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Michael G Edwards

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Address2RC2
Research 2
12700 East 19th Avenue - Mail Stop 8619
Aurora CO 80045
Phone303/724-6054

     Overview 
     overview
    I am an Assistant Professor in the division of Pulmonary Sciences and Critical Care Medicine at the University of Colorado Denver (UCD), specializing in bioinformatics. I am also the co-director of the Biostatistics, Informatics and Bioinformatics Core in the UC Denver Lung SPORE and a member of several genomics core groups, cancer centers and pulmonary disease firms at my institution. I have over fourteen years of experience working with array-based genomic studies and have recently moved into analyzing next-generation sequencing data. My research has mainly focused on the genomic analysis of pulmonary disease, with publications in fields such as lung cancer, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF) and pulmonary hypertension (PA). I am currently working on identifying cellular signaling pathways important in the formation and persistence of lung tumors, characterizing small RNA’s expressed from Mycobacterium tuberculosis during macrophage infection and constructing interacting networks from genes mutated in bladder cancer.


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sechler M, Borowicz S, Van Scoyk M, Avasarala S, Zerayesus S, Edwards MG, Kumar Karuppusamy Rathinam M, Zhao X, Wu PY, Tang K, Bikkavilli RK, Winn RA. Novel Role for ?-Catenin in the Regulation of Cancer Cell Migration via the Induction of Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1). J Biol Chem. 2015 Jun 19; 290(25):15610-20.
      View in: PubMed
    2. Mitchell AM, Stone AE, Cheng L, Ballinger K, Edwards MG, Stoddard M, Li H, Golden-Mason L, Shaw GM, Khetani S, Rosen HR. Transmitted/Founder Hepatitis C Viruses Induce Cell-Type- and Genotype-Specific Differences in Innate Signaling within the Liver. MBio. 2015; 6(2).
      View in: PubMed
    3. Griner EM, Dancik GM, Costello JC, Owens C, Guin S, Edwards MG, Brautigan DL, Theodorescu D. RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer. Mol Cancer Res. 2015 Mar; 13(3):483-92.
      View in: PubMed
    4. Giugliano S, Kriss M, Golden-Mason L, Dobrinskikh E, Stone AE, Soto-Gutierrez A, Mitchell A, Khetani SR, Yamane D, Stoddard M, Li H, Shaw GM, Edwards MG, Lemon SM, Gale M, Shah VH, Rosen HR. Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication. Gastroenterology. 2015 Feb; 148(2):392-402.e13.
      View in: PubMed
    5. Nickerson ML, Dancik GM, Im KM, Edwards MG, Turan S, Brown J, Ruiz-Rodriguez C, Owens C, Costello JC, Guo G, Tsang SX, Li Y, Zhou Q, Cai Z, Moore LE, Lucia MS, Dean M, Theodorescu D. Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer. Clin Cancer Res. 2014 Sep 15; 20(18):4935-48.
      View in: PubMed
    6. Bin L, Edwards MG, Heiser R, Streib JE, Richers B, Hall CF, Leung DY. Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum. J Allergy Clin Immunol. 2014 Oct; 134(4):848-55.
      View in: PubMed
    7. Wynes MW, Hinz TK, Gao D, Martini M, Marek LA, Ware KE, Edwards MG, Böhm D, Perner S, Helfrich BA, Dziadziuszko R, Jassem J, Wojtylak S, Sejda A, Gozgit JM, Bunn PA, Camidge DR, Tan AC, Hirsch FR, Heasley LE. FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies. Clin Cancer Res. 2014 Jun 15; 20(12):3299-309.
      View in: PubMed
    8. Nakachi I, Rice JL, Coldren CD, Edwards MG, Stearman RS, Glidewell SC, Varella-Garcia M, Franklin WA, Keith RL, Lewis MT, Gao B, Merrick DT, Miller YE, Geraci MW. Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions. Cancer Prev Res (Phila). 2014 Feb; 7(2):255-65.
      View in: PubMed
    9. Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM. Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):951-9.
      View in: PubMed
    10. Bahr TM, Hughes GJ, Armstrong M, Reisdorph R, Coldren CD, Edwards MG, Schnell C, Kedl R, LaFlamme DJ, Reisdorph N, Kechris KJ, Bowler RP. Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2013 Aug; 49(2):316-23.
      View in: PubMed
    11. Kratzer A, Salys J, Nold-Petry C, Cool C, Zamora M, Bowler R, Koczulla AR, Janciauskiene S, Edwards MG, Dinarello CA, Taraseviciene-Stewart L. Role of IL-18 in second-hand smoke-induced emphysema. Am J Respir Cell Mol Biol. 2013 Jun; 48(6):725-32.
      View in: PubMed
    12. Avasarala S, Van Scoyk M, Wang J, Sechler M, Vandervest K, Brzezinski C, Weekes C, Edwards MG, Arcaroli J, Davis RE, Bikkavilli RK, Winn RA. hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression. Biol Open. 2013 Jul 15; 2(7):675-85.
      View in: PubMed
    13. Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, Douglas IS. Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs. Am J Respir Crit Care Med. 2012 Jul 1; 186(1):72-81.
      View in: PubMed
    14. Clark DW, Phang T, Edwards MG, Geraci MW, Gillespie MN. Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription. Free Radic Biol Med. 2012 Jul 1; 53(1):51-9.
      View in: PubMed
    15. Michaelis KA, Knox AJ, Xu M, Kiseljak-Vassiliades K, Edwards MG, Geraci M, Kleinschmidt-DeMasters BK, Lillehei KO, Wierman ME. Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors. Endocrinology. 2011 Oct; 152(10):3603-13.
      View in: PubMed
    16. Wynes MW, Edelman BL, Kostyk AG, Edwards MG, Coldren C, Groshong SD, Cosgrove GP, Redente EF, Bamberg A, Brown KK, Reisdorph N, Keith RC, Frankel SK, Riches DW. Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis. J Immunol. 2011 Jul 1; 187(1):527-37.
      View in: PubMed
    17. Olincy A, House R, Gao B, Recksiek P, Phang TL, Sullivan B, Hollis JP, Hopkins J, Shade T, Edwards MG, Vianzon R, Griffiths C, Ceilley J, Helfrich RW, Ritvo J, Weis E, Weiss D, Gault J. Elevated DISC1 transcript levels in PBMCs during acute psychosis in patients with schizophrenia. Transl Biomed. 2011; 2(1).
      View in: PubMed
    18. Moré JM, Voelker DR, Silveira LJ, Edwards MG, Chan ED, Bowler RP. Smoking reduces surfactant protein D and phospholipids in patients with and without chronic obstructive pulmonary disease. BMC Pulm Med. 2010; 10:53.
      View in: PubMed
    19. Risbano MG, Meadows CA, Coldren CD, Jenkins TJ, Edwards MG, Collier D, Huber W, Mack DG, Fontenot AP, Geraci MW, Bull TM. Altered immune phenotype in peripheral blood cells of patients with scleroderma-associated pulmonary hypertension. Clin Transl Sci. 2010 Oct; 3(5):210-8.
      View in: PubMed
    20. Johannigman JA, Branson RD, Edwards MG. Closed loop control of inspired oxygen concentration in trauma patients. J Am Coll Surg. 2009 May; 208(5):763-8; discussion 768-9.
      View in: PubMed
    21. Anderson RM, Barger JL, Edwards MG, Braun KH, O'Connor CE, Prolla TA, Weindruch R. Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response. Aging Cell. 2008 Jan; 7(1):101-11.
      View in: PubMed
    22. Edwards MG, Anderson RM, Yuan M, Kendziorski CM, Weindruch R, Prolla TA. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. BMC Genomics. 2007; 8:80.
      View in: PubMed
    23. Black PJ, Cami-Kobeci G, Edwards MG, Slatford PA, Whittlesey MK, Williams JM. Borrowing hydrogen: iridium-catalysed reactions for the formation of C-C bonds from alcohols. Org Biomol Chem. 2006 Jan 7; 4(1):116-25.
      View in: PubMed
    24. Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA. Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 mice. Ann N Y Acad Sci. 2004 Jun; 1019:85-95.
      View in: PubMed
    25. Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA. Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart. Physiol Genomics. 2003 Apr 16; 13(2):119-27.
      View in: PubMed
    26. Tong L, Toliver-Kinsky T, Edwards M, Rassin DK, Werrbach-Perez K, Perez-Polo JR. Attenuated transcriptional responses to oxidative stress in the aged rat brain. J Neurosci Res. 2002 Nov 1; 70(3):318-26.
      View in: PubMed
    27. Edwards M, Kent TA, Rea HC, Wei J, Quast M, Izumi T, Mitra S, Perez-Polo JR. APE/Ref-1 responses to ischemia in rat brain. Neuroreport. 1998 Dec 21; 9(18):4015-8.
      View in: PubMed
    28. Edwards M, Rassin DK, Izumi T, Mitra S, Perez-Polo JR. APE/Ref-1 responses to oxidative stress in aged rats. J Neurosci Res. 1998 Dec 1; 54(5):635-8.
      View in: PubMed
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