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Lawrence D Horwitz

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-2089

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    R01HL024763     (HORWITZ, LAWRENCE)Mar 1, 1979 - Mar 31, 1987
    NIH/NHLBI
    LEFT VENTRICULAR FUNCTION IN EXERCISE
    Role: Principal Investigator

    T32HL007459     (HORWITZ, LAWRENCE)Jul 1, 1980 - Jun 30, 1990
    NIH/NHLBI
    CARDIOVASCULAR RESEARCH
    Role: Principal Investigator

    R01HL041661     (HORWITZ, LAWRENCE)Dec 1, 1988 - Nov 30, 1993
    NIH/NHLBI
    REPERFUSION INJURY TO CORONARY ENDOTHELIUM
    Role: Principal Investigator

    R01HL048177     (HORWITZ, LAWRENCE)May 1, 1992 - Apr 30, 1996
    NIH/NHLBI
    MECHANISMS OF MYOCARDIAL REPERFUSION INJURY
    Role: Principal Investigator

    R01HL055291     (HORWITZ, LAWRENCE)Feb 1, 1996 - Jan 31, 2008
    NIH/NHLBI
    Iron-Mediated Cardiovascular Injury
    Role: Principal Investigator

    R41DK072644     (HORWITZ, LAWRENCE)Sep 5, 2005 - Aug 31, 2007
    NIH/NIDDK
    BUCILLAMINE AND RADIOCONTRAST - INDUCED NEPHROPATHY
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Horwitz LD, Horwitz MA. The exochelins of pathogenic mycobacteria: unique, highly potent, lipid- and water-soluble hexadentate iron chelators with multiple potential therapeutic uses. Antioxid Redox Signal. 2014 Dec 01; 21(16):2246-61. PMID: 24684595.
      View in: PubMed
    2. Ambler SK, Hodges YK, Jones GM, Long CS, Horwitz LD. Prolonged administration of a dithiol antioxidant protects against ventricular remodeling due to ischemia-reperfusion in mice. Am J Physiol Heart Circ Physiol. 2008 Sep; 295(3):H1303-H1310. PMID: 18689493.
      View in: PubMed
    3. Anwar A, Gu M, Brady S, Qamar L, Behbakht K, Shellman YG, Agarwal R, Norris DA, Horwitz LD, Fujita M. Photoprotective effects of bucillamine against UV-induced damage in an SKH-1 hairless mouse model. Photochem Photobiol. 2008 Mar-Apr; 84(2):477-83. PMID: 18266821.
      View in: PubMed
    4. Pahl PM, Reese SM, Horwitz LD. A lipid-soluble iron chelator alters cell cycle regulatory protein binding in breast cancer cells compared to normal breast cells. J Exp Ther Oncol. 2007; 6(3):193-200. PMID: 17552359.
      View in: PubMed
    5. Hodges YK, Weinberger HD, Stephens J, Horwitz MA, Horwitz LD. Desferri-Exochelin, a lipid-soluble, hexadentate iron chelator, effectively removes tissue iron. Transl Res. 2006 Aug; 148(2):63-71. PMID: 16890146.
      View in: PubMed
    6. Lindenfeld J, Weil JV, Travis VL, Horwitz LD. Regulation of oxygen delivery during induced polycythemia in exercising dogs. Am J Physiol Heart Circ Physiol. 2005 Nov; 289(5):H1821-5. PMID: 16006540.
      View in: PubMed
    7. Hodges YK, Reese SM, Pahl PM, Horwitz LD. Paradoxical effects of iron chelation on growth of vascular endothelial cells. J Cardiovasc Pharmacol. 2005 Jun; 45(6):539-44. PMID: 15897780.
      View in: PubMed
    8. Pahl PM, Horwitz LD. Cell permeable iron chelators as potential cancer chemotherapeutic agents. Cancer Invest. 2005; 23(8):683-91. PMID: 16377587.
      View in: PubMed
    9. Hodges YK, Antholine WE, Horwitz LD. Effect on ribonucleotide reductase of novel lipophilic iron chelators: the desferri-exochelins. Biochem Biophys Res Commun. 2004 Mar 12; 315(3):595-8. PMID: 14975742.
      View in: PubMed
    10. Horwitz LD. Bucillamine: a potent thiol donor with multiple clinical applications. Cardiovasc Drug Rev. 2003; 21(2):77-90. PMID: 12847560.
      View in: PubMed
    11. Chong TW, Horwitz LD, Moore JW, Sowter HM, Harris AL. A mycobacterial iron chelator, desferri-exochelin, induces hypoxia-inducible factors 1 and 2, NIP3, and vascular endothelial growth factor in cancer cell lines. Cancer Res. 2002 Dec 01; 62(23):6924-7. PMID: 12460908.
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    12. Amersi F, Nelson SK, Shen XD, Kato H, Melinek J, Kupiec-Weglinski JW, Horwitz LD, Busuttil RW, Horwitz MA. Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8915-20. PMID: 12084933.
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    13. Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. J Immunol. 2002 Mar 01; 168(5):2560-7. PMID: 11859152.
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    14. Horwitz LD, Sherman NA. Bucillamine prevents myocardial reperfusion injury. J Cardiovasc Pharmacol. 2001 Dec; 38(6):859-67. PMID: 11707689.
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    15. Rosenthal EA, Bohlmeyer TJ, Monnet E, MacPhail C, Robertson AD, Horwitz MA, Burchenal JE, Horwitz LD. An iron-binding exochelin prevents restenosis due to coronary artery balloon injury in a porcine model. Circulation. 2001 Oct 30; 104(18):2222-7. PMID: 11684635.
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    16. Pahl PM, Horwitz MA, Horwitz KB, Horwitz LD. Desferri-exochelin induces death by apoptosis in human breast cancer cells but does not kill normal breast cells. Breast Cancer Res Treat. 2001 Sep; 69(1):69-79. PMID: 11759830.
      View in: PubMed
    17. Amersi F, Dulkanchainun T, Nelson SK, Farmer DG, Kato H, Zaky J, Melinek J, Shaw GD, Kupiec-Weglinski JW, Horwitz LD, Horwitz MA, Busuttil RW. A novel iron chelator in combination with a P-selectin antagonist prevents ischemia/reperfusion injury in a rat liver model. Transplantation. 2001 Jan 15; 71(1):112-8. PMID: 11211175.
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    18. Pahl PM, Yan XD, Hodges YK, Rosenthal EA, Horwitz MA, Horwitz LD. An exochelin of Mycobacterium tuberculosis reversibly arrests growth of human vascular smooth muscle cells in vitro. J Biol Chem. 2000 Jun 09; 275(23):17821-6. PMID: 10748174.
      View in: PubMed
    19. Hodges YK, Tung L, Yan XD, Graham JD, Horwitz KB, Horwitz LD. Estrogen receptors alpha and beta: prevalence of estrogen receptor beta mRNA in human vascular smooth muscle and transcriptional effects. Circulation. 2000 Apr 18; 101(15):1792-8. PMID: 10769279.
      View in: PubMed
    20. Hodges YK, Richer JK, Horwitz KB, Horwitz LD. Variant estrogen and progesterone receptor messages in human vascular smooth muscle. Circulation. 1999 May 25; 99(20):2688-93. PMID: 10338464.
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    21. Takimoto GS, Graham JD, Jackson TA, Tung L, Powell RL, Horwitz LD, Horwitz KB. Tamoxifen resistant breast cancer: coregulators determine the direction of transcription by antagonist-occupied steroid receptors. J Steroid Biochem Mol Biol. 1999 Apr-Jun; 69(1-6):45-50. PMID: 10418980.
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    22. Horwitz LD, Rosenthal EA. Iron-mediated cardiovascular injury. Vasc Med. 1999; 4(2):93-9. PMID: 10406456.
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    23. Horwitz LD, Kong Y, Robertson AD. Timing of treatment for myocardial reperfusion injury. J Cardiovasc Pharmacol. 1999 Jan; 33(1):19-29. PMID: 9890392.
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    24. Selzman CH, Gaynor JS, Turner AS, Whitehill TA, Horwitz LD, Harken AH. Estrogen replacement inhibits intimal hyperplasia and the accumulation and effects of transforming growth factor beta1. J Surg Res. 1998 Dec; 80(2):380-5. PMID: 9878341.
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    25. Selzman CH, Gaynor JS, Turner AS, Johnson SM, Horwitz LD, Whitehill TA, Harken AH. Ovarian ablation alone promotes aortic intimal hyperplasia and accumulation of fibroblast growth factor. Circulation. 1998 Nov 10; 98(19):2049-54. PMID: 9808604.
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    26. Pahl PM, Hodges YK, Meltesen L, Perryman MB, Horwitz KB, Horwitz LD. ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3. Genomics. 1998 Nov 01; 53(3):410-2. PMID: 9799612.
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    27. Hodges-Garcia YK, Madigan N, Horwitz LD. Primary human vascular smooth muscle cell culture enhanced by human umbilical cord serum. In Vitro Cell Dev Biol Anim. 1998 May; 34(5):364-6. PMID: 9639097.
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    28. Horwitz LD, Sherman NA, Kong Y, Pike AW, Gobin J, Fennessey PV, Horwitz MA. Lipophilic siderophores of Mycobacterium tuberculosis prevent cardiac reperfusion injury. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5263-8. PMID: 9560264.
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    29. Bisognano JD, Horwitz LD. Combination therapy with an angiotensin converting enzyme inhibitor and an angiotensin-II receptor antagonist for refractory essential hypertension. West J Med. 1998 Apr; 168(4):272-4. PMID: 9584674.
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    30. Horwitz LD, Weinberger HD, Clegg L. Comparison of amlodipine and long-acting diltiazem in the treatment of mild or moderate hypertension. Am J Hypertens. 1997 Nov; 10(11):1263-9. PMID: 9397246.
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    31. Keller M, Kong Y, Robertson AD, Horwitz L. Prevention of coronary vascular abnormalities early in reperfusion with TGF-beta may not prevent late coronary vascular injury. J Cardiovasc Pharmacol. 1997 Aug; 30(2):197-204. PMID: 9269947.
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    32. Horwitz LD, Kaufman D, Kong Y. An antibody to leukocyte integrins attenuates coronary vascular injury due to ischemia and reperfusion in dogs. Am J Physiol. 1997 Feb; 272(2 Pt 2):H618-24. PMID: 9124417.
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    33. Gill EA, Kong Y, Horwitz LD. An oligosaccharide sialyl-Lewis(x) analogue does not reduce myocardial infarct size after ischemia and reperfusion in dogs. Circulation. 1996 Aug 01; 94(3):542-6. PMID: 8759100.
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    34. Horwitz LD, Wallner JS, Decker DE, Buxser SE. Efficacy of lipid soluble, membrane-protective agents against hydrogen peroxide cytotoxicity in cardiac myocytes. Free Radic Biol Med. 1996; 21(6):743-53. PMID: 8902520.
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    35. Goldner B, Brandspiegel HZ, Horwitz L, Jadonath R, Cohen TJ. Utility of QT dispersion combined with the signal-averaged electrocardiogram in detecting patients susceptible to ventricular tachyarrhythmia. Am J Cardiol. 1995 Dec 01; 76(16):1192-4. PMID: 7484911.
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    36. Crowley ST, Ray CJ, Nawaz D, Majack RA, Horwitz LD. Multiple growth factors are released from mechanically injured vascular smooth muscle cells. Am J Physiol. 1995 Nov; 269(5 Pt 2):H1641-7. PMID: 7503260.
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    37. Horwitz LD, Leff JA. Catalase and hydrogen peroxide cytotoxicity in cultured cardiac myocytes. J Mol Cell Cardiol. 1995 Mar; 27(3):909-15. PMID: 7541472.
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    38. Kong Y, Lesnefsky EJ, Ye J, Horwitz LD. Prevention of lipid peroxidation does not prevent oxidant-induced myocardial contractile dysfunction. Am J Physiol. 1994 Dec; 267(6 Pt 2):H2371-7. PMID: 7810737.
      View in: PubMed
    39. Horwitz LD, Kaufman D, Keller MW, Kong Y. Time course of coronary endothelial healing after injury due to ischemia and reperfusion. Circulation. 1994 Nov; 90(5):2439-47. PMID: 7955201.
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    40. Crowley ST, Dempsey EC, Horwitz KB, Horwitz LD. Platelet-induced vascular smooth muscle cell proliferation is modulated by the growth amplification factors serotonin and adenosine diphosphate. Circulation. 1994 Oct; 90(4):1908-18. PMID: 7923679.
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    41. Hess AD, Fischer AC, Horwitz L, Bright EC, Laulis MK. Characterization of peripheral autoregulatory mechanisms that prevent development of cyclosporin-induced syngeneic graft-versus-host disease. J Immunol. 1994 Jul 01; 153(1):400-11. PMID: 8207251.
      View in: PubMed
    42. Horwitz LD, Fennessey PV, Shikes RH, Kong Y. Marked reduction in myocardial infarct size due to prolonged infusion of an antioxidant during reperfusion. Circulation. 1994 Apr; 89(4):1792-801. PMID: 8149545.
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    43. Byler RM, Sherman NA, Wallner JS, Horwitz LD. Hydrogen peroxide cytotoxicity in cultured cardiac myocytes is iron dependent. Am J Physiol. 1994 Jan; 266(1 Pt 2):H121-7. PMID: 8304492.
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    44. Dauber IM, Parsons PE, Welsh CH, Giclas PC, Whitman GJ, Wheeler GS, Horwitz LD, Weil JV. Peripheral bypass-induced pulmonary and coronary vascular injury. Association with increased levels of tumor necrosis factor. Circulation. 1993 Aug; 88(2):726-35. PMID: 8339433.
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    45. Rubinstein JD, Lesnefsky EJ, Byler RM, Fennessey PV, Horwitz LD. Trolox C, a lipid-soluble membrane protective agent, attenuates myocardial injury from ischemia and reperfusion. Free Radic Biol Med. 1992 Dec; 13(6):627-34. PMID: 1459482.
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    46. Lesnefsky EJ, Allen KG, Carrea FP, Horwitz LD. Iron-catalyzed reactions cause lipid peroxidation in the intact heart. J Mol Cell Cardiol. 1992 Sep; 24(9):1031-8. PMID: 1433319.
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    47. Carrea FP, Lesnefsky EJ, Kaiser DG, Horwitz LD. The lazaroid U74006F, a 21-aminosteroid inhibitor of lipid peroxidation, attenuates myocardial injury from ischemia and reperfusion. J Cardiovasc Pharmacol. 1992 Aug; 20(2):230-5. PMID: 1381014.
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    48. Dauber IM, Lesnefsky EJ, Ashmore RC, Martel DM, Sheridan FM, Weil JV, Horwitz LD. Coronary vascular injury due to ischemia-reperfusion is reduced by pentoxifylline. J Pharmacol Exp Ther. 1992 Mar; 260(3):1250-6. PMID: 1312165.
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    49. Sheridan FM, Dauber IM, McMurtry IF, Lesnefsky EJ, Horwitz LD. Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion. Circ Res. 1991 Dec; 69(6):1566-74. PMID: 1954676.
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    50. Sheridan FM, Horwitz LD, McMurtry IF. Effects of phorbol esters on canine coronary artery constriction and dilation in vitro. Am J Physiol. 1991 Jul; 261(1 Pt 2):H236-42. PMID: 1858925.
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    51. Carrea FP, Lesnefsky EJ, Repine JE, Shikes RH, Horwitz LD. Reduction of canine myocardial infarct size by a diffusible reactive oxygen metabolite scavenger. Efficacy of dimethylthiourea given at the onset of reperfusion. Circ Res. 1991 Jun; 68(6):1652-9. PMID: 1709840.
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    52. Terada LS, Rubinstein JD, Lesnefsky EJ, Horwitz LD, Leff JA, Repine JE. Existence and participation of xanthine oxidase in reperfusion injury of ischemic rabbit myocardium. Am J Physiol. 1991 Mar; 260(3 Pt 2):H805-10. PMID: 2000975.
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    53. Lesnefsky EJ, Dauber IM, Horwitz LD. Myocardial sulfhydryl pool alterations occur during reperfusion after brief and prolonged myocardial ischemia in vivo. Circ Res. 1991 Feb; 68(2):605-13. PMID: 1991359.
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    54. Lesnefsky EJ, Williams GR, Rubinstein JD, Hogue TS, Horwitz LD, Reiter MJ. Hydrogen peroxide decreases effective refractory period in the isolated heart. Free Radic Biol Med. 1991; 11(6):529-35. PMID: 1778500.
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    55. Dauber IM, Lesnefsky EJ, VanBenthuysen KM, Weil JV, Horwitz LD. Reactive oxygen metabolite scavengers decrease functional coronary microvascular injury due to ischemia-reperfusion. Am J Physiol. 1991 Jan; 260(1 Pt 2):H42-9. PMID: 1899542.
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    56. Lesnefsky EJ, Hedlund BE, Hallaway PE, Horwitz LD. High-dose iron-chelator therapy during reperfusion with deferoxamine-hydroxyethyl starch conjugate fails to reduce canine infarct size. J Cardiovasc Pharmacol. 1990 Oct; 16(4):523-8. PMID: 1706792.
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    57. Lesnefsky EJ, Repine JE, Horwitz LD. Deferoxamine pretreatment reduces canine infarct size and oxidative injury. J Pharmacol Exp Ther. 1990 Jun; 253(3):1103-9. PMID: 2359019.
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    58. Dauber IM, VanBenthuysen KM, McMurtry IF, Wheeler GS, Lesnefsky EJ, Horwitz LD, Weil JV. Functional coronary microvascular injury evident as increased permeability due to brief ischemia and reperfusion. Circ Res. 1990 Apr; 66(4):986-98. PMID: 2180590.
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    59. Ashmore RC, Corkadel LK, Green CL, Horwitz LD. Verapamil but not nifedipine impairs left ventricular function during exercise in hypertensive patients. Am Heart J. 1990 Mar; 119(3 Pt 1):636-41. PMID: 2309606.
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    60. Wolfel EE, Hiatt WR, Brammell HL, Travis V, Horwitz LD. Plasma catecholamine responses to exercise after training with beta-adrenergic blockade. J Appl Physiol (1985). 1990 Feb; 68(2):586-93. PMID: 1969402.
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    61. Ashmore RC, O'Brien RF, Stelzner TJ, Dauber IM, Horwitz LD, McMurtry IF, VanBenthuysen KM. Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides. Biochem Biophys Res Commun. 1990 Jan 30; 166(2):909-15. PMID: 2302246.
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    62. Horwitz LD, VanBenthuysen KM, Sheridan FM, Lesnefsky EJ, Dauber IM, McMurtry IF. Coronary endothelial dysfunction from ischemia and reperfusion: effect of reactive oxygen metabolite scavengers. Free Radic Biol Med. 1990; 8(4):381-6. PMID: 2116371.
      View in: PubMed
    63. Fischer AC, Laulis MK, Horwitz L, Beschorner WE, Hess A. Host resistance to cyclosporine induced syngeneic graft-versus-host disease. Requirement for two distinct lymphocyte subsets. J Immunol. 1989 Aug 01; 143(3):827-32. PMID: 2526175.
      View in: PubMed
    64. Lesnefsky EJ, VanBenthuysen KM, McMurtry IF, Shikes RH, Johnston RB, Horwitz LD. Lidocaine reduces canine infarct size and decreases release of a lipid peroxidation product. J Cardiovasc Pharmacol. 1989 Jun; 13(6):895-901. PMID: 2484084.
      View in: PubMed
    65. Lesnefsky EJ, Fennessey PM, Van Benthuysen KM, McMurtry IF, Travis VL, Horwitz LD. Superoxide dismutase decreases early reperfusion release of conjugated dienes following regional canine ischemia. Basic Res Cardiol. 1989 Mar-Apr; 84(2):191-6. PMID: 2730525.
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    66. Ades PA, Wolfel EE, Hiatt WR, Fee C, Rolfs R, Brammell HL, Horwitz LD. Exercise haemodynamic effects of beta-blockade and intrinsic sympathomimetic activity. Eur J Clin Pharmacol. 1989; 36(1):5-10. PMID: 2917588.
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    67. Lesnefsky EJ, Repine JE, Horwitz LD. Oxidation and release of glutathione from myocardium during early reperfusion. Free Radic Biol Med. 1989; 7(1):31-5. PMID: 2753394.
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    68. Portz SJ, Lesnefsky EJ, VanBenthuysen KM, Repine JE, Parker NB, McMurtry IF, Horwitz LD. Dimethylthiourea, but not dimethylsulfoxide, reduces canine myocardial infarct size. Free Radic Biol Med. 1989; 7(1):53-8. PMID: 2502484.
      View in: PubMed
    69. Wolfel EE, Lindenfeld J, Smoak J, Horwitz LD. Effects of chronic beta-adrenergic blockade on exercise training in dogs. J Appl Physiol (1985). 1988 May; 64(5):1960-7. PMID: 3391896.
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    70. Klein RC, Huang SK, Marcus FI, Horwitz L, Fenster PE, Rushforth N, Kirsten EB. Enhanced antiarrhythmic efficacy of propafenone when used in combination with procainamide or quinidine. Am Heart J. 1987 Sep; 114(3):551-8. PMID: 3630896.
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    71. Fenster PE, Reynolds D, Horwitz LD, Morrison D, Goldman S, Thadani U, Lazzara R, Serokman R, Marcus FI. Atenolol for ventricular ectopy: a dose-response study. Clin Pharmacol Ther. 1987 Jan; 41(1):118-23. PMID: 3802701.
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    72. VanBenthuysen KM, McMurtry IF, Horwitz LD. Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro. J Clin Invest. 1987 Jan; 79(1):265-74. PMID: 3793926.
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    73. Pacheco JP, Fan F, Wright RA, Corkadel LK, Horwitz LD, Reeves RL. Monotherapy of mild hypertension with nifedipine. Am J Med. 1986 Dec 15; 81(6A):20-4. PMID: 3541596.
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    74. Wolfel EE, Hiatt WR, Brammell HL, Carry MR, Ringel SP, Travis V, Horwitz LD. Effects of selective and nonselective beta-adrenergic blockade on mechanisms of exercise conditioning. Circulation. 1986 Oct; 74(4):664-74. PMID: 2875812.
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    75. Klein RC, Horwitz LD, Rushforth N. Efficacy and safety of oral cibenzoline for ventricular arrhythmias. Am J Cardiol. 1986 Mar 01; 57(8):592-7. PMID: 3953445.
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    76. Horwitz LD, Lindenfeld J. Effects of enhanced ventricular filling on cardiac pump performance in exercising dogs. J Appl Physiol (1985). 1985 Dec; 59(6):1886-90. PMID: 2416732.
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    77. Peck SL, Johnston RB, Horwitz LD. Reduced neutrophil superoxide anion release after prolonged infusions of lidocaine. J Pharmacol Exp Ther. 1985 Nov; 235(2):418-22. PMID: 2997433.
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    78. Ditchey RV, Horwitz LD. Metabolic evidence of inadequate coronary blood flow during closed-chest resuscitation in dogs. Cardiovasc Res. 1985 Jul; 19(7):419-25. PMID: 4016818.
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    79. Lindenfeld J, Weil JV, Travis VL, Horwitz LD. Hemodynamic response to normovolemic polycythemia at rest and during exercise in dogs. Circ Res. 1985 Jun; 56(6):793-800. PMID: 4006091.
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    80. Sorensen SG, Groves BM, Horwitz LD, Chaudhuri TK. Regional myocardial blood flow in man during dipyridamole coronary vasodilation. Chest. 1985 Jun; 87(6):735-9. PMID: 3996059.
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    81. Hiatt WR, Wolfel EE, Stoll S, Nies AS, Zerbe GO, Brammell HL, Horwitz LD. beta-2 Adrenergic blockade evaluated with epinephrine after placebo, atenolol, and nadolol. Clin Pharmacol Ther. 1985 Jan; 37(1):2-6. PMID: 2856902.
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    82. Hiatt WR, Travis VL, Horwitz KB, Horwitz LD. The effect of platelet protein and DNA on the measurement of human lymphocyte beta adrenergic receptor number. J Recept Res. 1985; 5(5-6):419-29. PMID: 3003354.
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    83. Ades PA, Brammell HL, Greenberg JH, Horwitz LD. Effect of beta blockade and intrinsic sympathomimetic activity on exercise performance. Am J Cardiol. 1984 Dec 01; 54(10):1337-41. PMID: 6507309.
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    84. Hiatt WR, Marsh RC, Brammell HL, Fee C, Horwitz LD. Effect of aerobic conditioning on the peripheral circulation during chronic beta-adrenergic blockade. J Am Coll Cardiol. 1984 Nov; 4(5):958-63. PMID: 6491088.
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    85. Gold FL, Horwitz LD, Bache RJ. Adrenergic coronary vasoconstriction in acute right ventricular hypertension. Cardiovasc Res. 1984 Jul; 18(7):447-54. PMID: 6744366.
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    86. Duffey DJ, Horwitz LD, Brammell HL. Nifedipine and the conditioning response. Am J Cardiol. 1984 Mar 15; 53(7):908-11. PMID: 6702646.
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    87. Marsh RC, Hiatt WR, Brammell HL, Horwitz LD. Attenuation of exercise conditioning by low dose beta-adrenergic receptor blockade. J Am Coll Cardiol. 1983 Sep; 2(3):551-6. PMID: 6135725.
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    88. Lindenfeld J, Reeves JT, Horwitz LD. Low exercise pulmonary resistance is not dependent on vasodilator prostaglandins. J Appl Physiol Respir Environ Exerc Physiol. 1983 Aug; 55(2):558-61. PMID: 6618948.
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    89. Sheehan MW, Brammell HL, Sable DL, Nies AS, Horwitz LD. Effect of beta-adrenergic blockade on circulating catecholamines and dopamine-beta-hydroxylase activity during exercise in normal subjects. Am Heart J. 1983 May; 105(5):777-82. PMID: 6303097.
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    90. Gross PA, Travis VL, Horwitz L, Schrier RW, Anderson RJ. Effect of desmopressin-induced water retention on systemic hemodynamics in rat. Am J Physiol. 1982 Dec; 243(6):H934-40. PMID: 7149046.
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    91. Horwitz LD, Groves BM, Walsh RA, Sorensen SM, Latson TW. Functional significance of coronary collateral vessels in patients with coronary artery disease. Am Heart J. 1982 Aug; 104(2 Pt 1):221-5. PMID: 7102505.
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    92. Morgan BJ, Brammell HL, Sable DL, Morton ML, Horwitz LD. Effect of aerobic conditioning on cardiovascular response to isometric exercise. J Appl Physiol Respir Environ Exerc Physiol. 1982 May; 52(5):1257-60. PMID: 6284687.
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    93. Horwitz KB, Horwitz LD. Canine vascular tissues are targets for androgens, estrogens, progestins, and glucocorticoids. J Clin Invest. 1982 Apr; 69(4):750-8. PMID: 6281310.
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    94. Sable DL, Brammell HL, Sheehan MW, Nies AS, Gerber J, Horwitz LD. Attenuation of exercise conditioning by beta-adrenergic blockade. Circulation. 1982 Apr; 65(4):679-84. PMID: 7060245.
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    95. Horwitz LD, Myers JH. Ethanol-induced alterations in pancreatic blood flow in conscious dogs. Circ Res. 1982 Feb; 50(2):250-6. PMID: 6799220.
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    96. Lindenfeld J, Horwitz LD. Effects of amitriptyline on left ventricular function in conscious dogs. J Cardiovasc Pharmacol. 1981 Nov-Dec; 3(6):1221-8. PMID: 6173521.
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    97. Gold FL, Horwitz LD. Hemodynamic effects of pirbuterol in conscious dogs. Am Heart J. 1981 Sep; 102(3 Pt 2):591-6. PMID: 6115576.
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    98. O'Rourke RA, Horwitz LD. Effects of chronic oral quinidine on left ventricular performance. Am Heart J. 1981 Jun; 101(6):769-73. PMID: 7234655.
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    99. Lindenfeld J, Crawford MH, O'Rourke RA, Levine SP, Montiel MM, Horwitz LD. Adrenergic responsiveness after abrupt propranolol withdrawal in normal subjects and in patients with angina pectoris. Circulation. 1980 Oct; 62(4):704-11. PMID: 7408143.
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    100. Lameire NH, Stein JH, Horwitz LD. Hemorrhage and regional renal blood flow in the conscious dog. Circ Shock. 1980; 7(3):289-98. PMID: 7449046.
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    101. Urschel CW, Vokonas PS, Henderson AH, Liedtke AJ, Horwitz LD, Sonnenblick EH. Critical evaluation of indices of myocardial contractility derived from the isovolumic phase of contraction. Cardiology. 1980; 65(1):4-22. PMID: 7363278.
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    102. Barnes GE, Horwitz LD, Bishop VS. Reliability of the maximum derivatives of left ventricular pressure and internal diameter as indices of the inotropic state of the depressed myocardium. Cardiovasc Res. 1979 Nov; 13(11):652-62. PMID: 519668.
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    103. Walsh RA, Horwitz LD. Adverse hemodynamic effects of intravenous disopyramide compared with quinidine in conscious dogs. Circulation. 1979 Nov; 60(5):1053-8. PMID: 487539.
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    104. Schwartz DA, Grover FL, Horwitz LD. Effect of isoproterenol on regional myocardial perfusion and tissue oxygenation in acute myocardial infarction. Am Heart J. 1979 Mar; 97(3):339-47. PMID: 420073.
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    105. Horwitz LD, Travis VL. Low serum dopamine beta-hydroxylase activity. A marker of congestive heart failure. J Clin Invest. 1978 Nov; 62(5):899-906. PMID: 711856.
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    106. Myers JH, Horwitz LD. Hemodynamic and metabolic response after abrupt uithdrawal of long-term propranolol. Circulation. 1978 Aug; 58(2):196-201. PMID: 566642.
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    107. Morgan SM, Fisher JD, Horwitz LD. Validation of regional myocardial flow measurements with scintillation camera detection of xenon-133. Invest Radiol. 1978 Mar-Apr; 13(2):132-7. PMID: 659084.
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    108. Horwitz LD, Peterson DF, Bishop VS. Effect of regional myocardial ischemia on cardiac pump performance during exercise. Am J Physiol. 1978 Feb; 234(2):H157-62. PMID: 623317.
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    109. Horwitz LD, Atkins JM, Saito M. Effect of digitalis on left ventricular function in exercising dogs. Circ Res. 1977 Dec; 41(6):744-50. PMID: 923025.
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    110. Bishop VS, Horwitz LD. Quantitative assessment of cardiac pump performance. J Physiol. 1977 Jul; 269(2):355-70. PMID: 894597.
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    111. Atkins JM, Horwitz LD. Cardiac autonomic blockade in exercising dogs. J Appl Physiol Respir Environ Exerc Physiol. 1977 Jun; 42(6):878-83. PMID: 881388.
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    112. Newman RK, Bishop VS, Peterson DF, Leroux EJ, Horwitz LD. Effect of verapamil on left ventricular performance in conscious dogs. J Pharmacol Exp Ther. 1977 Jun; 201(3):723-30. PMID: 16999.
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    113. Horwitz LD. Effects of intravenous anesthetic agents on left ventricular function in dogs. Am J Physiol. 1977 Jan; 232(1):H44-8. PMID: 835719.
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    114. Fixler DE, Atkins JM, Mitchell JH, Horwitz LD. Blood flow to respiratory, cardiac, and limb muscles in dogs during graded exercise. Am J Physiol. 1976 Nov; 231(5 Pt. 1):1515-9. PMID: 998797.
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    115. Lifschitz MD, Horwitz LD. Plasma renin activity during exercise in the dog. Circ Res. 1976 Jun; 38(6):483-7. PMID: 1269098.
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    116. Bishop VS, Peterson DF, Horwitz LD. Factors influencing cardiac performance. Int Rev Physiol. 1976; 9:239-73. PMID: 789282.
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    117. Horwitz LD, Atkins JM, Dunbar SA. Left ventricular dynamics during recovery from exercise. J Appl Physiol. 1975 Sep; 39(3):449-52. PMID: 1176410.
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    118. Schwartz DA, Horwitz LD. Effects of ketamine on left ventricular performance. J Pharmacol Exp Ther. 1975 Aug; 194(2):410-4. PMID: 1151766.
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    119. Willerson JT, Curry GC, Atkins JM, Parkey R, Horwitz LD. Influence of hypertonic mannitol on ventricular performance and coronary blood flow in patients. Circulation. 1975 Jun; 51(6):1095-100. PMID: 1132099.
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    120. Leshin SJ, Horwitz LD, Mitchell JH. Dimensional analysis of the left ventricle: effects of acute aortic regurgitation. Am J Physiol. 1975 Feb; 228(2):536-42. PMID: 123419.
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    121. Horwitz LD, Atkins JM, Leshin SJ. Effect of beta-adrenergic blockade on left ventricular function in exercise. Am J Physiol. 1974 Oct; 227(4):839-42. PMID: 4429132.
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    122. Horwitz LD, Curry GC, Parkey RW, Bonte FJ. Effect of isoproterenol on coronary blood flow in primary myocardial disease. Circulation. 1974 Sep; 50(3):560-4. PMID: 4606491.
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    123. Horwitz LD, Atkins JM. Acute effects of ethanol on left ventricular performance. Circulation. 1974 Jan; 49(1):124-8. PMID: 4808833.
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    124. Horwitz LD, Curry GC, Parkey RW, Bonte FJ. Differentiation of physiologically significant coronary artery lesions by coronary blood flow measurements during isoproterenol infusion. Circulation. 1974 Jan; 49(1):55-62. PMID: 4808849.
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    125. Horwitz LD, Mullins CB, Payne RM, Curry GC. Left ventricular function in mitral stenosis. Chest. 1973 Nov; 64(5):609-14. PMID: 4750333.
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    126. Atkins JM, Wildenthal K, Horwitz LD. Cardiovascular responses to hyperosmotic mannitol in anesthetized and conscious dogs. Am J Physiol. 1973 Jul; 225(1):132-7. PMID: 4714392.
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    127. Payne RM, Horwitz LD, Mullins CB. Comparison of isometric exercise and angiotensin infusion as stress test for evaluation of left ventricular function. Am J Cardiol. 1973 Apr; 31(4):428-33. PMID: 4348158.
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    128. Horwitz LD. Mechanism of action and clinical use of nitroglycerin. Postgrad Med. 1973 Apr; 53(4):167-9. PMID: 4632992.
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    129. Bonte FJ, Parkey RW, Stokely EM, Lewis SE, Horwitz LD, Curry GC. Radionuclide determination of myocardial blood flow. Semin Nucl Med. 1973 Apr; 3(2):153-63. PMID: 4572261.
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    130. Bishop VS, Horwitz LD. Influence of the cardiac sympathetics on left ventricular dynamics during tachycardia. Cardiology. 1973; 58(6):326-34. PMID: 4154066.
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    131. Horwitz LD, Atkins JM, Leshin SJ. Role of the Frank-Starling mechanism in exercise. Circ Res. 1972 Dec; 31(6):868-75. PMID: 4641783.
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    132. Horwitz LD, Bishop VS. Effect of acute volume loading on heart rate in the conscious dog. Circ Res. 1972 Mar; 30(3):316-21. PMID: 4400705.
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    133. Horwitz LD, Bishop VS. Left ventricular pressure-dimension relationships in the conscious dog. Cardiovasc Res. 1972 Mar; 6(2):163-71. PMID: 5034230.
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    134. Horwitz LD, Herman MV, Gorlin R. Clinical response to nitroglycerin as a diagnostic test for coronary artery disease. Am J Cardiol. 1972 Feb; 29(2):149-53. PMID: 4621671.
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    135. Bishop VS, Horwitz LD. Effects of altered autonomic control on left ventricular function in conscious dogs. Am J Physiol. 1971 Nov; 221(5):1278-82. PMID: 4399395.
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    136. Horwitz LD, Gorlin R, Taylor WJ, Kemp HG. Effects of nitroglycerin on regional myocardial blood flow in coronary artery disease. J Clin Invest. 1971 Aug; 50(8):1578-84. PMID: 4999635.
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    137. Erickson HH, Bishop VS, Kardon MB, Horwitz LD. Left ventricular internal diameter and cardiac function during exercise. J Appl Physiol. 1971 Apr; 30(4):473-8. PMID: 5572762.
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    138. Bishop VS, Stone HL, Horwitz LD. Effects of tachycardia and ventricular filling pressure on stroke volume in the conscious dog. Am J Physiol. 1971 Feb; 220(2):436-9. PMID: 5540893.
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    139. Bishop VS, Horwitz LD. Left ventricular transverse internal diameter: value in studying left ventricular function. Am Heart J. 1970 Oct; 80(4):507-14. PMID: 5471213.
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    140. Horwitz LD, Bishop VS. Effects of ouabain on left ventricular performance in conscious dogs. Cardiovasc Res. 1970 Jan; 4(1):31-5. PMID: 5416841.
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    141. Bishop VS, Horwitz LD, Stone HL, Stegall HF, Engelken EJ. Left ventricular internal diameter and cardiac function in conscious dogs. J Appl Physiol. 1969 Nov; 27(5):619-23. PMID: 5360431.
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    142. Horwitz LD, Bishop VS, Stone HL, Stegall HF. Cardiovascular effects of low-oxygen atmospheres in conscious and anesthetized dogs. J Appl Physiol. 1969 Sep; 27(3):370-3. PMID: 5804135.
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    143. Horwitz LD, Kim BM, Gray FD. Cardiopulmonary effects of distention of the urinary bladder. Am Heart J. 1966 Mar; 71(3):345-51. PMID: 5905448.
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