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Ivor S. Douglas

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Biography 
    Collapse awards and honors
    2016Outstanding Clinician Award, Denver Health Medical Center
    2014Outstanding Research Mentor Award, Clinical Science Graduate Program U. Colorado
    2012 - 2012Physician of the Year , Colorado Society for Respiratory Care (CSRC)
    2008 - 2018“Top Doctors” Critical Care, Denver 5280 Magazine
    2008 - 2018Best Doctors in America®, Best Doctors, Inc.
    2010 - 2013Rocky Mountain Society of Hospital Medicine, Peak Performers Award
    2010 - 2012Presidents’ Citation, Society of Critical Care Medicine
    20042004 Housestaff Teaching Award , U. Colorado Health Sciences

    Collapse Overview 
    Collapse overview
    IVOR S. DOUGLAS, MD, FCCP, FRCP (UK) Professor of Medicine
    Ivor S. Douglas, MD is Chief of the Division of Pulmonary Sciences and
    Critical Medicine at Denver Health Medical Center and the Director of the
    Medical Intensive Care Unit. He is an Associate Professor of Medicine at
    the University of Colorado, Denver. He is co-chair of the medical center’s
    critical care committee.
    He completed medical school in South Africa and Internal Medicine
    Residency training in London, Great Britain. He moved to the University of
    Chicago in 1994 and completed pulmonary and critical care fellowship
    training and achieved Board Certification. Dr. Douglas has been
    recognized annually for clinical care by 5280 Magazine and Best Doctors in America. In addition to championing the implementation of computerized provider order entry (CPOE) and ICU electronic medical record system at DHMC, Dr. Douglas oversees quality performance improvement for the ICU. Dr. Douglas has received housestaff teaching awards at the U. Chicago, Columbia University and UC Denver and the Outstanding Clinician award from Denver Health. Dr. Douglas is a Fellow of the Royal College of Physicians and the American College of Chest Physicians.
    Dr. Douglas is an NIH, DOD and industry-funded principle investigator for ongoing investigations in several aspects of clinical critical care including acute lung injury, sepsis, metabolic disturbances in critical illness, ventilator-associated pneumonia, the contribution of alcohol intoxication and withdrawal in critical illness and therapeutic strategies for sedation and delirium in the critically ill. Dr. Douglas is co-investigator for the NIH-funded Prevention and Early Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome Network (PETAL).
    Dr. Douglas is a peer reviewer for high impact medical journals; serves on NIH SEP study sections and steering and safety committees for several ongoing international critical care trials and represented the Soc. Of Critical Care Medicine to the Hospital Quality Alliance, a national body that endorsed and reported quality measures for hospitalized patients in the US.
    He was co-chair of the international Surviving Sepsis Campaign Guideline writing committee and was national PI for the CMMI-funded High Value Healthcare Collaborative's Sepsis Improvement project that is implementing sepsis-bundle care using Toyota Lean systems strategies.
    He served as Chair of the American Thoracic Society’s Critical Care Assembly program committee, Chair of the ATS Healthcare Policy Committee, and served on the board of Colorado’s QIO, the Colorado Foundation for Medical Care (CFMC). Dr. Douglas additionally represents the American Hospital Association on the Joint Commission’s Hospital Professional & Technical Advisory Committee (PTAC).

    • Denver Health:
    • Pulmonary/Critical Care:
    Visit Denver Health
    Contact Information:
    Ivor S. Douglas MD. FRCP(UK) (Adminstrator, Doris Quintana)
    Chief, Pulmonary Sciences & Critical Care Medicine
    Professor, Pulmonary Sciences and Critical Care
    Director; Medical Intensive Care; Denver Health
    Department of Medicine, MC 4000
    777 Bannock Street; Denver, CO 80204
    Telephone: (303) 602 5012; Fax: (303) 602 5755
    Twitter: @com543

    Collapse Research 
    Collapse research activities and funding
    K08HL070940     (DOUGLAS, IVOR SAMUEL)Sep 30, 2003 - Aug 31, 2010
    Angiogenesis in hyperoxic lung fibrosis
    Role: Principal Investigator

    R01NR016459     (CARSON, SHANNON S)Sep 26, 2016 - Jul 31, 2021
    Prediction of Functional Outcomes from Chronic Critical Illness
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Douglas IS, Bednash JS, Fein DG, Mallampalli RK, Mansoori J, Gershengorn HB. Update in Critical Care / ARDS 2018. Am J Respir Crit Care Med. 2019 Apr 08. PMID: 30958975.
      View in: PubMed
    2. Mehta AB, Walkey AJ, Curran-Everett D, Matlock D, Douglas IS. Hospital Mechanical Ventilation Volume and Patient Outcomes: Too Much of a Good Thing? Crit Care Med. 2019 Mar; 47(3):360-368. PMID: 30585831.
      View in: PubMed
    3. Borg B, Douglas IS, Hull M, Keniston A, Moss M, Clark BJ. Alcohol misuse and outpatient follow-up after hospital discharge: a retrospective cohort study. Addict Sci Clin Pract. 2018 Dec 04; 13(1):24. PMID: 30514357.
      View in: PubMed
    4. Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, Douglas IS, Malhotra A, Owens RL, Feinstein DJ, Khan B, Pisani MA, Hyzy RC, Schmidt GA, Schweickert WD, Hite RD, Bowton DL, Masica AL, Thompson JL, Chandrasekhar R, Pun BT, Strength C, Boehm LM, Jackson JC, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Bernard GR, Dittus RS, Ely EW. Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness. N Engl J Med. 2018 12 27; 379(26):2506-2516. PMID: 30346242.
      View in: PubMed
    5. Lahm T, Douglas IS, Archer SL, Bogaard HJ, Chesler NC, Haddad F, Hemnes AR, Kawut SM, Kline JA, Kolb TM, Mathai SC, Mercier O, Michelakis ED, Naeije R, Tuder RM, Ventetuolo CE, Vieillard-Baron A, Voelkel NF, Vonk-Noordegraaf A, Hassoun PM. Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2018 Aug 15; 198(4):e15-e43. PMID: 30109950.
      View in: PubMed
    6. Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI. Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial. Ann Emerg Med. 2018 Oct; 72(4):457-466. PMID: 29753517.
      View in: PubMed
    7. Park BH, Shin MH, Douglas IS, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Chang J, Kim YS, Park MS. Erythropoietin-Producing Hepatoma Receptor Tyrosine Kinase A2 Modulation Associates with Protective Effect of Prone Position in Ventilator-induced Lung Injury. Am J Respir Cell Mol Biol. 2018 Apr; 58(4):519-529. PMID: 29216437.
      View in: PubMed
    8. Mehta AB, Douglas IS, Walkey AJ. Evidence-based Utilization of Noninvasive Ventilation and Patient Outcomes. Ann Am Thorac Soc. 2017 Nov; 14(11):1667-1673. PMID: 28541747.
      View in: PubMed
    9. Fang WF, Douglas IS, Chen YM, Lin CY, Kao HC, Fang YT, Huang CH, Chang YT, Huang KT, Wang YH, Wang CC, Lin MC. Development and validation of immune dysfunction score to predict 28-day mortality of sepsis patients. PLoS One. 2017; 12(10):e0187088. PMID: 29073262.
      View in: PubMed
    10. Durfee J, Johnson T, Batal H, Long J, Rinehart D, Everhart R, Oronce CI, Douglas I, Moore K, Atherly A. The impact of tailored intervention services on charges and mortality for adult super-utilizers. Healthc (Amst). 2018 Dec; 6(4):253-258. PMID: 28847571.
      View in: PubMed
    11. Leem AY, Shin MH, Douglas IS, Song JH, Chung KS, Kim EY, Jung JY, Kang YA, Chang J, Kim YS, Park MS. All-trans retinoic acid attenuates bleomycin-induced pulmonary fibrosis via downregulating EphA2-EphrinA1 signaling. Biochem Biophys Res Commun. 2017 09 23; 491(3):721-726. PMID: 28743499.
      View in: PubMed
    12. Clark BJ, Jones J, Reed KD, Hodapp R, Douglas IS, Van Pelt D, Burnham EL, Moss M. The Experience of Patients with Alcohol Misuse after Surviving a Critical Illness. A Qualitative Study. Ann Am Thorac Soc. 2017 Jul; 14(7):1154-1161. PMID: 28406727.
      View in: PubMed
    13. Douglas IS. Pulmonary infections in critical/intensive care - rapid diagnosis and optimizing antimicrobial usage. Curr Opin Pulm Med. 2017 05; 23(3):198-203. PMID: 28257317.
      View in: PubMed
    14. Stahel PF, Douglas IS, VanderHeiden TF, Weckbach S. The history of risk: a review. World J Emerg Surg. 2017; 12:15. PMID: 28293279.
      View in: PubMed
    15. Holguin F, Moughrabieh MA, Ojeda V, Patel SR, Peyrani P, Pinedo M, Celedón JC, Douglas IS, Upson DJ, Roman J. Respiratory Health in Migrant Populations: A Crisis Overlooked. Ann Am Thorac Soc. 2017 Feb; 14(2):153-159. PMID: 28146384.
      View in: PubMed
    16. Maddux AB, Hiller TD, Overdier KH, Pyle LL, Douglas IS. Innate Immune Function and Organ Failure Recovery in Adults With Sepsis. J Intensive Care Med. 2017 Jan 01; 885066617701903. PMID: 28372498.
      View in: PubMed
    17. Mehta AB, Cooke CR, Douglas IS, Lindenauer PK, Wiener RS, Walkey AJ. Association of Early Do-Not-Resuscitate Orders with Unplanned Readmissions among Patients Hospitalized for Pneumonia. Ann Am Thorac Soc. 2017 Jan; 14(1):103-109. PMID: 27753520.
      View in: PubMed
    18. Mehta AB, Douglas IS, Walkey AJ. Reply: Hospital Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Another Look at the Same Coin. Ann Am Thorac Soc. 2016 12; 13(12):2279-2280. PMID: 27925793.
      View in: PubMed
    19. Mehta AB, Douglas IS, Walkey AJ. Hospital Noninvasive Ventilation Case Volume and Outcomes of Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2016 10; 13(10):1752-1759. PMID: 27404021.
      View in: PubMed
    20. Hong JY, Shin MH, Douglas IS, Chung KS, Kim EY, Jung JY, Kang YA, Kim SK, Chang J, Kim YS, Park MS. Inhibition of EphA2/EphrinA1 signal attenuates lipopolysaccharide-induced lung injury. Clin Sci (Lond). 2016 11 01; 130(21):1993-2003. PMID: 27549114.
      View in: PubMed
    21. Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ. Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 08 15; 194(4):439-49. PMID: 26926297.
      View in: PubMed
    22. Douglas IS. New diagnostic methods for pneumonia in the ICU. Curr Opin Infect Dis. 2016 Apr; 29(2):197-204. PMID: 26859725.
      View in: PubMed
    23. Wilson KC, Gould MK, Krishnan JA, Boyd CM, Brozek JL, Cooke CR, Douglas IS, Goodman RA, Joo MJ, Lareau S, Mularski RA, Patel MR, Rosenfeld RM, Shanawani H, Slatore C, Sockrider M, Sufian B, Thomson CC, Wiener RS. An Official American Thoracic Society Workshop Report. A Framework for Addressing Multimorbidity in Clinical Practice Guidelines for Pulmonary Disease, Critical Illness, and Sleep Disorders. Ann Am Thorac Soc. 2016 Mar; 13(3):S12-21. PMID: 26963362.
      View in: PubMed
    24. Lyon SM, Moore N, Douglas IS, Cooke CR. Update on the Affordable Care Act. King v. Burwell and Obergefell v. Hodge. Ann Am Thorac Soc. 2016 Mar; 13(3):324-8. PMID: 26731515.
      View in: PubMed
    25. Douglas IS, Albertson TE, Folan P, Hanania NA, Tashkin DP, Upson DJ, Leone FT. Implications of Marijuana Decriminalization on the Practice of Pulmonary, Critical Care, and Sleep Medicine. A Report of the American Thoracic Society Marijuana Workgroup. Ann Am Thorac Soc. 2015 Nov; 12(11):1700-10. PMID: 26540421.
      View in: PubMed
    26. Hough CL, Caldwell ES, Cox CE, Douglas IS, Kahn JM, White DB, Seeley EJ, Bangdiwala SI, Rubenfeld GD, Angus DC, Carson SS. Development and Validation of a Mortality Prediction Model for Patients Receiving 14 Days of Mechanical Ventilation. Crit Care Med. 2015 Nov; 43(11):2339-45. PMID: 26247337; PMCID: PMC4788381.
    27. Lammi MR, Aiello B, Burg GT, Rehman T, Douglas IS, Wheeler AP, deBoisblanc BP. Response to fluid boluses in the fluid and catheter treatment trial. Chest. 2015 Oct; 148(4):919-926. PMID: 26020673; PMCID: PMC4694152 [Available on 10/01/16].
    28. Ivor S. Douglas. Guest Commentary: Douglas: For Colorado’s public health, we must act on climate. 2015.
    29. Sun X, Li L, Overdier KH, Ammons LA, Douglas IS, Burlew CC, Zhang F, Schmidt EP, Chi L, Linhardt RJ. Analysis of Total Human Urinary Glycosaminoglycan Disaccharides by Liquid Chromatography-Tandem Mass Spectrometry. Anal Chem. 2015 Jun 16; 87(12):6220-7. PMID: 26005898.
      View in: PubMed
    30. Maddux AB, Douglas IS. Is the developmentally immature immune response in paediatric sepsis a recapitulation of immune tolerance? Immunology. 2015 May; 145(1):1-10. PMID: 25691226; PMCID: PMC4405319.
    31. Douglas IS, Price CS, Overdier KH, Wolken RF, Metzger SW, Hance KR, Howson DC. Rapid automated microscopy for microbiological surveillance of ventilator-associated pneumonia. Am J Respir Crit Care Med. 2015 Mar 01; 191(5):566-73. PMID: 25585163; PMCID: PMC4384769.
    32. Goodson CM, Clark BJ, Douglas IS. Predictors of severe alcohol withdrawal syndrome: a systematic review and meta-analysis. Alcohol Clin Exp Res. 2014 Oct; 38(10):2664-77. PMID: 25346507.
      View in: PubMed
    33. Fernandez-Bustamante A, Klawitter J, Repine JE, Agazio A, Janocha AJ, Shah C, Moss M, Douglas IS, Tran ZV, Erzurum SC, Christians U, Seres T. Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs. Anesthesiology. 2014 Sep; 121(3):469-81. PMID: 24809976; PMCID: PMC4165799.
    34. Liao MM, Lezotte D, Lowenstein SR, Howard K, Finley Z, Feng Z, Byyny RL, Sankoff JD, Douglas IS, Haukoos JS. Sensitivity of systemic inflammatory response syndrome for critical illness among ED patients. Am J Emerg Med. 2014 Nov; 32(11):1319-25. PMID: 25205616; PMCID: PMC4254326.
    35. Fang WF, Douglas IS, Wang CC, Kao HC, Chang YT, Tseng CC, Huang KT, Chang HC, Lin MC. 5-Lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates Lipid A endotoxin-induced inflammation. PLoS One. 2014; 9(7):e102622. PMID: 25025775; PMCID: PMC4099325.
    36. Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP, Hough CL, Hite RD, Thompson BT. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 05; 370(23):2191-200. PMID: 24835849; PMCID: PMC4241052.
    37. Lyon SM, Douglas IS, Cooke CR. Medicaid expansion under the Affordable Care Act. Implications for insurance-related disparities in pulmonary, critical care, and sleep. Ann Am Thorac Soc. 2014 May; 11(4):661-7. PMID: 24708065; PMCID: PMC4225799.
    38. Kahn JM, Gould MK, Krishnan JA, Wilson KC, Au DH, Cooke CR, Douglas IS, Feemster LC, Mularski RA, Slatore CG, Wiener RS. An official American thoracic society workshop report: developing performance measures from clinical practice guidelines. Ann Am Thorac Soc. 2014 May; 11(4):S186-95. PMID: 24828810.
      View in: PubMed
    39. Kim HJ, Ravichandran K, Ozkok A, Wang Q, He Z, Jani A, Ljubanovic D, Douglas IS, Edelstein CL. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun; 349(3):518-25. PMID: 24727856.
      View in: PubMed
    40. Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ. The circulating glycosaminoglycan signature of respiratory failure in critically ill adults. J Biol Chem. 2014 Mar 21; 289(12):8194-202. PMID: 24509853; PMCID: PMC3961648.
    41. Leone FT, Douglas IS. The emergence of e-cigarettes: a triumph of wishful thinking over science. Ann Am Thorac Soc. 2014 Feb; 11(2):216-9. PMID: 24575986.
      View in: PubMed
    42. Otten D, Liao MM, Wolken R, Douglas IS, Mishra R, Kao A, Barrett W, Drasler E, Byyny RL, Haukoos JS. Comparison of bag-valve-mask hand-sealing techniques in a simulated model. Ann Emerg Med. 2014 Jan; 63(1):6-12.e3. PMID: 23937957; PMCID: PMC4866830.
    43. Clark BJ, Keniston A, Douglas IS, Beresford T, Macht M, Williams A, Jones J, Burnham EL, Moss M. Healthcare utilization in medical intensive care unit survivors with alcohol withdrawal. Alcohol Clin Exp Res. 2013 Sep; 37(9):1536-43. PMID: 23647435; PMCID: PMC4045620.
    44. Lamontagne F, Quiroz Martinez H, Adhikari NK, Cook DJ, Koo KK, Lauzier F, Turgeon AF, Kho ME, Burns KE, Chant C, Fowler R, Douglas I, Poulin Y, Choong K, Ferguson ND, Meade MO. Corticosteroid use in the intensive care unit: a survey of intensivists. Can J Anaesth. 2013 Jul; 60(7):652-9. PMID: 23606231.
      View in: PubMed
    45. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013 Feb; 41(2):580-637. PMID: 23353941.
      View in: PubMed
    46. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013 Feb; 39(2):165-228. PMID: 23361625.
      View in: PubMed
    47. Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012 Aug; 18(8):1217-23. PMID: 22820644; PMCID: PMC3723751.
    48. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gårdlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med. 2012 May 31; 366(22):2055-64. PMID: 22616830.
      View in: PubMed
    49. Tonelli MR, Curtis JR, Guntupalli KK, Rubenfeld GD, Arroliga AC, Brochard L, Douglas IS, Gutterman DD, Hall JR, Kavanagh BP, Mancebo J, Misak CJ, Simpson SQ, Slutsky AS, Suffredini AF, Thompson BT, Ware LB, Wheeler AP, Levy MM. An official multi-society statement: the role of clinical research results in the practice of critical care medicine. Am J Respir Crit Care Med. 2012 May 15; 185(10):1117-24. PMID: 22589312.
      View in: PubMed
    50. Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, Douglas IS. Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs. Am J Respir Crit Care Med. 2012 Jul 01; 186(1):72-81. PMID: 22582160; PMCID: PMC3400991.
    51. Carson SS, Kahn JM, Hough CL, Seeley EJ, White DB, Douglas IS, Cox CE, Caldwell E, Bangdiwala SI, Garrett JM, Rubenfeld GD. A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation. Crit Care Med. 2012 Apr; 40(4):1171-6. PMID: 22080643; PMCID: PMC3395423.
    52. Man M, Close SL, Shaw AD, Bernard GR, Douglas IS, Kaner RJ, Payen D, Vincent JL, Fossceco S, Janes JM, Leishman AG, O'Brien L, Williams MD, Garcia JG. Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. Pharmacogenomics J. 2013 Jun; 13(3):218-26. PMID: 22310353.
      View in: PubMed
    53. Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD. Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med. 2011 Dec; 39(12):2665-71. PMID: 21785346; PMCID: PMC3220741.
    54. Wolken RF, Woodruff RJ, Smith J, Albert RK, Douglas IS. Observational study of head of bed elevation adherence using a continuous monitoring system in a medical intensive care unit. Respir Care. 2012 Apr; 57(4):537-43. PMID: 22005904.
      View in: PubMed
    55. Clark BJ, Smart A, House R, Douglas I, Burnham EL, Moss M. Severity of acute illness is associated with baseline readiness to change in medical intensive care unit patients with unhealthy alcohol use. Alcohol Clin Exp Res. 2012 Mar; 36(3):544-51. PMID: 21950704; PMCID: PMC3251713.
    56. Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, MacIntyre N, Moss M, Schoenfeld D, Steingrub J, Thompson BT. Randomized, placebo-controlled clinical trial of an aerosolized ß2-agonist for treatment of acute lung injury. Am J Respir Crit Care Med. 2011 Sep 01; 184(5):561-8. PMID: 21562125; PMCID: PMC3175548.
    57. Malcolm KC, Kret JE, Young RL, Poch KR, Caceres SM, Douglas IS, Coldren CD, Burnham EL, Moss M, Nick JA. Bacteria-specific neutrophil dysfunction associated with interferon-stimulated gene expression in the acute respiratory distress syndrome. PLoS One. 2011; 6(7):e21958. PMID: 21755013; PMCID: PMC3130788.
    58. Ranieri VM, Thompson BT, Finfer S, Barie PS, Dhainaut JF, Douglas IS, Gårdlund B, Marshall JC, Rhodes A. Unblinding plan of PROWESS-SHOCK trial. Intensive Care Med. 2011 Aug; 37(8):1384-5. PMID: 21691888.
      View in: PubMed
    59. Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H, Hoth JJ, Mikkelsen ME, Gentile NT, Gong MN, Talmor D, Bajwa E, Watkins TR, Festic E, Yilmaz M, Iscimen R, Kaufman DA, Esper AM, Sadikot R, Douglas I, Sevransky J, Malinchoc M. Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 2011 Feb 15; 183(4):462-70. PMID: 20802164; PMCID: PMC3056224.
    60. Thompson BT, Ranieri VM, Finfer S, Barie PS, Dhainaut JF, Douglas IS, Gårdlund B, Marshall JC, Rhodes A. Statistical analysis plan of PROWESS SHOCK study. Intensive Care Med. 2010 Nov; 36(11):1972-3. PMID: 20689934; PMCID: PMC3279641.
    61. Dennen P, Douglas IS, Anderson R. Acute kidney injury in the intensive care unit: an update and primer for the intensivist. Crit Care Med. 2010 Jan; 38(1):261-75. PMID: 19829099.
      View in: PubMed
    62. Graham BB, Keniston A, Gajic O, Trillo Alvarez CA, Medvedev S, Douglas IS. Diabetes mellitus does not adversely affect outcomes from a critical illness. Crit Care Med. 2010 Jan; 38(1):16-24. PMID: 19789450.
      View in: PubMed
    63. Tseng CC, Fang WF, Huang KT, Chang PW, Tu ML, Shiang YP, Douglas IS, Lin MC. Risk factors for mortality in patients with nosocomial Stenotrophomonas maltophilia pneumonia. Infect Control Hosp Epidemiol. 2009 Dec; 30(12):1193-202. PMID: 19852664.
      View in: PubMed
    64. Brown LK, Marcy TW, Kissner D, Douglas I. Approaches to achieving universal health care in the United States: where should the American thoracic society stand? Am J Respir Crit Care Med. 2009 Nov 15; 180(10):918-9. PMID: 19897770.
      View in: PubMed
    65. Tseng CC, Fang WF, Chung YH, Wang YH, Douglas IS, Lin MC. Clinical outcomes in patients with ICU-related pancreatitis. World J Gastroenterol. 2009 Oct 21; 15(39):4938-44. PMID: 19842226; PMCID: PMC2764973.
    66. Finfer S, Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Gårdlund B, Marshall JC, Rhodes A. Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med. 2008 Nov; 34(11):1935-47. PMID: 18839141; PMCID: PMC2995439.
    67. Robertson TE, Mann HJ, Hyzy R, Rogers A, Douglas I, Waxman AB, Weinert C, Alapat P, Guntupalli KK, Buchman TG. Multicenter implementation of a consensus-developed, evidence-based, spontaneous breathing trial protocol. Crit Care Med. 2008 Oct; 36(10):2753-62. PMID: 18828193.
      View in: PubMed
    68. Klein CL, Hoke TS, Fang WF, Altmann CJ, Douglas IS, Faubel S. Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy. Kidney Int. 2008 Oct; 74(7):901-9. PMID: 18596724.
      View in: PubMed
    69. Douglas IS. Junior doctors' working hours: a view from across the pond (3). Clin Med (Lond). 2008 Jun; 8(3):348. PMID: 18624056.
      View in: PubMed
    70. Douglas IS, Dassopoulos T. Rheostat regulation of integrin-mediated leukocyte adhesion. J Clin Invest. 2007 Sep; 117(9):2391-5. PMID: 17786236; PMCID: PMC1952648.
    71. Levi M, Levy M, Williams MD, Douglas I, Artigas A, Antonelli M, Wyncoll D, Janes J, Booth FV, Wang D, Sundin DP, Macias WL. Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). Am J Respir Crit Care Med. 2007 Sep 01; 176(5):483-90. PMID: 17556722.
      View in: PubMed
    72. Fang WF, Cho JH, He Q, Lin MC, Wu CC, Voelkel NF, Douglas IS. Lipid A fraction of LPS induces a discrete MAPK activation in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L336-44. PMID: 17496062.
      View in: PubMed
    73. Arciniegas E, Frid MG, Douglas IS, Stenmark KR. Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L1-8. PMID: 17384082.
      View in: PubMed
    74. Voelkel NF, Douglas IS, Nicolls M. Angiogenesis in chronic lung disease. Chest. 2007 Mar; 131(3):874-879. PMID: 17356107; PMCID: PMC4396181.
    75. O'Brien JM, Lu B, Ali NA, Martin GS, Aberegg SK, Marsh CB, Lemeshow S, Douglas IS. Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Crit Care Med. 2007 Feb; 35(2):345-50. PMID: 17205003.
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    76. Bull SV, Douglas IS, Foster M, Albert RK. Mandatory protocol for treating adult patients with diabetic ketoacidosis decreases intensive care unit and hospital lengths of stay: results of a nonrandomized trial. Crit Care Med. 2007 Jan; 35(1):41-6. PMID: 17095944.
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    77. Dexter ME, Cosgrove GP, Douglas IS. Managing a rare condition presenting with intractable hypoxemic respiratory failure. Chest. 2007 Jan; 131(1):320-7. PMID: 17218595.
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    78. Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S. Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007 Jan; 18(1):155-64. PMID: 17167117.
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    79. Taraseviciene-Stewart L, Douglas IS, Nana-Sinkam PS, Lee JD, Tuder RM, Nicolls MR, Voelkel NF. Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease? Proc Am Thorac Soc. 2006 Nov; 3(8):687-90. PMID: 17065374.
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    80. Henson PM, Vandivier RW, Douglas IS. Cell death, remodeling, and repair in chronic obstructive pulmonary disease? Proc Am Thorac Soc. 2006 Nov; 3(8):713-7. PMID: 17065379; PMCID: PMC2647658.
    81. Simonian PL, Roark CL, Diaz del Valle F, Palmer BE, Douglas IS, Ikuta K, Born WK, O'Brien RL, Fontenot AP. Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis. J Immunol. 2006 Oct 01; 177(7):4436-43. PMID: 16982878.
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    82. Clancy M, Graepler A, Wilson M, Douglas I, Johnson J, Price CS. Active screening in high-risk units is an effective and cost-avoidant method to reduce the rate of methicillin-resistant Staphylococcus aureus infection in the hospital. Infect Control Hosp Epidemiol. 2006 Oct; 27(10):1009-17. PMID: 17006806.
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    83. Douglas I. Hyponatremia: why it matters, how it presents, how we can manage it. Cleve Clin J Med. 2006 Sep; 73 Suppl 3:S4-12. PMID: 16970147.
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    84. Vandivier RW, Henson PM, Douglas IS. Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest. 2006 Jun; 129(6):1673-82. PMID: 16778289.
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    85. Rucker DW, Steele AW, Douglas IS, Coudere CA, Hardel GG. Design and use of a joint order vocabulary knowledge representation tier in a multi-tier CPOE architecture. AMIA Annu Symp Proc. 2006; 669-73. PMID: 17238425; PMCID: PMC1839695.
    86. Douglas IS, Diaz del Valle F, Winn RA, Voelkel NF. Beta-catenin in the fibroproliferative response to acute lung injury. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):274-85. PMID: 16272459; PMCID: PMC2644193.
    87. Douglas IS, Nicolls MR. Chemokine-mediated angiogenesis: an essential link in the evolution of airway fibrosis? J Clin Invest. 2005 May; 115(5):1133-6. PMID: 15864341; PMCID: PMC1087192.
    88. Kim JY, Park JS, Strassheim D, Douglas I, Diaz del Valle F, Asehnoune K, Mitra S, Kwak SH, Yamada S, Maruyama I, Ishizaka A, Abraham E. HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L958-65. PMID: 15640285.
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    89. Douglas IS. Possible explanations for the results of CRASH. Lancet. 2005 Jan 15-21; 365(9455):212; author reply 213-214. PMID: 15652596.
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    90. Fessler MB, O'Brien JM, Douglas IS. Laboratory predictors of relative adrenal insufficiency in septic shock. Crit Care Med. 2003 Aug; 31(8):2251-2; author reply 2252-3. PMID: 12973195.
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    91. Schleien CL, Osmond MH, Hickey R, Hutchison J, Buunk G, Douglas IS, Gervais HW, Wenzel V. Postresuscitation management. Ann Emerg Med. 2001 Apr; 37(4 Suppl):S182-95. PMID: 11290962.
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    92. Douglas IS, Leff AR, Sperling AI. CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation. J Immunol. 2000 Mar 15; 164(6):3385-91. PMID: 10706734.
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    93. Douglas IS, White SR. Should non-small cell carcinoma of the lung be treated with chemotherapy? Con: therapeutic empiricism--the case against chemotherapy in non-small cell lung cancer. Am J Respir Crit Care Med. 1995 May; 151(5):1288-91. PMID: 7735575.
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