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John D Beckham

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-4927

    Collapse Research 
    Collapse research activities and funding
    K08AI076518     (BECKHAM, JOHN DAVID)Jun 15, 2008 - Apr 30, 2013
    NIH/NIAID
    Mechanisms of Apoptosis in Virus-Infected Neurons
    Role: Principal Investigator
    I01BX003863     (BECKHAM, JOHN DAVID)Jul 1, 2017 - Jun 30, 2021
    VA
    Defining the Mechanism of Alpha-synuclein Dependent Restriction of Viral Neuroinvasion
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lesteberg KE, Beckham JD. Immunology of West Nile Virus Infection and the Role of Alpha-Synuclein as a Viral Restriction Factor. Viral Immunol. 2018 Sep 15. PMID: 30222521.
      View in: PubMed
    2. Brown B, Fidell A, Ingolia G, Murad E, Beckham JD. Defining diagnostic approaches and outcomes in patients with inflammatory CSF: A retrospective cohort study. Clin Neurol Neurosurg. 2018 Sep; 172:105-111. PMID: 29986194.
      View in: PubMed
    3. Kashef Hamadani BH, Franco-Paredes C, McCollister B, Shapiro L, Beckham JD, Henao-Martínez AF. Cryptococcosis and cryptococcal meningitis: New predictors and clinical outcomes at a United States academic medical centre. Mycoses. 2018 May; 61(5):314-320. PMID: 29284182.
      View in: PubMed
    4. Pastula DM, Durrant JC, Smith DE, Beckham JD, Tyler KL. Zika Virus Disease for the Neurointensivist. Neurocrit Care. 2017 Jun; 26(3):457-463. PMID: 27995511.
      View in: PubMed
    5. McGuinness I, Beckham JD, Tyler KL, Pastula DM. An Overview of Yellow Fever Virus Disease. Neurohospitalist. 2017 Oct; 7(4):157-158. PMID: 28974992.
      View in: PubMed
    6. Beckham JD. Zika virus, a novel mosquito-borne congenital virus infection. J Neurovirol. 2017 Jun; 23(3):339-340. PMID: 28429288.
      View in: PubMed
    7. Shives KD, Tyler KL, Beckham JD. Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis. J Neuroimmunol. 2017 Jul 15; 308:102-111. PMID: 28291542.
      View in: PubMed
    8. Duca LM, Beckham JD, Tyler KL, Pastula DM. Zika Virus Disease and Associated Neurologic Complications. Curr Infect Dis Rep. 2017 Jan; 19(1):4. PMID: 28220392.
      View in: PubMed
    9. Smith DE, Beckham JD, Tyler KL, Pastula DM. Zika virus disease for neurologists. Neurol Clin Pract. 2016 Dec; 6(6):515-522. PMID: 28058206.
      View in: PubMed
    10. Akiyama BM, Laurence HM, Massey AR, Costantino DA, Xie X, Yang Y, Shi PY, Nix JC, Beckham JD, Kieft JS. Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease. Science. 2016 12 02; 354(6316):1148-1152. PMID: 27934765.
      View in: PubMed
    11. Shives KD, Massey AR, May NA, Morrison TE, Beckham JD. 4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression. Viruses. 2016 10 18; 8(10). PMID: 27763553.
      View in: PubMed
    12. Massey AR, Beckham JD. Alpha-Synuclein, a Novel Viral Restriction Factor Hiding in Plain Sight. DNA Cell Biol. 2016 Nov; 35(11):643-645. PMID: 27631132.
      View in: PubMed
    13. Henao-Martínez AF, Gross L, Mcnair B, McCollister B, DeSanto K, Montoya JG, Shapiro L, Beckham JD. Risk Factors for Cryptococcal Meningitis: A Single United States Center Experience. Mycopathologia. 2016 Dec; 181(11-12):807-814. PMID: 27502502.
      View in: PubMed
    14. Beckham JD, Pastula DM, Massey A, Tyler KL. Zika Virus as an Emerging Global Pathogen: Neurological Complications of Zika Virus. JAMA Neurol. 2016 Jul 01; 73(7):875-9. PMID: 27183312.
      View in: PubMed
    15. Pastula DM, Smith DE, Beckham JD, Tyler KL. An Overview of Zika Virus Disease. Neurohospitalist. 2016 Jul; 6(3):93-4. PMID: 27366289; PMCID: PMC4906558.
      View in: PubMed, PubMed Central
    16. Pastula DM, Smith DE, Beckham JD, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases. J Neurovirol. 2016 06; 22(3):257-60. PMID: 26903031.
      View in: PubMed
    17. Beatman EL, Massey A, Shives KD, Burrack KS, Chamanian M, Morrison TE, Beckham JD. Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain. J Virol. 2015 Dec 30; 90(6):2767-82. PMID: 26719256; PMCID: PMC4810656.
      View in: PubMed, PubMed Central
    18. Beckham JD, Tyler KL. Arbovirus Infections. Continuum (Minneap Minn). 2015 Dec; 21(6 Neuroinfectious Disease):1599-611. PMID: 26633778.
      View in: PubMed
    19. Grubaugh ND, Massey A, Shives KD, Stenglein MD, Ebel GD, Beckham JD. West Nile Virus Population Structure, Injury, and Interferon-Stimulated Gene Expression in the Brain From a Fatal Case of Encephalitis. Open Forum Infect Dis. 2016 Jan; 3(1):ofv182. PMID: 26730392; PMCID: PMC4697916.
      View in: PubMed, PubMed Central
    20. Kleinschmidt-DeMasters BK, Beckham JD. West Nile Virus Encephalitis 16 Years Later. Brain Pathol. 2015 Sep; 25(5):625-33. PMID: 26276026.
      View in: PubMed
    21. Henao-Martínez AF, Beckham JD. Cryptococcosis in solid organ transplant recipients. Curr Opin Infect Dis. 2015 Aug; 28(4):300-7. PMID: 26098495.
      View in: PubMed
    22. Shives KD, Beatman EL, Chamanian M, O'Brien C, Hobson-Peters J, Beckham JD. West nile virus-induced activation of mammalian target of rapamycin complex 1 supports viral growth and viral protein expression. J Virol. 2014 Aug; 88(16):9458-71. PMID: 24920798; PMCID: PMC4136264.
      View in: PubMed, PubMed Central
    23. Steele AK, Lee EJ, Manuzak JA, Dillon SM, Beckham JD, McCarter MD, Santiago ML, Wilson CC. Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo. Retrovirology. 2014 Feb 04; 11:14. PMID: 24495380; PMCID: PMC3922902.
      View in: PubMed, PubMed Central
    24. Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol. 2014 Jan; 88(2):1080-9. PMID: 24198425; PMCID: PMC3911655.
      View in: PubMed, PubMed Central
    25. Davis LE, Oyer R, Beckham JD, Tyler KL. Elevated CSF cytokines in the Jarisch-Herxheimer reaction of general paresis. JAMA Neurol. 2013 Aug; 70(8):1060-4. PMID: 23732875.
      View in: PubMed
    26. Beatman E, Oyer R, Shives KD, Hedman K, Brault AC, Tyler KL, Beckham JD. West Nile virus growth is independent of autophagy activation. Virology. 2012 Nov 10; 433(1):262-72. PMID: 22939285; PMCID: PMC3444629.
      View in: PubMed, PubMed Central
    27. Beckham JD, Tyler KL. Neuro-intensive care of patients with acute CNS infections. Neurotherapeutics. 2012 Jan; 9(1):124-38. PMID: 22102180; PMCID: PMC3271160.
      View in: PubMed, PubMed Central
    28. Dionne KR, Leser JS, Lorenzen KA, Beckham JD, Tyler KL. A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition. Exp Neurol. 2011 Apr; 228(2):222-31. PMID: 21241693; PMCID: PMC3060973.
      View in: PubMed, PubMed Central
    29. Beckham JD, Tuttle KD, Tyler KL. Caspase-3 activation is required for reovirus-induced encephalitis in vivo. J Neurovirol. 2010 Jul; 16(4):306-17. PMID: 20626234; PMCID: PMC3023174.
      View in: PubMed, PubMed Central
    30. Clarke P, Beckham JD, Leser JS, Hoyt CC, Tyler KL. Fas-mediated apoptotic signaling in the mouse brain following reovirus infection. J Virol. 2009 Jun; 83(12):6161-70. PMID: 19321603; PMCID: PMC2687381.
      View in: PubMed, PubMed Central
    31. Beckham JD, Tuttle K, Tyler KL. Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection. J Virol. 2009 May; 83(10):5035-45. PMID: 19279118; PMCID: PMC2682065.
      View in: PubMed, PubMed Central
    32. Davis LE, Beckham JD, Tyler KL. North American encephalitic arboviruses. Neurol Clin. 2008 Aug; 26(3):727-57, ix. PMID: 18657724; PMCID: PMC2866042.
      View in: PubMed, PubMed Central
    33. Goody RJ, Beckham JD, Rubtsova K, Tyler KL. JAK-STAT signaling pathways are activated in the brain following reovirus infection. J Neurovirol. 2007 Aug; 13(4):373-83. PMID: 17849321; PMCID: PMC2367059.
      View in: PubMed, PubMed Central
    34. Beckham JD, Goody RJ, Clarke P, Bonny C, Tyler KL. Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase. J Virol. 2007 Jul; 81(13):6984-92. PMID: 17475657; PMCID: PMC1933289.
      View in: PubMed, PubMed Central
    35. Tyler KL, Beckham JD. Management of acute shingles (herpes zoster). Rev Neurol Dis. 2007; 4(4):203-8. PMID: 18195672.
      View in: PubMed
    36. Beckham JD, Tyler KL. Infectious disease - developments in the field of Creutzfeldt-Jakob disease. Rev Neurol Dis. 2007; 4(3):168-72. PMID: 17943072; PMCID: PMC2613287.
      View in: PubMed, PubMed Central
    37. Beckham JD, Tyler KL. Initial management of acute bacterial meningitis in adults: summary of IDSA guidelines. Rev Neurol Dis. 2006; 3(2):57-60. PMID: 16819421.
      View in: PubMed
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