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Maranke I Koster

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Dermatology
Phone303/724-1640

    Collapse Research 
    Collapse research activities and funding
    K99AR054696     (KOSTER, MARANKE I.)Aug 1, 2007 - Jul 31, 2009
    NIH/NIAMS
    The role of p63 in normal epidermal differentiation and ectodermal dysplasias
    Role: Principal Investigator

    R00AR054696     (KOSTER, MARANKE I.)Sep 14, 2009 - Jun 30, 2012
    NIH/NIAMS
    The role of p63 in normal epidermal differentiation and ectodermal dysplasias
    Role: Principal Investigator

    R01AR061506     (KOSTER, MARANKE I.)Jul 21, 2011 - Jun 30, 2016
    NIH/NIAMS
    The role of p63 in hair follicle stem cells and cancer
    Role: Principal Investigator

    R56AR066713     (KOCH, PETER J.)Sep 17, 2014 - Aug 31, 2016
    NIH/NIAMS
    Elucidating the molecular pathology of ectodermal dysplasias caused by TP63 mutat
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Goldstein NB, Koster MI, Hoaglin LG, Wright MJ, Robinson SE, Robinson WA, Roop DR, Norris DA, Birlea SA. Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection. Exp Dermatol. 2016 Oct; 25(10):805-11. PMID: 27193292.
      View in: PubMed
    2. Lakshmanachetty S, Koster MI. Emerging roles for collagen XV and XVIII in cancer progression. Exp Dermatol. 2016 May; 25(5):346-7. PMID: 26835883.
      View in: PubMed
    3. Goldstein NB, Koster MI, Hoaglin LG, Spoelstra NS, Kechris KJ, Robinson SE, Robinson WA, Roop DR, Norris DA, Birlea SA. Narrow Band Ultraviolet B Treatment for Human Vitiligo Is Associated with Proliferation, Migration, and Differentiation of Melanocyte Precursors. J Invest Dermatol. 2015 Aug; 135(8):2068-76. PMID: 25822579.
      View in: PubMed
    4. Dinella J, Koster MI, Koch PJ. Use of induced pluripotent stem cells in dermatological research. J Invest Dermatol. 2014 Aug; 134(8):e23. PMID: 25029325; PMCID: PMC4527532.
    5. Koch PJ, Dinella J, Fete M, Siegfried EC, Koster MI. Modeling AEC-New approaches to study rare genetic disorders. Am J Med Genet A. 2014 Oct; 164A(10):2443-54. PMID: 24665072; PMCID: PMC4526214.
    6. Koster MI, Dinella J, Chen J, O'Shea C, Koch PJ. Integrating animal models and in vitro tissue models to elucidate the role of desmosomal proteins in diseases. Cell Commun Adhes. 2014 Feb; 21(1):55-63. PMID: 24460201; PMCID: PMC4117210.
    7. Chari NS, Romano RA, Koster MI, Jaks V, Roop D, Flores ER, Teglund S, Sinha S, Gruber W, Aberger F, Medeiros LJ, Toftgard R, McDonnell TJ. Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis. Cell Death Differ. 2013 Aug; 20(8):1080-8. PMID: 23686138; PMCID: PMC3705600.
    8. Tao J, Koster MI, Harrison W, Moran JL, Beier DR, Roop DR, Overbeek PA. A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis. PLoS One. 2012; 7(11):e50634. PMID: 23226340; PMCID: PMC3511458.
    9. Koster MI. Building models for keratin disorders. J Invest Dermatol. 2012 May; 132(5):1324-6. PMID: 22499036.
      View in: PubMed
    10. Ferone G, Thomason HA, Antonini D, De Rosa L, Hu B, Gemei M, Zhou H, Ambrosio R, Rice DP, Acampora D, van Bokhoven H, Del Vecchio L, Koster MI, Tadini G, Spencer-Dene B, Dixon M, Dixon J, Missero C. Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome. EMBO Mol Med. 2012 Mar; 4(3):192-205. PMID: 22247000; PMCID: PMC3376849.
    11. Chen J, O'Shea C, Fitzpatrick JE, Koster MI, Koch PJ. Loss of Desmocollin 3 in skin tumor development and progression. Mol Carcinog. 2012 Jul; 51(7):535-45. PMID: 21681825; PMCID: PMC3178010.
    12. Koster MI. p63 in skin development and ectodermal dysplasias. J Invest Dermatol. 2010 Oct; 130(10):2352-8. PMID: 20445549; PMCID: PMC2919658.
    13. Honeycutt KA, Waikel RL, Koster MI, Wang XJ, Roop DR. The effect of c-myc on stem cell fate influences skin tumor phenotype. Mol Carcinog. 2010 Apr; 49(4):315-9. PMID: 20146250.
      View in: PubMed
    14. Mikkola ML, Costanzo A, Thesleff I, Roop DR, Koster MI. Treasure or artifact: a decade of p63 research speaks for itself. Cell Death Differ. 2010 Jan; 17(1):180-3; author reply 184-6. PMID: 19876067; PMCID: PMC2795030.
    15. Kim S, Choi IF, Quante JR, Zhang L, Roop DR, Koster MI. p63 directly induces expression of Alox12, a regulator of epidermal barrier formation. Exp Dermatol. 2009 Dec; 18(12):1016-21. PMID: 19555433; PMCID: PMC2857403.
    16. Koster MI, Marinari B, Payne AS, Kantaputra PN, Costanzo A, Roop DR. DeltaNp63 knockdown mice: A mouse model for AEC syndrome. Am J Med Genet A. 2009 Sep; 149A(9):1942-7. PMID: 19681108; PMCID: PMC2753548.
    17. Beaudry VG, Pathak N, Koster MI, Attardi LD. Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis. Am J Med Genet A. 2009 Sep; 149A(9):1952-7. PMID: 19353588; PMCID: PMC3982294.
    18. Fete M, vanBokhoven H, Clements SE, McKeon F, Roop DR, Koster MI, Missero C, Attardi LD, Lombillo VA, Ratovitski E, Julapalli M, Ruths D, Sybert VP, Siegfried EC, Bree AF. International Research Symposium on Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome. Am J Med Genet A. 2009 Sep; 149A(9):1885-93. PMID: 19353643; PMCID: PMC2736474.
    19. Koster MI. Making an epidermis. Ann N Y Acad Sci. 2009 Jul; 1170:7-10. PMID: 19686098; PMCID: PMC2861991.
    20. Takeda K, Okamoto M, de Langhe S, Dill E, Armstrong M, Reisdorf N, Irwin D, Koster M, Wilder J, Stenmark KR, West J, Klemm D, Gelfand EW, Nozik-Grayck E, Majka SM. Peroxisome proliferator-activated receptor-g agonist treatment increases septation and angiogenesis and decreases airway hyperresponsiveness in a model of experimental neonatal chronic lung disease. Anat Rec (Hoboken). 2009 Jul; 292(7):1045-61. PMID: 19484746; PMCID: PMC2873208.
    21. Marinari B, Ballaro C, Koster MI, Giustizieri ML, Moretti F, Crosti F, Papoutsaki M, Karin M, Alema S, Chimenti S, Roop DR, Costanzo A. IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias. J Invest Dermatol. 2009 Jan; 129(1):60-9. PMID: 18633439.
      View in: PubMed
    22. Koster MI, Roop DR. Sorting out the p63 signaling network. J Invest Dermatol. 2008 Jul; 128(7):1617-9. PMID: 18548078; PMCID: PMC2854628.
    23. Guttormsen J, Koster MI, Stevens JR, Roop DR, Williams T, Winger QA. Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice. Dev Biol. 2008 May 01; 317(1):187-95. PMID: 18353300; PMCID: PMC2435508.
    24. Shah VR, Koster MI, Roop DR, Spencer DM, Wei L, Li Q, Schwartz RJ, Chang J. Double-inducible gene activation system for caspase 3 and 9 in epidermis. Genesis. 2007 Apr; 45(4):194-9. PMID: 17417788; PMCID: PMC2566959.
    25. Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR. p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3255-60. PMID: 17360634; PMCID: PMC1805532.
    26. Koster MI, Dai D, Roop DR. Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle. 2007 Feb 01; 6(3):269-73. PMID: 17224652.
      View in: PubMed
    27. Koster MI, Roop DR. Mechanisms regulating epithelial stratification. Annu Rev Cell Dev Biol. 2007; 23:93-113. PMID: 17489688.
      View in: PubMed
    28. Keyes WM, Vogel H, Koster MI, Guo X, Qi Y, Petherbridge KM, Roop DR, Bradley A, Mills AA. p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8435-40. PMID: 16714381; PMCID: PMC1482510.
    29. Nguyen BC, Lefort K, Mandinova A, Antonini D, Devgan V, Della Gatta G, Koster MI, Zhang Z, Wang J, Tommasi di Vignano A, Kitajewski J, Chiorino G, Roop DR, Missero C, Dotto GP. Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev. 2006 Apr 15; 20(8):1028-42. PMID: 16618808; PMCID: PMC1472299.
    30. Koster MI, Lu SL, White LD, Wang XJ, Roop DR. Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression. Cancer Res. 2006 Apr 15; 66(8):3981-6. PMID: 16618715.
      View in: PubMed
    31. Honeycutt KA, Chen Z, Koster MI, Miers M, Nuchtern J, Hicks J, Roop DR, Shohet JM. Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis. Oncogene. 2006 Jul 06; 25(29):4027-32. PMID: 16518415.
      View in: PubMed
    32. Koster MI, Kim S, Huang J, Williams T, Roop DR. TAp63alpha induces AP-2gamma as an early event in epidermal morphogenesis. Dev Biol. 2006 Jan 01; 289(1):253-61. PMID: 16324689.
      View in: PubMed
    33. Koster MI, Kim S, Roop DR. P63 deficiency: a failure of lineage commitment or stem cell maintenance? J Investig Dermatol Symp Proc. 2005 Nov; 10(2):118-23. PMID: 16363063.
      View in: PubMed
    34. Koster MI, Roop DR. Asymmetric cell division in skin development: a new look at an old observation. Dev Cell. 2005 Oct; 9(4):444-6. PMID: 16198286.
      View in: PubMed
    35. Koster MI, Roop DR. Genetic pathways required for epidermal morphogenesis. Eur J Cell Biol. 2004 Dec; 83(11-12):625-9. PMID: 15679107.
      View in: PubMed
    36. Koster MI, Roop DR. p63 and epithelial appendage development. Differentiation. 2004 Oct; 72(8):364-70. PMID: 15606495.
      View in: PubMed
    37. Honeycutt KA, Koster MI, Roop DR. Genes involved in stem cell fate decisions and commitment to differentiation play a role in skin disease. J Investig Dermatol Symp Proc. 2004 Sep; 9(3):261-8. PMID: 15369222.
      View in: PubMed
    38. Koster MI, Roop DR. Transgenic mouse models provide new insights into the role of p63 in epidermal development. Cell Cycle. 2004 Apr; 3(4):411-3. PMID: 14976425.
      View in: PubMed
    39. Koster MI, Roop DR. The role of p63 in development and differentiation of the epidermis. J Dermatol Sci. 2004 Feb; 34(1):3-9. PMID: 14757276.
      View in: PubMed
    40. Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 2004 Jan 15; 18(2):126-31. PMID: 14729569; PMCID: PMC324418.
    41. Li AG, Koster MI, Wang XJ. Roles of TGFbeta signaling in epidermal/appendage development. Cytokine Growth Factor Rev. 2003 Apr; 14(2):99-111. PMID: 12651222.
      View in: PubMed
    42. Koster MI, Huntzinger KA, Roop DR. Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation. J Investig Dermatol Symp Proc. 2002 Dec; 7(1):41-5. PMID: 12518791.
      View in: PubMed
    43. Liefer KM, Koster MI, Wang XJ, Yang A, McKeon F, Roop DR. Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res. 2000 Aug 01; 60(15):4016-20. PMID: 10945600.
      View in: PubMed
    44. Phipps DC, West J, Eby R, Koster M, Madore DV, Quataert SA. An ELISA employing a Haemophilus influenzae type b oligosaccharide-human serum albumin conjugate correlates with the radioantigen binding assay. J Immunol Methods. 1990 Dec 31; 135(1-2):121-8. PMID: 2273252.
      View in: PubMed
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