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Sylvia A. McCune

TitleAssoc Professor Adjunct
InstitutionUniversity of Colorado Boulder
DepartmentIntegrative Physiology

    Collapse Research 
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    R03AG025133     (MCCUNE, SYLVIA A)Aug 15, 2005 - Jun 30, 2007
    NIH/NIA
    Exercise Increases Longevity in Aged SHHF Rats?
    Role: Principal Investigator

    R43HL090124     (MCCUNE, SYLVIA A)Sep 1, 2007 - Aug 29, 2008
    NIH/NHLBI
    Characterization and Development of a New Animal Model of Pulmonary Hypertension
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Le CH, Mulligan CM, Routh MA, Bouma GJ, Frye MA, Jeckel KM, Sparagna GC, Lynch JM, Moore RL, McCune SA, Bristow M, Zarini S, Murphy RC, Chicco AJ. Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure. Circ Heart Fail. 2014 Jan; 7(1):172-83. PMID: 24284026.
      View in: PubMed
    2. Sharkey LC, Radin MJ, Heller L, Rogers LK, Tobias A, Matise I, Wang Q, Apple FS, McCune SA. Differential cardiotoxicity in response to chronic doxorubicin treatment in male spontaneous hypertension-heart failure (SHHF), spontaneously hypertensive (SHR), and Wistar Kyoto (WKY) rats. Toxicol Appl Pharmacol. 2013 Nov 15; 273(1):47-57. PMID: 23993975.
      View in: PubMed
    3. Rees ML, Gioscia-Ryan RA, McCune SA, Browder JC, Zachman DK, Chicco AJ, Johnson CA, Murphy RC, Moore RL, Sparagna GC. The AIN-76A defined rodent diet accelerates the development of heart failure in SHHF rats: a cautionary note on its use in cardiac studies. J Anim Physiol Anim Nutr (Berl). 2014 Feb; 98(1):56-64. PMID: 23298172.
      View in: PubMed
    4. Knaub LA, McCune S, Chicco AJ, Miller M, Moore RL, Birdsey N, Lloyd MI, Villarreal J, Keller AC, Watson PA, Reusch JE. Impaired response to exercise intervention in the vasculature in metabolic syndrome. Diab Vasc Dis Res. 2013 May; 10(3):222-38. PMID: 23162060; PMCID: PMC4139293.
    5. Mulligan CM, Sparagna GC, Le CH, De Mooy AB, Routh MA, Holmes MG, Hickson-Bick DL, Zarini S, Murphy RC, Xu FY, Hatch GM, McCune SA, Moore RL, Chicco AJ. Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart. Cardiovasc Res. 2012 Jun 01; 94(3):460-8. PMID: 22411972; PMCID: PMC3353802.
    6. Radin MJ, Holycross BJ, McCune SA, Altschuld RA. Crosstalk between leptin and interleukin-1ß abrogates negative inotropic effects in a model of chronic hyperleptinemia. Exp Biol Med (Maywood). 2011 Nov; 236(11):1263-73. PMID: 21954221.
      View in: PubMed
    7. Lemon DD, Horn TR, Cavasin MA, Jeong MY, Haubold KW, Long CS, Irwin DC, McCune SA, Chung E, Leinwand LA, McKinsey TA. Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension. J Mol Cell Cardiol. 2011 Jul; 51(1):41-50. PMID: 21539845; PMCID: PMC3113526.
    8. Przybylski R, McCune S, Hollis B, Simpson RU. Vitamin D deficiency in the spontaneously hypertensive heart failure [SHHF] prone rat. Nutr Metab Cardiovasc Dis. 2010 Nov; 20(9):641-6. PMID: 19836216; PMCID: PMC2889219.
    9. Zachman DK, Chicco AJ, McCune SA, Murphy RC, Moore RL, Sparagna GC. The role of calcium-independent phospholipase A2 in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart. J Lipid Res. 2010 Mar; 51(3):525-34. PMID: 19741254; PMCID: PMC2817582.
    10. Saini-Chohan HK, Holmes MG, Chicco AJ, Taylor WA, Moore RL, McCune SA, Hickson-Bick DL, Hatch GM, Sparagna GC. Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure. J Lipid Res. 2009 Aug; 50(8):1600-8. PMID: 19001357; PMCID: PMC2724040.
    11. Radin MJ, Holycross BJ, Hoepf TM, McCune SA. Salt-induced cardiac hypertrophy is independent of blood pressure and endothelin in obese, heart failure-prone SHHF rats. Clin Exp Hypertens. 2008 Oct; 30(7):541-52. PMID: 18855258.
      View in: PubMed
    12. Chicco AJ, Sparagna GC, McCune SA, Johnson CA, Murphy RC, Bolden DA, Rees ML, Gardner RT, Moore RL. Linoleate-rich high-fat diet decreases mortality in hypertensive heart failure rats compared with lard and low-fat diets. Hypertension. 2008 Sep; 52(3):549-55. PMID: 18663155; PMCID: PMC2864132.
    13. Chicco AJ, McCune SA, Emter CA, Sparagna GC, Rees ML, Bolden DA, Marshall KD, Murphy RC, Moore RL. Low-intensity exercise training delays heart failure and improves survival in female hypertensive heart failure rats. Hypertension. 2008 Apr; 51(4):1096-102. PMID: 18259016.
      View in: PubMed
    14. Sparagna GC, Chicco AJ, Murphy RC, Bristow MR, Johnson CA, Rees ML, Maxey ML, McCune SA, Moore RL. Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure. J Lipid Res. 2007 Jul; 48(7):1559-70. PMID: 17426348.
      View in: PubMed
    15. Watson PA, Reusch JE, McCune SA, Leinwand LA, Luckey SW, Konhilas JP, Brown DA, Chicco AJ, Sparagna GC, Long CS, Moore RL. Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H246-59. PMID: 17337597.
      View in: PubMed
    16. Sridhar A, Dech SJ, Lacombe VA, Elton TS, McCune SA, Altschuld RA, Carnes CA. Abnormal diastolic currents in ventricular myocytes from spontaneous hypertensive heart failure rats. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2192-8. PMID: 16766638.
      View in: PubMed
    17. Emter CA, McCune SA, Sparagna GC, Radin MJ, Moore RL. Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats. Am J Physiol Heart Circ Physiol. 2005 Nov; 289(5):H2030-8. PMID: 15994855.
      View in: PubMed
    18. Sparagna GC, Johnson CA, McCune SA, Moore RL, Murphy RC. Quantitation of cardiolipin molecular species in spontaneously hypertensive heart failure rats using electrospray ionization mass spectrometry. J Lipid Res. 2005 Jun; 46(6):1196-204. PMID: 15772420.
      View in: PubMed
    19. Sharkey LC, Kirchain S, McCune SA, Simpson GI, Archambault EZ, Boatright NK, Hicks E, Fray J. Progesterone increases blood pressure in spontaneous gestational hypertension in rats. Am J Hypertens. 2005 Jan; 18(1):36-43. PMID: 15691615.
      View in: PubMed
    20. Park SC, Liu-Stratton Y, Medeiros LC, McCune SA, Radin MJ. Effect of male sex and obesity on platelet arachidonic acid in spontaneous hypertensive heart failure rats. Exp Biol Med (Maywood). 2004 Jul; 229(7):657-64. PMID: 15229360.
      View in: PubMed
    21. Kögler H, Fraser H, McCune S, Altschuld R, Marbán E. Disproportionate enhancement of myocardial contractility by the xanthine oxidase inhibitor oxypurinol in failing rat myocardium. Cardiovasc Res. 2003 Sep 01; 59(3):582-92. PMID: 14499859.
      View in: PubMed
    22. Kambara A, Holycross BJ, Wung P, Schanbacher B, Ghosh S, McCune SA, Bauer JA, Kwiatkowski P. Combined effects of low-dose oral spironolactone and captopril therapy in a rat model of spontaneous hypertension and heart failure. J Cardiovasc Pharmacol. 2003 Jun; 41(6):830-7. PMID: 12775959.
      View in: PubMed
    23. Meyers MB, Fischer A, Sun YJ, Lopes CM, Rohacs T, Nakamura TY, Zhou YY, Lee PC, Altschuld RA, McCune SA, Coetzee WA, Fishman GI. Sorcin regulates excitation-contraction coupling in the heart. J Biol Chem. 2003 Aug 01; 278(31):28865-71. PMID: 12754254.
      View in: PubMed
    24. Radin MJ, Holycross BJ, Hoepf TM, McCune SA. Increased salt sensitivity secondary to leptin resistance in SHHF rats is mediated by endothelin. Mol Cell Biochem. 2003 Jan; 242(1-2):57-63. PMID: 12619866.
      View in: PubMed
    25. Dumitrescu C, Narayan P, Efimov IR, Cheng Y, Radin MJ, McCune SA, Altschuld RA. Mechanical alternans and restitution in failing SHHF rat left ventricles. Am J Physiol Heart Circ Physiol. 2002 Apr; 282(4):H1320-6. PMID: 11893567.
      View in: PubMed
    26. Radin MJ, Holycross BJ, Sharkey LC, Shiry L, McCune SA. Gender modulates activation of renin-angiotensin and endothelin systems in hypertension and heart failure. J Appl Physiol (1985). 2002 Mar; 92(3):935-40. PMID: 11842023.
      View in: PubMed
    27. Tamura T, Said S, Andersen SM, McCune SA, Mochizuki S, Gerdes AM. Temporal regression of myocyte hypertrophy in hypertensive, heart failure-prone rats treated with an AT1-receptor antagonist. J Card Fail. 2002 Feb; 8(1):43-7. PMID: 11862582.
      View in: PubMed
    28. Medeiros DM, Velleman SG, Jarrold BB, Shiry LJ, Radin MJ, McCune SA. Ontogeny of enhanced decorin levels and distribution within myocardium of failing hearts. Connect Tissue Res. 2002; 43(1):32-43. PMID: 12180266.
      View in: PubMed
    29. Sharkey LC, McCune SA, Yuan O, Lange C, Fray J. Spontaneous pregnancy-induced hypertension and intrauterine growth restriction in rats. Am J Hypertens. 2001 Oct; 14(10):1058-66. PMID: 11710786.
      View in: PubMed
    30. Sharkey LC, Holycross BJ, McCune SA, Radin MJ. Obese female SHHF/Mcc-fa(cp) rats resist antihypertensive effects of renin-angiotensin system inhibition. Clin Exp Hypertens. 2001 Apr; 23(3):227-39. PMID: 11339689.
      View in: PubMed
    31. Chiasera JM, Ward-Cook KM, McCune SA, Wardlaw GM. Effect of aerobic training on diabetic nephropathy in a rat model of type 2 diabetes mellitus. Ann Clin Lab Sci. 2000 Oct; 30(4):346-53. PMID: 11045758.
      View in: PubMed
    32. Bergman MR, Kao RH, McCune SA, Holycross BJ. Myocardial tumor necrosis factor-alpha secretion in hypertensive and heart failure-prone rats. Am J Physiol. 1999 Aug; 277(2 Pt 2):H543-50. PMID: 10444479.
      View in: PubMed
    33. Sharkey LC, Holycross BJ, Park S, Shiry LJ, Hoepf TM, McCune SA, Radin MJ. Effect of ovariectomy and estrogen replacement on cardiovascular disease in heart failure-prone SHHF/Mcc- fa cp rats. J Mol Cell Cardiol. 1999 Aug; 31(8):1527-37. PMID: 10423350.
      View in: PubMed
    34. Park SC, Radin MJ, Hoepf T, McCune SA. Comparison of verapamil and felodipine treatment on lipid and glucose metabolism in obese female SHHF/Mcc-facp rats. Proc Soc Exp Biol Med. 1999 Jul; 221(3):224-33. PMID: 10404040.
      View in: PubMed
    35. Pérez NG, Hashimoto K, McCune S, Altschuld RA, Marbán E. Origin of contractile dysfunction in heart failure: calcium cycling versus myofilaments. Circulation. 1999 Mar 02; 99(8):1077-83. PMID: 10051303.
      View in: PubMed
    36. Carraway JW, Park S, McCune SA, Holycross BJ, Radin MJ. Comparison of irbesartan with captopril effects on cardiac hypertrophy and gene expression in heart failure-prone male SHHF/Mcc-fa(cp) rats. J Cardiovasc Pharmacol. 1999 Mar; 33(3):451-60. PMID: 10069682.
      View in: PubMed
    37. Shiry LJ, Medeiros DM, Bonagura JD, McCune SA. Heart murmurs, valvular regurgitation and electrical disturbances in copper-deficient genetically hypertensive, hypertrophic cardiomyopathic rats. J Am Coll Nutr. 1999 Feb; 18(1):51-60. PMID: 10067659.
      View in: PubMed
    38. Sharkey LC, Holycross BJ, Park S, McCune SA, Hoversland R, Radin MJ. Effect of ovariectomy in heart failure-prone SHHF/Mcc-facp rats. Am J Physiol. 1998 Dec; 275(6 Pt 2):R1968-76. PMID: 9843886.
      View in: PubMed
    39. Onodera T, Tamura T, Said S, McCune SA, Gerdes AM. Maladaptive remodeling of cardiac myocyte shape begins long before failure in hypertension. Hypertension. 1998 Oct; 32(4):753-7. PMID: 9774375.
      View in: PubMed
    40. Kim SH, Chu YK, Kwon OW, McCune SA, Davidorf FH. Morphologic studies of the retina in a new diabetic model; SHR/N:Mcc-cp rat. Yonsei Med J. 1998 Oct; 39(5):453-62. PMID: 9821795.
      View in: PubMed
    41. Michael O'Donnell J, Narayan P, Bailey MQ, Abduljalil AM, Altschuld RA, McCune SA, Robitaille PM. 31P-NMR analysis of congestive heart failure in the SHHF/Mcc-facp rat heart. J Mol Cell Cardiol. 1998 Feb; 30(2):235-41. PMID: 9515000.
      View in: PubMed
    42. Peters DG, Mitchell HL, McCune SA, Park S, Williams JH, Kandarian SC. Skeletal muscle sarcoplasmic reticulum Ca(2+)-ATPase gene expression in congestive heart failure. Circ Res. 1997 Nov; 81(5):703-10. PMID: 9351444.
      View in: PubMed
    43. Holycross BJ, Summers BM, Dunn RB, McCune SA. Plasma renin activity in heart failure-prone SHHF/Mcc-facp rats. Am J Physiol. 1997 Jul; 273(1 Pt 2):H228-33. PMID: 9249494.
      View in: PubMed
    44. Park S, McCune SA, Radin MJ, Hoepf TM, Hensley J, Hohl CM, Altschuld RA. Verapamil accelerates the transition to heart failure in obese, hypertensive, female SHHF/Mcc-fa(cp) rats. J Cardiovasc Pharmacol. 1997 Jun; 29(6):726-33. PMID: 9234652.
      View in: PubMed
    45. Gómez AM, Valdivia HH, Cheng H, Lederer MR, Santana LF, Cannell MB, McCune SA, Altschuld RA, Lederer WJ. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science. 1997 May 02; 276(5313):800-6. PMID: 9115206.
      View in: PubMed
    46. Friedman JE, Ferrara CM, Aulak KS, Hatzoglou M, McCune SA, Park S, Sherman WM. Exercise training down-regulates ob gene expression in the genetically obese SHHF/Mcc-fa(cp) rat. Horm Metab Res. 1997 May; 29(5):214-9. PMID: 9228205.
      View in: PubMed
    47. Sack MN, Rader TA, Park S, Bastin J, McCune SA, Kelly DP. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation. 1996 Dec 01; 94(11):2837-42. PMID: 8941110.
      View in: PubMed
    48. Gerdes AM, Onodera T, Wang X, McCune SA. Myocyte remodeling during the progression to failure in rats with hypertension. Hypertension. 1996 Oct; 28(4):609-14. PMID: 8843886.
      View in: PubMed
    49. Ferrara CM, Sherman WM, Leenders N, McCune SA, Roehrig K. Exercise training and the glucose transport system in obese SHHF/Mcc-fa(cp) rats. J Appl Physiol (1985). 1996 Oct; 81(4):1670-6. PMID: 8904585.
      View in: PubMed
    50. Haas GJ, McCune SA, Brown DM, Cody RJ. Echocardiographic characterization of left ventricular adaptation in a genetically determined heart failure rat model. Am Heart J. 1995 Oct; 130(4):806-11. PMID: 7572590.
      View in: PubMed
    51. Meier DA, Hennes MM, McCune SA, Kissebah AH. Effects of obesity and gender on insulin receptor expression in liver of SHHF/Mcc-FAcp rats. Obes Res. 1995 Sep; 3(5):465-70. PMID: 8521166.
      View in: PubMed
    52. Liao Z, Medeiros DM, McCune SA, Prochaska LJ. Cardiac levels of fibronectin, laminin, isomyosins, and cytochrome c oxidase of weanling rats are more vulnerable to copper deficiency than those of postweanling rats. J Nutr Biochem. 1995 Jul; 6(7):385-391. PMID: 12050000.
      View in: PubMed
    53. Liao Z, Allred J, Keen CL, McCune SA, Rucker RB, Medeiros DM. Copper deficiency alters isomyosin types and levels of laminin, fibronectin and cytochrome c oxidase subunits from rat hearts. Comp Biochem Physiol B Biochem Mol Biol. 1995 May; 111(1):61-7. PMID: 7749637.
      View in: PubMed
    54. Narayan P, McCune SA, Robitaille PM, Hohl CM, Altschuld RA. Mechanical alternans and the force-frequency relationship in failing rat hearts. J Mol Cell Cardiol. 1995 Jan; 27(1):523-30. PMID: 7760372.
      View in: PubMed
    55. De Sevilla L, McCune SA, White ME. Insulin-like growth factor mRNA expression in tissues of lean and obese male SHFF/Mcc-fa(cp) rats. Comp Biochem Physiol B Biochem Mol Biol. 1994 Oct-Nov; 109(2-3):371-82. PMID: 7553350.
      View in: PubMed
    56. Gao J, Sherman WM, McCune SA, Osei K. Effects of acute running exercise on whole body insulin action in obese male SHHF/Mcc-facp rats. J Appl Physiol (1985). 1994 Aug; 77(2):534-41. PMID: 8002497.
      View in: PubMed
    57. Radin MJ, Chu YY, Hoepf TM, McCune SA. Treatment of obese female and male SHHF/Mcc-fa(cp) rats with antihypertensive drugs, nifedipine and enalapril: effects on body weight, fat distribution, insulin resistance and systolic pressure. Obes Res. 1993 Nov; 1(6):433-42. PMID: 16350319.
      View in: PubMed
    58. Radin MJ, McCune SA. The effect of atrial natriuretic peptide infusion on renal haemodynamics and plasma lipoproteins in puromycin aminonucleoside nephrosis in rats. Clin Exp Pharmacol Physiol. 1993 Apr; 20(4):245-51. PMID: 8485924.
      View in: PubMed
    59. Pocchiari RJ, Hamlin RL, McCune SA. Electrocardiographic findings in rats with cardiomyopathy. Am J Vet Res. 1993 Apr; 54(4):607-11. PMID: 8484582.
      View in: PubMed
    60. Hohl CM, Hu B, Fertel RH, Russell JC, McCune SA, Altschuld RA. Effects of obesity and hypertension on ventricular myocytes: comparison of cells from adult SHHF/Mcc-cp and JCR:LA-cp rats. Cardiovasc Res. 1993 Feb; 27(2):238-42. PMID: 8386063.
      View in: PubMed
    61. Radin MJ, Jenkins JE, McCune SA, Jurin RR, Hamlin RL. Effects of enalapril and clonidine on glomerular structure, function, and atrial natriuretic peptide receptors in SHHF/Mcc-cp rats. J Cardiovasc Pharmacol. 1992 Mar; 19(3):464-72. PMID: 1378131.
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    62. Hennes MM, McCune SA, Shrago E, Kissebah AH. Synergistic effects of male sex and obesity on hepatic insulin dynamics in SHR/Mcc-cp rat. Diabetes. 1990 Jul; 39(7):789-95. PMID: 2191885.
      View in: PubMed
    63. McCune S, Short BL, Miller MK, Lotze A, Anderson KD. Extracorporeal membrane oxygenation therapy in neonates with septic shock. J Pediatr Surg. 1990 May; 25(5):479-82. PMID: 2352078.
      View in: PubMed
    64. McCune SA, Foe LG, Kemp RG, Jurin RR. Aurintricarboxylic acid is a potent inhibitor of phosphofructokinase. Biochem J. 1989 May 01; 259(3):925-7. PMID: 2525029; PMCID: PMC1138608.
    65. Allred JB, Roman-Lopez CR, Jurin RR, McCune SA. Mitochondrial storage forms of acetyl CoA carboxylase: mobilization/activation accounts for increased activity of the enzyme in liver of genetically obese Zucker rats. J Nutr. 1989 Mar; 119(3):478-83. PMID: 2564046.
      View in: PubMed
    66. McCune SA. Cardiovascular disease in genotypes for obesity and diabetes. Nutrition. 1989 Jan-Feb; 5(1):52-5. PMID: 2520259.
      View in: PubMed
    67. McCune SA, Durant PJ, Jenkins PA, Harris RA. Comparative studies on fatty acid synthesis, glycogen metabolism, and gluconeogenesis by hepatocytes isolated from lean and obese Zucker rats. Metabolism. 1981 Dec; 30(12):1170-8. PMID: 6273686.
      View in: PubMed
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