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Brian B Graham

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-3876

    Collapse Biography 
    Collapse awards and honors
    2014Giles F. Filley Memorial Award for Excellence in Respiratory Physiology and Medicine, American Physiological Society
    2014 - 2019Early Career Scholars Program, University of Colorado Department of Medicine
    2013Young Physician Scientist Award, American Society for Clinical Investigation
    2013Schistosomiasis Taskforce Award, Pulmonary Vascular Research Institute

    Collapse Overview 
    Collapse overview
    1. Research
    The focus of my research is investigating the pathogenesis of inflammatory pulmonary vascular disease. Many forms of pulmonary hypertension (PH) are associated with inflammation including connective tissue disease (CTD) and infections by HIV and Schistosoma. Starting in 2008 under the guidance of my mentor Rubin Tuder and in association with many collaborators worldwide we began investigating schistosomiasis-associated pulmonary hypertension, including developing and validating a novel mouse model of the disease, and comparing the mouse model to human tissue collected at autopsy from collaborators in Brazil. Using this approach, we have made the following major discoveries:
    • IL-4, IL-13 and TGF-beta signaling are all present in human and experimental disease. Together IL-4 and IL-13 signaling are necessary for disease pathogenesis, and regulate the production and activation of TGF-beta. TGF-beta, primarily released and/or activated by macrophages, induces vascular remodeling; blockade of TGF-beta signaling is also protective in experimental disease.
    • Persistent parasite antigens are not present in patients who die of the disease in modern samples.
    • Although Schistosoma exposure does not cause hypoxia, hypoxia related signaling is activated in human and experimental disease, and is necessary for the experimental disease pathogenesis.
    • IL-6 signaling is present in human and experimental disease, and is protective in the experimental disease model (mice with abrogated IL-6 signaling have worse disease), an effect potentially mediated via hypoxia signaling activation.
    We are currently the only group in the United States and one of a few worldwide studying Schistosoma-induced pulmonary vascular disease. As a result of our preliminary data and in support of these studies, I have successfully obtained multiple competitive grants, including:
    • K08: NIH / NHLBI
    • Research Fellowship: American Thoracic Society Foundation / Pulmonary Hypertension Association
    • Research Scholars Program in Pulmonary Arterial Hypertension: Gilead Sciences
    • Early Career Scholars Program: University of Colorado Department of Medicine
    • Career Development Award: Parker B. Francis Foundation
    • ASPIRE Investigator Award: Pfizer
    • Research Grant: Pulmonary Vascular Research Institute (PVRI)

    2. Clinical
    Outpatient Service
    • As a Co-Director for the Hereditary Hemorrhagic Telangiectasia Center of Excellence at UCH, I see all newly referred and follow up patients in clinic, and as appropriate refer the patients to additional services such as Interventional Radiology. We see 1-2 patients weekly in HHT clinic.
    • My other major clinic is Pulmonary Hypertension, since 2010, in which I see 5 old and 2 new patients per week.
    • Since 2010, I also attend twice yearly in the Pulmonary Fellow’s Clinic at UCH.
    Inpatient Service
    • Since 2010, I have attended 4-6 weeks annually on the Pulmonary Hypertension service at UCH, with an average inpatient census of 4-5 patients, and includes a PGY5 pulmonary fellow and an NP.
    • Starting in July 2014, I have also been an intensivist consultant in the Surgical Intensive Care Unit at the Denver Veteran Affairs Hospital, scheduled to attend 40 days per year on this service.

    3. Teaching
    • In July 2014 I became an Associate Program Director for the Internal Medicine Residency Program. My responsibilities include: approval of resident research projects; advising in fellowship applications; organization of categorical pathway and research track lectures, including delivering many of the lectures myself; participation in the residency application process; and reviewing one-fifth of the residency class.
    • Since 2012, I have given 2 one hour lectures to 1st year medical students in the Pulmonary Block “The Pulmonary Vasculature”, and “Pulmonary Hypertension”.
    • Since 2012 I have participated in a 2 hour Oxford-style debate (against Dr. Mark Earnest) to the 4th year medical students in the Integrated Clinicians Course in a session titled “The Politics of Pharmaceuticals”.
    • Since 2010 I have served as a small Group Facilitator for the Pulmonary Block (IDPT5005; MS1)
    • Since 2010 I have attended twice yearly in the Pulmonary Fellow’s Clinic
    • I have mentored a wide range of students, residents and fellows in the laboratory.


    Collapse Research 
    Collapse research activities and funding
    K08HL105536     (GRAHAM, BRIAN BARKLEY)Jul 1, 2011 - Jun 30, 2016
    NIH/NHLBI
    Schistosomiasis Associated Pulmonary Arterial Hypertension
    Role: Principal Investigator

    R03HL133306     (GRAHAM, BRIAN BARKLEY)Aug 15, 2016 - Jul 31, 2018
    NIH/NHLBI
    Role of Th2 CD4 T Cells in Schistosoma Pulmonary Hypertension
    Role: Principal Investigator

    R01HL135872     (GRAHAM, BRIAN BARKLEY)Dec 15, 2016 - Nov 30, 2021
    NIH/NHLBI
    Activation, Phenotype and Function of CD4 T Cells in Schistosoma-Pulmonary Hypertension
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 May 30; 8:15494. PMID: 28555642.
      View in: PubMed
    2. Pugliese SC, Kumar S, Janssen WJ, Graham BB, Frid MG, Riddle SR, El Kasmi KC, Stenmark KR. A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension. J Immunol. 2017 Jun 15; 198(12):4802-4812. PMID: 28500078.
      View in: PubMed
    3. Ali Z, Kosanovic D, Kolosionek E, Schermuly RT, Graham BB, Mathie A, Butrous G. Enhanced inflammatory cell profiles in schistosomiasis-induced pulmonary vascular remodeling. Pulm Circ. 2017 Mar; 7(1):244-252. PMID: 28680583.
      View in: PubMed
    4. Graham BB, Koyanagi D, Kandasamy B, Tuder RM. Right Ventricle Vasculature in Human Pulmonary Hypertension Assessed by Stereology. Am J Respir Crit Care Med. 2017 Mar 09. PMID: 28278380.
      View in: PubMed
    5. Graham BB, Robinson JC, Tuder RM. Fatty Acid Metabolism, Bone Morphogenetic Protein Receptor Type 2, and the Right Ventricle. Am J Respir Crit Care Med. 2016 Sep 15; 194(6):655-6. PMID: 27628075; PMCID: PMC5027232 [Available on 09/15/17].
    6. Xu W, Ghosh S, Comhair SA, Asosingh K, Janocha AJ, Mavrakis DA, Bennett CD, Gruca LL, Graham BB, Queisser KA, Kao CC, Wedes SH, Petrich JM, Tuder RM, Kalhan SC, Erzurum SC. Increased mitochondrial arginine metabolism supports bioenergetics in asthma. J Clin Invest. 2016 Jul 01; 126(7):2465-81. PMID: 27214549; PMCID: PMC4922712 [Available on 10/01/16].
    7. Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. Cell Rep. 2015 Nov 03; 13(5):1016-32. PMID: 26565914; PMCID: PMC4644508.
    8. Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med. 2015 Oct 15; 192(8):998-1008. PMID: 26192556; PMCID: PMC4642207 [Available on 10/15/16].
    9. Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM. Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 01; 309(5):L435-40. PMID: 26115672; PMCID: PMC4556932.
    10. White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med. 2015 Jun; 7(6):695-713. PMID: 25825391; PMCID: PMC4459813.
    11. Robinson JC, Graham BB, Rouault TC, Tuder RM. The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension. Am J Respir Cell Mol Biol. 2014 Dec; 51(6):721-9. PMID: 24988529; PMCID: PMC4291546.
    12. Graham BB, Kumar R. Schistosomiasis and the pulmonary vasculature (2013 Grover Conference series). Pulm Circ. 2014 Sep; 4(3):353-62. PMID: 25621148; PMCID: PMC4278594.
    13. Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014 Sep; 184(9):2382-9. PMID: 25016184; PMCID: PMC4188171.
    14. Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2014 Aug; 124(8):3514-28. PMID: 24960162; PMCID: PMC4109523.
    15. El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR. Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension. J Immunol. 2014 Jul 15; 193(2):597-609. PMID: 24928992; PMCID: PMC4100597.
    16. Chabon JJ, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, Rodriguez Garcia A, Sanders L, Perez M, Tuder RM, Graham BB. Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension. Pulm Circ. 2014 Jun; 4(2):289-99. PMID: 25006448; PMCID: PMC4070790.
    17. Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE, Hara N, Cogan JD, Phillips JA, Taylor MR, Graham BB, Tuder RM, Loyd JE, Geraci MW. Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014 May 01; 189(9):1110-20. PMID: 24605778; PMCID: PMC4098107.
    18. Tuder RM, Robinson JC, Graham BB. Fat and cardiotoxicity in hereditary pulmonary hypertension. Am J Respir Crit Care Med. 2014 Feb 01; 189(3):247-9. PMID: 24484329; PMCID: PMC3977738.
    19. Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM. Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):951-9. PMID: 23815102; PMCID: PMC3931110.
    20. Macht M, Robinson JC, Graham BB. Updated approach for the assessment of ventilator-associated pneumonia. Crit Care Med. 2013 Nov; 41(11):2641-2. PMID: 24162675; PMCID: PMC3828199.
    21. Tuder RM, Stacher E, Robinson J, Kumar R, Graham BB. Pathology of pulmonary hypertension. Clin Chest Med. 2013 Dec; 34(4):639-50. PMID: 24267295.
      View in: PubMed
    22. Hunt JM, Bethea B, Liu X, Gandjeva A, Mammen PP, Stacher E, Gandjeva MR, Parish E, Perez M, Smith L, Graham BB, Kuebler WM, Tuder RM. Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15; 305(10):L725-36. PMID: 24039255; PMCID: PMC3840271.
    23. Graham BB, Chabon J, Gebreab L, Poole J, Debella E, Davis L, Tanaka T, Sanders L, Dropcho N, Bandeira A, Vandivier RW, Champion HC, Butrous G, Wang XJ, Wynn TA, Tuder RM. Transforming growth factor-ß signaling promotes pulmonary hypertension caused by Schistosoma mansoni. Circulation. 2013 Sep 17; 128(12):1354-64. PMID: 23958565; PMCID: PMC3880024.
    24. Qi X, Hong J, Chaves L, Zhuang Y, Chen Y, Wang D, Chabon J, Graham B, Ohmori K, Li Y, Huang H. Antagonistic regulation by the transcription factors C/EBPa and MITF specifies basophil and mast cell fates. Immunity. 2013 Jul 25; 39(1):97-110. PMID: 23871207; PMCID: PMC3755602.
    25. Dorosz JL, Fonseca BM, Kay JD, Graham BB, Salcedo EE, Quaife RA. A sinus venosus atrial septal defect is diagnosed by echocardiography with an unusual bubble study. Echocardiography. 2013 Jul; 30(6):E182-3. PMID: 23551148.
      View in: PubMed
    26. Kolosionek E, King J, Rollinson D, Schermuly RT, Grimminger F, Graham BB, Morrell N, Butrous G. Schistosomiasis causes remodeling of pulmonary vessels in the lung in a heterogeneous localized manner: Detailed study. Pulm Circ. 2013 Apr; 3(2):356-62. PMID: 24015336; PMCID: PMC3757830.
    27. Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA. Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2a. Cell Metab. 2013 Feb 05; 17(2):271-81. PMID: 23395173; PMCID: PMC3569856.
    28. Lundgrin EL, Park MM, Sharp J, Tang WH, Thomas JD, Asosingh K, Comhair SA, DiFilippo FP, Neumann DR, Davis L, Graham BB, Tuder RM, Dostanic I, Erzurum SC. Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. Ann Am Thorac Soc. 2013 Feb; 10(1):1-9. PMID: 23509326; PMCID: PMC3960991.
    29. Chow K, Fessel JP, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan; 3(1):31-49. PMID: 23662173; PMCID: PMC3641738.
    30. Stacher E, Graham BB, Hunt JM, Gandjeva A, Groshong SD, McLaughlin VV, Jessup M, Grizzle WE, Aldred MA, Cool CD, Tuder RM. Modern age pathology of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012 Aug 01; 186(3):261-72. PMID: 22679007; PMCID: PMC3886716.
    31. Tuder RM, Davis LA, Graham BB. Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension. Am J Respir Crit Care Med. 2012 Feb 01; 185(3):260-6. PMID: 22077069; PMCID: PMC3297113.
    32. Graham BB, Chabon J, Bandeira A, Espinheira L, Butrous G, Tuder RM. Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension. Pulm Circ. 2011 Oct-Dec; 1(4):456-61. PMID: 22530100; PMCID: PMC3329075.
    33. Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Redente EF, Riches DW, Hassoun PM, Bandeira A, Champion HC, Butrous G, Wynn TA, Tuder RM. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol. 2010 Sep; 177(3):1549-61. PMID: 20671265; PMCID: PMC2928984.
    34. Cole BB, Smith RW, Jenkins KM, Graham BB, Reynolds PR, Reynolds SD. Tracheal Basal cells: a facultative progenitor cell pool. Am J Pathol. 2010 Jul; 177(1):362-76. PMID: 20522644; PMCID: PMC2893679.
    35. Graham BB, Bandeira AP, Morrell NW, Butrous G, Tuder RM. Schistosomiasis-associated pulmonary hypertension: pulmonary vascular disease: the global perspective. Chest. 2010 Jun; 137(6 Suppl):20S-29S. PMID: 20522577.
      View in: PubMed
    36. Graham BB, Keniston A, Gajic O, Trillo Alvarez CA, Medvedev S, Douglas IS. Diabetes mellitus does not adversely affect outcomes from a critical illness. Crit Care Med. 2010 Jan; 38(1):16-24. PMID: 19789450.
      View in: PubMed
    37. Graham BB, Tuder RM. [Pathogenesis of pulmonary hypertension]. Zhonghua Yi Xue Za Zhi. 2009 Aug 11; 89(30):2091-3. PMID: 20058607.
      View in: PubMed
    38. Borges VM, Vandivier RW, McPhillips KA, Kench JA, Morimoto K, Groshong SD, Richens TR, Graham BB, Muldrow AM, Van Heule L, Henson PM, Janssen WJ. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L586-95. PMID: 19648283; PMCID: PMC2770785.
    39. Graham BB, Kaul DR, Saint S, Janssen WJ. Clinical problem-solving. Kiss of death. N Engl J Med. 2009 Jun 11; 360(24):2564-8. PMID: 19516037.
      View in: PubMed
    40. Graham BB, Burnham EL, Janssen JS, Janssen WJ. Dyspnea, chest pain, and altered mental status in a 33-year-old carpenter. Chest. 2008 Nov; 134(5):1074-1079. PMID: 18988783.
      View in: PubMed
    41. Tuder RM, Yun JH, Graham BB. Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung. Am J Respir Cell Mol Biol. 2008 Jul; 39(1):1-6. PMID: 18441278; PMCID: PMC2720121.
    42. Graham BB, Mathisen DJ, Mark EJ, Takvorian RW. Primary pulmonary lymphoma. Ann Thorac Surg. 2005 Oct; 80(4):1248-53. PMID: 16181848.
      View in: PubMed
    43. Graham BB, Varvares MA. End-to-side venous anastomosis with the internal jugular vein stump: a preliminary report. Head Neck. 2004 Jun; 26(6):537-40. PMID: 15162355.
      View in: PubMed
    44. Wright CD, Graham BB, Grillo HC, Wain JC, Mathisen DJ. Pediatric tracheal surgery. Ann Thorac Surg. 2002 Aug; 74(2):308-13; discussion 314. PMID: 12173805.
      View in: PubMed
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