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Cara Lynn Mack

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone720/777-6470

    Collapse Research 
    Collapse research activities and funding
    K08DK060710     (MACK, CARA LYNN)Feb 15, 2002 - Dec 31, 2006
    NIH/NIDDK
    Immunologic Mechanism/Destruction/Biliary Artesia
    Role: Principal Investigator

    T32DK067009     (MACK, CARA LYNN)Jan 1, 2004 - Jun 30, 2020
    NIH/NIDDK
    Institutional Training Grant in Pediatric Gastroenterology
    Role: Co-Principal Investigator

    R03DK069818     (MACK, CARA LYNN)Sep 30, 2004 - Jul 31, 2006
    NIH/NIDDK
    Role of Cytokines and Autoimmunity in Murine BA
    Role: Principal Investigator

    R01DK078195     (MACK, CARA LYNN)Aug 15, 2007 - Jul 31, 2012
    NIH/NIDDK
    T Cell-Mediated Mechanisms of Autoimmunity in Murine and Human Biliary Atresia
    Role: Principal Investigator

    R56DK087691     (MACK, CARA LYNN)Sep 30, 2010 - Feb 29, 2012
    NIH/NIDDK
    Detection of HLA Predominance and Novel HLA Shared Epitopes in Biliary Atresia
    Role: Principal Investigator

    R01DK094937     (MACK, CARA LYNN)Jun 1, 2014 - May 31, 2018
    NIH/NIDDK
    Significance of B cells and humoral immunity in the pathogenesis of biliary atres
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mark JA, Mack CL, Marwan AI, Kramer RE. Use of Fully Covered Self-Expanding Metal Biliary Stents in Pediatrics: A Case Series. J Pediatr Gastroenterol Nutr. 2017 Aug 23. PMID: 28837510.
      View in: PubMed
    2. Sheiko MA, Sundaram SS, Capocelli KE, Pan Z, McCoy AM, Mack CL. Outcomes in Pediatric Autoimmune Hepatitis and Significance of Azathioprine Metabolites. J Pediatr Gastroenterol Nutr. 2017 Jul; 65(1):80-85. PMID: 28272159.
      View in: PubMed
    3. Deneau MR, El-Matary W, Valentino PL, Abdou R, Alqoaer K, Amin M, Amir AZ, Auth M, Bazerbachi F, Broderick A, Chan A, Cotter J, Doan S, El-Youssef M, Ferrari F, Furuya KN, Gottrand M, Gottrand F, Gupta N, Homan M, Kamath BM, Kim KM, Kolho KL, Konidari A, Koot B, Iorio R, Ledder O, Mack C, Martinez M, Miloh T, Mohan P, O'Cathain N, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Vos MB, Woynarowski M, Yap J, Jensen MK. The natural history of primary sclerosing cholangitis in 781 children: A multicenter, international collaboration. Hepatology. 2017 Aug; 66(2):518-527. PMID: 28390159.
      View in: PubMed
    4. Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider BL. Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology. 2017 May; 65(5):1645-1654. PMID: 28027587.
      View in: PubMed
    5. Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin VA, Molleston JP, Neimark E, Ng VL, Karpen SJ. Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2017 Jan; 64(1):154-168. PMID: 27429428.
      View in: PubMed
    6. Sundaram SS, Mack CL, Feldman AG, Sokol RJ. Biliary atresia: Indications and timing of liver transplantation and optimization of pretransplant care. Liver Transpl. 2017 Jan; 23(1):96-109. PMID: 27650268.
      View in: PubMed
    7. Sheiko MA, Golden-Mason L, Giugliano S, Hurtado CW, Mack CL, Narkewicz MR, Rosen HR. CD4+ and CD8+ T Cell Activation in Children with Hepatitis C. J Pediatr. 2016 Mar; 170:142-8.e1. PMID: 26743497; PMCID: PMC4833455 [Available on 03/01/17].
    8. Feldman AG, Mack CL. Biliary Atresia: Clinical Lessons Learned. J Pediatr Gastroenterol Nutr. 2015 Aug; 61(2):167-75. PMID: 25658057.
      View in: PubMed
    9. Mack CL. What Causes Biliary Atresia? Unique Aspects of the Neonatal Immune System Provide Clues to Disease Pathogenesis. Cell Mol Gastroenterol Hepatol. 2015 May 01; 1(3):267-274. PMID: 26090510.
      View in: PubMed
    10. Schwarz KB, Haber BH, Rosenthal P, Mack CL, Moore J, Bove K, Bezerra JA, Karpen SJ, Kerkar N, Shneider BL, Turmelle YP, Whitington PF, Molleston JP, Murray KF, Ng VL, Romero R, Wang KS, Sokol RJ, Magee JC. Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study. Hepatology. 2013 Nov; 58(5):1724-31. PMID: 23703680; PMCID: PMC3844083.
    11. Feldman AG, Tucker RM, Fenner EK, Pelanda R, Mack CL. B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia. PLoS One. 2013; 8(8):e73644. PMID: 23991203; PMCID: PMC3749125.
    12. Tucker RM, Feldman AG, Fenner EK, Mack CL. Regulatory T cells inhibit Th1 cell-mediated bile duct injury in murine biliary atresia. J Hepatol. 2013 Oct; 59(4):790-6. PMID: 23685050; PMCID: PMC3855478.
    13. Mack CL, Anderson KM, Aubrey MT, Rosenthal P, Sokol RJ, Freed BM. Lack of HLA predominance and HLA shared epitopes in biliary Atresia. Springerplus. 2013 Dec; 2(1):42. PMID: 23505615; PMCID: PMC3595468.
    14. Mack CL, Feldman AG, Sokol RJ. Clues to the etiology of bile duct injury in biliary atresia. Semin Liver Dis. 2012 Nov; 32(4):307-16. PMID: 23397531; PMCID: PMC3827890.
    15. Feldman AG, Mack CL. Biliary atresia: cellular dynamics and immune dysregulation. Semin Pediatr Surg. 2012 Aug; 21(3):192-200. PMID: 22800972; PMCID: PMC3399127.
    16. Brumbaugh D, Mack C. Conjugated hyperbilirubinemia in children. Pediatr Rev. 2012 Jul; 33(7):291-302. PMID: 22753787.
      View in: PubMed
    17. Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB. NASPGHAN practice guidelines: Diagnosis and management of hepatitis C infection in infants, children, and adolescents. J Pediatr Gastroenterol Nutr. 2012 Jun; 54(6):838-55. PMID: 22487950.
      View in: PubMed
    18. Brindley SM, Lanham AM, Karrer FM, Tucker RM, Fontenot AP, Mack CL. Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells. Hepatology. 2012 Apr; 55(4):1130-8. PMID: 22105891; PMCID: PMC3319336.
    19. Tucker RM, Mack CL. Generation of a cholangiocyte-specific cDNA expression library for the identification of B and T cell autoantigens in murine biliary disease. Hepatol Res. 2012 May; 42(5):502-7. PMID: 22236071; PMCID: PMC3798039.
    20. Lu BR, Brindley SM, Tucker RM, Lambert CL, Mack CL. a-enolase autoantibodies cross-reactive to viral proteins in a mouse model of biliary atresia. Gastroenterology. 2010 Nov; 139(5):1753-61. PMID: 20659472; PMCID: PMC3792016.
    21. Law YM, Mack CL, Sokol RJ, Rice M, Parsley L, Ivy D. Cardiopulmonary manifestations of portovenous shunts from congenital absence of the portal vein: pulmonary hypertension and pulmonary vascular dilatation. Pediatr Transplant. 2011 Dec; 15(8):E162-8. PMID: 20565694; PMCID: PMC3203339.
    22. Rand EB, Karpen SJ, Kelly S, Mack CL, Malatack JJ, Sokol RJ, Whitington PF. Treatment of neonatal hemochromatosis with exchange transfusion and intravenous immunoglobulin. J Pediatr. 2009 Oct; 155(4):566-71. PMID: 19560784.
      View in: PubMed
    23. Lu BR, Mack CL. Inflammation and biliary tract injury. Curr Opin Gastroenterol. 2009 May; 25(3):260-4. PMID: 19396964.
      View in: PubMed
    24. Barnes BH, Tucker RM, Wehrmann F, Mack DG, Ueno Y, Mack CL. Cholangiocytes as immune modulators in rotavirus-induced murine biliary atresia. Liver Int. 2009 Sep; 29(8):1253-61. PMID: 19040538; PMCID: PMC3783657.
    25. Mack CL. The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease. Semin Liver Dis. 2007 Aug; 27(3):233-42. PMID: 17682970; PMCID: PMC3796656.
    26. Mack CL. Serum cytokines as biomarkers of disease and clues to pathogenesis. Hepatology. 2007 Jul; 46(1):6-8. PMID: 17596866.
      View in: PubMed
    27. Mack CL, Falta MT, Sullivan AK, Karrer F, Sokol RJ, Freed BM, Fontenot AP. Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia. Gastroenterology. 2007 Jul; 133(1):278-87. PMID: 17631149; PMCID: PMC1949019.
    28. Tucker RM, Hendrickson RJ, Mukaida N, Gill RG, Mack CL. Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia. Viral Immunol. 2007; 20(1):34-43. PMID: 17425419; PMCID: PMC1978183.
    29. Mack CL, Tucker RM, Lu BR, Sokol RJ, Fontenot AP, Ueno Y, Gill RG. Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia. Hepatology. 2006 Nov; 44(5):1231-9. PMID: 17058262; PMCID: PMC1948978.
    30. Whitworth JR, Mack CL, O'Connor JA, Narkewicz MR, Mengshol S, Sokol RJ. Acute hepatitis and liver failure associated with influenza A infection in children. J Pediatr Gastroenterol Nutr. 2006 Oct; 43(4):536-8. PMID: 17033532.
      View in: PubMed
    31. Mack CL, Zelko FA, Lokar J, Superina R, Alonso EM, Blei AT, Whitington PF. Surgically restoring portal blood flow to the liver in children with primary extrahepatic portal vein thrombosis improves fluid neurocognitive ability. Pediatrics. 2006 Mar; 117(3):e405-12. PMID: 16481447.
      View in: PubMed
    32. Mack CL, Tucker RM, Sokol RJ, Kotzin BL. Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia. Clin Immunol. 2005 May; 115(2):200-9. PMID: 15885644; PMCID: PMC1950158.
    33. Whitington PF, Malladi P, Melin-Aldana H, Azzam R, Mack CL, Sahai A. Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresia. Pediatr Res. 2005 Jun; 57(6):837-44. PMID: 15845635.
      View in: PubMed
    34. Mack CL, Sokol RJ. Unraveling the pathogenesis and etiology of biliary atresia. Pediatr Res. 2005 May; 57(5 Pt 2):87R-94R. PMID: 15817506.
      View in: PubMed
    35. Sokol RJ, Mack CL. Optimizing outcomes and bridging biliary atresia into adulthood. Hepatology. 2005 Feb; 41(2):231-3. PMID: 15657917.
      View in: PubMed
    36. Mack CL, Tucker RM, Sokol RJ, Karrer FM, Kotzin BL, Whitington PF, Miller SD. Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation. Pediatr Res. 2004 Jul; 56(1):79-87. PMID: 15128911; PMCID: PMC1948976.
    37. Zhang DY, Sabla G, Shivakumar P, Tiao G, Sokol RJ, Mack C, Shneider BL, Aronow B, Bezerra JA. Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia. Hepatology. 2004 Apr; 39(4):954-62. PMID: 15057899.
      View in: PubMed
    38. Mack CL, Vanderlugt-Castaneda CL, Neville KL, Miller SD. Microglia are activated to become competent antigen presenting and effector cells in the inflammatory environment of the Theiler's virus model of multiple sclerosis. J Neuroimmunol. 2003 Nov; 144(1-2):68-79. PMID: 14597100.
      View in: PubMed
    39. Sokol RJ, Mack C, Narkewicz MR, Karrer FM. Pathogenesis and outcome of biliary atresia: current concepts. J Pediatr Gastroenterol Nutr. 2003 Jul; 37(1):4-21. PMID: 12827000.
      View in: PubMed
    40. Mack CL, Superina RA, Whitington PF. Surgical restoration of portal flow corrects procoagulant and anticoagulant deficiencies associated with extrahepatic portal vein thrombosis. J Pediatr. 2003 Feb; 142(2):197-9. PMID: 12584545.
      View in: PubMed
    41. Sokol RJ, Mack C. Etiopathogenesis of biliary atresia. Semin Liver Dis. 2001 Nov; 21(4):517-24. PMID: 11745039.
      View in: PubMed
    42. Mack CL, Ferrario M, Abecassis M, Whitington PF, Superina RA, Alonso EM. Living donor liver transplantation for children with liver failure and concurrent multiple organ system failure. Liver Transpl. 2001 Oct; 7(10):890-5. PMID: 11679988.
      View in: PubMed
    43. Mack CL, Emerick KM, Kovarik P, Charrow J. Early speech delay and hepatitis as presenting signs of homocystinuria. J Pediatr Gastroenterol Nutr. 2001 Aug; 33(2):221-3. PMID: 11568530.
      View in: PubMed
    44. Mack CL, Millis JM, Whitington PF, Alonso EM. Pulmonary complications following liver transplantation in pediatric patients. Pediatr Transplant. 2000 Feb; 4(1):39-44. PMID: 10731057.
      View in: PubMed
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