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Subbiah Pugazhenthi

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/399-8020

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pugazhenthi S. Metabolic Syndrome and the Cellular Phase of Alzheimer's Disease. Prog Mol Biol Transl Sci. 2017; 146:243-258. PMID: 28253987.
      View in: PubMed
    2. Goalstone ML, Pugazhenthi S. Editorial: Molecular Mechanism of Neuronal Dysfunction in the Diabetic Brain. Front Endocrinol (Lausanne). 2016; 7:45. PMID: 27242668.
      View in: PubMed
    3. Pugazhenthi S, Qin L, Reddy PH. Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease. Biochim Biophys Acta. 2016 May 06. PMID: 27156888.
      View in: PubMed
    4. Qin L, Bouchard R, Pugazhenthi S. Regulation of cyclic AMP response element-binding protein during neuroglial interactions. J Neurochem. 2016 Mar; 136(5):918-30. PMID: 26677139.
      View in: PubMed
    5. Qin L, Chong T, Rodriguez R, Pugazhenthi S. Glucagon-Like Peptide-1-Mediated Modulation of Inflammatory Pathways in the Diabetic Brain: Relevance to Alzheimer's Disease. Curr Alzheimer Res. 2016; 13(12):1346-1355. PMID: 27033055.
      View in: PubMed
    6. Pugazhenthi S, Qin L, Bouchard R. Dipeptidyl peptidase-4 inhibition in diabetic rats leads to activation of the transcription factor CREB in ß-cells. Eur J Pharmacol. 2015 May 15; 755:42-9. PMID: 25720341.
      View in: PubMed
    7. Geary K, Knaub LA, Schauer IE, Keller AC, Watson PA, Miller MW, Garat CV, Nadeau KJ, Cree-Green M, Pugazhenthi S, Regensteiner JG, Klemm DJ, Reusch JE. Targeting mitochondria to restore failed adaptation to exercise in diabetes. Biochem Soc Trans. 2014 Apr; 42(2):231-8. PMID: 24646223.
      View in: PubMed
    8. Bouchard R, Chong T, Pugazhenthi S. Laser capture microdissection of neurons from differentiated human neuroprogenitor cells in culture. J Vis Exp. 2013 Sep 16; (79):e50487. PMID: 24084642.
      View in: PubMed
    9. Pugazhenthi S, Zhang Y, Bouchard R, Mahaffey G. Induction of an inflammatory loop by interleukin-1ß and tumor necrosis factor-a involves NF-kB and STAT-1 in differentiated human neuroprogenitor cells. PLoS One. 2013; 8(7):e69585. PMID: 23922745.
      View in: PubMed
    10. Balamurugan AN, Kumaravel V, Pugazhenthi S, Naziruddin B. Islet cell biology, regeneration, and transplantation. Int J Endocrinol. 2012; 2012:139787. PMID: 23326263.
      View in: PubMed
    11. Velmurugan K, Bouchard R, Mahaffey G, Pugazhenthi S. Neuroprotective actions of glucagon-like peptide-1 in differentiated human neuroprogenitor cells. J Neurochem. 2012 Dec; 123(6):919-31. PMID: 23020846.
      View in: PubMed
    12. Wang M, Crager M, Pugazhenthi S. Modulation of apoptosis pathways by oxidative stress and autophagy in ß cells. Exp Diabetes Res. 2012; 2012:647914. PMID: 22474427.
      View in: PubMed
    13. Velmurugan K, Balamurugan AN, Loganathan G, Ahmad A, Hering BJ, Pugazhenthi S. Antiapoptotic actions of exendin-4 against hypoxia and cytokines are augmented by CREB. Endocrinology. 2012 Mar; 153(3):1116-28. PMID: 22253425.
      View in: PubMed
    14. Loganathan G, Dawra RK, Pugazhenthi S, Guo Z, Soltani SM, Wiseman A, Sanders MA, Papas KK, Velayutham K, Saluja AK, Sutherland DE, Hering BJ, Balamurugan AN. Insulin degradation by acinar cell proteases creates a dysfunctional environment for human islets before/after transplantation: benefits of a-1 antitrypsin treatment. Transplantation. 2011 Dec 15; 92(11):1222-30. PMID: 22089666.
      View in: PubMed
    15. Pugazhenthi S, Wang M, Pham S, Sze CI, Eckman CB. Downregulation of CREB expression in Alzheimer's brain and in Aß-treated rat hippocampal neurons. Mol Neurodegener. 2011 Aug 19; 6:60. PMID: 21854604.
      View in: PubMed
    16. Gilden D, Mahalingam R, Nagel MA, Pugazhenthi S, Cohrs RJ. Review: The neurobiology of varicella zoster virus infection. Neuropathol Appl Neurobiol. 2011 Aug; 37(5):441-63. PMID: 21342215.
      View in: PubMed
    17. Kachadourian R, Pugazhenthi S, Velmurugan K, Backos DS, Franklin CC, McCord JM, Day BJ. 2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways. Free Radic Biol Med. 2011 Sep 15; 51(6):1146-54. PMID: 21712085.
      View in: PubMed
    18. Pugazhenthi S, Nair S, Velmurugan K, Liang Q, Mahalingam R, Cohrs RJ, Nagel MA, Gilden D. Varicella-zoster virus infection of differentiated human neural stem cells. J Virol. 2011 Jul; 85(13):6678-86. PMID: 21525352.
      View in: PubMed
    19. Brazeau E, Wellish M, Kaufer BB, Tischer BK, Gray W, Zhou F, Osterrieder N, Hanlon T, Golive A, Hall T, Nair S, Owens GP, Mueller NH, Cohrs RJ, Pugazhenthi S, Gilden D, Mahalingam R. Simian varicella virus open reading frame 63/70 expression is required for efficient virus replication in culture. J Neurovirol. 2011 Jun; 17(3):274-80. PMID: 21479719.
      View in: PubMed
    20. Pugazhenthi U, Velmurugan K, Tran A, Mahaffey G, Pugazhenthi S. Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients. Diabetologia. 2010 Nov; 53(11):2357-68. PMID: 20635178.
      View in: PubMed
    21. Loganathan G, Dawra RK, Pugazhenthi S, Wiseman AC, Sanders MA, Saluja AK, Sutherland DE, Hering BJ, Balamurugan AN. Culture of impure human islet fractions in the presence of alpha-1 antitrypsin prevents insulin cleavage and improves islet recovery. Transplant Proc. 2010 Jul-Aug; 42(6):2055-7. PMID: 20692406.
      View in: PubMed
    22. Brazeau E, Mahalingam R, Gilden D, Wellish M, Kaufer BB, Osterrieder N, Pugazhenthi S. Varicella-zoster virus-induced apoptosis in MeWo cells is accompanied by down-regulation of Bcl-2 expression. J Neurovirol. 2010 Mar; 16(2):133-40. PMID: 20345323.
      View in: PubMed
    23. Li MY, Lai FJ, Hsu LJ, Lo CP, Cheng CL, Lin SR, Lee MH, Chang JY, Subhan D, Tsai MS, Sze CI, Pugazhenthi S, Chang NS, Chen ST. Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats. PLoS One. 2009 Nov 12; 4(11):e7820. PMID: 19918364.
      View in: PubMed
    24. Son KN, Pugazhenthi S, Lipton HL. Activation of tumor suppressor protein p53 is required for Theiler's murine encephalomyelitis virus-induced apoptosis in M1-D macrophages. J Virol. 2009 Oct; 83(20):10770-7. PMID: 19656889.
      View in: PubMed
    25. Pugazhenthi S, Gilden DH, Nair S, McAdoo A, Wellish M, Brazeau E, Mahalingam R. Simian varicella virus induces apoptosis in monkey kidney cells by the intrinsic pathway and involves downregulation of bcl-2 expression. J Virol. 2009 Sep; 83(18):9273-82. PMID: 19605493.
      View in: PubMed
    26. Balamurugan AN, Akhov L, Selvaraj G, Pugazhenthi S. Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation. Pancreas. 2009 May; 38(4):454-60. PMID: 19188863.
      View in: PubMed
    27. Sarkar SA, Kutlu B, Velmurugan K, Kizaka-Kondoh S, Lee CE, Wong R, Valentine A, Davidson HW, Hutton JC, Pugazhenthi S. Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line. Diabetologia. 2009 Jun; 52(6):1092-101. PMID: 19343319.
      View in: PubMed
    28. Gilden D, Nagel MA, Mahalingam R, Mueller NH, Brazeau EA, Pugazhenthi S, Cohrs RJ. Clinical and molecular aspects of varicella zoster virus infection. Future Neurol. 2009 Jan 01; 4(1):103-117. PMID: 19946620.
      View in: PubMed
    29. Velmurugan K, Alam J, McCord JM, Pugazhenthi S. Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim. Free Radic Biol Med. 2009 Feb 01; 46(3):430-40. PMID: 19056485.
      View in: PubMed
    30. Sivam SP, Pugazhenthi S, Pugazhenthi V, Brown H. L-DOPA-induced activation of striatal p38MAPK and CREB in neonatal dopaminergic denervated rat: relevance to self-injurious behavior. J Neurosci Res. 2008 Feb 01; 86(2):339-49. PMID: 17893915.
      View in: PubMed
    31. Sarkar SA, Gunter J, Bouchard R, Reusch JE, Wiseman A, Gill RG, Hutton JC, Pugazhenthi S. Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets. Diabetologia. 2007 Aug; 50(8):1649-59. PMID: 17593347.
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    32. Pugazhenthi S, Akhov L, Selvaraj G, Wang M, Alam J. Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells. Am J Physiol Endocrinol Metab. 2007 Sep; 293(3):E645-55. PMID: 17535857.
      View in: PubMed
    33. Mahalingam R, Gilden DH, Wellish M, Pugazhenthi S. Transactivation of the simian varicella virus (SVV) open reading frame (ORF) 21 promoter by SVV ORF 62 is upregulated in neuronal cells but downregulated in non-neuronal cells by SVV ORF 63 protein. Virology. 2006 Feb 05; 345(1):244-50. PMID: 16242745.
      View in: PubMed
    34. Pugazhenthi S, Phansalkar K, Audesirk G, West A, Cabell L. Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal. Free Radic Biol Med. 2006 Jan 01; 40(1):21-34. PMID: 16337876.
      View in: PubMed
    35. Sze CI, Su M, Pugazhenthi S, Jambal P, Hsu LJ, Heath J, Schultz L, Chang NS. Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease. J Biol Chem. 2004 Jul 16; 279(29):30498-506. PMID: 15126504.
      View in: PubMed
    36. Haskins K, Kench J, Powers K, Bradley B, Pugazhenthi S, Reusch J, McDuffie M. Role for oxidative stress in the regeneration of islet beta cells? J Investig Med. 2004 Jan; 52(1):45-9. PMID: 14989369.
      View in: PubMed
    37. Haskins K, Bradley B, Powers K, Fadok V, Flores S, Ling X, Pugazhenthi S, Reusch J, Kench J. Oxidative stress in type 1 diabetes. Ann N Y Acad Sci. 2003 Nov; 1005:43-54. PMID: 14679039.
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    38. Vaishnav D, Jambal P, Reusch JE, Pugazhenthi S. SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway. Biochem Biophys Res Commun. 2003 Aug 08; 307(4):855-60. PMID: 12878189.
      View in: PubMed
    39. Jambal P, Masterson S, Nesterova A, Bouchard R, Bergman B, Hutton JC, Boxer LM, Reusch JE, Pugazhenthi S. Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells. J Biol Chem. 2003 Jun 20; 278(25):23055-65. PMID: 12679364.
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    40. Pugazhenthi S, Nesterova A, Jambal P, Audesirk G, Kern M, Cabell L, Eves E, Rosner MR, Boxer LM, Reusch JE. Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons. J Neurochem. 2003 Mar; 84(5):982-96. PMID: 12603823.
      View in: PubMed
    41. Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE, Reusch JE. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem. 2000 Apr 14; 275(15):10761-6. PMID: 10753867.
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    42. Pugazhenthi S, Miller E, Sable C, Young P, Heidenreich KA, Boxer LM, Reusch JE. Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein. J Biol Chem. 1999 Sep 24; 274(39):27529-35. PMID: 10488088.
      View in: PubMed
    43. Pugazhenthi S, Boras T, O'Connor D, Meintzer MK, Heidenreich KA, Reusch JE. Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway. J Biol Chem. 1999 Jan 29; 274(5):2829-37. PMID: 9915817.
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    44. Pugazhenthi S, Khandelwal RL. Insulin action on protein phosphatase-1 activation is enhanced by the antidiabetic agent pioglitazone in cultured diabetic hepatocytes. Mol Cell Biochem. 1998 May; 182(1-2):185-91. PMID: 9609128.
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    45. Pugazhenthi S, Tanha F, Dahl B, Khandelwal RL. Inhibition of a Src homology 2 domain containing protein tyrosine phosphatase by vanadate in the primary culture of hepatocytes. Arch Biochem Biophys. 1996 Nov 15; 335(2):273-82. PMID: 8914924.
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    46. Rao PV, Pugazhenthi S, Khandelwal RL. Insulin decreases the glycogen synthase kinase-3 alpha mRNA levels by altering its stability in streptozotocin-induced diabetic rat liver. Biochem Biophys Res Commun. 1995 Dec 05; 217(1):250-6. PMID: 8526919.
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    47. King MJ, Pugazhenthi S, Khandelwal RL, Sharma RK. In vivo modulation of N-myristoyltransferase activity by orthovanadate. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):151-5. PMID: 8927031.
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    48. Pugazhenthi S, Tanha F, Dahl B, Khandelwal RL. Decrease in protein tyrosine phosphatase activities in vanadate-treated obese Zucker (fa/fa) rat liver. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):125-9. PMID: 8927027.
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    49. Khandelwal RL, Pugazhenthi S. In vivo effects of vanadate on hepatic glycogen metabolizing and lipogenic enzymes in insulin-dependent and insulin-resistant diabetic animals. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):87-94. PMID: 8927052.
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    50. Pugazhenthi S, Hussain A, Yu B, Brownsey RW, Angel JF, Khandelwal RL. Vanadate induces normolipidemia and a reduction in the levels of hepatic lipogenic enzymes in obese Zucker rat. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):211-5. PMID: 8927041.
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    51. Rao PV, Pugazhenthi S, Khandelwal RL. The effects of streptozotocin-induced diabetes and insulin supplementation on expression of the glycogen phosphorylase gene in rat liver. J Biol Chem. 1995 Oct 20; 270(42):24955-60. PMID: 7559622.
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    52. Pugazhenthi S, Khandelwal RL. Regulation of glycogen synthase activation in isolated hepatocytes. Mol Cell Biochem. 1995 Aug-Sep; 149-150:95-101. PMID: 8569754.
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    53. Yu B, Pugazhenthi S, Khandelwal RL. Effects of metformin on glucose and glucagon regulated gluconeogenesis in cultured normal and diabetic hepatocytes. Biochem Pharmacol. 1994 Aug 30; 48(5):949-54. PMID: 8093107.
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    54. Pugazhenthi S, Yu B, Gali RR, Khandelwal RL. Differential effects of calyculin A and okadaic acid on the glucose-induced regulation of glycogen synthase and phosphorylase activities in cultured hepatocytes. Biochim Biophys Acta. 1993 Nov 24; 1179(3):271-6. PMID: 8218371.
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    55. Pugazhenthi S, Khandelwal RL. Does the insulin-mimetic action of vanadate involve insulin receptor kinase? Mol Cell Biochem. 1993 Nov; 127-128:211-8. PMID: 7523848.
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    56. Gali RR, Pugazhenthi S, Khandelwal RL. Reciprocal effects of the protein kinase C inhibitors staurosporine and H-7 on the regulation of glycogen synthase and phosphorylase in the primary culture of hepatocytes. Metabolism. 1993 Nov; 42(11):1475-80. PMID: 8231844.
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    57. King MJ, Pugazhenthi S, Khandelwal RL, Sharma RK. Membrane-associated N-myristoyltransferase activity is reduced in obese (fa/fa) Zucker rat liver. Biochem Biophys Res Commun. 1993 Oct 29; 196(2):665-70. PMID: 8240341.
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    58. Pugazhenthi S, Angel JF, Khandelwal RL. Effects of high sucrose diet on insulin-like effects of vanadate in diabetic rats. Mol Cell Biochem. 1993 May 12; 122(1):77-84. PMID: 8350867.
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    59. Pugazhenthi S, Angel JF, Khandelwal RL. Effects of vanadate administration on the high sucrose diet-induced aberrations in normal rats. Mol Cell Biochem. 1993 May 12; 122(1):69-75. PMID: 8350866.
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    60. King MJ, Pugazhenthi S, Khandelwal RL, Sharma RK. Elevated N-myristoyl transferase activity is reversed by sodium orthovanadate in streptozotocin-induced diabetic rat. Biochim Biophys Acta. 1993 Jan 10; 1165(3):259-62. PMID: 8418883.
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    61. Pugazhenthi S, Khandelwal RL. Vanadate increases protein kinase C-induced phosphorylation of endogenous proteins of liver in vitro. Biochem Int. 1992 Feb; 26(2):241-7. PMID: 1558536.
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    62. Pugazhenthi S, Angel JF, Khandelwal RL. Long-term effects of vanadate treatment on glycogen metabolizing and lipogenic enzymes of liver in genetically diabetic (db/db) mice. Metabolism. 1991 Sep; 40(9):941-6. PMID: 1910143.
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    63. Pugazhenthi S, Khandelwal RL, Angel JF. Insulin-like effect of vanadate on malic enzyme and glucose-6-phosphate dehydrogenase activities in streptozotocin-induced diabetic rat liver. Biochim Biophys Acta. 1991 Jun 03; 1083(3):310-2. PMID: 2049397.
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    64. Pugazhenthi S, Khandelwal RL. Kinases and phosphatases of hepatic glycogen metabolism during fasted to refed transition in normal and streptozotocin-induced diabetic rats. Biochem Int. 1991 Feb; 23(3):515-24. PMID: 1652246.
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    65. Pugazhenthi S, Khandelwal RL. Insulinlike effects of vanadate on hepatic glycogen metabolism in nondiabetic and streptozocin-induced diabetic rats. Diabetes. 1990 Jul; 39(7):821-7. PMID: 2113014.
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    66. Roesler WJ, Pugazhenthi S, Khandelwal RL. Hepatic glycogen metabolism in the db/db mouse. Mol Cell Biochem. 1990 Feb 09; 92(2):99-106. PMID: 2407941.
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    67. Pugazhenthi S, Mantha SV, Khandelwal RL. Inhibitory effect of H-7, H-8 and polymyxin B on liver protein kinase C-induced phosphorylation of endogenous substrates. Biochem Int. 1990; 20(5):941-8. PMID: 2161662.
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    68. Pugazhenthi S, Mantha SV, Khandelwal RL. Decrease of liver protein kinase C in streptozotocin-induced diabetic rats and restoration by vanadate treatment. Biochem Int. 1990; 21(4):651-7. PMID: 2241991.
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    69. Babu BV, Moorti R, Pugazhenthi S, Prabhu KM, Murthy PS. Alloxan recovered rabbits as animal model for screening for hypoglycaemic activity of compounds. Indian J Biochem Biophys. 1988 Dec; 25(6):714-8. PMID: 3255686.
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