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John D Beckham

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
    Collapse research activities and funding
    K08AI076518     (BECKHAM, JOHN DAVID)Jun 15, 2008 - Apr 30, 2013
    Mechanisms of Apoptosis in Virus-Infected Neurons
    Role: Principal Investigator

    I01BX003863     (BECKHAM, JOHN DAVID)Jul 1, 2017 - Jun 30, 2021
    Defining the Mechanism of Alpha-synuclein Dependent Restriction of Viral Neuroinvasion
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Brown BL, Fidell A, Ingolia G, Murad E, Beckham JD. Infectious causes and outcomes in patients presenting with cerebral spinal fluid pleocytosis. J Neurovirol. 2019 Mar 08. PMID: 30850974.
      View in: PubMed
    2. Lesteberg KE, Beckham JD. Immunology of West Nile Virus Infection and the Role of Alpha-Synuclein as a Viral Restriction Factor. Viral Immunol. 2019 Jan/Feb; 32(1):38-47. PMID: 30222521.
      View in: PubMed
    3. Brown B, Fidell A, Ingolia G, Murad E, Beckham JD. Defining diagnostic approaches and outcomes in patients with inflammatory CSF: A retrospective cohort study. Clin Neurol Neurosurg. 2018 Sep; 172:105-111. PMID: 29986194.
      View in: PubMed
    4. Kashef Hamadani BH, Franco-Paredes C, McCollister B, Shapiro L, Beckham JD, Henao-Martínez AF. Cryptococcosis and cryptococcal meningitis: New predictors and clinical outcomes at a United States academic medical centre. Mycoses. 2018 May; 61(5):314-320. PMID: 29284182.
      View in: PubMed
    5. Pastula DM, Durrant JC, Smith DE, Beckham JD, Tyler KL. Zika Virus Disease for the Neurointensivist. Neurocrit Care. 2017 Jun; 26(3):457-463. PMID: 27995511.
      View in: PubMed
    6. McGuinness I, Beckham JD, Tyler KL, Pastula DM. An Overview of Yellow Fever Virus Disease. Neurohospitalist. 2017 Oct; 7(4):157-158. PMID: 28974992.
      View in: PubMed
    7. Beckham JD. Zika virus, a novel mosquito-borne congenital virus infection. J Neurovirol. 2017 06; 23(3):339-340. PMID: 28429288.
      View in: PubMed
    8. Shives KD, Tyler KL, Beckham JD. Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis. J Neuroimmunol. 2017 07 15; 308:102-111. PMID: 28291542.
      View in: PubMed
    9. Duca LM, Beckham JD, Tyler KL, Pastula DM. Zika Virus Disease and Associated Neurologic Complications. Curr Infect Dis Rep. 2017 Jan; 19(1):4. PMID: 28220392.
      View in: PubMed
    10. Smith DE, Beckham JD, Tyler KL, Pastula DM. Zika virus disease for neurologists. Neurol Clin Pract. 2016 Dec; 6(6):515-522. PMID: 28058206.
      View in: PubMed
    11. Akiyama BM, Laurence HM, Massey AR, Costantino DA, Xie X, Yang Y, Shi PY, Nix JC, Beckham JD, Kieft JS. Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease. Science. 2016 12 02; 354(6316):1148-1152. PMID: 27934765.
      View in: PubMed
    12. Shives KD, Massey AR, May NA, Morrison TE, Beckham JD. 4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression. Viruses. 2016 10 18; 8(10). PMID: 27763553.
      View in: PubMed
    13. Massey AR, Beckham JD. Alpha-Synuclein, a Novel Viral Restriction Factor Hiding in Plain Sight. DNA Cell Biol. 2016 Nov; 35(11):643-645. PMID: 27631132.
      View in: PubMed
    14. Henao-Martínez AF, Gross L, Mcnair B, McCollister B, DeSanto K, Montoya JG, Shapiro L, Beckham JD. Risk Factors for Cryptococcal Meningitis: A Single United States Center Experience. Mycopathologia. 2016 Dec; 181(11-12):807-814. PMID: 27502502.
      View in: PubMed
    15. Beckham JD, Pastula DM, Massey A, Tyler KL. Zika Virus as an Emerging Global Pathogen: Neurological Complications of Zika Virus. JAMA Neurol. 2016 Jul 01; 73(7):875-9. PMID: 27183312.
      View in: PubMed
    16. Pastula DM, Smith DE, Beckham JD, Tyler KL. An Overview of Zika Virus Disease. Neurohospitalist. 2016 Jul; 6(3):93-4. PMID: 27366289; PMCID: PMC4906558.
    17. Pastula DM, Smith DE, Beckham JD, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases. J Neurovirol. 2016 06; 22(3):257-60. PMID: 26903031.
      View in: PubMed
    18. Beatman EL, Massey A, Shives KD, Burrack KS, Chamanian M, Morrison TE, Beckham JD. Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain. J Virol. 2015 Dec 30; 90(6):2767-82. PMID: 26719256; PMCID: PMC4810656.
    19. Beckham JD, Tyler KL. Arbovirus Infections. Continuum (Minneap Minn). 2015 Dec; 21(6 Neuroinfectious Disease):1599-611. PMID: 26633778.
      View in: PubMed
    20. Grubaugh ND, Massey A, Shives KD, Stenglein MD, Ebel GD, Beckham JD. West Nile Virus Population Structure, Injury, and Interferon-Stimulated Gene Expression in the Brain From a Fatal Case of Encephalitis. Open Forum Infect Dis. 2016 Jan; 3(1):ofv182. PMID: 26730392; PMCID: PMC4697916.
    21. Kleinschmidt-DeMasters BK, Beckham JD. West Nile Virus Encephalitis 16 Years Later. Brain Pathol. 2015 Sep; 25(5):625-33. PMID: 26276026.
      View in: PubMed
    22. Henao-Martínez AF, Beckham JD. Cryptococcosis in solid organ transplant recipients. Curr Opin Infect Dis. 2015 Aug; 28(4):300-7. PMID: 26098495.
      View in: PubMed
    23. Shives KD, Beatman EL, Chamanian M, O'Brien C, Hobson-Peters J, Beckham JD. West nile virus-induced activation of mammalian target of rapamycin complex 1 supports viral growth and viral protein expression. J Virol. 2014 Aug; 88(16):9458-71. PMID: 24920798; PMCID: PMC4136264.
    24. Steele AK, Lee EJ, Manuzak JA, Dillon SM, Beckham JD, McCarter MD, Santiago ML, Wilson CC. Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo. Retrovirology. 2014 Feb 04; 11:14. PMID: 24495380; PMCID: PMC3922902.
    25. Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol. 2014 Jan; 88(2):1080-9. PMID: 24198425; PMCID: PMC3911655.
    26. Davis LE, Oyer R, Beckham JD, Tyler KL. Elevated CSF cytokines in the Jarisch-Herxheimer reaction of general paresis. JAMA Neurol. 2013 Aug; 70(8):1060-4. PMID: 23732875.
      View in: PubMed
    27. Beatman E, Oyer R, Shives KD, Hedman K, Brault AC, Tyler KL, Beckham JD. West Nile virus growth is independent of autophagy activation. Virology. 2012 Nov 10; 433(1):262-72. PMID: 22939285; PMCID: PMC3444629.
    28. Beckham JD, Tyler KL. Neuro-intensive care of patients with acute CNS infections. Neurotherapeutics. 2012 Jan; 9(1):124-38. PMID: 22102180; PMCID: PMC3271160.
    29. Dionne KR, Leser JS, Lorenzen KA, Beckham JD, Tyler KL. A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition. Exp Neurol. 2011 Apr; 228(2):222-31. PMID: 21241693; PMCID: PMC3060973.
    30. Beckham JD, Tuttle KD, Tyler KL. Caspase-3 activation is required for reovirus-induced encephalitis in vivo. J Neurovirol. 2010 Jul; 16(4):306-17. PMID: 20626234; PMCID: PMC3023174.
    31. Clarke P, Beckham JD, Leser JS, Hoyt CC, Tyler KL. Fas-mediated apoptotic signaling in the mouse brain following reovirus infection. J Virol. 2009 Jun; 83(12):6161-70. PMID: 19321603; PMCID: PMC2687381.
    32. Beckham JD, Tuttle K, Tyler KL. Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection. J Virol. 2009 May; 83(10):5035-45. PMID: 19279118; PMCID: PMC2682065.
    33. Davis LE, Beckham JD, Tyler KL. North American encephalitic arboviruses. Neurol Clin. 2008 Aug; 26(3):727-57, ix. PMID: 18657724; PMCID: PMC2866042.
    34. Goody RJ, Beckham JD, Rubtsova K, Tyler KL. JAK-STAT signaling pathways are activated in the brain following reovirus infection. J Neurovirol. 2007 Aug; 13(4):373-83. PMID: 17849321; PMCID: PMC2367059.
    35. Beckham JD, Goody RJ, Clarke P, Bonny C, Tyler KL. Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase. J Virol. 2007 Jul; 81(13):6984-92. PMID: 17475657; PMCID: PMC1933289.
    36. Tyler KL, Beckham JD. Management of acute shingles (herpes zoster). Rev Neurol Dis. 2007; 4(4):203-8. PMID: 18195672.
      View in: PubMed
    37. Beckham JD, Tyler KL. Infectious disease - developments in the field of Creutzfeldt-Jakob disease. Rev Neurol Dis. 2007; 4(3):168-72. PMID: 17943072; PMCID: PMC2613287.
    38. Beckham JD, Tyler KL. Initial management of acute bacterial meningitis in adults: summary of IDSA guidelines. Rev Neurol Dis. 2006; 3(2):57-60. PMID: 16819421.
      View in: PubMed
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