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Ronald G Gill

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-SRG
Phone303/724-5321

    Collapse Research 
    Collapse research activities and funding
    R01DK033470     (GILL, RONALD G)Apr 1, 1984 - Jan 31, 2007
    NIH/NIDDK
    Reversal of Diabetes by Islet Transplantation
    Role: Principal Investigator

    R01DK045773     (GILL, RONALD G)Jan 1, 1993 - Dec 31, 2006
    NIH/NIDDK
    Immunobiology of Pancreatic Islet Xenografting
    Role: Principal Investigator

    R01DK055333     (GILL, RONALD G)Sep 30, 1998 - Aug 31, 2006
    NIH/NIDDK
    T cell mediated injury to islet allografts
    Role: Principal Investigator

    R21DK058873     (GILL, RONALD G)Feb 1, 2001 - Jan 31, 2004
    NIH/NIDDK
    GENERATING OF ALLOREACTIVE CD4+T TRANSGENIC MICE
    Role: Principal Investigator

    U42RR016599     (GILL, RONALD G)Sep 30, 2001 - Aug 31, 2007
    NIH/NCRR
    ISLET CELL RESOURCES (ICR) FAC AT THE UNIVERSITY OF *
    Role: Principal Investigator

    R21AI060349     (GILL, RONALD G)Sep 30, 2003 - Feb 28, 2006
    NIH/NIAID
    Correcting dysregulated peripheral tolerance in NOD mice
    Role: Principal Investigator

    R01DK099187     (GILL, RONALD G)Jul 1, 2014 - Jun 30, 2017
    NIH/NIDDK
    Islet transplantation in autoimmune diabetes
    Role: Principal Investigator

    UC4DK104223     (GILL, RONALD G)Sep 30, 2014 - Jun 30, 2019
    NIH/NIDDK
    Analysis of human autoreactive T cell receptors in vivo
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nelsen MK, Beard KS, Plenter RJ, Kedl RM, Clambey ET, Gill RG. Disruption of Transplant Tolerance by an "Incognito" Form of CD8 T Cell-Dependent Memory. Am J Transplant. 2017 Jul; 17(7):1742-1753. PMID: 28066981.
      View in: PubMed
    2. Bishop NH, Nelsen MK, Beard KS, Coulombe M, Gill RG. Differential Impact of Chronic Hyperglycemia on Humoral Versus Cellular Primary Alloimmunity. Diabetes. 2017 Apr; 66(4):981-986. PMID: 28069641.
      View in: PubMed
    3. Lin CM, Plenter RJ, Coulombe M, Gill RG. Interferon Gamma and Contact-dependent Cytotoxicity Are Each Rate Limiting for Natural Killer Cell-Mediated Antibody-dependent Chronic Rejection. Am J Transplant. 2016 Nov; 16(11):3121-3130. PMID: 27163757.
      View in: PubMed
    4. Lin CM, Gill RG. Direct and indirect allograft recognition: pathways dictating graft rejection mechanisms. Curr Opin Organ Transplant. 2016 Feb; 21(1):40-4. PMID: 26575853; PMCID: PMC4701596 [Available on 02/01/17].
    5. Gill RG, Pagni PP, Kupfer T, Wasserfall CH, Deng S, Posgai A, Manenkova Y, Bel Hani A, Straub L, Bernstein P, Atkinson MA, Herold KC, von Herrath M, Staeva T, Ehlers MR, Nepom GT. A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice. Diabetes. 2016 May; 65(5):1310-6. PMID: 26718498.
      View in: PubMed
    6. Arefanian H, Tredget EB, Mok DC, Ramji Q, Rafati S, Rodriguez-Barbosa J, Korbutt GS, Rajotte RV, Gill RG, Rayat GR. Porcine Islet-Specific Tolerance Induced by the Combination of Anti-LFA-1 and Anti-CD154 mAbs Is Dependent on PD-1. Cell Transplant. 2016; 25(2):327-42. PMID: 26109574.
      View in: PubMed
    7. Plenter RJ, Grazia TJ, Nelson DP, Zamora MR, Gill RG, Pietra BA. Ectopic expression of Fas Ligand on cardiomyocytes renders cardiac allografts resistant to CD4(+) T-cell mediated rejection. Cell Immunol. 2015 Jan; 293(1):30-3. PMID: 25497973; PMCID: PMC4298462.
    8. Bishop NH, Beard KS, Gill RG. Resistance of spontaneously diabetic Ins2(akita) mice to allograft tolerance induced by anti-CD154 therapy. Transplant Proc. 2014 Jul-Aug; 46(6):2007-9. PMID: 25131095.
      View in: PubMed
    9. Sarikonda G, Sachithanantham S, Manenkova Y, Kupfer T, Posgai A, Wasserfall C, Bernstein P, Straub L, Pagni PP, Schneider D, Calvo TR, Coulombe M, Herold K, Gill RG, Atkinson M, Nepom G, Ehlers M, Staeva T, Garren H, Steinman L, Chan AC, von Herrath M. Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice. PLoS One. 2013; 8(2):e54712. PMID: 23405091; PMCID: PMC3566105.
    10. Stoermer KA, Burrack A, Oko L, Montgomery SA, Borst LB, Gill RG, Morrison TE. Genetic ablation of arginase 1 in macrophages and neutrophils enhances clearance of an arthritogenic alphavirus. J Immunol. 2012 Oct 15; 189(8):4047-59. PMID: 22972923; PMCID: PMC3466331.
    11. Gill RG, Bishop NH. Clinical islet transplantation: where immunity and metabolism intersect? Curr Opin Endocrinol Diabetes Obes. 2012 Aug; 19(4):249-54. PMID: 22647539.
      View in: PubMed
    12. Grazia TJ, Plenter RJ, Lepper HM, Victorino F, Miyamoto SD, Crossno JT, Pietra BA, Gill RG, Zamora MR. Prolongation of cardiac allograft survival by a novel population of autologous CD117+ bone marrow-derived progenitor cells. Am J Transplant. 2011 Jan; 11(1):34-44. PMID: 21114653; PMCID: PMC3059253.
    13. Gill RG. NK cells: elusive participants in transplantation immunity and tolerance. Curr Opin Immunol. 2010 Oct; 22(5):649-54. PMID: 20952173; PMCID: PMC2967580.
    14. Sklavos MM, Bertera S, Tse HM, Bottino R, He J, Beilke JN, Coulombe MG, Gill RG, Crapo JD, Trucco M, Piganelli JD. Redox modulation protects islets from transplant-related injury. Diabetes. 2010 Jul; 59(7):1731-8. PMID: 20413509; PMCID: PMC2889773.
    15. Arefanian H, Tredget EB, Rajotte RV, Gill RG, Korbutt GS, Rayat GR. Short-term administrations of a combination of anti-LFA-1 and anti-CD154 monoclonal antibodies induce tolerance to neonatal porcine islet xenografts in mice. Diabetes. 2010 Apr; 59(4):958-66. PMID: 20086231; PMCID: PMC2844843.
    16. Grazia TJ, Plenter RJ, Weber SM, Lepper HM, Victorino F, Zamora MR, Pietra BA, Gill RG. Acute cardiac allograft rejection by directly cytotoxic CD4 T cells: parallel requirements for Fas and perforin. Transplantation. 2010 Jan 15; 89(1):33-9. PMID: 20061916; PMCID: PMC2939493.
    17. Kupfer T, Beilke JN, Pham K, Buhrman J, Gill RG. "Indirect" acute islet allograft destruction in nonobese diabetic mice is independent of donor major histocompatibility complex and requires host B lymphocytes. Transplant Proc. 2008 Mar; 40(2):462-3. PMID: 18374102.
      View in: PubMed
    18. Tredget EB, Arefanian H, Gill RG, Rajotte RV, Rayat GR. Monotherapy with anti-LFA-1 monoclonal antibody promotes long-term survival of rat islet xenografts. Cell Transplant. 2008; 17(6):599-608. PMID: 18819248.
      View in: PubMed
    19. Beilke JN, Gill RG. Frontiers in nephrology: the varied faces of natural killer cells in transplantation--contributions to both allograft immunity and tolerance. J Am Soc Nephrol. 2007 Aug; 18(8):2262-7. PMID: 17634430.
      View in: PubMed
    20. Nakayama M, Beilke JN, Jasinski JM, Kobayashi M, Miao D, Li M, Coulombe MG, Liu E, Elliott JF, Gill RG, Eisenbarth GS. Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. J Clin Invest. 2007 Jul; 117(7):1835-43. PMID: 17607359; PMCID: PMC1904318.
    21. Grazia TJ, Plenter RJ, Doan AN, Kelly BP, Weber SM, Kurche JS, Cushing SO, Gill RG, Pietra BA. Spontaneous allograft tolerance in B7-deficient mice independent of preexisting endogenous CD4+CD25+ regulatory T-cells. Transplantation. 2007 Jun 15; 83(11):1449-58. PMID: 17565318; PMCID: PMC4427242.
    22. Arefanian H, Tredget EB, Rajotte RV, Korbutt GS, Gill RG, Rayat GR. Combination of anti-CD4 with anti-LFA-1 and anti-CD154 monoclonal antibodies promotes long-term survival and function of neonatal porcine islet xenografts in spontaneously diabetic NOD mice. Cell Transplant. 2007; 16(8):787-98. PMID: 18087999.
      View in: PubMed
    23. Sarkar SA, Wong R, Hackl SI, Moua O, Gill RG, Wiseman A, Davidson HW, Hutton JC. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. Diabetes. 2007 Jan; 56(1):72-9. PMID: 17192467.
      View in: PubMed
    24. Tucker RM, Hendrickson RJ, Mukaida N, Gill RG, Mack CL. Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia. Viral Immunol. 2007; 20(1):34-43. PMID: 17425419; PMCID: PMC1978183.
    25. Mack CL, Tucker RM, Lu BR, Sokol RJ, Fontenot AP, Ueno Y, Gill RG. Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia. Hepatology. 2006 Nov; 44(5):1231-9. PMID: 17058262; PMCID: PMC1948978.
    26. Beilke JN, Kuhl NR, Van Kaer L, Gill RG. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med. 2005 Oct; 11(10):1059-65. PMID: 16155578.
      View in: PubMed
    27. Grazia TJ, Gill RG, Gelhaus HC, Doan AN, Sleater ML, Pietra BA. Perturbation of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 results in differential outcomes in cardiac vs islet allograft survival. J Heart Lung Transplant. 2005 Sep; 24(9):1410-4. PMID: 16143264.
      View in: PubMed
    28. Kupfer TM, Crawford ML, Pham K, Gill RG. MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo. J Immunol. 2005 Aug 15; 175(4):2309-16. PMID: 16081800.
      View in: PubMed
    29. Murakawa T, Kerklo MM, Zamora MR, Wei Y, Gill RG, Henson PM, Grover FL, Nicolls MR. Simultaneous LFA-1 and CD40 ligand antagonism prevents airway remodeling in orthotopic airway transplantation: implications for the role of respiratory epithelium as a modulator of fibrosis. J Immunol. 2005 Apr 01; 174(7):3869-79. PMID: 15778341.
      View in: PubMed
    30. Rayat GR, Gill RG. Indefinite survival of neonatal porcine islet xenografts by simultaneous targeting of LFA-1 and CD154 or CD45RB. Diabetes. 2005 Feb; 54(2):443-51. PMID: 15677502.
      View in: PubMed
    31. Grazia TJ, Pietra BA, Johnson ZA, Kelly BP, Plenter RJ, Gill RG. A two-step model of acute CD4 T-cell mediated cardiac allograft rejection. J Immunol. 2004 Jun 15; 172(12):7451-8. PMID: 15187123; PMCID: PMC4427250.
    32. Beilke J, Johnson Z, Kuhl N, Gill RG. A major role for host MHC class I antigen presentation for promoting islet allograft survival. Transplant Proc. 2004 May; 36(4):1173-4. PMID: 15194406.
      View in: PubMed
    33. Johnson Z, Beilke J, Pietra B, Kelly B, Gill RG. Distinct requirements for host CD80/CD86 costimulatory molecules in cardiac versus islet rejection. Transplant Proc. 2004 May; 36(4):1171-2. PMID: 15194405.
      View in: PubMed
    34. Coulombe M, Gill RG. The immunobiology of pancreatic islet transplantation. Adv Exp Med Biol. 2004; 552:154-69. PMID: 15622963.
      View in: PubMed
    35. Moriyama H, Abiru N, Paronen J, Sikora K, Liu E, Miao D, Devendra D, Beilke J, Gianani R, Gill RG, Eisenbarth GS. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10376-81. PMID: 12925730; PMCID: PMC193569.
    36. Rayat GR, Gill RG. Pancreatic islet xenotransplantation: barriers and prospects. Curr Diab Rep. 2003 Aug; 3(4):336-43. PMID: 12866998.
      View in: PubMed
    37. Rayat GR, Johnson ZA, Beilke JN, Korbutt GS, Rajotte RV, Gill RG. The degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection. Diabetes. 2003 Jun; 52(6):1433-40. PMID: 12765954.
      View in: PubMed
    38. Nicolls MR, D'Antonio JM, Hutton JC, Gill RG, Czwornog JL, Duncan MW. Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets. J Proteome Res. 2003 Mar-Apr; 2(2):199-205. PMID: 12716134.
      View in: PubMed
    39. Nicolls MR, Coulombe M, Beilke J, Gelhaus HC, Gill RG. CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways. J Immunol. 2002 Nov 01; 169(9):4831-9. PMID: 12391193.
      View in: PubMed
    40. Nicolls MR, Coulombe M, Diamond AS, Beilke J, Gill RG. Interferon-gamma is not a universal requirement for islet allograft survival. Transplantation. 2002 Aug 27; 74(4):472-7. PMID: 12352904.
      View in: PubMed
    41. Stegall MD, Dean PG, Ninova D, Cohen AJ, Shepard GM, Gup C, Gill RG. alpha4 integrin in islet allograft rejection. Transplantation. 2001 Jun 15; 71(11):1549-55. PMID: 11435963.
      View in: PubMed
    42. Pietra BA, Gill RG. Immunobiology of cardiac allograft and xenograft transplantation. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2001; 4:123-57. PMID: 11460981.
      View in: PubMed
    43. Nicolls MR, Coulombe M, Yang H, Bolwerk A, Gill RG. Anti-LFA-1 therapy induces long-term islet allograft acceptance in the absence of IFN-gamma or IL-4. J Immunol. 2000 Apr 01; 164(7):3627-34. PMID: 10725719.
      View in: PubMed
    44. Kelemen K, Crawford ML, Gill RG, Hutton JC, Wegmann D. Cellular immune response to phogrin in the NOD mouse: cloned T-cells cause destruction of islet transplants. Diabetes. 1999 Aug; 48(8):1529-34. PMID: 10426369.
      View in: PubMed
    45. Coulombe M, Yang H, Wolf LA, Gill RG. Tolerance to antigen-presenting cell-depleted islet allografts is CD4 T cell dependent. J Immunol. 1999 Mar 01; 162(5):2503-10. PMID: 10072489.
      View in: PubMed
    46. Crawford M, Daniel D, Wegmann D, Yang H, Gill RG. Autoimmune islet damage mediated by insulin-specific T cells. Transplant Proc. 1997 Feb-Mar; 29(1-2):758-9. PMID: 9123512.
      View in: PubMed
    47. Coulombe M, Yang H, Guerder S, Flavell RA, Lafferty KJ, Gill RG. Tissue immunogenicity: the role of MHC antigen and the lymphocyte costimulator B7-1. J Immunol. 1996 Dec 01; 157(11):4790-5. PMID: 8943380.
      View in: PubMed
    48. Stegall MD, Loberman Z, Ostrowska A, Coulombe M, Gill RG. Autoimmune destruction of islet grafts in the NOD mouse is resistant to 15-deoxyspergualin but sensitive to anti-CD4 antibody. J Surg Res. 1996 Aug; 64(2):156-60. PMID: 8812627.
      View in: PubMed
    49. Stegall MD, Lafferty KJ, Kam I, Gill RG. Evidence of recurrent autoimmunity in human allogeneic islet transplantation. Transplantation. 1996 Apr 27; 61(8):1272-4. PMID: 8610431.
      View in: PubMed
    50. Coulombe M, Gill RG. T lymphocyte indifference to extrathymic islet allografts. J Immunol. 1996 Mar 01; 156(5):1998-2003. PMID: 8596055.
      View in: PubMed
    51. Gill RG, Coulombe M, Lafferty KJ. Pancreatic islet allograft immunity and tolerance: the two-signal hypothesis revisited. Immunol Rev. 1996 Feb; 149:75-96. PMID: 9005221.
      View in: PubMed
    52. Stegall MD, Ostrowska A, Haynes J, Karrer F, Kam I, Gill RG. Prolongation of islet allograft survival with an antibody to vascular cell adhesion molecule 1. Surgery. 1995 Aug; 118(2):366-9; discussion 369-70. PMID: 7543705.
      View in: PubMed
    53. Gill RG, Wolf L. Immunobiology of cellular transplantation. Cell Transplant. 1995 Jul-Aug; 4(4):361-70. PMID: 7582567.
      View in: PubMed
    54. Daniel D, Gill RG, Schloot N, Wegmann D. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol. 1995 Apr; 25(4):1056-62. PMID: 7537670.
      View in: PubMed
    55. Wegmann DR, Gill RG, Norbury-Glaser M, Schloot N, Daniel D. Analysis of the spontaneous T cell response to insulin in NOD mice. J Autoimmun. 1994 Dec; 7(6):833-43. PMID: 7888039.
      View in: PubMed
    56. Gill RG, Coulombe M. Islet xenografting in autoimmune diabetes. Transplant Proc. 1994 Jun; 26(3):1140. PMID: 7913256.
      View in: PubMed
    57. Coulombe M, Lafferty KJ, Gill RG. Nature of tolerance induction to peripheral (extrathymic) islet allografts. Transplant Proc. 1994 Apr; 26(2):720-1. PMID: 8171624.
      View in: PubMed
    58. Wegmann DR, Shehadeh N, Lafferty KJ, Norbury-Glaser M, Gill RG, Daniel D. Establishment of islet-specific T-cell lines and clones from islet isografts placed in spontaneously diabetic NOD mice. J Autoimmun. 1993 Oct; 6(5):517-27. PMID: 7902094.
      View in: PubMed
    59. Gill RG. T-cell-T-cell collaboration in allograft responses. Curr Opin Immunol. 1993 Oct; 5(5):782-7. PMID: 7902104.
      View in: PubMed
    60. Gill RG, Haskins K. Molecular mechanisms underlying diabetes and other autoimmune diseases. Immunol Today. 1993 Feb; 14(2):49-51. PMID: 8095390.
      View in: PubMed
    61. Gill RG. Pancreatic islet xenotransplantation. Autoimmunity. 1993; 15 Suppl:18-20. PMID: 8218845.
      View in: PubMed
    62. Hao L, Calcinaro F, Gill RG, Eugui EM, Allison AC, Lafferty KJ. Facilitation of specific tolerance induction in adult mice by RS-61443. Transplantation. 1992 Mar; 53(3):590-5. PMID: 1549852.
      View in: PubMed
    63. Gill RG, Wang Y, Lafferty KJ. Spontaneous tolerance induction in adult animals transplanted with allogeneic islets. Transplant Proc. 1988 Feb; 20(1):61-3. PMID: 3125639.
      View in: PubMed
    64. Wang Y, Hao L, Gill RG, Lafferty KJ. Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent. Diabetes. 1987 Apr; 36(4):535-8. PMID: 3102301.
      View in: PubMed
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