Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Contact Us
If you have any questions or feedback please contact us.

Peter M. Henson

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology
Address2RC1N
Research North Tower
12800 E 19th Ave, Bldg. RC1 North Room P18-9103
Aurora CO 80010

     Biography 
     awards and honors
    2011Distinguished Professor, Univeristy of Colorado
    2005Burns Amberson Lecture, ATS Centenary Meeting
    2002Honary Doctor of Medicine, University of Edinburgh
    1980Parke Davis Award, American Association of Pathologists
    1991Margaret A. Regan Professor of Pulmonary inflammation, National Jewish Health

     Overview 
     overview
    Peter Henson was born in England and spent his high school years in Southern Rhodesia (now Zimbabwe) where his interest in science and nature was kindled by outstanding teachers in Chemistry and Biology. Returning to the UK he received his Veterinary training and a microbiology degree from the University of Edinburgh, Scotland. After short stints of Veterinary practice he embarked on his research career by completing a PhD in Immunology at the University of Cambridge, focusing on biological activities of the complement system. A migration to La Jolla, California and the Scripps Research Institute to pursue a Postdoctoral Fellowship in Immunopathology, led to a stay of 10 years and his first foray into the world of lung inflammation. During that time, Dr Henson’s interest in mediators of inflammation led to the discovery of a unique phospholipid mediator, PAF (platelet activating factor) as well the demonstration that release of mediators from inflammatory cells involved active and controllable secretory processes (rather than passive release of constituents following cell lysis as was then believed). A provident move to Denver in 1977 to help revitalize the research program in Pediatrics at what is now National Jewish Health, included his joining the Pulmonary & Critical Care Division at the University of Colorado. From 1985 to 1987 he was Co-director of that Division and from 1982-1997, Vice President for Academic Affairs at National Jewish with responsibilities initially for both clinical and research activities at the institution. Recognizing that his research was suffering from this excursion into administration, Dr Henson happily relinquished these responsibilities in 1997 to focus full time on research. In the early 1980’s, his laboratory’s investigation of how pulmonary inflammation resolves led to the demonstration that inflammatory cells become apoptotic, expose phosphatidylserine on their surface and are cleared locally by phagocytic cells. The mechanisms and implications of this unique form of self recognition, its importance in innate immunity, development, tissue remodeling and homeostasis as well as in many forms of pulmonary disease, have been a research focus ever since. An honorary Doctorate of Medicine from the University of Edinburgh in 2002 gratifyingly justified his work in human medicine for the previous 25 years. Throughout his career he has been supported by his colleague and wife, Jan, who also provides ultrastructural and histologic validation of the cellular and tissue systems his laboratory investigates.


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Yunt ZX, Mohning MP, Barthel L, Kearns MT, Tuder RM, Hyde DM, Henson PM, Janssen WJ. Kinetics of the angiogenic response in lung endothelium following acute inflammatory injury with bleomycin. Exp Lung Res. 2014 Oct; 40(8):415-25.
      View in: PubMed
    2. Desch AN, Gibbings SL, Clambey ET, Janssen WJ, Slansky JE, Kedl RM, Henson PM, Jakubzick C. Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat Commun. 2014; 5:4674.
      View in: PubMed
    3. Kearns MT, Barthel L, Bednarek JM, Yunt ZX, Henson PM, Janssen WJ. Fas ligand-expressing lymphocytes enhance alveolar macrophage apoptosis in the resolution of acute pulmonary inflammation. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 1; 307(1):L62-70.
      View in: PubMed
    4. Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, Bratton DL, Riches DW. Tumor Necrosis Factor-a Accelerates the Resolution of Established Pulmonary Fibrosis in Mice by Targeting Profibrotic Lung Macrophages. Am J Respir Cell Mol Biol. 2014 Apr; 50(4):825-37.
      View in: PubMed
    5. Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Protein Tyrosine Phosphatase a Mediates Profibrotic Signaling in Lung Fibroblasts through TGF-ß Responsiveness. Am J Pathol. 2014 May; 184(5):1489-502.
      View in: PubMed
    6. Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b is required for airway defence. Nature. 2014 Jan 16; 505(7483):412-6.
      View in: PubMed
    7. Janssen WJ, Yunt ZX, Muldrow A, Kearns MT, Kloepfer A, Barthel L, Bratton DL, Bowler RP, Henson PM. Circulating Hematopoietic Progenitor Cells are Decreased in COPD. COPD. 2014 Jun; 11(3):277-89.
      View in: PubMed
    8. Jakubzick C, Gautier EL, Gibbings SL, Sojka DK, Schlitzer A, Johnson TE, Ivanov S, Duan Q, Bala S, Condon T, van Rooijen N, Grainger JR, Belkaid Y, Ma'ayan A, Riches DW, Yokoyama WM, Ginhoux F, Henson PM, Randolph GJ. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity. 2013 Sep 19; 39(3):599-610.
      View in: PubMed
    9. Xiong W, Frasch SC, Thomas SM, Bratton DL, Henson PM. Induction of TGF-ß1 synthesis by macrophages in response to apoptotic cells requires activation of the scavenger receptor CD36. PLoS One. 2013; 8(8):e72772.
      View in: PubMed
    10. Henson PM, Bratton DL. Antiinflammatory effects of apoptotic cells. J Clin Invest. 2013 Jul 1; 123(7):2773-4.
      View in: PubMed
    11. Desch AN, Henson PM, Jakubzick CV. Pulmonary dendritic cell development and antigen acquisition. Immunol Res. 2013 Mar; 55(1-3):178-86.
      View in: PubMed
    12. Henson PM, Bratton DL. Allergy: airway epithelial Rac1 suppresses allergic inflammation. Curr Biol. 2013 Feb 4; 23(3):R104-6.
      View in: PubMed
    13. Frasch SC, Fernandez-Boyanapalli RF, Berry KA, Murphy RC, Leslie CC, Nick JA, Henson PM, Bratton DL. Neutrophils regulate tissue Neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine. J Biol Chem. 2013 Feb 15; 288(7):4583-93.
      View in: PubMed
    14. Lara AR, Cosgrove GP, Janssen WJ, Huie TJ, Burnham EL, Heinz DE, Curran-Everett D, Sahin H, Schwarz MI, Cool CD, Groshong SD, Geraci MW, Tuder RM, Hyde DM, Henson PM. Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia. Chest. 2012 Dec; 142(6):1569-76.
      View in: PubMed
    15. Cole C, Thomas S, Filak H, Henson PM, Lenz LL. Nitric oxide increases susceptibility of Toll-like receptor-activated macrophages to spreading Listeria monocytogenes. Immunity. 2012 May 25; 36(5):807-20.
      View in: PubMed
    16. Kearns MT, Dalal S, Horstmann SA, Richens TR, Tanaka T, Doe JM, Boe DM, Voelkel NF, Taraseviciene-Stewart L, Janssen WJ, Lee CG, Elias JA, Bratton D, Tuder RM, Henson PM, Vandivier RW. Vascular endothelial growth factor enhances macrophage clearance of apoptotic cells. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1; 302(7):L711-8.
      View in: PubMed
    17. Janssen WJ, Henson PM. Cellular regulation of the inflammatory response. Toxicol Pathol. 2012; 40(2):166-73.
      View in: PubMed
    18. Korns D, Frasch SC, Fernandez-Boyanapalli R, Henson PM, Bratton DL. Modulation of macrophage efferocytosis in inflammation. Front Immunol. 2011; 2:57.
      View in: PubMed
    19. Janssen WJ, Barthel L, Muldrow A, Oberley-Deegan RE, Kearns MT, Jakubzick C, Henson PM. Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury. Am J Respir Crit Care Med. 2011 Sep 1; 184(5):547-60.
      View in: PubMed
    20. Zemans RL, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, De Langhe S, Reynolds SD, Mason RJ, Kahn M, Henson PM, Colgan SP, Downey GP. Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15990-5.
      View in: PubMed
    21. Desch AN, Randolph GJ, Murphy K, Gautier EL, Kedl RM, Lahoud MH, Caminschi I, Shortman K, Henson PM, Jakubzick CV. CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. J Exp Med. 2011 Aug 29; 208(9):1789-97.
      View in: PubMed
    22. Kenyon KD, Cole C, Crawford F, Kappler JW, Thurman JM, Bratton DL, Boackle SA, Henson PM. IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol. 2011 Sep 1; 187(5):2101-11.
      View in: PubMed
    23. Bratton DL, Henson PM. Neutrophil clearance: when the party is over, clean-up begins. Trends Immunol. 2011 Aug; 32(8):350-7.
      View in: PubMed
    24. Redente EF, Jacobsen KM, Solomon JJ, Lara AR, Faubel S, Keith RC, Henson PM, Downey GP, Riches DW. Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L510-8.
      View in: PubMed
    25. Zoller EE, Lykens JE, Terrell CE, Aliberti J, Filipovich AH, Henson PM, Jordan MB. Hemophagocytosis causes a consumptive anemia of inflammation. J Exp Med. 2011 Jun 6; 208(6):1203-14.
      View in: PubMed
    26. Berry KA, Li B, Reynolds SD, Barkley RM, Gijón MA, Hankin JA, Henson PM, Murphy RC. MALDI imaging MS of phospholipids in the mouse lung. J Lipid Res. 2011 Aug; 52(8):1551-60.
      View in: PubMed
    27. Frasch SC, Fernandez-Boyanapalli RF, Berry KZ, Leslie CC, Bonventre JV, Murphy RC, Henson PM, Bratton DL. Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity. J Biol Chem. 2011 Apr 8; 286(14):12108-22.
      View in: PubMed
    28. Park HJ, Choi YH, Cho YJ, Henson PM, Kang JL. RhoA-mediated signaling up-regulates hepatocyte growth factor gene and protein expression in response to apoptotic cells. J Leukoc Biol. 2011 Mar; 89(3):399-411.
      View in: PubMed
    29. Fernandez-Boyanapalli R, McPhillips KA, Frasch SC, Janssen WJ, Dinauer MC, Riches DW, Henson PM, Byrne A, Bratton DL. Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-? in a nitric oxide-dependent manner. J Immunol. 2010 Oct 1; 185(7):4030-41.
      View in: PubMed
    30. Fernandez-Boyanapalli R, Frasch SC, Riches DW, Vandivier RW, Henson PM, Bratton DL. PPAR? activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease. Blood. 2010 Nov 25; 116(22):4512-22.
      View in: PubMed
    31. Hong X, Zang J, White J, Wang C, Pan CH, Zhao R, Murphy RC, Dai S, Henson P, Kappler JW, Hagman J, Zhang G. Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14568-72.
      View in: PubMed
    32. Boé DM, Richens TR, Horstmann SA, Burnham EL, Janssen WJ, Henson PM, Moss M, Vandivier RW. Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alcohol Clin Exp Res. 2010 Oct; 34(10):1723-32.
      View in: PubMed
    33. Henson PM, Downey GP, Irvin CG. It's much more than just pretty pictures. Am J Respir Cell Mol Biol. 2010 May; 42(5):515-6.
      View in: PubMed
    34. Janssen WJ, Muldrow A, Kearns MT, Barthel L, Henson PM. Development and characterization of a lung-protective method of bone marrow transplantation in the mouse. J Immunol Methods. 2010 May 31; 357(1-2):1-9.
      View in: PubMed
    35. Henson PM. Phagocytosis: invitation to a feast. Curr Biol. 2009 Nov 17; 19(21):R989-91.
      View in: PubMed
    36. Borges VM, Vandivier RW, McPhillips KA, Kench JA, Morimoto K, Groshong SD, Richens TR, Graham BB, Muldrow AM, Van Heule L, Henson PM, Janssen WJ. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L586-95.
      View in: PubMed
    37. Vandivier RW, Richens TR, Horstmann SA, deCathelineau AM, Ghosh M, Reynolds SD, Xiao YQ, Riches DW, Plumb J, Vachon E, Downey GP, Henson PM. Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L677-86.
      View in: PubMed
    38. Monks J, Henson PM. Differentiation of the mammary epithelial cell during involution: implications for breast cancer. J Mammary Gland Biol Neoplasia. 2009 Jun; 14(2):159-70.
      View in: PubMed
    39. Anwar A, Keating AK, Joung D, Sather S, Kim GK, Sawczyn KK, Brandão L, Henson PM, Graham DK. Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress. J Leukoc Biol. 2009 Jul; 86(1):73-9.
      View in: PubMed
    40. Guth AM, Janssen WJ, Bosio CM, Crouch EC, Henson PM, Dow SW. Lung environment determines unique phenotype of alveolar macrophages. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L936-46.
      View in: PubMed
    41. Richens TR, Linderman DJ, Horstmann SA, Lambert C, Xiao YQ, Keith RL, Boé DM, Morimoto K, Bowler RP, Day BJ, Janssen WJ, Henson PM, Vandivier RW. Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am J Respir Crit Care Med. 2009 Jun 1; 179(11):1011-21.
      View in: PubMed
    42. Nakanishi Y, Henson PM, Shiratsuchi A. Pattern recognition in phagocytic clearance of altered self. Adv Exp Med Biol. 2009; 653:129-38.
      View in: PubMed
    43. Yun JH, Henson PM, Tuder RM. Phagocytic clearance of apoptotic cells: role in lung disease. Expert Rev Respir Med. 2008 Dec; 2(6):753-65.
      View in: PubMed
    44. Berry KA, Henson PM, Murphy RC. Effects of acrolein on leukotriene biosynthesis in human neutrophils. Chem Res Toxicol. 2008 Dec; 21(12):2424-32.
      View in: PubMed
    45. Fernandez-Boyanapalli RF, Frasch SC, McPhillips K, Vandivier RW, Harry BL, Riches DW, Henson PM, Bratton DL. Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4. Blood. 2009 Feb 26; 113(9):2047-55.
      View in: PubMed
    46. Frasch SC, Berry KZ, Fernandez-Boyanapalli R, Jin HS, Leslie C, Henson PM, Murphy RC, Bratton DL. NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A. J Biol Chem. 2008 Nov 28; 283(48):33736-49.
      View in: PubMed
    47. Xiao YQ, Freire-de-Lima CG, Schiemann WP, Bratton DL, Vandivier RW, Henson PM. Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells. J Immunol. 2008 Sep 1; 181(5):3575-85.
      View in: PubMed
    48. Janssen WJ, McPhillips KA, Dickinson MG, Linderman DJ, Morimoto K, Xiao YQ, Oldham KM, Vandivier RW, Henson PM, Gardai SJ. Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha. Am J Respir Crit Care Med. 2008 Jul 15; 178(2):158-67.
      View in: PubMed
    49. Bratton DL, Henson PM. Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up? Curr Biol. 2008 Jan 22; 18(2):R76-9.
      View in: PubMed
    50. Monks J, Smith-Steinhart C, Kruk ER, Fadok VA, Henson PM. Epithelial cells remove apoptotic epithelial cells during post-lactation involution of the mouse mammary gland. Biol Reprod. 2008 Apr; 78(4):586-94.
      View in: PubMed
    51. Babu AN, Murakawa T, Thurman JM, Miller EJ, Henson PM, Zamora MR, Voelkel NF, Nicolls MR. Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis. J Clin Invest. 2007 Dec; 117(12):3774-85.
      View in: PubMed
    52. Nix RN, Altschuler SE, Henson PM, Detweiler CS. Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. PLoS Pathog. 2007 Dec; 3(12):e193.
      View in: PubMed
    53. Erwig LP, Henson PM. Immunological consequences of apoptotic cell phagocytosis. Am J Pathol. 2007 Jul; 171(1):2-8.
      View in: PubMed
    54. McPhillips K, Janssen WJ, Ghosh M, Byrne A, Gardai S, Remigio L, Bratton DL, Kang JL, Henson P. TNF-alpha inhibits macrophage clearance of apoptotic cells via cytosolic phospholipase A2 and oxidant-dependent mechanisms. J Immunol. 2007 Jun 15; 178(12):8117-26.
      View in: PubMed
    55. Frasch SC, Zemski-Berry K, Murphy RC, Borregaard N, Henson PM, Bratton DL. Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A. J Immunol. 2007 May 15; 178(10):6540-8.
      View in: PubMed
    56. Henson PM, Vandivier RW, Douglas IS. Cell death, remodeling, and repair in chronic obstructive pulmonary disease? Proc Am Thorac Soc. 2006 Nov; 3(8):713-7.
      View in: PubMed
    57. Freire-de-Lima CG, Xiao YQ, Gardai SJ, Bratton DL, Schiemann WP, Henson PM. Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages. J Biol Chem. 2006 Dec 15; 281(50):38376-84.
      View in: PubMed
    58. Sather S, Kenyon KD, Lefkowitz JB, Liang X, Varnum BC, Henson PM, Graham DK. A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood. 2007 Feb 1; 109(3):1026-33.
      View in: PubMed
    59. Erwig LP, McPhilips KA, Wynes MW, Ivetic A, Ridley AJ, Henson PM. Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins. Proc Natl Acad Sci U S A. 2006 Aug 22; 103(34):12825-30.
      View in: PubMed
    60. Jehle AW, Gardai SJ, Li S, Linsel-Nitschke P, Morimoto K, Janssen WJ, Vandivier RW, Wang N, Greenberg S, Dale BM, Qin C, Henson PM, Tall AR. ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J Cell Biol. 2006 Aug 14; 174(4):547-56.
      View in: PubMed
    61. Henson PM, Cosgrove GP, Vandivier RW. State of the art. Apoptosis and cell homeostasis in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):512-6.
      View in: PubMed
    62. Morimoto K, Janssen WJ, Fessler MB, Xiao YQ, McPhillips KA, Borges VM, Kench JA, Henson PM, Vandivier RW. Statins enhance clearance of apoptotic cells through modulation of Rho-GTPases. Proc Am Thorac Soc. 2006 Aug; 3(6):516-7.
      View in: PubMed
    63. Cool CD, Groshong SD, Rai PR, Henson PM, Stewart JS, Brown KK. Fibroblast foci are not discrete sites of lung injury or repair: the fibroblast reticulum. Am J Respir Crit Care Med. 2006 Sep 15; 174(6):654-8.
      View in: PubMed
    64. Morimoto K, Janssen WJ, Fessler MB, McPhillips KA, Borges VM, Bowler RP, Xiao YQ, Kench JA, Henson PM, Vandivier RW. Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease. J Immunol. 2006 Jun 15; 176(12):7657-65.
      View in: PubMed
    65. Vandivier RW, Henson PM, Douglas IS. Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest. 2006 Jun; 129(6):1673-82.
      View in: PubMed
    66. Gardai SJ, Bratton DL, Ogden CA, Henson PM. Recognition ligands on apoptotic cells: a perspective. J Leukoc Biol. 2006 May; 79(5):896-903.
      View in: PubMed
    67. Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson PM, Bhardwaj N. The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function. Blood. 2006 Aug 1; 108(3):947-55.
      View in: PubMed
    68. Henson PM, Hume DA. Apoptotic cell removal in development and tissue homeostasis. Trends Immunol. 2006 May; 27(5):244-50.
      View in: PubMed
    69. Henson PM, Vandivier RW. The matrix degrades, neutrophils invade. Nat Med. 2006 Mar; 12(3):280-1.
      View in: PubMed
    70. Xiao YQ, Freire-de-Lima CG, Janssen WJ, Morimoto K, Lyu D, Bratton DL, Henson PM. Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production. J Immunol. 2006 Jan 15; 176(2):1209-17.
      View in: PubMed
    71. Stuart LM, Henson PM, Vandivier RW. Collectins: opsonins for apoptotic cells and regulators of inflammation. Curr Dir Autoimmun. 2006; 9:143-61.
      View in: PubMed
    72. Henson PM. Dampening inflammation. Nat Immunol. 2005 Dec; 6(12):1179-81.
      View in: PubMed
    73. Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, Bratton DL, Oldenborg PA, Michalak M, Henson PM. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell. 2005 Oct 21; 123(2):321-34.
      View in: PubMed
    74. Murakawa T, Kerklo MM, Zamora MR, Wei Y, Gill RG, Henson PM, Grover FL, Nicolls MR. Simultaneous LFA-1 and CD40 ligand antagonism prevents airway remodeling in orthotopic airway transplantation: implications for the role of respiratory epithelium as a modulator of fibrosis. J Immunol. 2005 Apr 1; 174(7):3869-79.
      View in: PubMed
    75. Hoffmann PR, Kench JA, Vondracek A, Kruk E, Daleke DL, Jordan M, Marrack P, Henson PM, Fadok VA. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol. 2005 Feb 1; 174(3):1393-404.
      View in: PubMed
    76. Henson PM. Engulfment: ingestion and migration with Rac, Rho and TRIO. Curr Biol. 2005 Jan 11; 15(1):R29-30.
      View in: PubMed
    77. Bratton DL, Henson PM. Autoimmunity and apoptosis: refusing to go quietly. Nat Med. 2005 Jan; 11(1):26-7.
      View in: PubMed
    78. Henson PM. Fingering IL-12 with apoptotic cells. Immunity. 2004 Nov; 21(5):604-6.
      View in: PubMed
    79. Golpon HA, Fadok VA, Taraseviciene-Stewart L, Scerbavicius R, Sauer C, Welte T, Henson PM, Voelkel NF. Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. FASEB J. 2004 Nov; 18(14):1716-8.
      View in: PubMed
    80. Manaka J, Kuraishi T, Shiratsuchi A, Nakai Y, Higashida H, Henson P, Nakanishi Y. Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages. J Biol Chem. 2004 Nov 12; 279(46):48466-76.
      View in: PubMed
    81. Gardai SJ, Whitlock BB, Xiao YQ, Bratton DB, Henson PM. Oxidants inhibit ERK/MAPK and prevent its ability to delay neutrophil apoptosis downstream of mitochondrial changes and at the level of XIAP. J Biol Chem. 2004 Oct 22; 279(43):44695-703.
      View in: PubMed
    82. Suratt BT, Petty JM, Young SK, Malcolm KC, Lieber JG, Nick JA, Gonzalo JA, Henson PM, Worthen GS. Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. Blood. 2004 Jul 15; 104(2):565-71.
      View in: PubMed
    83. Gardai SJ, Hildeman DA, Frankel SK, Whitlock BB, Frasch SC, Borregaard N, Marrack P, Bratton DL, Henson PM. Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem. 2004 May 14; 279(20):21085-95.
      View in: PubMed
    84. Frasch SC, Henson PM, Nagaosa K, Fessler MB, Borregaard N, Bratton DL. Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils. J Biol Chem. 2004 Apr 23; 279(17):17625-33.
      View in: PubMed
    85. Wang X, Wu YC, Fadok VA, Lee MC, Gengyo-Ando K, Cheng LC, Ledwich D, Hsu PK, Chen JY, Chou BK, Henson P, Mitani S, Xue D. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science. 2003 Nov 28; 302(5650):1563-6.
      View in: PubMed
    86. Gardai SJ, Xiao YQ, Dickinson M, Nick JA, Voelker DR, Greene KE, Henson PM. By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell. 2003 Oct 3; 115(1):13-23.
      View in: PubMed
    87. Henson PM. Possible roles for apoptosis and apoptotic cell recognition in inflammation and fibrosis. Am J Respir Cell Mol Biol. 2003 Sep; 29(3 Suppl):S70-6.
      View in: PubMed
    88. Fadok VA, Henson PM. Apoptosis: giving phosphatidylserine recognition an assist--with a twist. Curr Biol. 2003 Aug 19; 13(16):R655-7.
      View in: PubMed
    89. Tuder RM, Petrache I, Elias JA, Voelkel NF, Henson PM. Apoptosis and emphysema: the missing link. Am J Respir Cell Mol Biol. 2003 May; 28(5):551-4.
      View in: PubMed
    90. deCathelineau AM, Henson PM. The final step in programmed cell death: phagocytes carry apoptotic cells to the grave. Essays Biochem. 2003; 39:105-17.
      View in: PubMed
    91. Sala A, Profita M, Siena L, Henson PM, Murphy RC, Paternò A, Bonanno A, Riccobono L, Mirabella A, Bonsignore G, Vignola AM. Il-4-induced lipid mediators class switching in human normal mononuclear phagocytes. Adv Exp Med Biol. 2003; 525:15-8.
      View in: PubMed
    92. Gardai SJ, Hoontrakoon R, Goddard CD, Day BJ, Chang LY, Henson PM, Bratton DL. Oxidant-mediated mitochondrial injury in eosinophil apoptosis: enhancement by glucocorticoids and inhibition by granulocyte-macrophage colony-stimulating factor. J Immunol. 2003 Jan 1; 170(1):556-66.
      View in: PubMed
    93. Nick JA, Young SK, Arndt PG, Lieber JG, Suratt BT, Poch KR, Avdi NJ, Malcolm KC, Taube C, Henson PM, Worthen GS. Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase. J Immunol. 2002 Nov 1; 169(9):5260-9.
      View in: PubMed
    94. Vandivier RW, Ogden CA, Fadok VA, Hoffmann PR, Brown KK, Botto M, Walport MJ, Fisher JH, Henson PM, Greene KE. Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol. 2002 Oct 1; 169(7):3978-86.
      View in: PubMed
    95. Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Puré E, Henson PM, Noble PW. Resolution of lung inflammation by CD44. Science. 2002 Apr 5; 296(5565):155-8.
      View in: PubMed
    96. Hoontrakoon R, Chu HW, Gardai SJ, Wenzel SE, McDonald P, Fadok VA, Henson PM, Bratton DL. Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation. Am J Respir Cell Mol Biol. 2002 Apr; 26(4):404-12.
      View in: PubMed
    97. Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK, Brain JD, Accurso FJ, Henson PM. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest. 2002 Mar; 109(5):661-70.
      View in: PubMed
    98. Profita M, Sala A, Siena L, Henson PM, Murphy RC, Paternò A, Bonanno A, Riccobono L, Mirabella A, Bonsignore G, Vignola AM. Leukotriene B4 production in human mononuclear phagocytes is modulated by interleukin-4-induced 15-lipoxygenase. J Pharmacol Exp Ther. 2002 Mar; 300(3):868-75.
      View in: PubMed
    99. Vandivier RW, Fadok VA, Ogden CA, Hoffmann PR, Brain JD, Accurso FJ, Fisher JH, Greene KE, Henson PM. Impaired clearance of apoptotic cells from cystic fibrosis airways. Chest. 2002 Mar; 121(3 Suppl):89S.
      View in: PubMed
    100. Xiao YQ, Malcolm K, Worthen GS, Gardai S, Schiemann WP, Fadok VA, Bratton DL, Henson PM. Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta. J Biol Chem. 2002 Apr 26; 277(17):14884-93.
      View in: PubMed
    101. Huynh ML, Fadok VA, Henson PM. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest. 2002 Jan; 109(1):41-50.
      View in: PubMed
    102. Su HP, Nakada-Tsukui K, Tosello-Trampont AC, Li Y, Bu G, Henson PM, Ravichandran KS. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). J Biol Chem. 2002 Apr 5; 277(14):11772-9.
      View in: PubMed
    103. Gardai S, Whitlock BB, Helgason C, Ambruso D, Fadok V, Bratton D, Henson PM. Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils. J Biol Chem. 2002 Feb 15; 277(7):5236-46.
      View in: PubMed
    Henson's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts
    _
    Co-Authors
    _
    Similar People
    _
    Same Department
    Physical Neighbors
    _

    Copyright © 2012 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.5.1)