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Neil F Box

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
    Collapse research activities and funding
    R01CA074592     (CRANE, LORI A)Sep 15, 1997 - Jan 31, 2015
    Risk Factors for Nevus Development in Children
    Role: Co-Principal Investigator

    R03AR066880     (BOX, NEIL FREDERICK)Jul 20, 2015 - Jun 30, 2018
    The role of keratinocyte p53 in development of pigmented lesions
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bagati A, Moparthy S, Fink EE, Bianchi-Smiraglia A, Yun DH, Kolesnikova M, Udartseva OO, Wolff DW, Roll MV, Lipchick BC, Han Z, Kozlova NI, Jowdy P, Berman AE, Box NF, Rodriguez C, Bshara W, Kandel ES, Soengas MS, Paragh G, Nikiforov MA. KLF9-dependent ROS regulate melanoma progression in stage-specific manner. Oncogene. 2019 Jan 21. PMID: 30664687.
      View in: PubMed
    2. Asdigian NL, Barón AE, Morelli JG, Mokrohisky ST, Aalborg J, Dellavalle RP, Daley MF, Berwick M, Muller KE, Box NF, Crane LA. Trajectories of Nevus Development From Age 3 to 16 Years in the Colorado Kids Sun Care Program Cohort. JAMA Dermatol. 2018 Nov 01; 154(11):1272-1280. PMID: 30208471.
      View in: PubMed
    3. Filipp FV, Birlea S, Bosenberg MW, Brash D, Cassidy PB, Chen S, D'Orazio JA, Fujita M, Goh BK, Herlyn M, Indra AK, Larue L, Leachman SA, Le Poole C, Liu-Smith F, Manga P, Montoliu L, Norris DA, Shellman Y, Smalley KSM, Spritz RA, Sturm RA, Swetter SM, Terzian T, Wakamatsu K, Weber JS, Box NF. Frontiers in pigment cell and melanoma research. Pigment Cell Melanoma Res. 2018 11; 31(6):728-735. PMID: 30281213.
      View in: PubMed
    4. Box NF, Larue L, Manga P, Montoliu L, Spritz RA, Filipp FV. The triennial International Pigment Cell Conference (IPCC). J Transl Med. 2018 10 03; 16(1):252. PMID: 30285864.
      View in: PubMed
    5. Jeter JM, Bowles TL, Curiel-Lewandrowski C, Swetter SM, Filipp FV, Abdel-Malek ZA, Geskin LJ, Brewer JD, Arbiser JL, Gershenwald JE, Chu EY, Kirkwood JM, Box NF, Funchain P, Fisher DE, Kendra KL, Marghoob AA, Chen SC, Ming ME, Albertini MR, Vetto JT, Margolin KA, Pagoto SL, Hay JL, Grossman D, Ellis DL, Kashani-Sabet M, Mangold AR, Markovic SN, Nelson KC, Powers JG, Robinson JK, Sahni D, Sekulic A, Sondak VK, Wei ML, Zager JS, Dellavalle RP, Thompson JA, Weinstock MA, Leachman SA, Cassidy PB. Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials. Cancer. 2019 Jan 01; 125(1):18-44. PMID: 30281145.
      View in: PubMed
    6. Bagati A, Bianchi-Smiraglia A, Moparthy S, Kolesnikova K, Fink EE, Kolesnikova M, Roll MV, Jowdy P, Wolff DW, Polechetti A, Yun DH, Lipchick BC, Paul LM, Wrazen B, Moparthy K, Mudambi S, Morozevich GE, Georgieva SG, Wang J, Shafirstein G, Liu S, Kandel ES, Berman AE, Box NF, Paragh G, Nikiforov MA. FOXQ1 controls the induced differentiation of melanocytic cells. Cell Death Differ. 2018 Jun; 25(6):1040-1049. PMID: 29463842.
      View in: PubMed
    7. Hintzsche JD, Gorden NT, Amato CM, Kim J, Wuensch KE, Robinson SE, Applegate AJ, Couts KL, Medina TM, Wells KR, Wisell JA, McCarter MD, Box NF, Shellman YG, Gonzalez RC, Lewis KD, Tentler JJ, Tan AC, Robinson WA. Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma. Melanoma Res. 2017 06; 27(3):189-199. PMID: 28296713.
      View in: PubMed
    8. Mounessa JS, Box NF, Asdigian NL, Braunberger T, Dunnick CA, Crane LA, Dellavalle RR. Portable equipment for taking dramatic sun-damage revealing photos at skin cancer prevention outreach events. Dermatol Online J. 2017 May 15; 23(5). PMID: 28537858.
      View in: PubMed
    9. Joselow A, Lynn D, Terzian T, Box NF. Senescence-Like Phenotypes in Human Nevi. Methods Mol Biol. 2017; 1534:175-184. PMID: 27812879.
      View in: PubMed
    10. Hintzsche J, Kim J, Yadav V, Amato C, Robinson SE, Seelenfreund E, Shellman Y, Wisell J, Applegate A, McCarter M, Box N, Tentler J, De S, Robinson WA, Tan AC. IMPACT: a whole-exome sequencing analysis pipeline for integrating molecular profiles with actionable therapeutics in clinical samples. J Am Med Inform Assoc. 2016 07; 23(4):721-30. PMID: 27026619.
      View in: PubMed
    11. Shellman YG, Lambert KA, Brauweiler A, Fain P, Spritz RA, Martini M, Janssen KP, Box NF, Terzian T, Rewers M, Horvath A, Stratakis CA, Robinson WA, Robinson SE, Norris DA, Artinger KB, Pacheco TR. SASH1 Is Involved in an Autosomal Dominant Lentiginous Phenotype. J Invest Dermatol. 2015 Dec; 135(12):3192-3194. PMID: 26203640; PMCID: PMC4648645.
    12. Barón AE, Asdigian NL, Gonzalez V, Aalborg J, Terzian T, Stiegmann RA, Torchia EC, Berwick M, Dellavalle RP, Morelli JG, Mokrohisky ST, Crane LA, Box NF. Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes. Cancer Epidemiol Biomarkers Prev. 2014 Dec; 23(12):2829-39. PMID: 25410285; PMCID: PMC4257874.
    13. Wallace MD, Box NF, Bond GL. SNPing away at human skin color. Pigment Cell Melanoma Res. 2014 May; 27(3):322-3. PMID: 24517848.
      View in: PubMed
    14. Box NF, Vukmer TO, Terzian T. Targeting p53 in melanoma. Pigment Cell Melanoma Res. 2014 Jan; 27(1):8-10. PMID: 24118922; PMCID: PMC4112749.
    15. Zeron-Medina J, Wang X, Repapi E, Campbell MR, Su D, Castro-Giner F, Davies B, Peterse EF, Sacilotto N, Walker GJ, Terzian T, Tomlinson IP, Box NF, Meinshausen N, De Val S, Bell DA, Bond GL. A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection. Cell. 2013 Oct 10; 155(2):410-22. PMID: 24120139.
      View in: PubMed
    16. Terzian T, Box N. Genetics of ribosomal proteins: "curiouser and curiouser". PLoS Genet. 2013; 9(1):e1003300. PMID: 23382707; PMCID: PMC3561088.
    17. Handoko HY, Box NF, Walker GJ. Modeling epidermal melanoma in mice: moving into new realms but with unexpected complexities. J Invest Dermatol. 2012 Sep; 132(9):2299-302. PMID: 22696058.
      View in: PubMed
    18. Gamble RG, Asdigian NL, Aalborg J, Gonzalez V, Box NF, Huff LS, Barón AE, Morelli JG, Mokrohisky ST, Crane LA, Dellavalle RP. Sun damage in ultraviolet photographs correlates with phenotypic melanoma risk factors in 12-year-old children. J Am Acad Dermatol. 2012 Oct; 67(4):587-97. PMID: 22406230; PMCID: PMC3888435.
    19. Tran AD, Aalborg J, Asdigian NL, Morelli JG, Mokrohisky ST, Dellavalle RP, Berwick M, Box NF, Crane LA. Parents' perceptions of skin cancer threat and children's physical activity. Prev Chronic Dis. 2012; 9:E143. PMID: 22935145; PMCID: PMC3475504.
    20. Walker GJ, Soyer HP, Terzian T, Box NF. Modelling melanoma in mice. Pigment Cell Melanoma Res. 2011 Dec; 24(6):1158-76. PMID: 21985222.
      View in: PubMed
    21. Torchia EC, Caulin C, Acin S, Terzian T, Kubick BJ, Box NF, Roop DR. Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma. Oncogene. 2012 May 24; 31(21):2680-90. PMID: 21963848; PMCID: PMC4576849.
    22. Terzian T, Dumble M, Arbab F, Thaller C, Donehower LA, Lozano G, Justice MJ, Roop DR, Box NF. Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug; 224(4):540-52. PMID: 21674502; PMCID: PMC3632393.
    23. Walker GJ, Soyer HP, Handoko HY, Ferguson B, Kunisada T, Khosrotehrani K, Box NF, Muller HK. Superficial spreading-like melanoma in Arf(-/-)::Tyr-Nras(Q61K)::K14-Kitl mice: keratinocyte Kit ligand expression sufficient to "translocate" melanomas from dermis to epidermis. J Invest Dermatol. 2011 Jun; 131(6):1384-7. PMID: 21307875; PMCID: PMC3138531.
    24. Terzian T, Torchia EC, Dai D, Robinson SE, Murao K, Stiegmann RA, Gonzalez V, Boyle GM, Powell MB, Pollock PM, Lozano G, Robinson WA, Roop DR, Box NF. p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation. Pigment Cell Melanoma Res. 2010 Dec; 23(6):781-94. PMID: 20849464; PMCID: PMC3137930.
    25. Box NF, Torchia EC, Roop DR. Are stem cell niches shared for skin cancers? Pigment Cell Melanoma Res. 2010 Aug; 23(4):517-20. PMID: 20546533; PMCID: PMC3137929.
    26. Chen D, Lin Q, Box N, Roop D, Ishii S, Matsuzaki K, Fan T, Hornyak TJ, Reed JA, Stavnezer E, Timchenko NA, Medrano EE. SKI knockdown inhibits human melanoma tumor growth in vivo. Pigment Cell Melanoma Res. 2009 Dec; 22(6):761-72. PMID: 19845874.
      View in: PubMed
    27. Aalborg J, Morelli JG, Mokrohisky ST, Asdigian NL, Byers TE, Dellavalle RP, Box NF, Crane LA. Tanning and increased nevus development in very-light-skinned children without red hair. Arch Dermatol. 2009 Sep; 145(9):989-96. PMID: 19770437; PMCID: PMC2924169.
    28. Valentin-Vega YA, Box N, Terzian T, Lozano G. Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities. Differentiation. 2009 Jun; 77(5):442-9. PMID: 19371999; PMCID: PMC4041067.
    29. Walker G, Box N. Ribosomal stress, p53 activation and the tanning response. Expert Rev Dermatol. 2008 Dec; 3(6):649-656. PMID: 22927886.
      View in: PubMed
    30. Liu G, Terzian T, Xiong S, Van Pelt CS, Audiffred A, Box NF, Lozano G. The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development. J Pathol. 2007 Dec; 213(4):360-8. PMID: 17893884.
      View in: PubMed
    31. Box NF, Terzian T. The role of p53 in pigmentation, tanning and melanoma. Pigment Cell Melanoma Res. 2008 Oct; 21(5):525-33. PMID: 18761658.
      View in: PubMed
    32. Terzian T, Wang Y, Van Pelt CS, Box NF, Travis EL, Lozano G. Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development. Mol Cell Biol. 2007 Aug; 27(15):5479-85. PMID: 17526734; PMCID: PMC1952101.
    33. Duffy DL, Box NF, Chen W, Palmer JS, Montgomery GW, James MR, Hayward NK, Martin NG, Sturm RA. Interactive effects of MC1R and OCA2 on melanoma risk phenotypes. Hum Mol Genet. 2004 Feb 15; 13(4):447-61. PMID: 14709592.
      View in: PubMed
    34. Kile BT, Hentges KE, Clark AT, Nakamura H, Salinger AP, Liu B, Box N, Stockton DW, Johnson RL, Behringer RR, Bradley A, Justice MJ. Functional genetic analysis of mouse chromosome 11. Nature. 2003 Sep 04; 425(6953):81-6. PMID: 12955145.
      View in: PubMed
    35. Sturm RA, Duffy DL, Box NF, Newton RA, Shepherd AG, Chen W, Marks LH, Leonard JH, Martin NG. Genetic association and cellular function of MC1R variant alleles in human pigmentation. Ann N Y Acad Sci. 2003 Jun; 994:348-58. PMID: 12851335.
      View in: PubMed
    36. Sturm RA, Duffy DL, Box NF, Chen W, Smit DJ, Brown DL, Stow JL, Leonard JH, Martin NG. The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes. Pigment Cell Res. 2003 Jun; 16(3):266-72. PMID: 12753400.
      View in: PubMed
    37. Smith AG, Box NF, Marks LH, Chen W, Smit DJ, Wyeth JR, Huttley GA, Easteal S, Sturm RA. The human melanocortin-1 receptor locus: analysis of transcription unit, locus polymorphism and haplotype evolution. Gene. 2001 Dec 27; 281(1-2):81-94. PMID: 11750130.
      View in: PubMed
    38. Sturm RA, Teasdale RD, Box NF. Human pigmentation genes: identification, structure and consequences of polymorphic variation. Gene. 2001 Oct 17; 277(1-2):49-62. PMID: 11602344.
      View in: PubMed
    39. Box NF, Duffy DL, Chen W, Stark M, Martin NG, Sturm RA, Hayward NK. MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. Am J Hum Genet. 2001 Oct; 69(4):765-73. PMID: 11500805; PMCID: PMC1226062.
    40. Voisey J, Box NF, van Daal A. A polymorphism study of the human Agouti gene and its association with MC1R. Pigment Cell Res. 2001 Aug; 14(4):264-7. PMID: 11549109.
      View in: PubMed
    41. Box NF, Duffy DL, Irving RE, Russell A, Chen W, Griffyths LR, Parsons PG, Green AC, Sturm RA. Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma. J Invest Dermatol. 2001 Feb; 116(2):224-9. PMID: 11179997.
      View in: PubMed
    42. Palmer JS, Duffy DL, Box NF, Aitken JF, O'Gorman LE, Green AC, Hayward NK, Martin NG, Sturm RA. Melanocortin-1 receptor polymorphisms and risk of melanoma: is the association explained solely by pigmentation phenotype? Am J Hum Genet. 2000 Jan; 66(1):176-86. PMID: 10631149; PMCID: PMC1288324.
    43. Sturm RA, Box NF, Ramsay M. Human pigmentation genetics: the difference is only skin deep. Bioessays. 1998 Sep; 20(9):712-21. PMID: 9819560.
      View in: PubMed
    44. Box NF, Wyeth JR, Mayne CJ, O'Gorman LE, Martin NG, Sturm RA. Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1. Mamm Genome. 1998 Jan; 9(1):50-3. PMID: 9434945.
      View in: PubMed
    45. Manga P, Kromberg JG, Box NF, Sturm RA, Jenkins T, Ramsay M. Rufous oculocutaneous albinism in southern African Blacks is caused by mutations in the TYRP1 gene. Am J Hum Genet. 1997 Nov; 61(5):1095-101. PMID: 9345097; PMCID: PMC1716031.
    46. Box NF, Wyeth JR, O'Gorman LE, Martin NG, Sturm RA. Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. Hum Mol Genet. 1997 Oct; 6(11):1891-7. PMID: 9302268.
      View in: PubMed
    47. Sturm RA, O'Sullivan BJ, Box NF, Smith AG, Smit SE, Puttick ER, Parsons PG, Dunn IS. Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. Genomics. 1995 Sep 01; 29(1):24-34. PMID: 8530077.
      View in: PubMed
    48. Box NF, Sturm RA. Dinucleotide repeat polymorphism at the human TYRP1 locus. Hum Mol Genet. 1994 Dec; 3(12):2270. PMID: 7881448.
      View in: PubMed
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