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Carsten Schmitz

TitleAssoc Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology

    Collapse Research 
    Collapse research activities and funding
    K08AI060926     (SCHMITZ, CARSTEN)Jul 1, 2004 - Apr 30, 2008
    The Role of Magnesium in B-Cell Signaling
    Role: Principal Investigator

    R21AI088421     (SCHMITZ, CARSTEN)Jun 1, 2010 - May 31, 2012
    Modulation of PLCgamma2-Mediated Signaling Via its C2-Domain in B Lymphocytes
    Role: Principal Investigator

    R01GM090123     (SCHMITZ, CARSTEN)Jun 1, 2010 - May 31, 2015
    Structure-function relationships of the chimeric TRPM7 channel-kinase
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Krishnamoorthy M, Wasim L, Buhari FHM, Zhao T, Mahtani T, Ho J, Kang S, Deason-Towne F, Perraud AL, Schmitz C, Treanor B. The channel-kinase TRPM7 regulates antigen gathering and internalization in B cells. Sci Signal. 2018 Jun 05; 11(533). PMID: 29871912.
      View in: PubMed
    2. Suzuki S, Lis A, Schmitz C, Penner R, Fleig A. The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins. Cell Mol Life Sci. 2018 08; 75(16):3069-3078. PMID: 29500477.
      View in: PubMed
    3. Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A. TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice. Arterioscler Thromb Vasc Biol. 2018 02; 38(2):344-352. PMID: 29146750.
      View in: PubMed
    4. Gally F, Rao DM, Schmitz C, Colvin KL, Yeager ME, Perraud AL. The TRPM2 ion channel contributes to cytokine hyperproduction in a mouse model of Down Syndrome. Biochim Biophys Acta Mol Basis Dis. 2018 Jan; 1864(1):126-132. PMID: 28970008.
      View in: PubMed
    5. Rao D, Perraud AL, Schmitz C, Gally F. Cigarette smoke inhibits LPS-induced FABP5 expression by preventing c-Jun binding to the FABP5 promoter. PLoS One. 2017; 12(5):e0178021. PMID: 28542209.
      View in: PubMed
    6. Davenport B, Li Y, Heizer JW, Schmitz C, Perraud AL. Signature Channels of Excitability no More: L-Type Channels in Immune Cells. Front Immunol. 2015; 6:375. PMID: 26257741; PMCID: PMC4512153.
    7. Brandao K, Deason-Towne F, Zhao X, Perraud AL, Schmitz C. TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions. Cell Mol Life Sci. 2014 Dec; 71(24):4853-67. PMID: 24858416; PMCID: PMC4234683.
    8. Zhang Z, Yu H, Huang J, Faouzi M, Schmitz C, Penner R, Fleig A. The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels. J Biol Chem. 2014 Feb 21; 289(8):5217-27. PMID: 24385424; PMCID: PMC3931078.
    9. Schmitz C, Brandao K, Perraud AL. The channel-kinase TRPM7, revealing the untold story of Mg(2+) in cellular signaling. Magnes Res. 2014 Jan-Mar; 27(1):9-15. PMID: 24752033.
      View in: PubMed
    10. Yogi A, Callera GE, O'Connor S, Antunes TT, Valinsky W, Miquel P, Montezano AC, Perraud AL, Schmitz C, Shrier A, Touyz RM. Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its a-kinase domain. Cell Signal. 2013 Nov; 25(11):2163-75. PMID: 23838006; PMCID: PMC4293696.
    11. Brandao K, Deason-Towne F, Perraud AL, Schmitz C. The role of Mg2+ in immune cells. Immunol Res. 2013 Mar; 55(1-3):261-9. PMID: 22990458.
      View in: PubMed
    12. Deason-Towne F, Perraud AL, Schmitz C. Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C ?2 (PLC?2) using TRPM7-kinase. Cell Signal. 2012 Nov; 24(11):2070-5. PMID: 22759789; PMCID: PMC4049354.
    13. Deason-Towne F, Perraud AL, Schmitz C. The Mg2+ transporter MagT1 partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7. FEBS Lett. 2011 Jul 21; 585(14):2275-8. PMID: 21627970; PMCID: PMC3139019.
    14. Perraud AL, Zhao X, Ryazanov AG, Schmitz C. The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k. Cell Signal. 2011 Mar; 23(3):586-93. PMID: 21112387; PMCID: PMC3038675.
    15. Hermosura MC, Cui AM, Go RC, Davenport B, Shetler CM, Heizer JW, Schmitz C, Mocz G, Garruto RM, Perraud AL. Altered functional properties of a TRPM2 variant in Guamanian ALS and PD. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):18029-34. PMID: 19004782; PMCID: PMC2584682.
    16. Schmitz C, Deason F, Perraud AL. Molecular components of vertebrate Mg2+-homeostasis regulation. Magnes Res. 2007 Mar; 20(1):6-18. PMID: 17536484.
      View in: PubMed
    17. Perraud AL, Schmitz C, Scharenberg AM. Calcium signaling, ion channels and more. The DT40 system as a model of vertebrate ion homeostasis and cell physiology. Subcell Biochem. 2006; 40:257-70. PMID: 17623910; PMCID: PMC3628819.
    18. Perraud AL, Schmitz C, Scharenberg AM. Analysis of cellular Mg2+ in DT40 cells. Subcell Biochem. 2006; 40:373-8. PMID: 17623923.
      View in: PubMed
    19. Schmitz C, Dorovkov MV, Zhao X, Davenport BJ, Ryazanov AG, Perraud AL. The channel kinases TRPM6 and TRPM7 are functionally nonredundant. J Biol Chem. 2005 Nov 11; 280(45):37763-71. PMID: 16150690.
      View in: PubMed
    20. Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem. 2005 Feb 18; 280(7):6138-48. PMID: 15561722.
      View in: PubMed
    21. Takezawa R, Schmitz C, Demeuse P, Scharenberg AM, Penner R, Fleig A. Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6009-14. PMID: 15069188; PMCID: PMC395914.
    22. Schmitz C, Perraud AL, Fleig A, Scharenberg AM. Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms. Pediatr Res. 2004 May; 55(5):734-7. PMID: 14764909.
      View in: PubMed
    23. Schmitz C, Perraud AL, Johnson CO, Inabe K, Smith MK, Penner R, Kurosaki T, Fleig A, Scharenberg AM. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell. 2003 Jul 25; 114(2):191-200. PMID: 12887921.
      View in: PubMed
    24. Perraud AL, Schmitz C, Scharenberg AM. TRPM2 Ca2+ permeable cation channels: from gene to biological function. Cell Calcium. 2003 May-Jun; 33(5-6):519-31. PMID: 12765697.
      View in: PubMed
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