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Derek Strassheim

TitleResearch Associate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-DERM General Operations

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Strassheim D, Sullivan T, Irwin DC, Gerasimovskaya E, Lahm T, Klemm DJ, Dempsey EC, Stenmark KR, Karoor V. Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases. Cells. 2021 11 29; 10(12). PMID: 34943862.
      View in: PubMed
    2. Karoor V, Swindle D, Pak DI, Strassheim D, Fini MA, Dempsey E, Stenmark KR, Hassell K, Nuss R, Buehler PW, Irwin DC. Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia. Pulm Circ. 2021 Oct-Dec; 11(4):20458940211056806. PMID: 34777787.
      View in: PubMed
    3. Karoor V, Strassheim D, Sullivan T, Verin A, Umapathy NS, Dempsey EC, Frank DN, Stenmark KR, Gerasimovskaya E. The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension. Int J Mol Sci. 2021 Sep 14; 22(18). PMID: 34576081.
      View in: PubMed
    4. Strassheim D, Verin A, Batori R, Nijmeh H, Burns N, Kovacs-Kasa A, Umapathy NS, Kotamarthi J, Gokhale YS, Karoor V, Stenmark KR, Gerasimovskaya E. P2Y Purinergic Receptors, Endothelial Dysfunction, and Cardiovascular Diseases. Int J Mol Sci. 2020 Sep 18; 21(18). PMID: 32962005.
      View in: PubMed
    5. Verin AD, Batori R, Kovacs-Kasa A, Cherian-Shaw M, Kumar S, Czikora I, Karoor V, Strassheim D, Stenmark KR, Gerasimovskaya EV. Extracellular adenosine enhances pulmonary artery vasa vasorum endothelial cell barrier function via Gi/ELMO1/Rac1/PKA-dependent signaling mechanisms. Am J Physiol Cell Physiol. 2020 07 01; 319(1):C183-C193. PMID: 32432925.
      View in: PubMed
    6. Strassheim D, Karoor V, Nijmeh H, Weston P, Lapel M, Schaack J, Sullivan T, Dempsey EC, Stenmark KR, Gerasimovskaya E. c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells. Cells. 2020 02 11; 9(2). PMID: 32054096.
      View in: PubMed
    7. Dempsey E, Strassheim D, Karoor V. Impaired vascular function with age and RhoGTPase. Aging (Albany NY). 2020 01 06; 12(1):1-2. PMID: 31905168.
      View in: PubMed
    8. Strassheim D, Dempsey EC, Gerasimovskaya E, Stenmark K, Karoor V. Role of Inflammatory Cell Subtypes in Heart Failure. J Immunol Res. 2019; 2019:2164017. PMID: 31565659.
      View in: PubMed
    9. Strassheim D, Gerasimovskaya E, Irwin D, Dempsey EC, Stenmark K, Karoor V. RhoGTPase in Vascular Disease. Cells. 2019 06 06; 8(6). PMID: 31174369.
      View in: PubMed
    10. Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF. Corrigendum: C/EBPß Deletion Promotes Expansion of Functionally Poor Intestinal Regulatory T Cells. J Crohns Colitis. 2019 04 26; 13(5):672. PMID: 30624617.
      View in: PubMed
    11. Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF. C/EBPß Deletion Promotes Expansion of Poorly Functional Intestinal Regulatory T Cells. J Crohns Colitis. 2018 Nov 28; 12(12):1475-1485. PMID: 30085016.
      View in: PubMed
    12. Strassheim D, Karoor V, Stenmark K, Verin A, Gerasimovskaya E. A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention. Vessel Plus. 2018; 2. PMID: 31380505.
      View in: PubMed
    13. Lapel M, Weston P, Strassheim D, Karoor V, Burns N, Lyubchenko T, Paucek P, Stenmark KR, Gerasimovskaya EV. Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells. Am J Physiol Cell Physiol. 2017 Jan 01; 312(1):C56-C70. PMID: 27856430.
      View in: PubMed
    14. Collins CB, Strassheim D, Aherne CM, Yeckes AR, Jedlicka P, de Zoeten EF. Targeted inhibition of heat shock protein 90 suppresses tumor necrosis factor-a and ameliorates murine intestinal inflammation. Inflamm Bowel Dis. 2014 Apr; 20(4):685-94. PMID: 24552830.
      View in: PubMed
    15. Fuquay R, Renner B, Kulik L, McCullough JW, Amura C, Strassheim D, Pelanda R, Torres R, Thurman JM. Renal ischemia-reperfusion injury amplifies the humoral immune response. J Am Soc Nephrol. 2013 Jun; 24(7):1063-72. PMID: 23641055.
      View in: PubMed
    16. Strassheim D, Renner B, Panzer S, Fuquay R, Kulik L, Ljubanovic D, Holers VM, Thurman JM. IgM contributes to glomerular injury in FSGS. J Am Soc Nephrol. 2013 Feb; 24(3):393-406. PMID: 23393315.
      View in: PubMed
    17. Li M, Riddle SR, Frid MG, El Kasmi KC, McKinsey TA, Sokol RJ, Strassheim D, Meyrick B, Yeager ME, Flockton AR, McKeon BA, Lemon DD, Horn TR, Anwar A, Barajas C, Stenmark KR. Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension. J Immunol. 2011 Sep 01; 187(5):2711-22. PMID: 21813768.
      View in: PubMed
    18. Renner B, Ferreira VP, Cortes C, Goldberg R, Ljubanovic D, Pangburn MK, Pickering MC, Tomlinson S, Holland-Neidermyer A, Strassheim D, Holers VM, Thurman JM. Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney Int. 2011 Jul; 80(2):165-73. PMID: 21544060.
      View in: PubMed
    19. Renner B, Strassheim D, Amura CR, Kulik L, Ljubanovic D, Glogowska MJ, Takahashi K, Carroll MC, Holers VM, Thurman JM. B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion. J Immunol. 2010 Oct 01; 185(7):4393-400. PMID: 20810984.
      View in: PubMed
    20. Strassheim D, Riddle SR, Burke DL, Geraci MW, Stenmark KR. Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner. J Immunol. 2009 Dec 01; 183(11):6981-8. PMID: 19915063.
      View in: PubMed
    21. Frid MG, Li M, Gnanasekharan M, Burke DL, Fragoso M, Strassheim D, Sylman JL, Stenmark KR. Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1059-72. PMID: 19767409.
      View in: PubMed
    22. Burke DL, Frid MG, Kunrath CL, Karoor V, Anwar A, Wagner BD, Strassheim D, Stenmark KR. Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment. Am J Physiol Lung Cell Mol Physiol. 2009 Aug; 297(2):L238-50. PMID: 19465514.
      View in: PubMed
    23. Park JS, Gamboni-Robertson F, He Q, Svetkauskaite D, Kim JY, Strassheim D, Sohn JW, Yamada S, Maruyama I, Banerjee A, Ishizaka A, Abraham E. High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C917-24. PMID: 16267105.
      View in: PubMed
    24. Kwak SH, Mitra S, Bdeir K, Strassheim D, Park JS, Kim JY, Idell S, Cines D, Abraham E. The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins. J Leukoc Biol. 2005 Oct; 78(4):937-45. PMID: 16033814.
      View in: PubMed
    25. Strassheim D, Kim JY, Park JS, Mitra S, Abraham E. Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury. J Immunol. 2005 Jun 15; 174(12):8064-71. PMID: 15944314.
      View in: PubMed
    26. Asehnoune K, Strassheim D, Mitra S, Yeol Kim J, Abraham E. Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB. Cell Signal. 2005 Mar; 17(3):385-94. PMID: 15567069.
      View in: PubMed
    27. Kim JY, Park JS, Strassheim D, Douglas I, Diaz del Valle F, Asehnoune K, Mitra S, Kwak SH, Yamada S, Maruyama I, Ishizaka A, Abraham E. HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L958-65. PMID: 15640285.
      View in: PubMed
    28. Strassheim D, Asehnoune K, Park JS, Kim JY, He Q, Richter D, Kuhn K, Mitra S, Abraham E. Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils. J Immunol. 2004 May 01; 172(9):5727-33. PMID: 15100319.
      View in: PubMed
    29. Asehnoune K, Strassheim D, Mitra S, Kim JY, Abraham E. Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol. 2004 Feb 15; 172(4):2522-9. PMID: 14764725.
      View in: PubMed
    30. Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, Abraham E. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem. 2004 Feb 27; 279(9):7370-7. PMID: 14660645.
      View in: PubMed
    31. Strassheim D, Asehnoune K, Park JS, Kim JY, He Q, Richter D, Mitra S, Arcaroli J, Kuhn K, Abraham E. Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression. Am J Physiol Cell Physiol. 2004 Mar; 286(3):C683-92. PMID: 14656721.
      View in: PubMed
    32. Abraham E, Gyetko MR, Kuhn K, Arcaroli J, Strassheim D, Park JS, Shetty S, Idell S. Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation. J Immunol. 2003 Jun 01; 170(11):5644-51. PMID: 12759445.
      View in: PubMed
    33. Park JS, Arcaroli J, Yum HK, Yang H, Wang H, Yang KY, Choe KH, Strassheim D, Pitts TM, Tracey KJ, Abraham E. Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C870-9. PMID: 12620891.
      View in: PubMed
    34. Strassheim D, Park JS, Abraham E. Sepsis: current concepts in intracellular signaling. Int J Biochem Cell Biol. 2002 Dec; 34(12):1527-33. PMID: 12379274.
      View in: PubMed
    35. Arcaroli J, Yang KY, Yum HK, Kupfner J, Pitts TM, Park JS, Strassheim D, Abraham E. Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia. J Leukoc Biol. 2002 Sep; 72(3):571-9. PMID: 12223526.
      View in: PubMed
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