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Robert Corwine Roach Jr.

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-1671

    Collapse Overview 
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    My research focuses on the broad area of human responses to hypoxia. Current research is focused on three major areas: cerebrovascular hemodynamics in hypoxia and exercise; transcriptomic prediction of human responses to hypoxia; and the integration of systems biology with integrative, whole body physiology to understand the molecular and cellular mechanisms of oxygen sensing in humans.

    Cerebrovascular Hemodynamics: We have recently shown that hypoxia impairs cerebral autoregulation; research is underway to begin to understand the importance of this finding and its possible mechanisms.

    Prediction of Human Responses to Hypoxia: We found that a gene expression signature from a blood sample collected in Denver predicted >95% of those who later developed acute mountain sickness. A recent validation study at lower altitudes in a more diverse population confirmed these findings. Studies are underway to examine the physiological links of these transcriptomic markers and pathways that lead to susceptibility to altitude illness.

    Systems biology and human integrative physiological responses to hypoxia: We are undertaking studies to link a comprehensive ‘omics’ pathway of oxygen sensing (transcriptomics, epigenetics, proteomics, metabolomics) to physiological responses that serve to improve oxygen transport during acute and chronic hypoxia.

    At the Altitude Research Center I have mentored 17 junior researchers, ranging from research fellows in Emergency Medicine, Neurology and Pulmonary Medicine to medical students, postdoctoral fellows and undergraduate students. I am active on the Department of Emergency Medicine research council, and mentor an additional six junior faculty on hypoxia research-related topics.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7045433.
      View in: PubMed
    2. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 20884383.
      View in: PubMed
    3. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19142194.
      View in: PubMed
    4. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19150853.
      View in: PubMed
    5. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19303436.
      View in: PubMed
    6. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11450659.
      View in: PubMed
    7. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 10658026.
      View in: PubMed
    8. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22736248.
      View in: PubMed
    9. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11581330.
      View in: PubMed
    10. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1739236.
      View in: PubMed
    11. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2287258.
      View in: PubMed
    12. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21452960.
      View in: PubMed
    13. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21310179.
      View in: PubMed
    14. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11960941.
      View in: PubMed
    15. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8908337.
      View in: PubMed
    16. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2912009.
      View in: PubMed
    17. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18500043.
      View in: PubMed
    18. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21393464.
      View in: PubMed
    19. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8476367.
      View in: PubMed
    20. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21921244.
      View in: PubMed
    21. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 6347173.
      View in: PubMed
    22. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9777029.
      View in: PubMed
    23. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9128904.
      View in: PubMed
    24. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8941508.
      View in: PubMed
    25. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21603073.
      View in: PubMed
    26. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9950843.
      View in: PubMed
    27. Julian CG, Subudhi AW, Wilson MJ, Dimmen AC, Pecha T, Roach RC. Acute mountain sickness, inflammation, and permeability: new insights from a blood biomarker study. J Appl Physiol (1985). 2011 Aug; 111(2):392-9. PMID: 21636566.
      View in: PubMed
    28. Ezzati M, Horwitz ME, Thomas DS, Friedman AB, Roach R, Clark T, Murray CJ, Honigman B. Altitude, life expectancy and mortality from ischaemic heart disease, stroke, COPD and cancers: national population-based analysis of US counties. J Epidemiol Community Health. 2012 Jul; 66(7):e17. PMID: 21406589.
      View in: PubMed
    29. Browne VA, Toledo-Jaldin L, Davila RD, Lopez LP, Yamashiro H, Cioffi-Ragan D, Julian CG, Wilson MJ, Bigham AW, Shriver MD, Honigman B, Vargas E, Roach R, Moore LG. High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude. Am J Physiol Regul Integr Comp Physiol. 2011 May; 300(5):R1221-9. PMID: 21325643.
      View in: PubMed
    30. Imray C, Wright A, Subudhi A, Roach R. Acute mountain sickness: pathophysiology, prevention, and treatment. Prog Cardiovasc Dis. 2010 May-Jun; 52(6):467-84. PMID: 20417340.
      View in: PubMed
    31. Subudhi AW, Panerai RB, Roach RC. Effects of hypobaric hypoxia on cerebral autoregulation. Stroke. 2010 Apr; 41(4):641-6. PMID: 20185774.
      View in: PubMed
    32. Subudhi AW, Panerai RB, Roach RC. Acute hypoxia impairs dynamic cerebral autoregulation: results from two independent techniques. J Appl Physiol (1985). 2009 Oct; 107(4):1165-71. PMID: 19661450.
      View in: PubMed
    33. Heine M, Subudhi AW, Roach RC. Effect of ventilation on cerebral oxygenation during exercise: insights from canonical correlation. Respir Physiol Neurobiol. 2009 Apr 30; 166(2):125-8. PMID: 19429529.
      View in: PubMed
    34. Firth PG, Zheng H, Windsor JS, Sutherland AI, Imray CH, Moore GW, Semple JL, Roach RC, Salisbury RA. Mortality on Mount Everest, 1921-2006: descriptive study. BMJ. 2008 Dec 11; 337:a2654. PMID: 19074222.
      View in: PubMed
    35. Subudhi AW, Roach RC. Endurance performance at altitude. Curr Sports Med Rep. 2008 Feb; 7(1):6-7. PMID: 18296936.
      View in: PubMed
    36. Sutherland AI, Morris DS, Owen CG, Bron AJ, Roach RC. Optic nerve sheath diameter, intracranial pressure and acute mountain sickness on Mount Everest: a longitudinal cohort study. Br J Sports Med. 2008 Mar; 42(3):183-8. PMID: 18182624.
      View in: PubMed
    37. Loeppky JA, Icenogle MV, Charlton GA, Conn CA, Maes D, Riboni K, Gates L, Melo MF, Roach RC. Hypoxemia and acute mountain sickness: which comes first? High Alt Med Biol. 2008; 9(4):271-9. PMID: 19115910.
      View in: PubMed
    38. Subudhi AW, Lorenz MC, Fulco CS, Roach RC. Cerebrovascular responses to incremental exercise during hypobaric hypoxia: effect of oxygenation on maximal performance. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H164-71. PMID: 18032522.
      View in: PubMed
    39. Subudhi AW, Dimmen AC, Roach RC. Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise. J Appl Physiol (1985). 2007 Jul; 103(1):177-83. PMID: 17431082.
      View in: PubMed
    40. Roach R, Kayser B. Measuring mountain maladies. High Alt Med Biol. 2007; 8(3):171-2. PMID: 17824814.
      View in: PubMed
    41. Loeppky JA, Roach RC, Maes D, Hinghofer-Szalkay H, Roessler A, Gates L, Fletcher ER, Icenogle MV. Role of hypobaria in fluid balance response to hypoxia. High Alt Med Biol. 2005; 6(1):60-71. PMID: 15772501.
      View in: PubMed
    42. León-Velarde F, Maggiorini M, Reeves JT, Aldashev A, Asmus I, Bernardi L, Ge RL, Hackett P, Kobayashi T, Moore LG, Penaloza D, Richalet JP, Roach R, Wu T, Vargas E, Zubieta-Castillo G, Zubieta-Calleja G. Consensus statement on chronic and subacute high altitude diseases. High Alt Med Biol. 2005; 6(2):147-57. PMID: 16060849.
      View in: PubMed
    43. Loeppky JA, Icenogle MV, Maes D, Riboni K, Hinghofer-Szalkay H, Roach RC. Early fluid retention and severe acute mountain sickness. J Appl Physiol (1985). 2005 Feb; 98(2):591-7. PMID: 15501929.
      View in: PubMed
    44. Appenzeller O, Passino C, Roach R, Gamboa J, Gamboa A, Bernardi L, Bonfichi M, Malcovati L. Cerebral vasoreactivity in Andeans and headache at sea level. J Neurol Sci. 2004 Apr 15; 219(1-2):101-6. PMID: 15050445.
      View in: PubMed
    45. Greene ER, Roach RC. Doppler ultrasound determination of the distribution of human cardiac output: effects of age and physical stresses. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:3704-7. PMID: 17271098.
      View in: PubMed
    46. Hackett PH, Roach RC. High altitude cerebral edema. High Alt Med Biol. 2004; 5(2):136-46. PMID: 15265335.
      View in: PubMed
    47. Bernardi L, Roach RC, Keyl C, Spicuzza L, Passino C, Bonfichi M, Gamboa A, Gamboa J, Malcovati L, Schneider A, Casiraghi N, Mori A, Leon-Velarde F. Ventilation, autonomic function, sleep and erythropoietin. Chronic mountain sickness of Andean natives. Adv Exp Med Biol. 2003; 543:161-75. PMID: 14713121.
      View in: PubMed
    48. Loeppky JA, Icenogle MV, Maes D, Riboni K, Scotto P, Roach RC. Body temperature, autonomic responses, and acute mountain sickness. High Alt Med Biol. 2003; 4(3):367-73. PMID: 14561242.
      View in: PubMed
    49. Møller K, Paulson OB, Hornbein TF, Colier WN, Paulson AS, Roach RC, Holm S, Knudsen GM. Unchanged cerebral blood flow and oxidative metabolism after acclimatization to high altitude. J Cereb Blood Flow Metab. 2002 Jan; 22(1):118-26. PMID: 11807401.
      View in: PubMed
    50. Sandoval DA, Maes DP, D'Acquisto L, Icenogle M, Roach RC. Oral contraceptives, exercise, and acute mountain sickness in women. Aviat Space Environ Med. 2001 Aug; 72(8):733-8. PMID: 11506235.
      View in: PubMed
    51. Loeppky JA, Scotto P, Charlton GC, Gates L, Icenogle M, Roach RC. Ventilation is greater in women than men, but the increase during acute altitude hypoxia is the same. Respir Physiol. 2001 Apr; 125(3):225-37. PMID: 11282389.
      View in: PubMed
    52. Pollard AJ, Niermeyer S, Barry P, Bärtsch P, Berghold F, Bishop RA, Clarke C, Dhillon S, Dietz TE, Durmowicz A, Durrer B, Eldridge M, Hackett P, Jean D, Kriemler S, Litch JA, Murdoch D, Nickol A, Richalet JP, Roach R, Shlim DR, Wiget U, Yaron M, Zubieta-Castillo G, Zubieta-Calleja GR. Children at high altitude: an international consensus statement by an ad hoc committee of the International Society for Mountain Medicine, March 12, 2001. High Alt Med Biol. 2001; 2(3):389-403. PMID: 11682018.
      View in: PubMed
    53. Levine BD, Zhang R, Roach RC. Dynamic cerebral autoregulation at high altitude. Adv Exp Med Biol. 1999; 474:319-22. PMID: 10635010.
      View in: PubMed
    54. Roach RC, Greene ER, Schoene RB, Hackett PH. Arterial oxygen saturation for prediction of acute mountain sickness. Aviat Space Environ Med. 1998 Dec; 69(12):1182-5. PMID: 9856544.
      View in: PubMed
    55. Saltin B, Rådegran G, Koskolou MD, Roach RC. Skeletal muscle blood flow in humans and its regulation during exercise. Acta Physiol Scand. 1998 Mar; 162(3):421-36. PMID: 9578388.
      View in: PubMed
    56. Koskolou MD, Roach RC, Calbet JA, Rådegran G, Saltin B. Cardiovascular responses to dynamic exercise with acute anemia in humans. Am J Physiol. 1997 10; 273(4):H1787-93. PMID: 9362244.
      View in: PubMed
    57. Koskolou MD, Calbet JA, Rådegran G, Roach RC. Hypoxia and the cardiovascular response to dynamic knee-extensor exercise. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2655-63. PMID: 9227543.
      View in: PubMed
    58. Honigman B, Read M, Lezotte D, Roach RC. Sea-level physical activity and acute mountain sickness at moderate altitude. West J Med. 1995 Aug; 163(2):117-21. PMID: 7571557.
      View in: PubMed
    59. Roach RC, Houston CS, Honigman B, Nicholas RA, Yaron M, Grissom CK, Alexander JK, Hultgren HN. How well do older persons tolerate moderate altitude? West J Med. 1995 Jan; 162(1):32-6. PMID: 7863654.
      View in: PubMed
    60. Loeppky JA, Fletcher ER, Roach RC, Luft UC. Relationship between whole blood base excess and CO2 content in vivo. Respir Physiol. 1993 Oct; 94(1):109-20. PMID: 8272578.
      View in: PubMed
    61. Honigman B, Theis MK, Koziol-McLain J, Roach R, Yip R, Houston C, Moore LG, Pearce P. Acute mountain sickness in a general tourist population at moderate altitudes. Ann Intern Med. 1993 Apr 15; 118(8):587-92. PMID: 8452324.
      View in: PubMed
    62. Loeppky JA, Roach RC, Selland MA, Scotto P, Luft FC, Luft UC. Body fluid alterations during head-down bed rest in men at moderate altitude. Aviat Space Environ Med. 1993 Apr; 64(4):265-74. PMID: 8476366.
      View in: PubMed
    63. Hackett PH, Roach RC, Hartig GS, Greene ER, Levine BD. The effect of vasodilators on pulmonary hemodynamics in high altitude pulmonary edema: a comparison. Int J Sports Med. 1992 Oct; 13 Suppl 1:S68-71. PMID: 1483798.
      View in: PubMed
    64. Loeppky JA, Scotto P, Riedel CE, Roach RC, Chick TW. Effects of acid-base status on acute hypoxic pulmonary vasoconstriction and gas exchange. J Appl Physiol (1985). 1992 May; 72(5):1787-97. PMID: 1601787.
      View in: PubMed
    65. Swenson ER, Leatham KL, Roach RC, Schoene RB, Mills WJ, Hackett PH. Renal carbonic anhydrase inhibition reduces high altitude sleep periodic breathing. Respir Physiol. 1991 Dec; 86(3):333-43. PMID: 1788493.
      View in: PubMed
    66. Kasic JF, Yaron M, Nicholas RA, Lickteig JA, Roach R. Treatment of acute mountain sickness: hyperbaric versus oxygen therapy. Ann Emerg Med. 1991 Oct; 20(10):1109-12. PMID: 1928883.
      View in: PubMed
    67. Levine BD, Grayburn PA, Voyles WF, Greene ER, Roach RC, Hackett PH. Intracardiac shunting across a patent foramen ovale may exacerbate hypoxemia in high-altitude pulmonary edema. Ann Intern Med. 1991 Apr 01; 114(7):569-70. PMID: 2001089.
      View in: PubMed
    68. Hackett PH, Roach RC, Wood RA, Foutch RG, Meehan RT, Rennie D, Mills WJ. Dexamethasone for prevention and treatment of acute mountain sickness. Aviat Space Environ Med. 1988 Oct; 59(10):950-4. PMID: 3190622.
      View in: PubMed
    69. Schoene RB, Swenson ER, Pizzo CJ, Hackett PH, Roach RC, Mills WJ, Henderson WR, Martin TR. The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary edema. J Appl Physiol (1985). 1988 Jun; 64(6):2605-13. PMID: 3403445.
      View in: PubMed
    70. Hackett PH, Roach RC, Schoene RB, Harrison GL, Mills WJ. Abnormal control of ventilation in high-altitude pulmonary edema. J Appl Physiol (1985). 1988 Mar; 64(3):1268-72. PMID: 3366741.
      View in: PubMed
    71. Hackett PH, Roach RC. Medical therapy of altitude illness. Ann Emerg Med. 1987 Sep; 16(9):980-6. PMID: 3307558.
      View in: PubMed
    72. Hackett PH, Roach RC, Harrison GL, Schoene RB, Mills WJ. Respiratory stimulants and sleep periodic breathing at high altitude. Almitrine versus acetazolamide. Am Rev Respir Dis. 1987 Apr; 135(4):896-8. PMID: 3565935.
      View in: PubMed
    73. Schoene RB, Hackett PH, Henderson WR, Sage EH, Chow M, Roach RC, Mills WJ, Martin TR. High-altitude pulmonary edema. Characteristics of lung lavage fluid. JAMA. 1986 Jul 04; 256(1):63-9. PMID: 3012134.
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    74. Hackett PH, Rodriguez G, Roach RC. Clove cigarettes and high-altitude pulmonary edema. JAMA. 1985 Jun 28; 253(24):3551-2. PMID: 3999337.
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    75. Schoene RB, Roach RC, Hackett PH, Harrison G, Mills WJ. High altitude pulmonary edema and exercise at 4,400 meters on Mount McKinley. Effect of expiratory positive airway pressure. Chest. 1985 Mar; 87(3):330-3. PMID: 3882350.
      View in: PubMed
    76. Belko AZ, Obarzanek E, Roach R, Rotter M, Urban G, Weinberg S, Roe DA. Effects of aerobic exercise and weight loss on riboflavin requirements of moderately obese, marginally deficient young women. Am J Clin Nutr. 1984 Sep; 40(3):553-61. PMID: 6475825.
      View in: PubMed
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