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Ivor S. Douglas

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Address2SOM
School of Medicine
13001 East 17th Place
Aurora CO 80045

     Biography 
     awards and honors
    2014Outstanding Research Mentor Award , Clinical Science Graduate Program U. of Colorado Denver
    2012Physician of the Year 2012, Colorado Society for Respiratory Care (CSRC)
    2008 - 2014“Top Doctors”, Denver 5280 Magazine
    2008 - 2014Best Doctors in America®, Best Doctors, Inc.
    20042004 Housestaff Teaching Award , U. Colorado Health Sciences
    2010 - 2012Presidents’ Citation, Society of Critical Care Medicine
    2010 - 2013Rocky Mountain Society of Hospital Medicine, Peak Performers Award

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Douglas IS, Price CS, Overdier KH, Wolken RF, Metzger SW, Hance KR, Howson DC. Rapid Automated Microscopy for Microbiological Surveillance of Ventilator-associated Pneumonia. Am J Respir Crit Care Med. 2015 Mar 1; 191(5):566-73.
      View in: PubMed
    2. Goodson CM, Clark BJ, Douglas IS. Predictors of severe alcohol withdrawal syndrome: a systematic review and meta-analysis. Alcohol Clin Exp Res. 2014 Oct; 38(10):2664-77.
      View in: PubMed
    3. Fernandez-Bustamante A, Klawitter J, Repine JE, Agazio A, Janocha AJ, Shah C, Moss M, Douglas IS, Tran ZV, Erzurum SC, Christians U, Seres T. Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs. Anesthesiology. 2014 Sep; 121(3):469-81.
      View in: PubMed
    4. Liao MM, Lezotte D, Lowenstein SR, Howard K, Finley Z, Feng Z, Byyny RL, Sankoff JD, Douglas IS, Haukoos JS. Sensitivity of systemic inflammatory response syndrome for critical illness among ED patients. Am J Emerg Med. 2014 Nov; 32(11):1319-25.
      View in: PubMed
    5. Fang WF, Douglas IS, Wang CC, Kao HC, Chang YT, Tseng CC, Huang KT, Chang HC, Lin MC. 5-Lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates Lipid A endotoxin-induced inflammation. PLoS One. 2014; 9(7):e102622.
      View in: PubMed
    6. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 5; 370(23):2191-200.
      View in: PubMed
    7. Kahn JM, Gould MK, Krishnan JA, Wilson KC, Au DH, Cooke CR, Douglas IS, Feemster LC, Mularski RA, Slatore CG, Wiener RS. An official American Thoracic Society workshop report: developing performance measures from clinical practice guidelines. Ann Am Thorac Soc. 2014 May; 11(4):S186-95.
      View in: PubMed
    8. Lyon SM, Douglas IS, Cooke CR. Medicaid expansion under the Affordable Care Act. Implications for insurance-related disparities in pulmonary, critical care, and sleep. Ann Am Thorac Soc. 2014 May; 11(4):661-7.
      View in: PubMed
    9. Kim HJ, Ravichandran K, Ozkok A, Wang Q, He Z, Jani A, Ljubanovic D, Douglas IS, Edelstein CL. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun; 349(3):518-25.
      View in: PubMed
    10. Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ. The circulating glycosaminoglycan signature of respiratory failure in critically ill adults. J Biol Chem. 2014 Mar 21; 289(12):8194-202.
      View in: PubMed
    11. Leone FT, Douglas IS. The emergence of e-cigarettes: a triumph of wishful thinking over science. Ann Am Thorac Soc. 2014 Feb; 11(2):216-9.
      View in: PubMed
    12. Otten D, Liao MM, Wolken R, Douglas IS, Mishra R, Kao A, Barrett W, Drasler E, Byyny RL, Haukoos JS. Comparison of bag-valve-mask hand-sealing techniques in a simulated model. Ann Emerg Med. 2014 Jan; 63(1):6-12.e3.
      View in: PubMed
    13. Clark BJ, Keniston A, Douglas IS, Beresford T, Macht M, Williams A, Jones J, Burnham EL, Moss M. Healthcare utilization in medical intensive care unit survivors with alcohol withdrawal. Alcohol Clin Exp Res. 2013 Sep; 37(9):1536-43.
      View in: PubMed
    14. Lamontagne F, Quiroz Martinez H, Adhikari NK, Cook DJ, Koo KK, Lauzier F, Turgeon AF, Kho ME, Burns KE, Chant C, Fowler R, Douglas I, Poulin Y, Choong K, Ferguson ND, Meade MO. Corticosteroid use in the intensive care unit: a survey of intensivists. Can J Anaesth. 2013 Jul; 60(7):652-9.
      View in: PubMed
    15. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013 Feb; 41(2):580-637.
      View in: PubMed
    16. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013 Feb; 39(2):165-228.
      View in: PubMed
    17. Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012 Aug; 18(8):1217-23.
      View in: PubMed
    18. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gårdlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med. 2012 May 31; 366(22):2055-64.
      View in: PubMed
    19. Tonelli MR, Curtis JR, Guntupalli KK, Rubenfeld GD, Arroliga AC, Brochard L, Douglas IS, Gutterman DD, Hall JR, Kavanagh BP, Mancebo J, Misak CJ, Simpson SQ, Slutsky AS, Suffredini AF, Thompson BT, Ware LB, Wheeler AP, Levy MM. An official multi-society statement: the role of clinical research results in the practice of critical care medicine. Am J Respir Crit Care Med. 2012 May 15; 185(10):1117-24.
      View in: PubMed
    20. Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, Douglas IS. Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs. Am J Respir Crit Care Med. 2012 Jul 1; 186(1):72-81.
      View in: PubMed
    21. Carson SS, Kahn JM, Hough CL, Seeley EJ, White DB, Douglas IS, Cox CE, Caldwell E, Bangdiwala SI, Garrett JM, Rubenfeld GD. A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation. Crit Care Med. 2012 Apr; 40(4):1171-6.
      View in: PubMed
    22. Man M, Close SL, Shaw AD, Bernard GR, Douglas IS, Kaner RJ, Payen D, Vincent JL, Fossceco S, Janes JM, Leishman AG, O'Brien L, Williams MD, Garcia JG. Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. Pharmacogenomics J. 2013 Jun; 13(3):218-26.
      View in: PubMed
    23. Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD. Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med. 2011 Dec; 39(12):2665-71.
      View in: PubMed
    24. Wolken RF, Woodruff RJ, Smith J, Albert RK, Douglas IS. Observational study of head of bed elevation adherence using a continuous monitoring system in a medical intensive care unit. Respir Care. 2012 Apr; 57(4):537-43.
      View in: PubMed
    25. Clark BJ, Smart A, House R, Douglas I, Burnham EL, Moss M. Severity of acute illness is associated with baseline readiness to change in medical intensive care unit patients with unhealthy alcohol use. Alcohol Clin Exp Res. 2012 Mar; 36(3):544-51.
      View in: PubMed
    26. Randomized, placebo-controlled clinical trial of an aerosolized ß2-agonist for treatment of acute lung injury. Am J Respir Crit Care Med. 2011 Sep 1; 184(5):561-8.
      View in: PubMed
    27. Malcolm KC, Kret JE, Young RL, Poch KR, Caceres SM, Douglas IS, Coldren CD, Burnham EL, Moss M, Nick JA. Bacteria-specific neutrophil dysfunction associated with interferon-stimulated gene expression in the acute respiratory distress syndrome. PLoS One. 2011; 6(7):e21958.
      View in: PubMed
    28. Ranieri VM, Thompson BT, Finfer S, Barie PS, Dhainaut JF, Douglas IS, Gårdlund B, Marshall JC, Rhodes A. Unblinding plan of PROWESS-SHOCK trial. Intensive Care Med. 2011 Aug; 37(8):1384-5.
      View in: PubMed
    29. Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H, Hoth JJ, Mikkelsen ME, Gentile NT, Gong MN, Talmor D, Bajwa E, Watkins TR, Festic E, Yilmaz M, Iscimen R, Kaufman DA, Esper AM, Sadikot R, Douglas I, Sevransky J, Malinchoc M. Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 2011 Feb 15; 183(4):462-70.
      View in: PubMed
    30. Statistical analysis plan of PROWESS SHOCK study. Intensive Care Med. 2010 Nov; 36(11):1972-3.
      View in: PubMed
    31. Dennen P, Douglas IS, Anderson R. Acute kidney injury in the intensive care unit: an update and primer for the intensivist. Crit Care Med. 2010 Jan; 38(1):261-75.
      View in: PubMed
    32. Graham BB, Keniston A, Gajic O, Trillo Alvarez CA, Medvedev S, Douglas IS. Diabetes mellitus does not adversely affect outcomes from a critical illness. Crit Care Med. 2010 Jan; 38(1):16-24.
      View in: PubMed
    33. Tseng CC, Fang WF, Huang KT, Chang PW, Tu ML, Shiang YP, Douglas IS, Lin MC. Risk factors for mortality in patients with nosocomial Stenotrophomonas maltophilia pneumonia. Infect Control Hosp Epidemiol. 2009 Dec; 30(12):1193-202.
      View in: PubMed
    34. Brown LK, Marcy TW, Kissner D, Douglas I. Approaches to achieving universal health care in the United States: where should the American thoracic society stand? Am J Respir Crit Care Med. 2009 Nov 15; 180(10):918-9.
      View in: PubMed
    35. Tseng CC, Fang WF, Chung YH, Wang YH, Douglas IS, Lin MC. Clinical outcomes in patients with ICU-related pancreatitis. World J Gastroenterol. 2009 Oct 21; 15(39):4938-44.
      View in: PubMed
    36. Finfer S, Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Gårdlund B, Marshall JC, Rhodes A. Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med. 2008 Nov; 34(11):1935-47.
      View in: PubMed
    37. Robertson TE, Mann HJ, Hyzy R, Rogers A, Douglas I, Waxman AB, Weinert C, Alapat P, Guntupalli KK, Buchman TG. Multicenter implementation of a consensus-developed, evidence-based, spontaneous breathing trial protocol. Crit Care Med. 2008 Oct; 36(10):2753-62.
      View in: PubMed
    38. Klein CL, Hoke TS, Fang WF, Altmann CJ, Douglas IS, Faubel S. Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy. Kidney Int. 2008 Oct; 74(7):901-9.
      View in: PubMed
    39. Douglas IS. Junior doctors' working hours: a view from across the pond (3). Clin Med. 2008 Jun; 8(3):348.
      View in: PubMed
    40. Douglas IS, Dassopoulos T. Rheostat regulation of integrin-mediated leukocyte adhesion. J Clin Invest. 2007 Sep; 117(9):2391-5.
      View in: PubMed
    41. Levi M, Levy M, Williams MD, Douglas I, Artigas A, Antonelli M, Wyncoll D, Janes J, Booth FV, Wang D, Sundin DP, Macias WL. Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). Am J Respir Crit Care Med. 2007 Sep 1; 176(5):483-90.
      View in: PubMed
    42. Fang WF, Cho JH, He Q, Lin MC, Wu CC, Voelkel NF, Douglas IS. Lipid A fraction of LPS induces a discrete MAPK activation in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L336-44.
      View in: PubMed
    43. Arciniegas E, Frid MG, Douglas IS, Stenmark KR. Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L1-8.
      View in: PubMed
    44. Voelkel NF, Douglas IS, Nicolls M. Angiogenesis in chronic lung disease. Chest. 2007 Mar; 131(3):874-9.
      View in: PubMed
    45. O'Brien JM, Lu B, Ali NA, Martin GS, Aberegg SK, Marsh CB, Lemeshow S, Douglas IS. Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Crit Care Med. 2007 Feb; 35(2):345-50.
      View in: PubMed
    46. Bull SV, Douglas IS, Foster M, Albert RK. Mandatory protocol for treating adult patients with diabetic ketoacidosis decreases intensive care unit and hospital lengths of stay: results of a nonrandomized trial. Crit Care Med. 2007 Jan; 35(1):41-6.
      View in: PubMed
    47. Dexter ME, Cosgrove GP, Douglas IS. Managing a rare condition presenting with intractable hypoxemic respiratory failure. Chest. 2007 Jan; 131(1):320-7.
      View in: PubMed
    48. Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S. Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007 Jan; 18(1):155-64.
      View in: PubMed
    49. Taraseviciene-Stewart L, Douglas IS, Nana-Sinkam PS, Lee JD, Tuder RM, Nicolls MR, Voelkel NF. Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease? Proc Am Thorac Soc. 2006 Nov; 3(8):687-90.
      View in: PubMed
    50. Henson PM, Vandivier RW, Douglas IS. Cell death, remodeling, and repair in chronic obstructive pulmonary disease? Proc Am Thorac Soc. 2006 Nov; 3(8):713-7.
      View in: PubMed
    51. Simonian PL, Roark CL, Diaz del Valle F, Palmer BE, Douglas IS, Ikuta K, Born WK, O'Brien RL, Fontenot AP. Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis. J Immunol. 2006 Oct 1; 177(7):4436-43.
      View in: PubMed
    52. Clancy M, Graepler A, Wilson M, Douglas I, Johnson J, Price CS. Active screening in high-risk units is an effective and cost-avoidant method to reduce the rate of methicillin-resistant Staphylococcus aureus infection in the hospital. Infect Control Hosp Epidemiol. 2006 Oct; 27(10):1009-17.
      View in: PubMed
    53. Douglas I. Hyponatremia: why it matters, how it presents, how we can manage it. Cleve Clin J Med. 2006 Sep; 73 Suppl 3:S4-12.
      View in: PubMed
    54. Vandivier RW, Henson PM, Douglas IS. Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest. 2006 Jun; 129(6):1673-82.
      View in: PubMed
    55. Rucker DW, Steele AW, Douglas IS, Coudere CA, Hardel GG. Design and use of a joint order vocabulary knowledge representation tier in a multi-tier CPOE architecture. AMIA Annu Symp Proc. 2006; 669-73.
      View in: PubMed
    56. Douglas IS, Diaz del Valle F, Winn RA, Voelkel NF. Beta-catenin in the fibroproliferative response to acute lung injury. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):274-85.
      View in: PubMed
    57. Douglas IS, Nicolls MR. Chemokine-mediated angiogenesis: an essential link in the evolution of airway fibrosis? J Clin Invest. 2005 May; 115(5):1133-6.
      View in: PubMed
    58. Kim JY, Park JS, Strassheim D, Douglas I, Diaz del Valle F, Asehnoune K, Mitra S, Kwak SH, Yamada S, Maruyama I, Ishizaka A, Abraham E. HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L958-65.
      View in: PubMed
    59. Douglas IS. Possible explanations for the results of CRASH. Lancet. 2005 Jan 15-21; 365(9455):212; author reply 213-214.
      View in: PubMed
    60. Fessler MB, O'Brien JM, Douglas IS. Laboratory predictors of relative adrenal insufficiency in septic shock. Crit Care Med. 2003 Aug; 31(8):2251-2; author reply 2252-3.
      View in: PubMed
    61. Schleien CL, Osmond MH, Hickey R, Hutchison J, Buunk G, Douglas IS, Gervais HW, Wenzel V. Postresuscitation management. Ann Emerg Med. 2001 Apr; 37(4 Suppl):S182-95.
      View in: PubMed
    62. Douglas IS, Leff AR, Sperling AI. CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation. J Immunol. 2000 Mar 15; 164(6):3385-91.
      View in: PubMed
    63. Douglas IS, White SR. Should non-small cell carcinoma of the lung be treated with chemotherapy? Con: therapeutic empiricism--the case against chemotherapy in non-small cell lung cancer. Am J Respir Crit Care Med. 1995 May; 151(5):1288-91.
      View in: PubMed
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