Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Natalie Serkova

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-RAD General Operations
Phone303/724-1086
    Other Positions
    TitleAssoc Chair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-RAD General Operations


    Collapse Research 
    Collapse research activities and funding
    S10OD027023     (SERKOVA, NATALIE J)Jul 1, 2020 - Jun 30, 2021
    NIH
    Multi-Modal Optical/ microCT system for Colorado Animal Imaging Resource
    Role: Principal Investigator
    S10OD023485     (SERKOVA, NATALIE J)Mar 1, 2017 - Feb 28, 2019
    NIH
    Bruker 9.4T/ 20cm BioSpec MR Scanner for Colorado Animal Imaging Shared Resources
    Role: Principal Investigator
    R21CA108624     (SERKOVA, NATALIE J)Apr 1, 2005 - Mar 31, 2008
    NIH
    Metabolic Signature of Imatinib Resistance
    Role: Principal Investigator
    S10RR019316     (SERKOVA, NATALIE J)Apr 1, 2005 - Mar 31, 2006
    NIH
    In-Vivo Spectroscopy/Imaging System PharmaScan 47/16
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wolin AR, Vincent MY, Hotz T, Purdy SC, Rosenbaum SR, Hughes CJ, Hsu JY, Oliphant MUJ, Armstrong B, Wessells V, Varella-Garcia M, Galbraith MD, Pierce A, Wang D, Venkataraman S, Danis E, Veo B, Serkova N, Espinosa JM, Gustafson DL, Vibhakar R, Ford HL. EYA2 tyrosine phosphatase inhibition reduces MYC and prevents medulloblastoma progression. Neuro Oncol. 2023 12 08; 25(12):2287-2301. PMID: 37486991.
      View in: PubMed
    2. Martinez P, Song JJ, Garay FG, Song KH, Mufford T, Steiner J, DeSisto J, Ellens N, Serkova NJ, Green AL, Borden M. Comprehensive Assessment of Blood-Brain Barrier Opening and Sterile Inflammatory Response: Unraveling the Therapeutic Window. bioRxiv. 2023 Oct 25. PMID: 37961395.
      View in: PubMed
    3. Martinez P, Nault G, Steiner J, Wempe MF, Pierce A, Brunt B, Slade M, Song JJ, Mongin A, Song KH, Ellens N, Serkova N, Green AL, Borden M. MRI-guided focused ultrasound blood-brain barrier opening increases drug delivery and efficacy in a diffuse midline glioma mouse model. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad111. PMID: 37795179.
      View in: PubMed
    4. Knox AJ, Van Court B, Oweida A, Barsh E, DeSisto J, Flannery P, Lemma R, Chatwin H, Vibhakar R, Dorris K, Serkova NJ, Karam SD, Gilani A, Green AL. A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease. Front Oncol. 2023; 13:1105395. PMID: 37124531.
      View in: PubMed
    5. Renner B, Poppelaars F, Laskowski J, Serkova NJ, Kulik L, Holers VM, Thurman JM. Noninvasive Detection of iC3b/C3d Deposits in the Kidney Using a Novel Bioluminescent Imaging Probe. J Am Soc Nephrol. 2023 07 01; 34(7):1151-1154. PMID: 36995143.
      View in: PubMed
    6. Koza LA, Pena C, Russell M, Smith AC, Molnar J, Devine M, Serkova NJ, Linseman DA. Immunocal? limits gliosis in mouse models of repetitive mild-moderate traumatic brain injury. Brain Res. 2023 06 01; 1808:148338. PMID: 36966959.
      View in: PubMed
    7. Timkovich AE, Sikes KJ, Andrie KM, Afzali MF, Sanford J, Fernandez K, Burnett DJ, Hurley E, Daniel T, Serkova NJ, Donahue TH, Santangelo KS. Full and Partial Mid-substance ACL Rupture Using Mechanical Tibial Displacement in Male and Female Mice. Ann Biomed Eng. 2023 Mar; 51(3):579-593. PMID: 36070048.
      View in: PubMed
    8. Alimova I, Wang D, Danis E, Pierce A, Donson A, Serkova N, Madhavan K, Lakshmanachetty S, Balakrishnan I, Foreman NK, Mitra S, Venkataraman S, Vibhakar R. Targeting the TP53/MDM2 axis enhances radiation sensitivity in atypical teratoid rhabdoid tumors. Int J Oncol. 2022 Mar; 60(3). PMID: 35179215.
      View in: PubMed
    9. Hopp K, Catenacci VA, Dwivedi N, Kline TL, Wang W, You Z, Nguyen DT, Bing K, Poudyal B, Johnson GC, Jackman MR, Miller M, Steele CN, Serkova NJ, MacLean PS, Nemenoff RA, Gitomer B, Chonchol M, Nowak KL. Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease. iScience. 2022 Jan 21; 25(1):103697. PMID: 35059607.
      View in: PubMed
    10. Sikes KJ, McConnell A, Serkova N, Cole B, Frisbie D. Untargeted metabolomics analysis identifies creatine, myo-inositol, and lipid pathway modulation in a murine model of tendinopathy. J Orthop Res. 2022 04; 40(4):965-976. PMID: 34081345.
      View in: PubMed
    11. Veo B, Danis E, Pierce A, Wang D, Fosmire S, Sullivan KD, Joshi M, Khanal S, Dahl N, Karam S, Serkova N, Venkataraman S, Vibhakar R. Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma. Cell Rep. 2021 04 27; 35(4):109013. PMID: 33910002.
      View in: PubMed
    12. Serkova NJ, Glunde K, Haney CR, Farhoud M, De Lille A, Redente EF, Simberg D, Westerly DC, Griffin L, Mason RP. Preclinical Applications of Multi-Platform Imaging in Animal Models of Cancer. Cancer Res. 2021 03 01; 81(5):1189-1200. PMID: 33262127.
      View in: PubMed
    13. Balakrishnan I, Danis E, Pierce A, Madhavan K, Wang D, Dahl N, Sanford B, Birks DK, Davidson N, Metselaar DS, Meel MH, Lemma R, Donson A, Vijmasi T, Katagi H, Sola I, Fosmire S, Alimova I, Steiner J, Gilani A, Hulleman E, Serkova NJ, Hashizume R, Hawkins C, Carcaboso AM, Gupta N, Monje M, Jabado N, Jones K, Foreman N, Green A, Vibhakar R, Venkataraman S. Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG. Cell Rep. 2020 10 20; 33(3):108286. PMID: 33086074.
      View in: PubMed
    14. Laskowski J, Renner B, Pickering MC, Serkova NJ, Smith-Jones PM, Clambey ET, Nemenoff RA, Thurman JM. Complement factor H-deficient mice develop spontaneous hepatic tumors. J Clin Invest. 2020 08 03; 130(8):4039-4054. PMID: 32369457.
      View in: PubMed
    15. Dahl NA, Danis E, Balakrishnan I, Wang D, Pierce A, Walker FM, Gilani A, Serkova NJ, Madhavan K, Fosmire S, Green AL, Foreman NK, Venkataraman S, Vibhakar R. Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma. Cell Rep. 2020 04 07; 31(1):107485. PMID: 32268092.
      View in: PubMed
    16. Green AL, DeSisto J, Flannery P, Lemma R, Knox A, Lemieux M, Sanford B, O'Rourke R, Ramkissoon S, Jones K, Perry J, Hui X, Moroze E, Balakrishnan I, O'Neill AF, Dunn K, DeRyckere D, Danis E, Safadi A, Gilani A, Hubbell-Engler B, Nuss Z, Levy JMM, Serkova N, Venkataraman S, Graham DK, Foreman N, Ligon K, Jones K, Kung AL, Vibhakar R. Correction: BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway. Oncogene. 2020 Mar; 39(12):2641. PMID: 31969682.
      View in: PubMed
    17. Pierce AM, Witt DA, Donson AM, Gilani A, Sanford B, Sill M, Van Court B, Oweida A, Prince EW, Steiner J, Danis E, Dorris K, Hankinson T, Handler MH, Jones KL, Karam SD, Serkova NJ, Vibhakar R, Foreman NK, Griesinger AM. Establishment of patient-derived orthotopic xenograft model of 1q+ posterior fossa group A ependymoma. Neuro Oncol. 2019 12 17; 21(12):1540-1551. PMID: 31276586.
      View in: PubMed
    18. Green AL, DeSisto J, Flannery P, Lemma R, Knox A, Lemieux M, Sanford B, O'Rourke R, Ramkissoon S, Jones K, Perry J, Hui X, Moroze E, Balakrishnan I, O'Neill AF, Dunn K, DeRyckere D, Danis E, Safadi A, Gilani A, Hubbell-Engler B, Nuss Z, Levy JMM, Serkova N, Venkataraman S, Graham DK, Foreman N, Ligon K, Jones K, Kung AL, Vibhakar R. BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway. Oncogene. 2020 03; 39(11):2305-2327. PMID: 31844250.
      View in: PubMed
    19. Behbahani RA, Diot Q, Kavanagh B, Serkova NJ, Miften M, Westerly DC. Electromagnetic wave propagation in a fast pulse line ion accelerator. Med Phys. 2019 Dec; 46(12):5714-5721. PMID: 31622500.
      View in: PubMed
    20. Wang G, Serkova NJ, Groman EV, Scheinman RI, Simberg D. Feraheme (Ferumoxytol) Is Recognized by Proinflammatory and Anti-inflammatory Macrophages via Scavenger Receptor Type AI/II. Mol Pharm. 2019 10 07; 16(10):4274-4281. PMID: 31556296.
      View in: PubMed
    21. Dhar D, Raina K, Kant R, Wempe MF, Serkova NJ, Agarwal C, Agarwal R. Bitter melon juice-intake modulates glucose metabolism and lactate efflux in tumors in its efficacy against pancreatic cancer. Carcinogenesis. 2019 Sep 18; 40(9):1164-1176. PMID: 31194859.
      View in: PubMed
    22. Oweida AJ, Bhatia S, Van Court B, Darragh L, Serkova N, Karam SD. Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment. J Vis Exp. 2019 04 22; (146). PMID: 31058896.
      View in: PubMed
    23. Bhatia S, Oweida A, Lennon S, Darragh LB, Milner D, Phan AV, Mueller AC, Van Court B, Raben D, Serkova NJ, Wang XJ, Jimeno A, Clambey ET, Pasquale EB, Karam SD. Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers. Cancer Res. 2019 05 15; 79(10):2722-2735. PMID: 30894369.
      View in: PubMed
    24. Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW, Friedman JE, Wesolowski SR. Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver. Am J Physiol Regul Integr Comp Physiol. 2019 05 01; 316(5):R427-R440. PMID: 30758974.
      View in: PubMed
    25. Keenan KE, Biller JR, Delfino JG, Boss MA, Does MD, Evelhoch JL, Griswold MA, Gunter JL, Hinks RS, Hoffman SW, Kim G, Lattanzi R, Li X, Marinelli L, Metzger GJ, Mukherjee P, Nordstrom RJ, Peskin AP, Perez E, Russek SE, Sahiner B, Serkova N, Shukla-Dave A, Steckner M, Stupic KF, Wilmes LJ, Wu HH, Zhang H, Jackson EF, Sullivan DC. Recommendations towards standards for quantitative MRI (qMRI) and outstanding needs. J Magn Reson Imaging. 2019 Jun; 49(7):e26-e39. PMID: 30680836.
      View in: PubMed
    26. Veo B, Danis E, Pierce A, Sola I, Wang D, Foreman NK, Jin J, Ma A, Serkova N, Venkataraman S, Vibhakar R. Combined functional genomic and chemical screens identify SETD8 as a therapeutic target in MYC-driven medulloblastoma. JCI Insight. 2019 Jan 10; 4(1). PMID: 30626740.
      View in: PubMed
    27. Serkova NJ, Davis DM, Steiner J, Agarwal R. Quantitative NMR-Based Metabolomics on Tissue Biomarkers and Its Translation into In Vivo Magnetic Resonance Spectroscopy. Methods Mol Biol. 2019; 1978:369-387. PMID: 31119675.
      View in: PubMed
    28. Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT. Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Cancer Cell. 2018 10 08; 34(4):659-673.e6. PMID: 30270124.
      View in: PubMed
    29. Scott AJ, Arcaroli JJ, Bagby SM, Yahn R, Huber KM, Serkova NJ, Nguyen A, Kim J, Thorburn A, Vogel J, Quackenbush KS, Capasso A, Schreiber A, Blatchford P, Klauck PJ, Pitts TM, Eckhardt SG, Messersmith WA. Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms. Mol Cancer Ther. 2018 10; 17(10):2112-2122. PMID: 30026382.
      View in: PubMed
    30. Ignowski E, Winter AN, Duval N, Fleming H, Wallace T, Manning E, Koza L, Huber K, Serkova NJ, Linseman DA. The cysteine-rich whey protein supplement, Immunocal?, preserves brain glutathione and improves cognitive, motor, and histopathological indices of traumatic brain injury in a mouse model of controlled cortical impact. Free Radic Biol Med. 2018 08 20; 124:328-341. PMID: 29940352.
      View in: PubMed
    31. Cao Y, Liu H, Gao L, Lu L, Du L, Bai H, Li J, Said S, Wang XJ, Song J, Serkova N, Wei M, Xiao J, Lu SL. Cooperation Between Pten and Smad4 in Murine Salivary Gland Tumor Formation and Progression. Neoplasia. 2018 08; 20(8):764-774. PMID: 29958137.
      View in: PubMed
    32. Westerly DC, Behbahani RA, Kavanagh B, Liu A, Miften M, Serkova NJ, Diot Q. Design considerations for a pulse line ion accelerator (PLIA)-based PET isotope generator. Med Phys. 2018 Jun 15. PMID: 29905959.
      View in: PubMed
    33. Marwan AI, Shabeka U, Reisz JA, Zheng C, Serkova NJ, Dobrinskikh E. Unique Heterogeneous Topological Pattern of the Metabolic Landscape in Rabbit Fetal Lungs following Tracheal Occlusion. Fetal Diagn Ther. 2019; 45(3):145-154. PMID: 29669344.
      View in: PubMed
    34. Contreras-Z?rate MJ, Ormond DR, Gillen AE, Hanna C, Day NL, Serkova NJ, Jacobsen BM, Edgerton SM, Thor AD, Borges VF, Lillehei KO, Graner MW, Kabos P, Cittelly DM. Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases. Front Oncol. 2017; 7:252. PMID: 29164052.
      View in: PubMed
    35. Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Mat?s JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 09 11; 32(3):392. PMID: 28898700.
      View in: PubMed
    36. Henry CJ, Nemkov T, Cas?s-Selves M, Bilousova G, Zaberezhnyy V, Higa KC, Serkova NJ, Hansen KC, D'Alessandro A, DeGregori J. Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis. Haematologica. 2017 12; 102(12):1985-1994. PMID: 28883079.
      View in: PubMed
    37. Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 2017; 6(10):e1356153. PMID: 29123967.
      View in: PubMed
    38. Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Mat?s JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 07 10; 32(1):71-87.e7. PMID: 28697344.
      View in: PubMed
    39. Serkova NJ. Nanoparticle-Based Magnetic Resonance Imaging on Tumor-Associated Macrophages and Inflammation. Front Immunol. 2017; 8:590. PMID: 28588582.
      View in: PubMed
    40. Anchordoquy TJ, Barenholz Y, Boraschi D, Chorny M, Decuzzi P, Dobrovolskaia MA, Farhangrazi ZS, Farrell D, Gabizon A, Ghandehari H, Godin B, La-Beck NM, Ljubimova J, Moghimi SM, Pagliaro L, Park JH, Peer D, Ruoslahti E, Serkova NJ, Simberg D. Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions. ACS Nano. 2017 01 24; 11(1):12-18. PMID: 28068099.
      View in: PubMed
    41. Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):E6669-E6678. PMID: 27791036.
      View in: PubMed
    42. Deep G, Kumar R, Nambiar DK, Jain AK, Ramteke AM, Serkova NJ, Agarwal C, Agarwal R. Silibinin inhibits hypoxia-induced HIF-1a-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics. Mol Carcinog. 2017 03; 56(3):833-848. PMID: 27533043.
      View in: PubMed
    43. Li M, Riddle S, Zhang H, D'Alessandro A, Flockton A, Serkova NJ, Hansen KC, Moldovan R, McKeon BA, Frid M, Kumar S, Li H, Liu H, Ca?novas A, Medrano JF, Thomas MG, Iloska D, Plecit?-Hlavat? L, Je?ek P, Pullamsetti S, Fini MA, El Kasmi KC, Zhang Q, Stenmark KR. Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1. Circulation. 2016 10 11; 134(15):1105-1121. PMID: 27562971.
      View in: PubMed
    44. Serkova NJ, Eckhardt SG. Metabolic Imaging to Assess Treatment Response to Cytotoxic and Cytostatic Agents. Front Oncol. 2016; 6:152. PMID: 27471678.
      View in: PubMed
    45. Fredrickson J, Serkova NJ, Wyatt SK, Carano RA, Pirzkall A, Rhee I, Rosen LS, Bessudo A, Weekes C, de Crespigny A. Clinical translation of ferumoxytol-based vessel size imaging (VSI): Feasibility in a phase I oncology clinical trial population. Magn Reson Med. 2017 02; 77(2):814-825. PMID: 26918893.
      View in: PubMed
    46. Henry CJ, Cas?s-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J. Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest. 2015 Dec; 125(12):4666-80. PMID: 26551682.
      View in: PubMed
    47. Sartorius CA, Hanna CT, Gril B, Cruz H, Serkova NJ, Huber KM, Kabos P, Schedin TB, Borges VF, Steeg PS, Cittelly DM. Estrogen promotes the brain metastatic colonization of triple negative breast cancer cells via an astrocyte-mediated paracrine mechanism. Oncogene. 2016 06 02; 35(22):2881-92. PMID: 26411365.
      View in: PubMed
    48. Schlaepfer IR, Glod? LM, Hitz CA, Pac CT, Boyle KE, Maroni P, Deep G, Agarwal R, Lucia SM, Cramer SD, Serkova NJ, Eckel RH. Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[(18)F]Fluoro-D-Glucose Uptake in Prostate Cancer Mouse Xenografts. Mol Imaging Biol. 2015 Aug; 17(4):529-38. PMID: 25561013.
      View in: PubMed
    49. Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM. Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 01; 309(5):L435-40. PMID: 26115672.
      View in: PubMed
    50. Thurman JM, Serkova NJ. Non-invasive imaging to monitor lupus nephritis and neuropsychiatric systemic lupus erythematosus. F1000Res. 2015; 4:153. PMID: 26309728.
      View in: PubMed
    51. Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J. Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations. Clin Cancer Res. 2015 Mar 15; 21(6):1360-72. PMID: 25547679.
      View in: PubMed
    52. Wang G, Inturi S, Serkova NJ, Merkulov S, McCrae K, Russek SE, Banda NK, Simberg D. High-relaxivity superparamagnetic iron oxide nanoworms with decreased immune recognition and long-circulating properties. ACS Nano. 2014 Dec 23; 8(12):12437-49. PMID: 25419856.
      View in: PubMed
    53. Kavitha CV, Jain AK, Agarwal C, Pierce A, Keating A, Huber KM, Serkova NJ, Wempe MF, Agarwal R, Deep G. Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo. Mol Carcinog. 2015 Nov; 54(11):1417-29. PMID: 25252179.
      View in: PubMed
    54. Bogren LK, Murphy CJ, Johnston EL, Sinha N, Serkova NJ, Drew KL. 1H-NMR metabolomic biomarkers of poor outcome after hemorrhagic shock are absent in hibernators. PLoS One. 2014; 9(9):e107493. PMID: 25211248.
      View in: PubMed
    55. Rudolph MC, Wellberg EA, Lewis AS, Terrell KL, Merz AL, Maluf NK, Serkova NJ, Anderson SM. Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium. J Lipid Res. 2014 06; 55(6):1052-65. PMID: 24771867.
      View in: PubMed
    56. Corser-Jensen CE, Goodell DJ, Freund RK, Serbedzija P, Murphy RC, Farias SE, Dell'Acqua ML, Frey LC, Serkova N, Heidenreich KA. Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits. Exp Neurol. 2014 Jun; 256:7-16. PMID: 24681156.
      View in: PubMed
    57. Frey L, Lepkin A, Schickedanz A, Huber K, Brown MS, Serkova N. ADC mapping and T1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury. Neurol Res. 2014 Jan; 36(1):26-37. PMID: 24107461.
      View in: PubMed
    58. Thurman JM, Serkova NJ. Nanosized contrast agents to noninvasively detect kidney inflammation by magnetic resonance imaging. Adv Chronic Kidney Dis. 2013 Nov; 20(6):488-99. PMID: 24206601.
      View in: PubMed
    59. Yang X, La Rosa FG, Genova EE, Huber K, Schaack J, Degregori J, Serkova NJ, Li Y, Su LJ, Kessler E, Flaig TW. Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia. PLoS One. 2013; 8(9):e74809. PMID: 24058630.
      View in: PubMed
    60. Wilson J, Higgins D, Hutting H, Serkova N, Baird C, Khailova L, Queensland K, Vu Tran Z, Weitzel L, Wischmeyer PE. Early propranolol treatment induces lung heme-oxygenase-1, attenuates metabolic dysfunction, and improves survival following experimental sepsis. Crit Care. 2013 Sep 10; 17(5):R195. PMID: 24020447.
      View in: PubMed
    61. Epple LM, Dodd RD, Merz AL, Dechkovskaia AM, Herring M, Winston BA, Lencioni AM, Russell RL, Madsen H, Nega M, Dusto NL, White J, Bigner DD, Nicchitta CV, Serkova NJ, Graner MW. Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells. PLoS One. 2013; 8(8):e73267. PMID: 24039668.
      View in: PubMed
    62. Derry MM, Raina K, Balaiya V, Jain AK, Shrotriya S, Huber KM, Serkova NJ, Agarwal R, Agarwal C. Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation. Cancer Prev Res (Phila). 2013 Jul; 6(7):625-33. PMID: 23639480.
      View in: PubMed
    63. Weitzel LB, Ambardekar AV, Brieke A, Cleveland JC, Serkova NJ, Wischmeyer PE, Lowes BD. Left ventricular assist device effects on metabolic substrates in the failing heart. PLoS One. 2013; 8(4):e60292. PMID: 23560088.
      View in: PubMed
    64. Bradshaw-Pierce EL, Pitts TM, Kulikowski G, Selby H, Merz AL, Gustafson DL, Serkova NJ, Eckhardt SG, Weekes CD. Utilization of quantitative in vivo pharmacology approaches to assess combination effects of everolimus and irinotecan in mouse xenograft models of colorectal cancer. PLoS One. 2013; 8(3):e58089. PMID: 23520486.
      View in: PubMed
    65. Raina K, Agarwal C, Wadhwa R, Serkova NJ, Agarwal R. Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries. Autophagy. 2013 May; 9(5):697-713. PMID: 23445752.
      View in: PubMed
    66. Yap TA, Arkenau HT, Camidge DR, George S, Serkova NJ, Gwyther SJ, Spratlin JL, Lal R, Spicer J, Desouza NM, Leach MO, Chick J, Poondru S, Boinpally R, Gedrich R, Brock K, Stephens A, Eckhardt SG, Kaye SB, Demetri G, Scurr M. First-in-human phase I trial of two schedules of OSI-930, a novel multikinase inhibitor, incorporating translational proof-of-mechanism studies. Clin Cancer Res. 2013 Feb 15; 19(4):909-19. PMID: 23403628.
      View in: PubMed
    67. Raina K, Ravichandran K, Rajamanickam S, Huber KM, Serkova NJ, Agarwal R. Inositol hexaphosphate inhibits tumor growth, vascularity, and metabolism in TRAMP mice: a multiparametric magnetic resonance study. Cancer Prev Res (Phila). 2013 Jan; 6(1):40-50. PMID: 23213071.
      View in: PubMed
    68. Beresford T, Fay T, Serkova NJ, Wu PH. Immunophyllin ligands show differential effects on alcohol self-administration in C57BL mice. J Pharmacol Exp Ther. 2012 Jun; 341(3):611-6. PMID: 22375069.
      View in: PubMed
    69. Serkova NJ, Brown MS. Quantitative analysis in magnetic resonance spectroscopy: from metabolic profiling to in vivo biomarkers. Bioanalysis. 2012 Feb; 4(3):321-41. PMID: 22303835.
      View in: PubMed
    70. Morelli MP, Tentler JJ, Kulikowski GN, Tan AC, Bradshaw-Pierce EL, Pitts TM, Brown AM, Nallapareddy S, Arcaroli JJ, Serkova NJ, Hidalgo M, Ciardiello F, Eckhardt SG. Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models. Clin Cancer Res. 2012 Feb 15; 18(4):1051-62. PMID: 22173548.
      View in: PubMed
    71. Sargsyan SA, Serkova NJ, Renner B, Hasebroock KM, Larsen B, Stoldt C, McFann K, Pickering MC, Thurman JM. Detection of glomerular complement C3 fragments by magnetic resonance imaging in murine lupus nephritis. Kidney Int. 2012 Jan; 81(2):152-9. PMID: 21956190.
      View in: PubMed
    72. Serkova NJ, Standiford TJ, Stringer KA. The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses. Am J Respir Crit Care Med. 2011 Sep 15; 184(6):647-55. PMID: 21680948.
      View in: PubMed
    73. Serkova NJ. Translational imaging endpoints to predict treatment response to novel targeted anticancer agents. Drug Resist Updat. 2011 Aug-Oct; 14(4-5):224-35. PMID: 21640633.
      View in: PubMed
    74. Spratlin JL, Pitts TM, Kulikowski GN, Morelli MP, Tentler JJ, Serkova NJ, Eckhardt SG. Synergistic activity of histone deacetylase and proteasome inhibition against pancreatic and hepatocellular cancer cell lines. Anticancer Res. 2011 Apr; 31(4):1093-103. PMID: 21508352.
      View in: PubMed
    75. Ramasamy K, Dwyer-Nield LD, Serkova NJ, Hasebroock KM, Tyagi A, Raina K, Singh RP, Malkinson AM, Agarwal R. Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies. Clin Cancer Res. 2011 Feb 15; 17(4):753-61. PMID: 21148748.
      View in: PubMed
    76. Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology. 2011 Jan; 32(1):50-7. PMID: 21075140.
      View in: PubMed
    77. Martinez-Palli G, Hirose R, Liu T, Xu F, Dang K, Feiner J, Serkova NJ, Niemann CU. Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model. Nephrol Dial Transplant. 2011 Jun; 26(6):1813-20. PMID: 21068143.
      View in: PubMed
    78. Stringer KA, Serkova NJ, Karnovsky A, Guire K, Paine R, Standiford TJ. Metabolic consequences of sepsis-induced acute lung injury revealed by plasma ?H-nuclear magnetic resonance quantitative metabolomics and computational analysis. Am J Physiol Lung Cell Mol Physiol. 2011 Jan; 300(1):L4-L11. PMID: 20889676.
      View in: PubMed
    79. Cohen MJ, Serkova NJ, Wiener-Kronish J, Pittet JF, Niemann CU. 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients--beyond lactate and base deficit. J Trauma. 2010 Jul; 69(1):31-40. PMID: 20622576.
      View in: PubMed
    80. Vincenti M, Behrends M, Dang K, Park YH, Hirose R, Blasi-Ibanez A, Liu T, Serkova NJ, Niemann CU. Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats. J Gastroenterol. 2010 Nov; 45(11):1103-10. PMID: 20549254.
      View in: PubMed
    81. Tentler JJ, Bradshaw-Pierce EL, Serkova NJ, Hasebroock KM, Pitts TM, Diamond JR, Fletcher GC, Bray MR, Eckhardt SG. Assessment of the in vivo antitumor effects of ENMD-2076, a novel multitargeted kinase inhibitor, against primary and cell line-derived human colorectal cancer xenograft models. Clin Cancer Res. 2010 Jun 01; 16(11):2989-2998. PMID: 20406842.
      View in: PubMed
    82. Doctor RB, Serkova NJ, Hasebroock KM, Zafar I, Edelstein CL. Distinct patterns of kidney and liver cyst growth in pkd2(WS25/-) mice. Nephrol Dial Transplant. 2010 Nov; 25(11):3496-504. PMID: 20388629.
      View in: PubMed
    83. Serkova NJ, Renner B, Larsen BA, Stoldt CR, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, Thurman JM. Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in mice. Radiology. 2010 May; 255(2):517-26. PMID: 20332377.
      View in: PubMed
    84. Klawitter J, Gottschalk S, Hainz C, Leibfritz D, Christians U, Serkova NJ. Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolism. Chem Res Toxicol. 2010 Mar 15; 23(3):608-19. PMID: 20148532.
      View in: PubMed
    85. Spratlin JL, Cohen RB, Eadens M, Gore L, Camidge DR, Diab S, Leong S, O'Bryant C, Chow LQ, Serkova NJ, Meropol NJ, Lewis NL, Chiorean EG, Fox F, Youssoufian H, Rowinsky EK, Eckhardt SG. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol. 2010 Feb 10; 28(5):780-7. PMID: 20048182.
      View in: PubMed
    86. Klawitter J, Zhang YL, Klawitter J, Anderson N, Serkova NJ, Christians U. Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture. Biomed Chromatogr. 2009 Dec; 23(12):1251-8. PMID: 19517424.
      View in: PubMed
    87. Serkova NJ. Imaging biochemistry noninvasively: magnetic resonance spectroscopy in liver disease. JPEN J Parenter Enteral Nutr. 2009 Nov-Dec; 33(6):726-8. PMID: 19892909.
      View in: PubMed
    88. Tissot van Patot MC, Murray AJ, Beckey V, Cindrova-Davies T, Johns J, Zwerdlinger L, Jauniaux E, Burton GJ, Serkova NJ. Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning. Am J Physiol Regul Integr Comp Physiol. 2010 Jan; 298(1):R166-72. PMID: 19864339.
      View in: PubMed
    89. Klawitter J, Kominsky DJ, Brown JL, Klawitter J, Christians U, Leibfritz D, Melo JV, Eckhardt SG, Serkova NJ. Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells. Br J Pharmacol. 2009 Sep; 158(2):588-600. PMID: 19663881.
      View in: PubMed
    90. Serkova NJ, Freund AS, Brown JL, Kominsky DJ. Use of the 1-mm micro-probe for metabolic analysis on small volume biological samples. J Cell Mol Med. 2009 Aug; 13(8B):1933-1941. PMID: 19267884.
      View in: PubMed
    91. Merz AL, Serkova NJ. Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer. Biomark Med. 2009 Jun 01; 3(3):289-306. PMID: 20160999.
      View in: PubMed
    92. Kominsky DJ, Klawitter J, Brown JL, Boros LG, Melo JV, Eckhardt SG, Serkova NJ. Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells. Clin Cancer Res. 2009 May 15; 15(10):3442-50. PMID: 19401345.
      View in: PubMed
    93. Raina K, Serkova NJ, Agarwal R. Silibinin feeding alters the metabolic profile in TRAMP prostatic tumors: 1H-NMRS-based metabolomics study. Cancer Res. 2009 May 01; 69(9):3731-5. PMID: 19366793.
      View in: PubMed
    94. Hasebroock KM, Serkova NJ. Toxicity of MRI and CT contrast agents. Expert Opin Drug Metab Toxicol. 2009 Apr; 5(4):403-16. PMID: 19368492.
      View in: PubMed
    95. Tissot van Patot MC, Serkova NJ, Haschke M, Kominsky DJ, Roach RC, Christians U, Henthorn TK, Honigman B. Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m. Free Radic Biol Med. 2009 Jun 01; 46(11):1551-7. PMID: 19303436.
      View in: PubMed
    96. Klawitter J, Anderson N, Klawitter J, Christians U, Leibfritz D, Eckhardt SG, Serkova NJ. Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study. Br J Cancer. 2009 Mar 24; 100(6):923-31. PMID: 19259085.
      View in: PubMed
    97. Spratlin JL, Serkova NJ, Eckhardt SG. Clinical applications of metabolomics in oncology: a review. Clin Cancer Res. 2009 Jan 15; 15(2):431-40. PMID: 19147747.
      View in: PubMed
    98. Serkova NJ, Glunde K. Metabolomics of cancer. Methods Mol Biol. 2009; 520:273-95. PMID: 19381962.
      View in: PubMed
    99. Serkova NJ, Hasebroock KM, Kraft SL. Magnetic resonance spectroscopy of living tissues. Methods Mol Biol. 2009; 520:315-27. PMID: 19381964.
      View in: PubMed
    100. Serkova NJ, Garg K, Bradshaw-Pierce EL. Oncologic imaging end-points for the assessment of therapy response. Recent Pat Anticancer Drug Discov. 2009 Jan; 4(1):36-53. PMID: 19149687.
      View in: PubMed
    101. Lam ET, O'Bryant CL, Basche M, Gustafson DL, Serkova N, Baron A, Holden SN, Dancey J, Eckhardt SG, Gore L. A phase I study of gefitinib, capecitabine, and celecoxib in patients with advanced solid tumors. Mol Cancer Ther. 2008 Dec; 7(12):3685-94. PMID: 19074845.
      View in: PubMed
    102. Frey LC, Hellier J, Unkart C, Lepkin A, Howard A, Hasebroock K, Serkova N, Liang L, Patel M, Soltesz I, Staley K. A novel apparatus for lateral fluid percussion injury in the rat. J Neurosci Methods. 2009 Mar 15; 177(2):267-72. PMID: 19022291.
      View in: PubMed
    103. Young CD, Nolte EC, Lewis A, Serkova NJ, Anderson SM. Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3. Breast Cancer Res. 2008; 10(4):R70. PMID: 18700973.
      View in: PubMed
    104. Larsen BA, Haag MA, Serkova NJ, Shroyer KR, Stoldt CR. Controlled aggregation of superparamagnetic iron oxide nanoparticles for the development of molecular magnetic resonance imaging probes. Nanotechnology. 2008 Jul 02; 19(26):265102. PMID: 21828671.
      View in: PubMed
    105. Serkova NJ, Gamito EJ, Jones RH, O'Donnell C, Brown JL, Green S, Sullivan H, Hedlund T, Crawford ED. The metabolites citrate, myo-inositol, and spermine are potential age-independent markers of prostate cancer in human expressed prostatic secretions. Prostate. 2008 May 01; 68(6):620-8. PMID: 18213632.
      View in: PubMed
    106. Serkova NJ, Van Rheen Z, Tobias M, Pitzer JE, Wilkinson JE, Stringer KA. Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Jul; 295(1):L152-61. PMID: 18441091.
      View in: PubMed
    107. Serkova NJ, Reisdorph NA, Tissot van Patot MC. Metabolic markers of hypoxia: systems biology application in biomedicine. Toxicol Mech Methods. 2008; 18(1):81-95. PMID: 20020894.
      View in: PubMed
    108. Serkova NJ, Spratlin JL, Eckhardt SG. NMR-based metabolomics: translational application and treatment of cancer. Curr Opin Mol Ther. 2007 Dec; 9(6):572-85. PMID: 18041668.
      View in: PubMed
    109. Troiani T, Serkova NJ, Gustafson DL, Henthorn TK, Lockerbie O, Merz A, Long M, Morrow M, Ciardiello F, Eckhardt SG. Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model. Clin Cancer Res. 2007 Nov 01; 13(21):6450-8. PMID: 17975157.
      View in: PubMed
    110. Niemann CU, Serkova NJ. Biochemical mechanisms of nephrotoxicity: application for metabolomics. Expert Opin Drug Metab Toxicol. 2007 Aug; 3(4):527-44. PMID: 17696804.
      View in: PubMed
    111. Serkova NJ, Rose JC, Epperson LE, Carey HV, Martin SL. Quantitative analysis of liver metabolites in three stages of the circannual hibernation cycle in 13-lined ground squirrels by NMR. Physiol Genomics. 2007 Sep 19; 31(1):15-24. PMID: 17536023.
      View in: PubMed
    112. Serkova NJ, Zhang Y, Coatney JL, Hunter L, Wachs ME, Niemann CU, Mandell MS. Early detection of graft failure using the blood metabolic profile of a liver recipient. Transplantation. 2007 Feb 27; 83(4):517-21. PMID: 17318087.
      View in: PubMed
    113. Rudolph MC, McManaman JL, Phang T, Russell T, Kominsky DJ, Serkova NJ, Stein T, Anderson SM, Neville MC. Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine. Physiol Genomics. 2007 Feb 12; 28(3):323-36. PMID: 17105756.
      View in: PubMed
    114. Park Y, Hirose R, Coatney JL, Ferrell L, Behrends M, Roberts JP, Serkova NJ, Niemann CU. Ischemia-reperfusion injury is more severe in older versus young rat livers. J Surg Res. 2007 Jan; 137(1):96-102. PMID: 17064732.
      View in: PubMed
    115. Glunde K, Serkova NJ. Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism. Pharmacogenomics. 2006 Oct; 7(7):1109-23. PMID: 17054420.
      View in: PubMed
    116. Serkova NJ, Niemann CU. Pattern recognition and biomarker validation using quantitative 1H-NMR-based metabolomics. Expert Rev Mol Diagn. 2006 Sep; 6(5):717-31. PMID: 17009906.
      View in: PubMed
    117. Peng ZY, Serkova NJ, Kominsky DJ, Brown JL, Wischmeyer PE. Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression. JPEN J Parenter Enteral Nutr. 2006 Sep-Oct; 30(5):373-8; discussion 379. PMID: 16931604.
      View in: PubMed
    118. Behrends M, Hirose R, Serkova NJ, Coatney JL, Bedolli M, Yardi J, Park YH, Niemann CU. Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats. Liver Int. 2006 Aug; 26(6):734-41. PMID: 16842331.
      View in: PubMed
    119. Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ. Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion. Surgery. 2006 Sep; 140(3):404-12. PMID: 16934602.
      View in: PubMed
    120. Niemann CU, Hirose R, Liu T, Behrends M, Brown JL, Kominsky DF, Roberts JP, Serkova N. Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers. Anesth Analg. 2005 Dec; 101(6):1577-1583. PMID: 16301222.
      View in: PubMed
    121. Serkova NJ, Christians U. Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood. Ther Drug Monit. 2005 Dec; 27(6):733-7. PMID: 16404806.
      View in: PubMed
    122. Serkova NJ, Jackman M, Brown JL, Liu T, Hirose R, Roberts JP, Maher JJ, Niemann CU. Metabolic profiling of livers and blood from obese Zucker rats. J Hepatol. 2006 May; 44(5):956-62. PMID: 16223541.
      View in: PubMed
    123. Singleton KD, Serkova N, Beckey VE, Wischmeyer PE. Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. Crit Care Med. 2005 Jun; 33(6):1206-13. PMID: 15942332.
      View in: PubMed
    124. Serkova N, Fuller TF, Klawitter J, Freise CE, Niemann CU. H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. Kidney Int. 2005 Mar; 67(3):1142-51. PMID: 15698456.
      View in: PubMed
    125. Singleton KD, Serkova N, Banerjee A, Meng X, Gamboni-Robertson F, Wischmeyer PE. Glutamine attenuates endotoxin-induced lung metabolic dysfunction: potential role of enhanced heat shock protein 70. Nutrition. 2005 Feb; 21(2):214-23. PMID: 15723751.
      View in: PubMed
    126. Serkova N, Boros LG. Detection of resistance to imatinib by metabolic profiling: clinical and drug development implications. Am J Pharmacogenomics. 2005; 5(5):293-302. PMID: 16196499.
      View in: PubMed
    127. Gottschalk S, Anderson N, Hainz C, Eckhardt SG, Serkova NJ. Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells. Clin Cancer Res. 2004 Oct 01; 10(19):6661-8. PMID: 15475456.
      View in: PubMed
    128. Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Br J Pharmacol. 2004 Oct; 143(3):388-96. PMID: 15339861.
      View in: PubMed
    129. Tissot van Patot MC, Bendrick-Peart J, Beckey VE, Serkova N, Zwerdlinger L. Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L525-32. PMID: 15132953.
      View in: PubMed
    130. Serkova NJ, Christians U, Benet LZ. Biochemical mechanisms of cyclosporine neurotoxicity. Mol Interv. 2004 Apr; 4(2):97-107. PMID: 15087483.
      View in: PubMed
    131. Fuller TF, Serkova N, Niemann CU, Freise CE. Influence of donor pretreatment with N-acetylcysteine on ischemia/reperfusion injury in rat kidney grafts. J Urol. 2004 Mar; 171(3):1296-300. PMID: 14767336.
      View in: PubMed
    132. Fuller TF, Freise CE, Serkova N, Niemann CU, Olson JL, Feng S. Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injury. Transplantation. 2003 Dec 15; 76(11):1594-9. PMID: 14702530.
      View in: PubMed
    133. Serkova N, Christians U. Transplantation: toxicokinetics and mechanisms of toxicity of cyclosporine and macrolides. Curr Opin Investig Drugs. 2003 Nov; 4(11):1287-96. PMID: 14758767.
      View in: PubMed
    134. Wischmeyer PE, Jayakar D, Williams U, Singleton KD, Riehm J, Bacha EA, Jeevanandam V, Christians U, Serkova N. Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. JPEN J Parenter Enteral Nutr. 2003 Nov-Dec; 27(6):396-403. PMID: 14621120.
      View in: PubMed
    135. Serkova N, Klawitter J, Niemann CU. Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the rat. Transpl Int. 2003 Oct; 16(10):748-55. PMID: 12827232.
      View in: PubMed
    136. Serkova N, Bendrick-Peart J, Alexander B, Tissot van Patot MC. Metabolite concentrations in human term placentae and their changes due to delayed collection after delivery. Placenta. 2003 Feb-Mar; 24(2-3):227-35. PMID: 12566250.
      View in: PubMed
    137. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. J Cereb Blood Flow Metab. 2002 Mar; 22(3):342-52. PMID: 11891440.
      View in: PubMed
    138. Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U. Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. Br J Pharmacol. 2001 Jul; 133(6):875-85. PMID: 11454661.
      View in: PubMed
    139. Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U. Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD. Transplant Proc. 2001 Feb-Mar; 33(1-2):514-5. PMID: 11266932.
      View in: PubMed
    140. Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, Manns MP, Kirchner GI. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. J Chromatogr B Biomed Sci Appl. 2000 Oct 01; 748(1):41-53. PMID: 11092585.
      View in: PubMed
    141. Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, Christians U. Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine. J Pharmacol Exp Ther. 2000 Jul; 294(1):323-32. PMID: 10871329.
      View in: PubMed
    142. Hausen B, Gummert J, Berry GJ, Christians U, Serkova N, Ikonen T, Hook L, Legay F, Schuler W, Schreier MH, Morris RE. Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low doses of both microemulsion cyclosporine and 40-O-(2-hydroxyethyl)-rapamycin. Transplantation. 2000 Feb 27; 69(4):488-96. PMID: 10708100.
      View in: PubMed
    143. Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U. The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates. Br J Pharmacol. 2000 Feb; 129(3):485-92. PMID: 10711346.
      View in: PubMed
    144. Hausen B, Ikonen T, Briffa N, Berry GJ, Christians U, Robbins RC, Hook L, Serkova N, Benet LZ, Schuler W, Morris RE. Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability. Transplantation. 2000 Jan 15; 69(1):76-86. PMID: 10653384.
      View in: PubMed
    145. Ikonen TS, Gummert JF, Serkova N, Hayase M, Honda Y, Kobayase Y, Hausen B, Yock PG, Christians U, Morris RE. Efficacies of sirolimus (rapamycin) and cyclosporine in allograft vascular disease in non-human primates: trough levels of sirolimus correlate with inhibition of progression of arterial intimal thickening. Transpl Int. 2000; 13 Suppl 1:S314-20. PMID: 11112022.
      View in: PubMed
    146. Serkova N, Litt L, James TL, Sad?e W, Leibfritz D, Benet LZ, Christians U. Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy. J Pharmacol Exp Ther. 1999 May; 289(2):800-6. PMID: 10215655.
      View in: PubMed
    147. Serkova N, Christians U, Fl?gel U, Pfeuffer J, Leibfritz D. Assessment of the mechanism of astrocyte swelling induced by the macrolide immunosuppressant sirolimus using multinuclear nuclear magnetic resonance spectroscopy. Chem Res Toxicol. 1997 Dec; 10(12):1359-63. PMID: 9437526.
      View in: PubMed
    148. Serkova N, Brand A, Christians U, Leibfritz D. Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy. Biochim Biophys Acta. 1996 Nov 08; 1314(1-2):93-104. PMID: 8972722.
      View in: PubMed
    Serkova's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (676) concept(s)
    _
    Co-Authors Expand Description
    See all (114) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2024 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)