Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Cara Lynn Mack

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone720/777-6470

    Collapse Research 
    Collapse research activities and funding
    K08DK060710     (MACK, CARA LYNN)Aug 15, 2002 - Dec 31, 2006
    NIH/NIDDK
    Immunologic Mechanism/Destruction/Biliary Artesia
    Role: Principal Investigator

    R03DK069818     (MACK, CARA LYNN)Sep 30, 2004 - Jul 31, 2006
    NIH/NIDDK
    Role of Cytokines and Autoimmunity in Murine BA
    Role: Principal Investigator

    T32DK067009     (SOKOL, RONALD J.)Jul 1, 2005 - Jun 30, 2020
    NIH/NIDDK
    Institutional Training Grant in Pediatric Gastroenterology
    Role: Co-Principal Investigator

    R01DK078195     (MACK, CARA LYNN)Aug 15, 2007 - Jul 31, 2012
    NIH/NIDDK
    T Cell-Mediated Mechanisms of Autoimmunity in Murine and Human Biliary Atresia
    Role: Principal Investigator

    R56DK087691     (MACK, CARA LYNN)Sep 30, 2010 - Feb 29, 2012
    NIH/NIDDK
    Detection of HLA Predominance and Novel HLA Shared Epitopes in Biliary Atresia
    Role: Principal Investigator

    R01DK094937     (MACK, CARA LYNN)Jun 1, 2014 - May 31, 2018
    NIH/NIDDK
    Significance of B cells and humoral immunity in the pathogenesis of biliary atres
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Venkat V, Ng VL, Magee JC, Ye W, Hawthorne K, Harpavat S, Molleston JP, Murray KF, Wang KS, Soufi N, Bass LM, Alonso EM, Bezerra JA, Jensen MK, Kamath BM, Loomes KM, Mack CL, Rosenthal P, Shneider BL, Squires RH, Sokol RJ, Karpen SJ. Modeling Outcomes in Children With Biliary Atresia With Native Liver After 2 Years of Age. Hepatol Commun. 2020 Dec; 4(12):1824-1834. PMID: 33305153.
      View in: PubMed
    2. Deneau MR, Mack C, Mogul D, Perito ER, Valentino PL, Amir AZ, DiGuglielmo M, Draijer LG, El-Matary W, Furuya KN, Gupta N, Hochberg JT, Horslen S, Jensen MK, Jonas MM, Kerkar N, Koot BGP, Laborda TJ, Lee CK, Loomes KM, Martinez M, Miethke A, Miloh T, Mohammad S, Ovchinsky N, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Vitola B, Zizzo A, Guthery SL. Oral vancomycin, ursodeoxycholic acid or no therapy for pediatric primary sclerosing cholangitis: a matched analysis. Hepatology. 2020 Sep 18. PMID: 32946600.
      View in: PubMed
    3. Kemme S, Stahl M, Brigham D, Lovell MA, Nakano T, Feldman AG, Mack C. Outcomes of Severe Seronegative Hepatitis-Associated Aplastic Anemia: A Pediatric Case Series. J Pediatr Gastroenterol Nutr. 2020 Sep 09. PMID: 32925550.
      View in: PubMed
    4. Azeltine MW, Chavez EJ, Nemec KM, Bednarek JM, Asokan R, Balasubramaniyan N, Zgheib C, Mack CL, Roach JP. Inflammation Drives MicroRNAs to Limit Hepatocyte Bile Acid Transport in Murine Biliary Atresia. J Surg Res. 2020 Aug 17; 256:663-672. PMID: 32818799.
      View in: PubMed
    5. Luo Y, Brigham D, Bednarek J, Torres R, Wang D, Ahmad S, Mack CL. Unique cholangiocyte-targeted IgM autoantibodies correlate with poor outcome in biliary atresia. Hepatology. 2020 Aug 07. PMID: 32767570.
      View in: PubMed
    6. Vierling JM, Kerkar N, Czaja AJ, Mack CL, Adams D, Assis DN, Manns MP, Mayo MJ, Nayfeh T, Majzoub AMM, Alzuabi MA, Ding J, Haffar S, Murad MH, Alsawas M. Immunosuppressive Treatment Regimens in Autoimmune Hepatitis: Systematic Reviews and Meta-Analyses Supporting American Association for the Study of Liver Diseases Guidelines. Hepatology. 2020 Aug; 72(2):753-769. PMID: 32500593.
      View in: PubMed
    7. Karpen SJ, Kelly D, Mack C, Stein P. Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders. Hepatol Int. 2020 Sep; 14(5):677-689. PMID: 32653991.
      View in: PubMed
    8. Feldman AG, Parsons JA, Dutmer CM, Veerapandiyan A, Hafberg E, Maloney N, Mack CL. Subacute Liver Failure Following Gene Replacement Therapy for Spinal Muscular Atrophy Type 1. J Pediatr. 2020 Oct; 225:252-258.e1. PMID: 32473148.
      View in: PubMed
    9. Deneau MR, Mack C, Perito ER, Ricciuto A, Valentino PL, Amin M, Amir AZ, Aumar M, Auth M, Broderick A, DiGuglielmo M, Draijer LG, Tavares Fagundes ED, El-Matary W, Ferrari F, Furuya KN, Gupta N, Hochberg JT, Homan M, Horslen S, Iorio R, Jensen MK, Jonas MM, Kamath BM, Kerkar N, Kim KM, Kolho KL, Koot BG, Laborda TJ, Lee CK, Loomes KM, Martinez M, Miethke A, Miloh T, Mogul D, Mohammed S, Mohan P, Moroz S, Ovchinsky N, Palle S, Papadopoulou A, Rao G, Rodrigues Ferreira A, Sathya P, Schwarz KB, Shah U, Shteyer E, Singh R, Smolka V, Soufi N, Tanaka A, Varier R, Vitola B, Woynarowski M, Zerofsky M, Zizzo A, Guthery SL. The Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) index: a prognostic tool for children. Hepatology. 2020 May 28. PMID: 32464706.
      View in: PubMed
    10. Kamath BM, Spino C, McLain R, Magee JC, Fredericks EM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Alonso EM, Murray KF, Loomes KM, Kyle Jensen M, Karpen SJ, Rosenthal P, Thomas D, Sokol RJ, Shneider BL. Unraveling the Relationship Between Itching, Scratch Scales, and Biomarkers in Children With Alagille Syndrome. Hepatol Commun. 2020 Jul; 4(7):1012-1018. PMID: 32626833.
      View in: PubMed
    11. Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, Vierling JM, Alsawas M, Murad MH, Czaja AJ. Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases. Hepatology. 2020 Aug; 72(2):671-722. PMID: 31863477.
      View in: PubMed
    12. El-Matary W, Guthery SL, Amir AZ, DiGuglielmo M, Draijer LG, Furuya KN, Gupta N, Hochberg JT, Horslen S, Kerkar N, Koot BGP, Laborda TJ, Loomes KM, Mack C, Martinez M, Miethke A, Miloh T, Mogul D, Mohammed S, Moroz S, Ovchinsky N, Perito ER, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Soufi N, Valentino PL, Zizzo A, Deneau MR. Colorectal Dysplasia and Cancer in Pediatric-Onset Ulcerative Colitis Associated With Primary Sclerosing Cholangitis. Clin Gastroenterol Hepatol. 2020 Apr 29. PMID: 32360820.
      View in: PubMed
    13. Goldberg A, Mack CL. Inherited Cholestatic Diseases in the Era of Personalized Medicine. Clin Liver Dis (Hoboken). 2020 Mar; 15(3):105-109. PMID: 32257121.
      View in: PubMed
    14. Kamath BM, Ye W, Goodrich NP, Loomes KM, Romero R, Heubi JE, Leung DH, Spinner NB, Piccoli DA, Alonso EM, Guthery SL, Karpen SJ, Mack CL, Molleston JP, Murray KF, Rosenthal P, Squires JE, Teckman J, Wang KS, Thompson R, Magee JC, Sokol RJ. Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multicenter Observational Study. Hepatol Commun. 2020 Mar; 4(3):387-398. PMID: 33313463.
      View in: PubMed
    15. Feldman AG, Hsu EK, Mack CL. The Importance of Prioritizing Pre and Posttransplant Immunizations in an Era of Vaccine Refusal and Epidemic Outbreaks. Transplantation. 2020 01; 104(1):33-38. PMID: 31876696.
      View in: PubMed
    16. Deneau MR, Valentino PL, Mack C, Alqoaer K, Amin M, Amir AZ, Aumar M, Auth M, Broderick A, DiGuglielmo M, Draijer LG, El-Matary W, Ferrari F, Furuya KN, Gottrand F, Gupta N, Homan M, Jensen MK, Kamath BM, Kim KM, Kolho KL, Koot B, Iorio R, Martinez M, Miloh T, Mohan P, Palle S, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Woynarowski M, Guthery S. Assessing the Validity of Adult-derived Prognostic Models for Primary Sclerosing Cholangitis Outcomes in Children. J Pediatr Gastroenterol Nutr. 2020 01; 70(1):e12-e17. PMID: 31651664.
      View in: PubMed
    17. Black DD, Mack C, Kerkar N, Miloh T, Sundaram SS, Anand R, Gupta A, Alonso E, Arnon R, Bulut P, Karpen S, Lin CH, Rosenthal P, Ryan M, Squires RH, Valentino P, Elsea SH, Shneider BL. A Prospective Trial of Withdrawal and Reinstitution of Ursodeoxycholic Acid in Pediatric Primary Sclerosing Cholangitis. Hepatol Commun. 2019 Nov; 3(11):1482-1495. PMID: 31701072.
      View in: PubMed
    18. Taylor SA, Assis DN, Mack CL. The Contribution of B Cells in Autoimmune Liver Diseases. Semin Liver Dis. 2019 11; 39(4):422-431. PMID: 31226726.
      View in: PubMed
    19. Jaramillo C, Gilani A, Haag M, Donaldson N, Mack C. Synovial Cell Sarcoma in an Adolescent Liver Transplant Recipient. ACG Case Rep J. 2019 May; 6(5):e00091. PMID: 31616756.
      View in: PubMed
    20. Mack CL, Spino C, Alonso EM, Bezerra JA, Moore J, Goodhue C, Ng VL, Karpen SJ, Venkat V, Loomes KM, Wang K, Sherker AH, Magee JC, Sokol RJ. A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia. J Pediatr Gastroenterol Nutr. 2019 04; 68(4):495-501. PMID: 30664564.
      View in: PubMed
    21. Kim S, Moore J, Alonso E, Bednarek J, Bezerra JA, Goodhue C, Karpen SJ, Loomes KM, Magee JC, Ng VL, Sherker AH, Smith C, Spino C, Venkat V, Wang K, Sokol RJ, Mack CL. Correlation of Immune Markers With Outcomes in Biliary Atresia Following Intravenous Immunoglobulin Therapy. Hepatol Commun. 2019 May; 3(5):685-696. PMID: 31061956.
      View in: PubMed
    22. Deneau M, Perito E, Ricciuto A, Gupta N, Kamath BM, Palle S, Vitola B, Smolka V, Ferrari F, Amir AZ, Miloh T, Papadopoulou A, Mohan P, Mack C, Kolho KL, Iorio R, El-Matary W, Venkat V, Chan A, Saubermann L, Valentino PL, Shah U, Miethke A, Lin H, Jensen MK. Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis: Predictors of Gamma Glutamyltransferase Normalization and Favorable Clinical Course. J Pediatr. 2019 06; 209:92-96.e1. PMID: 30878206.
      View in: PubMed
    23. Kamath B, Mack C. From Hepatocyte to Cholangiocyte: The Remarkable Potential of Transdifferentiation to Treat Cholestatic Diseases. Hepatology. 2019 04; 69(4):1828-1830. PMID: 30179266.
      View in: PubMed
    24. Deneau MR, Mack C, Abdou R, Amin M, Amir A, Auth M, Bazerbachi F, Marie Broderick A, Chan A, DiGuglielmo M, El-Matary W, El-Youssef M, Ferrari F, Furuya KN, Gottrand F, Gupta N, Homan M, Jensen MK, Kamath BM, Mo Kim K, Kolho KL, Konidari A, Koot B, Iorio R, Martinez M, Mohan P, Palle S, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Valentino PL, Varier R, Venkat V, Vitola B, Vos MB, Woynarowski M, Yap J, Miloh T. Gamma Glutamyltransferase Reduction Is Associated With Favorable Outcomes in Pediatric Primary Sclerosing Cholangitis. Hepatol Commun. 2018 Nov; 2(11):1369-1378. PMID: 30411083.
      View in: PubMed
    25. Shneider BL, Spino C, Kamath BM, Magee JC, Bass LM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Murray KF, Loomes KM, Rosenthal P, Karpen SJ, Leung DH, Guthery SL, Thomas D, Sherker AH, Sokol RJ. Placebo-Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome. Hepatol Commun. 2018 Oct; 2(10):1184-1198. PMID: 30288474.
      View in: PubMed
    26. Alonso EM, Ye W, Hawthorne K, Venkat V, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Suchy FJ, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Bezerra JA, Magee JC. Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial. J Pediatr. 2018 11; 202:179-185.e4. PMID: 30244988.
      View in: PubMed
    27. Bezerra JA, Wells RG, Mack CL, Karpen SJ, Hoofnagle JH, Doo E, Sokol RJ. Biliary Atresia: Clinical and Research Challenges for the Twenty-First Century. Hepatology. 2018 09; 68(3):1163-1173. PMID: 29604222.
      View in: PubMed
    28. Bednarek J, Traxinger B, Brigham D, Roach J, Orlicky D, Wang D, Pelanda R, Mack CL. Cytokine-Producing B Cells Promote Immune-Mediated Bile Duct Injury in Murine Biliary Atresia. Hepatology. 2018 11; 68(5):1890-1904. PMID: 29679373.
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    29. Mack CL. Introducing Ronald J. Sokol, M.D.-our 2018 AASLD president. Hepatology. 2018 05; 67(5):1669-1672. PMID: 29466842.
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    30. Mark JA, Mack CL, Marwan AI, Kramer RE. Use of Fully Covered Self-expanding Metal Biliary Stents in Pediatrics: A Case Series. J Pediatr Gastroenterol Nutr. 2018 03; 66(3):e71-e75. PMID: 28837510.
      View in: PubMed
    31. Cotter JM, Browne LP, Capocelli KE, McCoy A, Mack CL. Lack of Correlation of Liver Tests With Fibrosis Stage at Diagnosis in Pediatric Primary Sclerosing Cholangitis. J Pediatr Gastroenterol Nutr. 2018 02; 66(2):227-233. PMID: 29356767.
      View in: PubMed
    32. Cotter JM, Mack CL. Primary sclerosing cholangitis: Unique aspects of disease in children. Clin Liver Dis (Hoboken). 2017 Nov; 10(5):120-123. PMID: 30992770.
      View in: PubMed
    33. Kilgore A, Mack CL. Update on investigations pertaining to the pathogenesis of biliary atresia. Pediatr Surg Int. 2017 Dec; 33(12):1233-1241. PMID: 29063959.
      View in: PubMed
    34. Sheiko MA, Sundaram SS, Capocelli KE, Pan Z, McCoy AM, Mack CL. Outcomes in Pediatric Autoimmune Hepatitis and Significance of Azathioprine Metabolites. J Pediatr Gastroenterol Nutr. 2017 07; 65(1):80-85. PMID: 28272159.
      View in: PubMed
    35. Deneau MR, El-Matary W, Valentino PL, Abdou R, Alqoaer K, Amin M, Amir AZ, Auth M, Bazerbachi F, Broderick A, Chan A, Cotter J, Doan S, El-Youssef M, Ferrari F, Furuya KN, Gottrand M, Gottrand F, Gupta N, Homan M, Kamath BM, Kim KM, Kolho KL, Konidari A, Koot B, Iorio R, Ledder O, Mack C, Martinez M, Miloh T, Mohan P, O'Cathain N, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Vos MB, Woynarowski M, Yap J, Jensen MK. The natural history of primary sclerosing cholangitis in 781 children: A multicenter, international collaboration. Hepatology. 2017 08; 66(2):518-527. PMID: 28390159.
      View in: PubMed
    36. Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider BL. Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology. 2017 05; 65(5):1645-1654. PMID: 28027587.
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    37. Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin VA, Molleston JP, Neimark E, Ng VL, Karpen SJ. Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2017 01; 64(1):154-168. PMID: 27429428.
      View in: PubMed
    38. Sundaram SS, Mack CL, Feldman AG, Sokol RJ. Biliary atresia: Indications and timing of liver transplantation and optimization of pretransplant care. Liver Transpl. 2017 01; 23(1):96-109. PMID: 27650268.
      View in: PubMed
    39. Sheiko MA, Golden-Mason L, Giugliano S, Hurtado CW, Mack CL, Narkewicz MR, Rosen HR. CD4+ and CD8+ T Cell Activation in Children with Hepatitis C. J Pediatr. 2016 Mar; 170:142-8.e1. PMID: 26743497.
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    40. Feldman AG, Mack CL. Biliary Atresia: Clinical Lessons Learned. J Pediatr Gastroenterol Nutr. 2015 Aug; 61(2):167-75. PMID: 25658057.
      View in: PubMed
    41. Mack CL. What Causes Biliary Atresia? Unique Aspects of the Neonatal Immune System Provide Clues to Disease Pathogenesis. Cell Mol Gastroenterol Hepatol. 2015 May 01; 1(3):267-274. PMID: 26090510.
      View in: PubMed
    42. Fenner EK, Boguniewicz J, Tucker RM, Sokol RJ, Mack CL. High-dose IgG therapy mitigates bile duct-targeted inflammation and obstruction in a mouse model of biliary atresia. Pediatr Res. 2014 Jul; 76(1):72-80. PMID: 24727948.
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    43. Schwarz KB, Haber BH, Rosenthal P, Mack CL, Moore J, Bove K, Bezerra JA, Karpen SJ, Kerkar N, Shneider BL, Turmelle YP, Whitington PF, Molleston JP, Murray KF, Ng VL, Romero R, Wang KS, Sokol RJ, Magee JC. Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study. Hepatology. 2013 Nov; 58(5):1724-31. PMID: 23703680.
      View in: PubMed
    44. Feldman AG, Tucker RM, Fenner EK, Pelanda R, Mack CL. B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia. PLoS One. 2013; 8(8):e73644. PMID: 23991203.
      View in: PubMed
    45. Tucker RM, Feldman AG, Fenner EK, Mack CL. Regulatory T cells inhibit Th1 cell-mediated bile duct injury in murine biliary atresia. J Hepatol. 2013 Oct; 59(4):790-6. PMID: 23685050.
      View in: PubMed
    46. Mack CL, Anderson KM, Aubrey MT, Rosenthal P, Sokol RJ, Freed BM. Lack of HLA predominance and HLA shared epitopes in biliary Atresia. Springerplus. 2013 Dec; 2(1):42. PMID: 23505615.
      View in: PubMed
    47. Mack CL, Feldman AG, Sokol RJ. Clues to the etiology of bile duct injury in biliary atresia. Semin Liver Dis. 2012 Nov; 32(4):307-16. PMID: 23397531.
      View in: PubMed
    48. Feldman AG, Mack CL. Biliary atresia: cellular dynamics and immune dysregulation. Semin Pediatr Surg. 2012 Aug; 21(3):192-200. PMID: 22800972.
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    49. Brumbaugh D, Mack C. Conjugated hyperbilirubinemia in children. Pediatr Rev. 2012 Jul; 33(7):291-302. PMID: 22753787.
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    50. Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB. NASPGHAN practice guidelines: Diagnosis and management of hepatitis C infection in infants, children, and adolescents. J Pediatr Gastroenterol Nutr. 2012 Jun; 54(6):838-55. PMID: 22487950.
      View in: PubMed
    51. Brindley SM, Lanham AM, Karrer FM, Tucker RM, Fontenot AP, Mack CL. Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells. Hepatology. 2012 Apr; 55(4):1130-8. PMID: 22105891.
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    52. Tucker RM, Mack CL. Generation of a cholangiocyte-specific cDNA expression library for the identification of B and T cell autoantigens in murine biliary disease. Hepatol Res. 2012 May; 42(5):502-7. PMID: 22236071.
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    53. Lu BR, Brindley SM, Tucker RM, Lambert CL, Mack CL. a-enolase autoantibodies cross-reactive to viral proteins in a mouse model of biliary atresia. Gastroenterology. 2010 Nov; 139(5):1753-61. PMID: 20659472.
      View in: PubMed
    54. Law YM, Mack CL, Sokol RJ, Rice M, Parsley L, Ivy D. Cardiopulmonary manifestations of portovenous shunts from congenital absence of the portal vein: pulmonary hypertension and pulmonary vascular dilatation. Pediatr Transplant. 2011 Dec; 15(8):E162-8. PMID: 20565694.
      View in: PubMed
    55. Rand EB, Karpen SJ, Kelly S, Mack CL, Malatack JJ, Sokol RJ, Whitington PF. Treatment of neonatal hemochromatosis with exchange transfusion and intravenous immunoglobulin. J Pediatr. 2009 Oct; 155(4):566-71. PMID: 19560784.
      View in: PubMed
    56. Lu BR, Mack CL. Inflammation and biliary tract injury. Curr Opin Gastroenterol. 2009 May; 25(3):260-4. PMID: 19396964.
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    57. Barnes BH, Tucker RM, Wehrmann F, Mack DG, Ueno Y, Mack CL. Cholangiocytes as immune modulators in rotavirus-induced murine biliary atresia. Liver Int. 2009 Sep; 29(8):1253-61. PMID: 19040538.
      View in: PubMed
    58. Mack CL. The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease. Semin Liver Dis. 2007 Aug; 27(3):233-42. PMID: 17682970.
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    59. Mack CL. Serum cytokines as biomarkers of disease and clues to pathogenesis. Hepatology. 2007 Jul; 46(1):6-8. PMID: 17596866.
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    60. Mack CL, Falta MT, Sullivan AK, Karrer F, Sokol RJ, Freed BM, Fontenot AP. Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia. Gastroenterology. 2007 Jul; 133(1):278-87. PMID: 17631149.
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    61. Tucker RM, Hendrickson RJ, Mukaida N, Gill RG, Mack CL. Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia. Viral Immunol. 2007; 20(1):34-43. PMID: 17425419.
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    62. Mack CL, Tucker RM, Lu BR, Sokol RJ, Fontenot AP, Ueno Y, Gill RG. Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia. Hepatology. 2006 Nov; 44(5):1231-9. PMID: 17058262.
      View in: PubMed
    63. Whitworth JR, Mack CL, O'Connor JA, Narkewicz MR, Mengshol S, Sokol RJ. Acute hepatitis and liver failure associated with influenza A infection in children. J Pediatr Gastroenterol Nutr. 2006 Oct; 43(4):536-8. PMID: 17033532.
      View in: PubMed
    64. Mack CL, Zelko FA, Lokar J, Superina R, Alonso EM, Blei AT, Whitington PF. Surgically restoring portal blood flow to the liver in children with primary extrahepatic portal vein thrombosis improves fluid neurocognitive ability. Pediatrics. 2006 Mar; 117(3):e405-12. PMID: 16481447.
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    65. Mack CL, Tucker RM, Sokol RJ, Kotzin BL. Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia. Clin Immunol. 2005 May; 115(2):200-9. PMID: 15885644.
      View in: PubMed
    66. Whitington PF, Malladi P, Melin-Aldana H, Azzam R, Mack CL, Sahai A. Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresia. Pediatr Res. 2005 Jun; 57(6):837-44. PMID: 15845635.
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    67. Mack CL, Sokol RJ. Unraveling the pathogenesis and etiology of biliary atresia. Pediatr Res. 2005 May; 57(5 Pt 2):87R-94R. PMID: 15817506.
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    68. Sokol RJ, Mack CL. Optimizing outcomes and bridging biliary atresia into adulthood. Hepatology. 2005 Feb; 41(2):231-3. PMID: 15657917.
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    69. Mack CL, Tucker RM, Sokol RJ, Karrer FM, Kotzin BL, Whitington PF, Miller SD. Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation. Pediatr Res. 2004 Jul; 56(1):79-87. PMID: 15128911.
      View in: PubMed
    70. Zhang DY, Sabla G, Shivakumar P, Tiao G, Sokol RJ, Mack C, Shneider BL, Aronow B, Bezerra JA. Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia. Hepatology. 2004 Apr; 39(4):954-62. PMID: 15057899.
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    71. Mack CL, Vanderlugt-Castaneda CL, Neville KL, Miller SD. Microglia are activated to become competent antigen presenting and effector cells in the inflammatory environment of the Theiler's virus model of multiple sclerosis. J Neuroimmunol. 2003 Nov; 144(1-2):68-79. PMID: 14597100.
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    72. Sokol RJ, Mack C, Narkewicz MR, Karrer FM. Pathogenesis and outcome of biliary atresia: current concepts. J Pediatr Gastroenterol Nutr. 2003 Jul; 37(1):4-21. PMID: 12827000.
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    73. Mack CL, Superina RA, Whitington PF. Surgical restoration of portal flow corrects procoagulant and anticoagulant deficiencies associated with extrahepatic portal vein thrombosis. J Pediatr. 2003 Feb; 142(2):197-9. PMID: 12584545.
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    74. Sokol RJ, Mack C. Etiopathogenesis of biliary atresia. Semin Liver Dis. 2001 Nov; 21(4):517-24. PMID: 11745039.
      View in: PubMed
    75. Mack CL, Ferrario M, Abecassis M, Whitington PF, Superina RA, Alonso EM. Living donor liver transplantation for children with liver failure and concurrent multiple organ system failure. Liver Transpl. 2001 Oct; 7(10):890-5. PMID: 11679988.
      View in: PubMed
    76. Mack CL, Emerick KM, Kovarik P, Charrow J. Early speech delay and hepatitis as presenting signs of homocystinuria. J Pediatr Gastroenterol Nutr. 2001 Aug; 33(2):221-3. PMID: 11568530.
      View in: PubMed
    77. Grossman DC, Cummings P, Koepsell TD, Marshall J, D'Ambrosio L, Thompson RS, Mack C. Firearm safety counseling in primary care pediatrics: a randomized, controlled trial. Pediatrics. 2000 Jul; 106(1 Pt 1):22-6. PMID: 10878144.
      View in: PubMed
    78. Mack CL, Millis JM, Whitington PF, Alonso EM. Pulmonary complications following liver transplantation in pediatric patients. Pediatr Transplant. 2000 Feb; 4(1):39-44. PMID: 10731057.
      View in: PubMed
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