S, Gobel M, Thayer M, Harter PN, Ravid K, Eltzschig HK, Mittelbronn M, Walker L, Eckle T. Differential Tissue-Specific Function of Adora2b in Cardioprotection. J Immunol. 2015 Aug 15; 195(4):1732-43.
      View in: PubMed
    5. Bruns DR, Brown RD, Stenmark KR, Buttrick PM, Walker LA. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15; 308(2):L158-67.
      View in: PubMed
    6. Sutliff RL, Walp ER, Kim YH, Walker LA, El-Ali AM, Ma J, Bonsall R, Ramosevac S, Eaton DC, Verlander JW, Hansen L, Gleason RL, Pham TD, Hong S, Pech V, Wall SM. Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling. PLoS One. 2014; 9(8):e105101.
      View in: PubMed
    7. Kwartler CS, Chen J, Thakur D, Li S, Baskin K, Wang S, Wang ZV, Walker L, Hill JA, Epstein HF, Taegtmeyer H, Milewicz DM. Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cells. J Biol Chem. 2014 May 16; 289(20):14075-88.
      View in: PubMed
    8. Thoemmes SF, Stutzke CA, Du Y, Browning MD, Buttrick PM, Walker LA. Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation. J Immunol Methods. 2014 Jan 31; 403(1-2):66-71.
      View in: PubMed
    9. Bonney S, Kominsky D, Brodsky K, Eltzschig H, Walker L, Eckle T. Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. PLoS One. 2013; 8(8):e71493.
      View in: PubMed
    10. Walker LA, Fullerton DA, Buttrick PM. Contractile protein phosphorylation predicts human heart disease phenotypes. Am J Physiol Heart Circ Physiol. 2013 Jun 15; 304(12):H1644-50.
      View in: PubMed
    11. Walker LA, Buttrick PM. The right ventricle: biologic insights and response to disease: updated. Curr Cardiol Rev. 2013 Feb 01; 9(1):73-81.
      View in: PubMed
    12. Bonney S, Hughes K, Harter PN, Mittelbronn M, Walker L, Eckle T. Cardiac period 2 in myocardial ischemia: clinical implications of a light dependent protein. Int J Biochem Cell Biol. 2013 Mar; 45(3):667-71.
      View in: PubMed
    13. Lewandowski ED, Fischer SK, Fasano M, Banke NH, Walker LA, Huqi A, Wang X, Lopaschuk GD, O'Donnell JM. Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy. Circ Res. 2013 Jan 04; 112(1):57-65.
      View in: PubMed
    14. Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP, Eltzschig HK. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med. 2012 Apr 15; 18(5):774-82.
      View in: PubMed
    15. Vitello AM, Du Y, Buttrick PM, Walker LA. Serendipitous discovery of a novel protein signaling mechanism in heart failure. Biochem Biophys Res Commun. 2012 May 11; 421(3):431-5.
      View in: PubMed
    16. Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res. 2012 Mar 02; 110(5):739-48.
      View in: PubMed
    17. Port JD, Walker LA, Polk J, Nunley K, Buttrick PM, Sucharov CC. Temporal expression of miRNAs and mRNAs in a mouse model of myocardial infarction. Physiol Genomics. 2011 Oct 06; 43(19):1087-95.
      View in: PubMed
    18. Walker LA, Walker JS, Glazier A, Brown DR, Stenmark KR, Buttrick PM. Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H832-40.
      View in: PubMed
    19. Ambardekar AV, Walker JS, Walker LA, Cleveland JC, Lowes BD, Buttrick PM. Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support. Circ Heart Fail. 2011 Jul; 4(4):425-32.
      View in: PubMed
    20. Walker JS, Walker LA, Margulies K, Buttrick P, de Tombe P. Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H138-46.
      View in: PubMed
    21. Walker LA, Medway AM, Walker JS, Cleveland JC, Buttrick PM. Tissue procurement strategies affect the protein biochemistry of human heart samples. J Muscle Res Cell Motil. 2011 Mar; 31(5-6):309-14.
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    22. Boontje NM, Merkus D, Zaremba R, Versteilen A, de Waard MC, Mearini G, de Beer VJ, Carrier L, Walker LA, Niessen HW, Dobrev D, Stienen GJ, Duncker DJ, van der Velden J. Enhanced myofilament responsiveness upon ß-adrenergic stimulation in post-infarct remodeled myocardium. J Mol Cell Cardiol. 2011 Mar; 50(3):487-99.
      View in: PubMed
    23. Walker LA, Walker JS, Ambler SK, Buttrick PM. Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice. J Mol Cell Cardiol. 2010 Jun; 48(6):1180-6.
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    24. Duncker DJ, Boontje NM, Merkus D, Versteilen A, Krysiak J, Mearini G, El-Armouche A, de Beer VJ, Lamers JM, Carrier L, Walker LA, Linke WA, Stienen GJ, van der Velden J. Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling. Circ Heart Fail. 2009 May; 2(3):233-42.
      View in: PubMed
    25. Luckey SW, Walker LA, Smyth T, Mansoori J, Messmer-Kratzsch A, Rosenzweig A, Olson EN, Leinwand LA. The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2009 May; 46(5):739-47.
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    26. Walker LA, Buttrick PM. The right ventricle: biologic insights and response to disease. Curr Cardiol Rev. 2009 Jan; 5(1):22-8.
      View in: PubMed
    27. Homma N, Nagaoka T, Karoor V, Imamura M, Taraseviciene-Stewart L, Walker LA, Fagan KA, McMurtry IF, Oka M. Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone. Am J Physiol Lung Cell Mol Physiol. 2008 Jul; 295(1):L71-8.
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    28. Lamberts RR, Hamdani N, Soekhoe TW, Boontje NM, Zaremba R, Walker LA, de Tombe PP, van der Velden J, Stienen GJ. Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. J Physiol. 2007 Jul 15; 582(Pt 2):695-709.
      View in: PubMed
    29. Martin AF, Bhatti S, Pyne-Geithman GJ, Farjah M, Manaves V, Walker L, Franks R, Strauch AR, Paul RJ. Expression and function of COOH-terminal myosin heavy chain isoforms in mouse smooth muscle. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C238-45.
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    30. Dias FA, Walker LA, Arteaga GM, Walker JS, Vijayan K, Peña JR, Ke Y, Fogaca RT, Sanbe A, Robbins J, Wolska BM. The effect of myosin regulatory light chain phosphorylation on the frequency-dependent regulation of cardiac function. J Mol Cell Cardiol. 2006 Aug; 41(2):330-9.
      View in: PubMed
    31. Belin RJ, Sumandea MP, Kobayashi T, Walker LA, Rundell VL, Urboniene D, Yuzhakova M, Ruch SH, Geenen DL, Solaro RJ, de Tombe PP. Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2344-53.
      View in: PubMed
    32. Scruggs SB, Walker LA, Lyu T, Geenen DL, Solaro RJ, Buttrick PM, Goldspink PH. Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol. 2006 Apr; 40(4):465-73.
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    33. Jweied EE, McKinney RD, Walker LA, Brodsky I, Geha AS, Massad MG, Buttrick PM, de Tombe PP. Depressed cardiac myofilament function in human diabetes mellitus. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2478-83.
      View in: PubMed
    34. Urboniene D, Dias FA, Peña JR, Walker LA, Solaro RJ, Wolska BM. Expression of slow skeletal troponin I in adult mouse heart helps to maintain the left ventricular systolic function during respiratory hypercapnia. Circ Res. 2005 Jul 08; 97(1):70-7.
      View in: PubMed
    35. Kobayashi T, Yang X, Walker LA, Van Breemen RB, Solaro RJ. A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J Mol Cell Cardiol. 2005 Jan; 38(1):213-8.
      View in: PubMed
    36. Goldspink PH, Montgomery DE, Walker LA, Urboniene D, McKinney RD, Geenen DL, Solaro RJ, Buttrick PM. Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure. Circ Res. 2004 Aug 20; 95(4):424-32.
      View in: PubMed
    37. Walker LA, MacDonald JA, Liu X, Nakamoto RK, Haystead TA, Somlyo AV, Somlyo AP. Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle. J Biol Chem. 2001 Jul 06; 276(27):24519-24.
      View in: PubMed
    38. Walker JS, Walker LA, Etter EF, Murphy RA. A dilution immunoassay to measure myosin regulatory light chain phosphorylation. Anal Biochem. 2000 Sep 10; 284(2):173-82.
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    39. MacDonald JA, Walker LA, Nakamoto RK, Gorenne I, Somlyo AV, Somlyo AP, Haystead TA. Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle. FEBS Lett. 2000 Aug 18; 479(3):83-8.
      View in: PubMed
    40. Read PW, Liu X, Longenecker K, Dipierro CG, Walker LA, Somlyo AV, Somlyo AP, Nakamoto RK. Human RhoA/RhoGDI complex expressed in yeast: GTP exchange is sufficient for translocation of RhoA to liposomes. Protein Sci. 2000 Feb; 9(2):376-86.
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    41. Longenecker K, Read P, Derewenda U, Dauter Z, Liu X, Garrard S, Walker L, Somlyo AV, Nakamoto RK, Somlyo AP, Derewenda ZS. How RhoGDI binds Rho. Acta Crystallogr D Biol Crystallogr. 1999 Sep; 55(Pt 9):1503-15.
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    42. Nguyen DH, Catling AD, Webb DJ, Sankovic M, Walker LA, Somlyo AV, Weber MJ, Gonias SL. Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J Cell Biol. 1999 Jul 12; 146(1):149-64.
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    43. Somlyo AP, Wu X, Walker LA, Somlyo AV. Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. Rev Physiol Biochem Pharmacol. 1999; 134:201-34.
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    44. Walker LA, Gailly P, Jensen PE, Somlyo AV, Somlyo AP. The unimportance of being (protein kinase C) epsilon. FASEB J. 1998 Jul; 12(10):813-21.
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    45. Fujihara H, Walker LA, Gong MC, Lemichez E, Boquet P, Somlyo AV, Somlyo AP. Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B. Mol Biol Cell. 1997 Dec; 8(12):2437-47.
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    46. Gong MC, Fujihara H, Walker LA, Somlyo AV, Somlyo AP. Down-regulation of G-protein-mediated Ca2+ sensitization in smooth muscle. Mol Biol Cell. 1997 Feb; 8(2):279-86.
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    47. Semenchuk LA, Di Salvo J. Receptor-activated increases in intracellular calcium and protein tyrosine phosphorylation in vascular smooth muscle cells. FEBS Lett. 1995 Aug 14; 370(1-2):127-30.
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    48. Steusloff A, Paul E, Semenchuk LA, Di Salvo J, Pfitzer G. Modulation of Ca2+ sensitivity in smooth muscle by genistein and protein tyrosine phosphorylation. Arch Biochem Biophys. 1995 Jul 10; 320(2):236-42.
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    49. Di Salvo J, Pfitzer G, Semenchuk LA. Protein tyrosine phosphorylation, cellular Ca2+, and Ca2+ sensitivity for contraction of smooth muscle. Can J Physiol Pharmacol. 1994 Nov; 72(11):1434-9.
      View in: PubMed
    50. Di Salvo J, Semenchuk LA, Lauer J. Vanadate-induced contraction of smooth muscle and enhanced protein tyrosine phosphorylation. Arch Biochem Biophys. 1993 Aug 01; 304(2):386-91.
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    51. Di Salvo J, Steusloff A, Semenchuk L, Satoh S, Kolquist K, Pfitzer G. Tyrosine kinase inhibitors suppress agonist-induced contraction in smooth muscle. Biochem Biophys Res Commun. 1993 Feb 15; 190(3):968-74.
      View in: PubMed
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