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Derek Strassheim

TitleInstructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lapel M, Weston P, Strassheim D, Karoor V, Burns N, Lyubchenko T, Paucek P, Stenmark KR, Gerasimovskaya EV. Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells. Am J Physiol Cell Physiol. 2017 Jan 01; 312(1):C56-C70. PMID: 27856430.
      View in: PubMed
    2. Collins CB, Strassheim D, Aherne CM, Yeckes AR, Jedlicka P, de Zoeten EF. Targeted inhibition of heat shock protein 90 suppresses tumor necrosis factor-a and ameliorates murine intestinal inflammation. Inflamm Bowel Dis. 2014 Apr; 20(4):685-94. PMID: 24552830; PMCID: PMC4418437.
    3. Fuquay R, Renner B, Kulik L, McCullough JW, Amura C, Strassheim D, Pelanda R, Torres R, Thurman JM. Renal ischemia-reperfusion injury amplifies the humoral immune response. J Am Soc Nephrol. 2013 Jun; 24(7):1063-72. PMID: 23641055; PMCID: PMC3699821.
    4. Strassheim D, Renner B, Panzer S, Fuquay R, Kulik L, Ljubanovic D, Holers VM, Thurman JM. IgM contributes to glomerular injury in FSGS. J Am Soc Nephrol. 2013 Feb; 24(3):393-406. PMID: 23393315; PMCID: PMC3582199.
    5. Li M, Riddle SR, Frid MG, El Kasmi KC, McKinsey TA, Sokol RJ, Strassheim D, Meyrick B, Yeager ME, Flockton AR, McKeon BA, Lemon DD, Horn TR, Anwar A, Barajas C, Stenmark KR. Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension. J Immunol. 2011 Sep 01; 187(5):2711-22. PMID: 21813768; PMCID: PMC3159707.
    6. Renner B, Ferreira VP, Cortes C, Goldberg R, Ljubanovic D, Pangburn MK, Pickering MC, Tomlinson S, Holland-Neidermyer A, Strassheim D, Holers VM, Thurman JM. Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney Int. 2011 Jul; 80(2):165-73. PMID: 21544060; PMCID: PMC3133686.
    7. Renner B, Strassheim D, Amura CR, Kulik L, Ljubanovic D, Glogowska MJ, Takahashi K, Carroll MC, Holers VM, Thurman JM. B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion. J Immunol. 2010 Oct 01; 185(7):4393-400. PMID: 20810984; PMCID: PMC3133676.
    8. Strassheim D, Riddle SR, Burke DL, Geraci MW, Stenmark KR. Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner. J Immunol. 2009 Dec 01; 183(11):6981-8. PMID: 19915063; PMCID: PMC2783325.
    9. Frid MG, Li M, Gnanasekharan M, Burke DL, Fragoso M, Strassheim D, Sylman JL, Stenmark KR. Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1059-72. PMID: 19767409; PMCID: PMC2793191.
    10. Burke DL, Frid MG, Kunrath CL, Karoor V, Anwar A, Wagner BD, Strassheim D, Stenmark KR. Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment. Am J Physiol Lung Cell Mol Physiol. 2009 Aug; 297(2):L238-50. PMID: 19465514; PMCID: PMC2742800.
    11. Park JS, Gamboni-Robertson F, He Q, Svetkauskaite D, Kim JY, Strassheim D, Sohn JW, Yamada S, Maruyama I, Banerjee A, Ishizaka A, Abraham E. High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C917-24. PMID: 16267105.
      View in: PubMed
    12. Kwak SH, Mitra S, Bdeir K, Strassheim D, Park JS, Kim JY, Idell S, Cines D, Abraham E. The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins. J Leukoc Biol. 2005 Oct; 78(4):937-45. PMID: 16033814.
      View in: PubMed
    13. Strassheim D, Kim JY, Park JS, Mitra S, Abraham E. Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury. J Immunol. 2005 Jun 15; 174(12):8064-71. PMID: 15944314.
      View in: PubMed
    14. Asehnoune K, Strassheim D, Mitra S, Yeol Kim J, Abraham E. Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB. Cell Signal. 2005 Mar; 17(3):385-94. PMID: 15567069.
      View in: PubMed
    15. Kim JY, Park JS, Strassheim D, Douglas I, Diaz del Valle F, Asehnoune K, Mitra S, Kwak SH, Yamada S, Maruyama I, Ishizaka A, Abraham E. HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L958-65. PMID: 15640285.
      View in: PubMed
    16. Strassheim D, Asehnoune K, Park JS, Kim JY, He Q, Richter D, Kuhn K, Mitra S, Abraham E. Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils. J Immunol. 2004 May 01; 172(9):5727-33. PMID: 15100319.
      View in: PubMed
    17. Asehnoune K, Strassheim D, Mitra S, Kim JY, Abraham E. Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol. 2004 Feb 15; 172(4):2522-9. PMID: 14764725.
      View in: PubMed
    18. Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, Abraham E. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem. 2004 Feb 27; 279(9):7370-7. PMID: 14660645.
      View in: PubMed
    19. Strassheim D, Asehnoune K, Park JS, Kim JY, He Q, Richter D, Mitra S, Arcaroli J, Kuhn K, Abraham E. Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression. Am J Physiol Cell Physiol. 2004 Mar; 286(3):C683-92. PMID: 14656721.
      View in: PubMed
    20. Abraham E, Gyetko MR, Kuhn K, Arcaroli J, Strassheim D, Park JS, Shetty S, Idell S. Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation. J Immunol. 2003 Jun 01; 170(11):5644-51. PMID: 12759445.
      View in: PubMed
    21. Park JS, Arcaroli J, Yum HK, Yang H, Wang H, Yang KY, Choe KH, Strassheim D, Pitts TM, Tracey KJ, Abraham E. Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C870-9. PMID: 12620891.
      View in: PubMed
    22. Strassheim D, Park JS, Abraham E. Sepsis: current concepts in intracellular signaling. Int J Biochem Cell Biol. 2002 Dec; 34(12):1527-33. PMID: 12379274.
      View in: PubMed
    23. Arcaroli J, Yang KY, Yum HK, Kupfner J, Pitts TM, Park JS, Strassheim D, Abraham E. Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia. J Leukoc Biol. 2002 Sep; 72(3):571-9. PMID: 12223526.
      View in: PubMed
    24. Strassheim D, Williams CL. P2Y2 purinergic and M3 muscarinic acetylcholine receptors activate different phospholipase C-beta isoforms that are uniquely susceptible to protein kinase C-dependent phosphorylation and inactivation. J Biol Chem. 2000 Dec 15; 275(50):39767-72. PMID: 10995776.
      View in: PubMed
    25. Strassheim D, Shafer SH, Phelps SH, Williams CL. Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma. Cancer Res. 2000 May 15; 60(10):2730-6. PMID: 10825148.
      View in: PubMed
    26. Strassheim D, Porter RA, Phelps SH, Williams CL. Unique in vivo associations with SmgGDS and RhoGDI and different guanine nucleotide exchange activities exhibited by RhoA, dominant negative RhoA(Asn-19), and activated RhoA(Val-14). J Biol Chem. 2000 Mar 10; 275(10):6699-702. PMID: 10702222.
      View in: PubMed
    27. Strassheim D, May LG, Varker KA, Puhl HL, Phelps SH, Porter RA, Aronstam RS, Noti JD, Williams CL. M3 muscarinic acetylcholine receptors regulate cytoplasmic myosin by a process involving RhoA and requiring conventional protein kinase C isoforms. J Biol Chem. 1999 Jun 25; 274(26):18675-85. PMID: 10373480.
      View in: PubMed
    28. Strassheim D, Law PY, Loh HH. Contribution of phospholipase C-beta3 phosphorylation to the rapid attenuation of opioid-activated phosphoinositide response. Mol Pharmacol. 1998 Jun; 53(6):1047-53. PMID: 9614207.
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    29. Strassheim D, Malbon CC. Phosphorylation of Gi alpha 2 attenuates inhibitory adenylyl cyclase in neuroblastoma/glioma hybrid (NG-108-15) cells. J Biol Chem. 1994 May 13; 269(19):14307-13. PMID: 7514603.
      View in: PubMed
    30. Strassheim D, Houslay MD, Milligan G. Regulation of cardiac adenylate cyclase activity in rodent models of obesity. Biochem J. 1992 Apr 01; 283 ( Pt 1):203-8. PMID: 1348926; PMCID: PMC1131015.
    31. Strassheim D, Palmer T, Milligan G, Houslay MD. Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese (fa/fa) Zucker rats. Biochem J. 1991 May 15; 276 ( Pt 1):197-202. PMID: 1903933; PMCID: PMC1151164.
    32. Strassheim D, Palmer T, Houslay MD. Genetically acquired diabetes: adipocyte guanine nucleotide regulatory protein expression and adenylate cyclase regulation. Biochim Biophys Acta. 1991 Feb 22; 1096(2):121-6. PMID: 1848112.
      View in: PubMed
    33. Strassheim D, Milligan G, Houslay MD. Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (Gi) on adipocyte adenylate cyclase activity. Biochem J. 1990 Mar 01; 266(2):521-6. PMID: 2156498; PMCID: PMC1131163.
    34. Bushfield M, Griffiths SL, Strassheim D, Tang E, Shakur Y, Lavan B, Houslay MD. Guanine-nucleotide-binding proteins in diabetes and insulin-resistant states. Biochem Soc Symp. 1990; 56:137-54. PMID: 2124120.
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    35. Houslay MD, Pyne NJ, O'Brien RM, Siddle K, Strassheim D, Palmer T, Spence S, Woods M, Wilson A, Lavan B, et al. Guanine nucleotide regulatory proteins in insulin's action and in diabetes. Biochem Soc Trans. 1989 Aug; 17(4):627-9. PMID: 2504628.
      View in: PubMed
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