Richard E Davis
Title | Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-BioChem&Molecular Genetics |
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Phone | 303/724-3226 |
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Overview The Davis Lab studies the molecular biology of parasitic worms (primarily schistosomes and parasitic nematodes) with a focus on atypical molecular processes including spliced leader RNA trans-splicing and programmed DNA elimination. Our previous studies on trans-splicing used cell-free in vitro systems, biolistic RNA transfection, enzymatic, and structural biology approaches to examine the cellular and biochemical adaptations of mRNA translation and decay to trans-splicing. Current studies are focused on programmed DNA elimination in parasitic nematodes, a phenomenon where chromosomes break and regions of chromosomes are reproducibly lost during early development. We use a variety of approaches to study DNA elimination including genomics and transcriptomics, biochemistry, analysis of small RNAs and Argonautes, chromatin and chromosome analyses, and analysis of chromosome segregation.
Research F32AM007086 (DAVIS, RICHARD E.)Feb 1, 1985 NIH/NIADDK STUDY OF THE OPRTASE-ODCASE COMPLEX AND GENE(S) Role: Principal Investigator |
| R15AI032709 (DAVIS, RICHARD E.)Jun 1, 1992 - May 31, 1996 NIH/NIAID TRANS-SPLICING IN PARASITIC FLATWORMS Role: Principal Investigator |
| R15AI039714 (DAVIS, RICHARD E.)Jul 1, 1995 - Jun 30, 1998 NIH/NIAID TRANS SPLICING AND PRIMARY TRANSCRIPTS IN ACARIS Role: Principal Investigator |
| R15AI043300 (DAVIS, RICHARD E.)Jul 1, 1998 - Mar 31, 2000 NIH/NIAID ASCARIS MRNA PROCESSING--EXON/INTRON DEFINITION AND CAP Role: Principal Investigator |
| R01AI049558 (DAVIS, RICHARD E.)Aug 1, 2000 - May 31, 2016 NIH/NIAID Cap-interacting proteins in metazoan trans-splicing Role: Principal Investigator |
| R21AI078087 (DAVIS, RICHARD E.)Jun 15, 2008 - May 31, 2011 NIH/NIAID Small RNA Discovery and Analysis in Ascaris Role: Principal Investigator |
| R03AI080805 (DAVIS, RICHARD E.)Feb 15, 2009 - Jan 31, 2012 NIH/NIAID Structural Analysis of Helminth mRNA Cap-Binding Proteins Role: Principal Investigator |
| R21AI098421 (DAVIS, RICHARD E.)Feb 15, 2012 - Jan 31, 2014 NIH/NIAID Chromatin Diminution in Ascaris Role: Principal Investigator |
| R01AI114054 (DAVIS, RICHARD E.)Aug 20, 2015 - Jan 31, 2020 NIH/NIAID Chromatin diminution in nematodes Role: Principal Investigator |
| R13AI129271 (DAVIS, RICHARD E.)Aug 10, 2017 - Jul 31, 2018 NIH/NIAID 11th Molecular and Cellular Biology of Helminth Parasites Meeting Role: Principal Investigator |
| R13AI133919 (DAVIS, RICHARD E.)Jul 3, 2018 - Jun 30, 2019 NIH/NIAID Molecular and Cellular Biology of Helminth Parasites Role: Principal Investigator |
Bibliographic
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Wang J, Veronezi GMB, Kang Y, Zagoskin M, O'Toole ET, Davis RE. Comprehensive Chromosome End Remodeling during Programmed DNA Elimination. Curr Biol. 2020 Sep 07; 30(17):3397-3413.e4. PMID: 32679104.
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Wang J, Davis RE. Ascaris. Curr Biol. 2020 May 18; 30(10):R423-R425. PMID: 32428467.
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Wang J, Gao S, Mostovoy Y, Kang Y, Zagoskin M, Sun Y, Zhang B, White LK, Easton A, Nutman TB, Kwok PY, Hu S, Nielsen MK, Davis RE. Comparative genome analysis of programmed DNA elimination in nematodes. Genome Res. 2017 12; 27(12):2001-2014. PMID: 29118011.
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Kang Y, Wang J, Davis RE. Nuclei Isolation from Nematode Ascaris. Bio Protoc. 2017 May 05; 7(9). PMID: 29082294.
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Kang Y, Wang J, Neff A, Kratzer S, Kimura H, Davis RE. Differential Chromosomal Localization of Centromeric Histone CENP-A Contributes to Nematode Programmed DNA Elimination. Cell Rep. 2016 08 30; 16(9):2308-16. PMID: 27545882.
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Streit A, Wang J, Kang Y, Davis RE. Gene silencing and sex determination by programmed DNA elimination in parasitic nematodes. Curr Opin Microbiol. 2016 08; 32:120-127. PMID: 27315434.
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Zhu L, Zhao J, Wang J, Hu C, Peng J, Luo R, Zhou C, Liu J, Lin J, Jin Y, Davis RE, Cheng G. MicroRNAs Are Involved in the Regulation of Ovary Development in the Pathogenic Blood Fluke Schistosoma japonicum. PLoS Pathog. 2016 Feb; 12(2):e1005423. PMID: 26871705.
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Neff AT, Wang J, Davis RE. "Father knows best?". EMBO J. 2014 Aug 18; 33(16):1729-31. PMID: 25061225.
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Wang J, Davis RE. Programmed DNA elimination in multicellular organisms. Curr Opin Genet Dev. 2014 Aug; 27:26-34. PMID: 24886889.
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Wang J, Davis RE. Contribution of transcription to animal early development. Transcription. 2014; 5(4):e967602. PMID: 25483604.
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Wang J, Garrey J, Davis RE. Transcription in pronuclei and one- to four-cell embryos drives early development in a nematode. Curr Biol. 2014 Jan 20; 24(2):124-33. PMID: 24374308.
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Wang J, Mitreva M, Berriman M, Thorne A, Magrini V, Koutsovoulos G, Kumar S, Blaxter ML, Davis RE. Silencing of germline-expressed genes by DNA elimination in somatic cells. Dev Cell. 2012 Nov 13; 23(5):1072-80. PMID: 23123092.
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Liu W, Jankowska-Anyszka M, Piecyk K, Dickson L, Wallace A, Niedzwiecka A, Stepinski J, Stolarski R, Darzynkiewicz E, Kieft J, Zhao R, Jones DN, Davis RE. Structural basis for nematode eIF4E binding an m(2,2,7)G-Cap and its implications for translation initiation. Nucleic Acids Res. 2011 Nov 01; 39(20):8820-32. PMID: 21965542.
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Wang J, Czech B, Crunk A, Wallace A, Mitreva M, Hannon GJ, Davis RE. Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles. Genome Res. 2011 Sep; 21(9):1462-77. PMID: 21685128.
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Wallace A, Filbin ME, Veo B, McFarland C, Stepinski J, Jankowska-Anyszka M, Darzynkiewicz E, Davis RE. The nematode eukaryotic translation initiation factor 4E/G complex works with a trans-spliced leader stem-loop to enable efficient translation of trimethylguanosine-capped RNAs. Mol Cell Biol. 2010 Apr; 30(8):1958-70. PMID: 20154140.
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Liu W, Zhao R, McFarland C, Kieft J, Niedzwiecka A, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Jones DN, Davis RE. Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps. J Biol Chem. 2009 Nov 06; 284(45):31336-49. PMID: 19710013.
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Cheng G, Davis RE. An improved and secreted luciferase reporter for schistosomes. Mol Biochem Parasitol. 2007 Oct; 155(2):167-71. PMID: 17681388.
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Cheng G, Cohen L, Mikhli C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE. In vivo translation and stability of trans-spliced mRNAs in nematode embryos. Mol Biochem Parasitol. 2007 Jun; 153(2):95-106. PMID: 17391777.
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Cheng G, Cohen L, Ndegwa D, Davis RE. The flatworm spliced leader 3'-terminal AUG as a translation initiator methionine. J Biol Chem. 2006 Jan 13; 281(2):733-43. PMID: 16230357.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2005 | 1 | 2007 | 2 | 2009 | 1 | 2010 | 1 | 2011 | 2 | 2012 | 1 | 2013 | 1 | 2014 | 3 | 2016 | 3 | 2017 | 2 | 2020 | 2 |
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