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Paul J Rozance

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-1149

    Collapse Research 
    Collapse research activities and funding
    K08HD060688     (ROZANCE, PAUL JOSEPH)Sep 1, 2009 - Aug 31, 2014
    NIH/NICHD
    Pancreatic beta-cell endothelial cell function and signaling in intrauterine grow
    Role: Principal Investigator

    R01DK088139     (ROZANCE, PAUL JOSEPH)Sep 15, 2011 - Jun 30, 2021
    NIH/NIDDK
    Nutrient Coordination of Pancreatic Vasculature and Beta-Cells
    Role: Principal Investigator

    R13HD086963     (ROZANCE, PAUL JOSEPH)Mar 1, 2016 - Feb 28, 2017
    NIH/NICHD
    2016 Aspen/Snowmass Perinatal Biology Meeting
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bourque SL, Rozance PJ. Does dextrose gel prevent treatment failure in infants with neonatal hypoglycaemia? Acta Paediatr. 2017 Jul; 106(7):1201. PMID: 28220533.
      View in: PubMed
    2. Limesand SW, Rozance PJ. Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency. J Physiol. 2017 Feb 14. PMID: 28194805.
      View in: PubMed
    3. Brown LD, Kohn JR, Rozance PJ, Hay WW, Wesolowski SR. Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 May 01; 312(5):R654-R663. PMID: 28179229.
      View in: PubMed
    4. Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 01; 312(4):R492-R500. PMID: 28100476.
      View in: PubMed
    5. Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 03; 232(3):475-491. PMID: 28053000.
      View in: PubMed
    6. Rozance PJ, Hay WW. Modern Management of Preterm Infants Prevents Adverse Developmental Outcomes From Hypoglycemia. Pediatrics. 2016 Dec; 138(6). PMID: 27940727.
      View in: PubMed
    7. Brown LD, Davis M, Wai S, Wesolowski SR, Hay WW, Limesand SW, Rozance PJ. Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep. Endocrinology. 2016 Oct; 157(10):3788-3799. PMID: 27501184.
      View in: PubMed
    8. Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2016 Jul 01; 311(1):R200-8. PMID: 27170658; PMCID: PMC4967231 [Available on 07/01/17].
    9. Hay WW, Brown LD, Rozance PJ, Wesolowski SR, Limesand SW. Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep. Acta Paediatr. 2016 Aug; 105(8):881-9. PMID: 27028695.
      View in: PubMed
    10. Rozance PJ, Hay WW. New approaches to management of neonatal hypoglycemia. Matern Health Neonatol Perinatol. 2016; 2:3. PMID: 27168942; PMCID: PMC4862061.
    11. Brown LD, Wesolowski SR, Kailey J, Bourque S, Wilson A, Andrews SE, Hay WW, Rozance PJ. Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle. Endocrinology. 2016 Jun; 157(6):2447-60. PMID: 27049667; PMCID: PMC4891788 [Available on 06/01/17].
    12. Rozance PJ. 50 Years Ago in The Journal of Pediatrics: Perinatal Stress and the Premature Neonate. II. Effect of Fluid and Calorie Deprivation on Blood Glucose. J Pediatr. 2016 Mar; 170:89. PMID: 26922762.
      View in: PubMed
    13. Barry JS, Rozance PJ, Brown LD, Anthony RV, Thornburg KL, Hay WW. Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood). 2016 Apr; 241(8):839-47. PMID: 26873920.
      View in: PubMed
    14. Rozance PJ, Hay WW. Pancreatic islet hepatocyte growth factor and vascular endothelial growth factor A signaling in growth restricted fetuses. Mol Cell Endocrinol. 2016 Nov 05; 435:78-84. PMID: 26820125; PMCID: PMC4959995 [Available on 11/05/17].
    15. Brown LD, Rozance PJ. A Sweet Addition for the Treatment of Neonatal Hypoglycemia. J Pediatr. 2016 Mar; 170:10-2. PMID: 26746122.
      View in: PubMed
    16. Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW, Wesolowski SR. Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15; 309(8):R920-8. PMID: 26224688; PMCID: PMC4666949 [Available on 10/15/16].
    17. Thornton PS, Stanley CA, De Leon DD, Harris D, Haymond MW, Hussain K, Levitsky LL, Murad MH, Rozance PJ, Simmons RA, Sperling MA, Weinstein DA, White NH, Wolfsdorf JI. Recommendations from the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children. J Pediatr. 2015 Aug; 167(2):238-45. PMID: 25957977.
      View in: PubMed
    18. Stanley CA, Rozance PJ, Thornton PS, De Leon DD, Harris D, Haymond MW, Hussain K, Levitsky LL, Murad MH, Simmons RA, Sperling MA, Weinstein DA, White NH, Wolfsdorf JI. Re-evaluating "transitional neonatal hypoglycemia": mechanism and implications for management. J Pediatr. 2015 Jun; 166(6):1520-5.e1. PMID: 25819173; PMCID: PMC4659381.
    19. Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan; 156(1):367-76. PMID: 25343274; PMCID: PMC4272391.
    20. Houin SS, Rozance PJ, Brown LD, Hay WW, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2015 Feb 15; 308(4):E306-14. PMID: 25516551; PMCID: PMC4329495.
    21. Rozance PJ, Anderson M, Martinez M, Fahy A, Macko AR, Kailey J, Seedorf GJ, Abman SH, Hay WW, Limesand SW. Placental insufficiency decreases pancreatic vascularity and disrupts hepatocyte growth factor signaling in the pancreatic islet endothelial cell in fetal sheep. Diabetes. 2015 Feb; 64(2):555-64. PMID: 25249573; PMCID: PMC4303968.
    22. Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ. A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia. Physiol Rep. 2014 Jun 18; 2(6). PMID: 24944291; PMCID: PMC4208658.
    23. Houin S, Rozance PJ. 50 years ago in the Journal of pediatrics: The incidence of neonatal hypoglycemia in a nursery for premature infants. J Pediatr. 2014 Jun; 164(6):1485. PMID: 24855928; PMCID: PMC4428118.
    24. Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ. Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep. J Anim Sci Biotechnol. 2014; 5(1):28. PMID: 24917928; PMCID: PMC4051387.
    25. Rozance PJ. Update on neonatal hypoglycemia. Curr Opin Endocrinol Diabetes Obes. 2014 Feb; 21(1):45-50. PMID: 24275620; PMCID: PMC4012366.
    26. Dodson RB, Rozance PJ, Petrash CC, Hunter KS, Ferguson VL. Thoracic and abdominal aortas stiffen through unique extracellular matrix changes in intrauterine growth restricted fetal sheep. Am J Physiol Heart Circ Physiol. 2014 Feb; 306(3):H429-37. PMID: 24322609; PMCID: PMC3920138.
    27. Dodson RB, Rozance PJ, Reina-Romo E, Ferguson VL, Hunter KS. Hyperelastic remodeling in the intrauterine growth restricted (IUGR) carotid artery in the near-term fetus. J Biomech. 2013 Mar 15; 46(5):956-63. PMID: 23332229; PMCID: PMC3742322.
    28. Limesand SW, Rozance PJ, Macko AR, Anderson MJ, Kelly AC, Hay WW. Reductions in insulin concentrations and ß-cell mass precede growth restriction in sheep fetuses with placental insufficiency. Am J Physiol Endocrinol Metab. 2013 Mar 01; 304(5):E516-23. PMID: 23277186; PMCID: PMC3602661.
    29. Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW, Brown LD, Rozance PJ. Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ß-cell mass in fetal sheep. Am J Physiol Endocrinol Metab. 2013 Feb 15; 304(4):E352-62. PMID: 23211516; PMCID: PMC3566506.
    30. Dodson RB, Rozance PJ, Fleenor BS, Petrash CC, Shoemaker LG, Hunter KS, Ferguson VL. Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth-restricted fetal sheep. Pediatr Res. 2013 Feb; 73(2):147-54. PMID: 23154756; PMCID: PMC3742323.
    31. Lavezzi JR, Thorn SR, O'Meara MC, LoTurco D, Brown LD, Hay WW, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 01; 304(1):R50-8. PMID: 23135788; PMCID: PMC3543651.
    32. Frost MS, Zehri AH, Limesand SW, Hay WW, Rozance PJ. Differential effects of chronic pulsatile versus chronic constant maternal hyperglycemia on fetal pancreatic ß-cells. J Pregnancy. 2012; 2012:812094. PMID: 23133755; PMCID: PMC3486011.
    33. Thorn SR, Sekar SM, Lavezzi JR, O'Meara MC, Brown LD, Hay WW, Rozance PJ. A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15; 303(8):R861-9. PMID: 22933022; PMCID: PMC3469666.
    34. Thorn SR, Brown LD, Rozance PJ, Hay WW, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan; 62(1):65-73. PMID: 22933111; PMCID: PMC3526037.
    35. Rozance PJ, Hay WW. Neonatal hypoglycemia--answers, but more questions. J Pediatr. 2012 Nov; 161(5):775-6. PMID: 22809663; PMCID: PMC3688464.
    36. Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E352-64. PMID: 22649066; PMCID: PMC3423121.
    37. Chen X, Rozance PJ, Hay WW, Limesand SW. Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas. Exp Biol Med (Maywood). 2012 May; 237(5):524-9. PMID: 22581814; PMCID: PMC3404611.
    38. Delaney CA, Rozance PJ, Sandoval JA, Bealer JF, Kinsella JP. Late onset diaphragmatic hernia complicated by intestinal strangulation. Curr Opin Pediatr. 2012 Apr; 24(2):274-6. PMID: 22327952; PMCID: PMC3403714.
    39. Maliszewski AM, Gadhia MM, O'Meara MC, Thorn SR, Rozance PJ, Brown LD. Prolonged infusion of amino acids increases leucine oxidation in fetal sheep. Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1483-92. PMID: 22454287; PMCID: PMC3378157.
    40. Rozance PJ, Seedorf GJ, Brown A, Roe G, O'Meara MC, Gien J, Tang JR, Abman SH. Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro in fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2011 Dec; 301(6):L860-71. PMID: 21873446; PMCID: PMC3233832.
    41. Thorn SR, Rozance PJ, Brown LD, Hay WW. The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin Reprod Med. 2011 May; 29(3):225-36. PMID: 21710398; PMCID: PMC3216466.
    42. Rozance PJ. Glucose metabolism in the preterm infant. J Pediatr. 2011 Jun; 158(6):874-5. PMID: 21429504.
      View in: PubMed
    43. Green AS, Macko AR, Rozance PJ, Yates DT, Chen X, Hay WW, Limesand SW. Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus. Am J Physiol Endocrinol Metab. 2011 May; 300(5):E817-23. PMID: 21343544; PMCID: PMC3093975.
    44. Brown LD, Green AS, Limesand SW, Rozance PJ. Maternal amino acid supplementation for intrauterine growth restriction. Front Biosci (Schol Ed). 2011 Jan 01; 3:428-44. PMID: 21196387; PMCID: PMC3181118.
    45. Rozance PJ, Hay WW. Describing hypoglycemia--definition or operational threshold? Early Hum Dev. 2010 May; 86(5):275-80. PMID: 20554129; PMCID: PMC2900507.
    46. Hay WW, Rozance PJ. Continuous glucose monitoring for diagnosis and treatment of neonatal hypoglycemia. J Pediatr. 2010 Aug; 157(2):180-2. PMID: 20472249; PMCID: PMC2905477.
    47. Green AS, Rozance PJ, Limesand SW. Consequences of a compromised intrauterine environment on islet function. J Endocrinol. 2010 Jun; 205(3):211-24. PMID: 20223861; PMCID: PMC3526069.
    48. Rozance PJ, Crispo MM, Barry JS, O'Meara MC, Frost MS, Hansen KC, Hay WW, Brown LD. Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation. Am J Physiol Endocrinol Metab. 2009 Sep; 297(3):E638-46. PMID: 19602583; PMCID: PMC2739698.
    49. Thorn SR, Regnault TR, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW, Friedman JE. Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle. Endocrinology. 2009 Jul; 150(7):3021-30. PMID: 19342452; PMCID: PMC2703533.
    50. Limesand SW, Rozance PJ, Brown LD, Hay WW. Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep. Am J Physiol Endocrinol Metab. 2009 Apr; 296(4):E879-87. PMID: 19190258; PMCID: PMC2670627.
    51. Rozance PJ, Limesand SW, Barry JS, Brown LD, Hay WW. Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. Pediatr Res. 2009 Jan; 65(1):72-8. PMID: 18704001; PMCID: PMC2678008.
    52. Brown LD, Rozance PJ, Barry JS, Friedman JE, Hay WW. Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus. Am J Physiol Endocrinol Metab. 2009 Jan; 296(1):E56-63. PMID: 18940943; PMCID: PMC2636989.
    53. Barry JS, Rozance PJ, Anthony RV. An animal model of placental insufficiency-induced intrauterine growth restriction. Semin Perinatol. 2008 Jun; 32(3):225-30. PMID: 18482626.
      View in: PubMed
    54. Rozance PJ, Limesand SW, Barry JS, Brown LD, Thorn SR, LoTurco D, Regnault TR, Friedman JE, Hay WW. Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep. Am J Physiol Endocrinol Metab. 2008 Feb; 294(2):E365-70. PMID: 18056789; PMCID: PMC3857025.
    55. Limesand SW, Rozance PJ, Smith D, Hay WW. Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1716-25. PMID: 17895285.
      View in: PubMed
    56. Rozance PJ, Limesand SW, Zerbe GO, Hay WW. Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cells. Am J Physiol Endocrinol Metab. 2007 May; 292(5):E1256-64. PMID: 17213478.
      View in: PubMed
    57. Rozance PJ, Limesand SW, Hay WW. Decreased nutrient-stimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defect. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E404-11. PMID: 16569758.
      View in: PubMed
    58. Rozance PJ, Hay WW. Hypoglycemia in newborn infants: Features associated with adverse outcomes. Biol Neonate. 2006; 90(2):74-86. PMID: 16534190.
      View in: PubMed
    59. Limesand SW, Rozance PJ, Zerbe GO, Hutton JC, Hay WW. Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction. Endocrinology. 2006 Mar; 147(3):1488-97. PMID: 16339204.
      View in: PubMed
    60. Colby C, Rozance P, Goodwin TL, Fisher PG. Rapid deterioration of a newborn with congenital spinal cord astrocytoma. Med Pediatr Oncol. 2001 Apr; 36(4):500-2. PMID: 11260577.
      View in: PubMed
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