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Kevin D Deane

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-7608

    Collapse Research 
    Collapse research activities and funding
    K23AR051461     (DEANE, KEVIN D)Sep 1, 2004 - Aug 31, 2010
    NIH/NIAMS
    Genetics, Exposures, and RA-Related Autoimmunity
    Role: Principal Investigator

    R56AI103023     (DEANE, KEVIN D)Aug 15, 2013 - Jul 31, 2014
    NIH/NIAID
    The Role of the Lung in the Initiation of Rheumatoid Arthritis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Demoruelle MK, Harrall KK, Ho L, Purmalek MM, Seto NL, Rothfuss HM, Weisman MH, Solomon JJ, Fischer A, Okamoto Y, Kelmenson LB, Parish MC, Feser M, Fleischer C, Anderson C, Mahler M, Norris JM, Kaplan MJ, Cherrington BD, Holers VM, Deane KD. Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients. Arthritis Rheumatol. 2017 Jun; 69(6):1165-1175. PMID: 28182854.
      View in: PubMed
    2. Deane KD, Striebich CC, Holers VM. Editorial: Prevention of Rheumatoid Arthritis: Now Is the Time, but How to Proceed? Arthritis Rheumatol. 2017 May; 69(5):873-877. PMID: 28217918.
      View in: PubMed
    3. Ercan A, Kohrt WM, Cui J, Deane KD, Pezer M, Yu EW, Hausmann JS, Campbell H, Kaiser UB, Rudd PM, Lauc G, Wilson JF, Finkelstein JS, Nigrovic PA. Estrogens regulate glycosylation of IgG in women and men. JCI Insight. 2017 Feb 23; 2(4):e89703. PMID: 28239652.
      View in: PubMed
    4. Kelmenson LB, Demoruelle MK, Deane KD. The Complex Role of the Lung in the Pathogenesis and Clinical Outcomes of Rheumatoid Arthritis. Curr Rheumatol Rep. 2016 Nov; 18(11):69. PMID: 27796844.
      View in: PubMed
    5. Kinslow JD, Blum LK, Deane KD, Demoruelle MK, Okamoto Y, Parish MC, Kongpachith S, Lahey LJ, Norris JM, Robinson WH, Holers VM. Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis. Arthritis Rheumatol. 2016 Oct; 68(10):2372-83. PMID: 27273876.
      View in: PubMed
    6. Sparks JA, Chang SC, Deane KD, Gan RW, Kristen Demoruelle M, Feser ML, Moss L, Buckner JH, Keating RM, Costenbader KH, Gregersen PK, Weisman MH, Mikuls TR, O'Dell JR, Michael Holers V, Norris JM, Karlson EW. Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis. Arthritis Rheumatol. 2016 Aug; 68(8):1828-38. PMID: 26866831.
      View in: PubMed
    7. Deane KD, Samwell Ngalya P, Boniface L, Bulugu G, Urassa M. Exploring the relationship between population mobility and HIV risk: Evidence from Tanzania. Glob Public Health. 2016 May 27; 1-16. PMID: 27230067.
      View in: PubMed
    8. Gan RW, Demoruelle MK, Deane KD, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Fingerlin TE, Zerbe GO, Clare-Salzler MJ, Holers VM, Norris JM. Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis. Ann Rheum Dis. 2017 Jan; 76(1):147-152. PMID: 27190099.
      View in: PubMed
    9. Mikuls TR, Payne JB, Deane KD, Thiele GM. Autoimmunity of the lung and oral mucosa in a multisystem inflammatory disease: The spark that lights the fire in rheumatoid arthritis? J Allergy Clin Immunol. 2016 Jan; 137(1):28-34. PMID: 26768760.
      View in: PubMed
    10. Deane KD. Do We Need Early ACPA Testing in Inflammatory Arthritis? J Rheumatol. 2016 Jan; 43(1):1-2. PMID: 26523028.
      View in: PubMed
    11. Deane KD. Rheumatoid arthritis: Autoantibodies, citrullinated histones and initiation of synovitis. Nat Rev Rheumatol. 2015 Dec; 11(12):688-9. PMID: 26416595.
      View in: PubMed
    12. Gan RW, Young KA, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Clare-Salzler MJ, Deane KD, Holers VM, Norris JM. Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study. Rheumatology (Oxford). 2016 Feb; 55(2):367-76. PMID: 26370400; PMCID: PMC5009416 [Available on 02/01/17].
    13. Mackey RH, Kuller LH, Deane KD, Walitt BT, Chang YF, Holers VM, Robinson WH, Tracy RP, Hlatky MA, Eaton CB, Liu S, Freiberg MS, Talabi MB, Schelbert EB, Moreland LW. Rheumatoid Arthritis, Anti-Cyclic Citrullinated Peptide Positivity, and Cardiovascular Disease Risk in the Women's Health Initiative. Arthritis Rheumatol. 2015 Sep; 67(9):2311-22. PMID: 25988241; PMCID: PMC4551571.
    14. Gan RW, Trouw LA, Shi J, Toes RE, Huizinga TW, Demoruelle MK, Kolfenbach JR, Zerbe GO, Deane KD, Edison JD, Gilliland WR, Norris JM, Holers VM. Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis. J Rheumatol. 2015 Apr; 42(4):572-9. PMID: 25593232; PMCID: PMC4383711.
    15. Catrina AI, Deane KD, Scher JU. Gene, environment, microbiome and mucosal immune tolerance in rheumatoid arthritis. Rheumatology (Oxford). 2016 Mar; 55(3):391-402. PMID: 25539828; PMCID: PMC4746430 [Available on 03/01/17].
    16. Liang MH, Couto MC, Duarte CC, Gall V, White P, Naides S, Schumacher HR, Hwang AS, Holers VM, Deane KD, Gupta S, Ho IC, Finckh A, Kopec J, Choi CB, Sayre EC. An Internet-based technique for the identification of persons with symptoms of inflammatory polyarthritis of less than 12 weeks. Clin Rheumatol. 2015 Mar; 34(3):465-70. PMID: 25339123.
      View in: PubMed
    17. Bykerk VP, Costenbader KH, Deane K. Preclinical rheumatic disease. Rheum Dis Clin North Am. 2014 Nov; 40(4):xv-xviii. PMID: 25437295.
      View in: PubMed
    18. Finckh A, Deane KD. Prevention of rheumatic diseases: strategies, caveats, and future directions. Rheum Dis Clin North Am. 2014 Nov; 40(4):771-85. PMID: 25437291; PMCID: PMC4250827.
    19. Sparks JA, Iversen MD, Miller Kroouze R, Mahmoud TG, Triedman NA, Kalia SS, Atkinson ML, Lu B, Deane KD, Costenbader KH, Green RC, Karlson EW. Personalized Risk Estimator for Rheumatoid Arthritis (PRE-RA) Family Study: rationale and design for a randomized controlled trial evaluating rheumatoid arthritis risk education to first-degree relatives. Contemp Clin Trials. 2014 Sep; 39(1):145-57. PMID: 25151341; PMCID: PMC4175164.
    20. Deane KD. Preclinical rheumatoid arthritis (autoantibodies): an updated review. Curr Rheumatol Rep. 2014 May; 16(5):419. PMID: 24643396; PMCID: PMC4059414.
    21. Kuller LH, Mackey RH, Walitt BT, Deane KD, Holers VM, Robinson WH, Sokolove J, Chang Y, Liu S, Parks CG, Wright NC, Moreland LW. Determinants of mortality among postmenopausal women in the women's health initiative who report rheumatoid arthritis. Arthritis Rheumatol. 2014 Mar; 66(3):497-507. PMID: 24574208.
      View in: PubMed
    22. Kuller LH, Mackey RH, Walitt BT, Deane KD, Holers VM, Robinson WH, Sokolove J, Chang Y, Moreland LW. Rheumatoid arthritis in the Women's Health Initiative: methods and baseline evaluation. Am J Epidemiol. 2014 Apr 01; 179(7):917-26. PMID: 24569640; PMCID: PMC3969537.
    23. Deane KD, El-Gabalawy H. Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE. Nat Rev Rheumatol. 2014 Apr; 10(4):212-28. PMID: 24514912; PMCID: PMC4090326.
    24. Demoruelle MK, Deane KD, Holers VM. When and where does inflammation begin in rheumatoid arthritis? Curr Opin Rheumatol. 2014 Jan; 26(1):64-71. PMID: 24247116; PMCID: PMC4033623.
    25. Demoruelle MK, Solomon JJ, Fischer A, Deane KD. The lung may play a role in the pathogenesis of rheumatoid arthritis. Int J Clin Rheumtol. 2014; 9(3):295-309. PMID: 26089988.
      View in: PubMed
    26. Deane KD. Can rheumatoid arthritis be prevented? Best Pract Res Clin Rheumatol. 2013 Aug; 27(4):467-85. PMID: 24315049; PMCID: PMC3926812.
    27. Willis VC, Demoruelle MK, Derber LA, Chartier-Logan CJ, Parish MC, Pedraza IF, Weisman MH, Norris JM, Holers VM, Deane KD. Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at risk of future clinically apparent disease. Arthritis Rheum. 2013 Oct; 65(10):2545-54. PMID: 23817979; PMCID: PMC4066465.
    28. Demoruelle MK, Parish MC, Derber LA, Kolfenbach JR, Hughes-Austin JM, Weisman MH, Gilliland W, Edison JD, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Norris JM, Holers VM, Deane KD. Performance of anti-cyclic citrullinated Peptide assays differs in subjects at increased risk of rheumatoid arthritis and subjects with established disease. Arthritis Rheum. 2013 Sep; 65(9):2243-52. PMID: 23686569; PMCID: PMC3776020.
    29. Moreau KL, Deane KD, Meditz AL, Kohrt WM. Tumor necrosis factor-a inhibition improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women. Atherosclerosis. 2013 Oct; 230(2):390-6. PMID: 24075772; PMCID: PMC3815590.
    30. Young KA, Deane KD, Derber LA, Hughes-Austin JM, Wagner CA, Sokolove J, Weisman MH, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Robinson WH, Holers VM, Norris JM. Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis. Arthritis Rheum. 2013 Aug; 65(8):1995-2004. PMID: 23754702; PMCID: PMC3729718.
    31. Demoruelle MK, Deane KD. Reply: To PMID 22183986. Arthritis Rheum. 2013 Jun; 65(6):1673-4. PMID: 23436248.
      View in: PubMed
    32. Gan RW, Deane KD, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Holers VM, Norris JM. Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA. Ann Rheum Dis. 2013 Dec; 72(12):2002-5. PMID: 23572338; PMCID: PMC3818364.
    33. Deane KD, Nicolls MR. Developing better biomarkers for connective tissue disease-associated interstitial lung disease: citrullinated hsp90 autoantibodies in rheumatoid arthritis. Arthritis Rheum. 2013 Apr; 65(4):864-8. PMID: 23400799; PMCID: PMC4036626.
    34. Walitt B, Mackey R, Kuller L, Deane KD, Robinson W, Holers VM, Chang YF, Moreland L. Predictive value of autoantibody testing for validating self-reported diagnoses of rheumatoid arthritis in the Women's Health Initiative. Am J Epidemiol. 2013 May 01; 177(9):887-93. PMID: 23492764; PMCID: PMC4023293.
    35. Demoruelle MK, Kahr A, Verilhac K, Deane K, Fischer A, West S. Recent-onset systemic lupus erythematosus complicated by acute respiratory failure. Arthritis Care Res (Hoboken). 2013 Feb; 65(2):314-23. PMID: 22972558.
      View in: PubMed
    36. Mikuls TR, Thiele GM, Deane KD, Payne JB, O'Dell JR, Yu F, Sayles H, Weisman MH, Gregersen PK, Buckner JH, Keating RM, Derber LA, Robinson WH, Holers VM, Norris JM. Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis Rheum. 2012 Nov; 64(11):3522-30. PMID: 22736291; PMCID: PMC3467347.
    37. Demoruelle MK, Deane KD. Treatment strategies in early rheumatoid arthritis and prevention of rheumatoid arthritis. Curr Rheumatol Rep. 2012 Oct; 14(5):472-80. PMID: 22773387; PMCID: PMC3616381.
    38. Moreau KL, Hildreth KL, Meditz AL, Deane KD, Kohrt WM. Endothelial function is impaired across the stages of the menopause transition in healthy women. J Clin Endocrinol Metab. 2012 Dec; 97(12):4692-700. PMID: 22969140; PMCID: PMC3513538.
    39. Hughes-Austin JM, Deane KD, Derber LA, Kolfenbach JR, Zerbe GO, Sokolove J, Lahey LJ, Weisman MH, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Robinson WH, Holers VM, Norris JM. Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA). Ann Rheum Dis. 2013 Jun; 72(6):901-7. PMID: 22915618; PMCID: PMC3726193.
    40. Deane KD. Learning about the natural history of rheumatoid arthritis development through prospective study of subjects at high risk of rheumatoid arthritis-related autoimmunity. Arthritis Rheum. 2012 Jun; 64(6):1708-12. PMID: 22354795; PMCID: PMC4527318.
    41. Karlson EW, Deane K. Environmental and gene-environment interactions and risk of rheumatoid arthritis. Rheum Dis Clin North Am. 2012 May; 38(2):405-26. PMID: 22819092; PMCID: PMC3402910.
    42. Sokolove J, Bromberg R, Deane KD, Lahey LJ, Derber LA, Chandra PE, Edison JD, Gilliland WR, Tibshirani RJ, Norris JM, Holers VM, Robinson WH. Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. PLoS One. 2012; 7(5):e35296. PMID: 22662108; PMCID: PMC3360701.
    43. Fischer A, Solomon JJ, du Bois RM, Deane KD, Olson AL, Fernandez-Perez ER, Huie TJ, Stevens AD, Gill MB, Rabinovitch AM, Lynch DA, Burns DA, Pineiro IS, Groshong SD, Duarte Achcar RD, Brown KK, Martin RJ, Swigris JJ. Lung disease with anti-CCP antibodies but not rheumatoid arthritis or connective tissue disease. Respir Med. 2012 Jul; 106(7):1040-7. PMID: 22503074; PMCID: PMC3753791.
    44. Moreau KL, Meditz A, Deane KD, Kohrt WM. Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women. Am J Physiol Heart Circ Physiol. 2012 Mar 01; 302(5):H1211-8. PMID: 22245769; PMCID: PMC3311456.
    45. Demoruelle MK, Weisman MH, Simonian PL, Lynch DA, Sachs PB, Pedraza IF, Harrington AR, Kolfenbach JR, Striebich CC, Pham QN, Strickland CD, Petersen BD, Parish MC, Derber LA, Norris JM, Holers VM, Deane KD. Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity? Arthritis Rheum. 2012 Jun; 64(6):1756-61. PMID: 22183986; PMCID: PMC3319006.
    46. Demoruelle MK, Deane K. Antibodies to citrullinated protein antigens (ACPAs): clinical and pathophysiologic significance. Curr Rheumatol Rep. 2011 Oct; 13(5):421-30. PMID: 21713412; PMCID: PMC4095867.
    47. Deane KD, Tyler KN, Johnson DW, Tanabe JL, Oskarrson BE, Nitka EE, Brass E, Davies JK, Striebich CC. Susac syndrome and pregnancy: disease management. J Clin Rheumatol. 2011 Mar; 17(2):83-8. PMID: 21325959.
      View in: PubMed
    48. Deane KD, O'Donnell CI, Hueber W, Majka DS, Lazar AA, Derber LA, Gilliland WR, Edison JD, Norris JM, Robinson WH, Holers VM. The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner. Arthritis Rheum. 2010 Nov; 62(11):3161-72. PMID: 20597112; PMCID: PMC2980824.
    49. Deane KD, Parkhurst JO, Johnston D. Linking migration, mobility and HIV. Trop Med Int Health. 2010 Dec; 15(12):1458-63. PMID: 20958895.
      View in: PubMed
    50. Kolfenbach JR, Deane KD, Derber LA, O'Donnell CI, Gilliland WR, Edison JD, Rosen A, Darrah E, Norris JM, Holers VM. Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis. Arthritis Rheum. 2010 Sep; 62(9):2633-9. PMID: 20496417; PMCID: PMC2946499.
    51. Ercan A, Cui J, Chatterton DE, Deane KD, Hazen MM, Brintnell W, O'Donnell CI, Derber LA, Weinblatt ME, Shadick NA, Bell DA, Cairns E, Solomon DH, Holers VM, Rudd PM, Lee DM. Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis Rheum. 2010 Aug; 62(8):2239-48. PMID: 20506563; PMCID: PMC4118465.
    52. Deane KD, Norris JM, Holers VM. Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation. Rheum Dis Clin North Am. 2010 May; 36(2):213-41. PMID: 20510231; PMCID: PMC2879710.
    53. Kolfenbach JR, Deane KD, Derber LA, O'Donnell C, Weisman MH, Buckner JH, Gersuk VH, Wei S, Mikuls TR, O'Dell J, Gregersen PK, Keating RM, Norris JM, Holers VM. A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA. Arthritis Rheum. 2009 Dec 15; 61(12):1735-42. PMID: 19950324; PMCID: PMC2795101.
    54. Deane KD, Striebich CC, Goldstein BL, Derber LA, Parish MC, Feser ML, Hamburger EM, Brake S, Belz C, Goddard J, Norris JM, Karlson EW, Holers VM. Identification of undiagnosed inflammatory arthritis in a community health fair screen. Arthritis Rheum. 2009 Dec 15; 61(12):1642-9. PMID: 19950306; PMCID: PMC2913880.
    55. Feser M, Derber LA, Deane KD, Lezotte DC, Weisman MH, Buckner JH, Mikuls T, O'Dell J, Gregersen PK, Holers VM, Norris JM. Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA. J Rheumatol. 2009 May; 36(5):943-6. PMID: 19286844; PMCID: PMC2745328.
    56. Gizinski AM, Mascolo M, Loucks JL, Kervitsky A, Meehan RT, Brown KK, Holers VM, Deane KD. Rheumatoid arthritis (RA)-specific autoantibodies in patients with interstitial lung disease and absence of clinically apparent articular RA. Clin Rheumatol. 2009 May; 28(5):611-3. PMID: 19252818; PMCID: PMC4084723.
    57. Majka DS, Deane KD, Parrish LA, Lazar AA, BarĂ³n AE, Walker CW, Rubertone MV, Gilliland WR, Norris JM, Holers VM. Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis. Ann Rheum Dis. 2008 Jun; 67(6):801-7. PMID: 17974596; PMCID: PMC3761074.
    58. Young KA, Parrish LA, Zerbe GO, Rewers M, Deane KD, Michael Holers V, Norris JM. Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population. Ann Rheum Dis. 2007 Feb; 66(2):179-83. PMID: 17242018; PMCID: PMC1798519.
    59. Bhatia SS, Majka DS, Kittelson JM, Parrish LA, Ferucci ED, Deane KD, Arend WP, Rewers M, Michael Holers V, Norris JM. Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis. Ann Rheum Dis. 2007 Feb; 66(2):267-9. PMID: 16868018; PMCID: PMC1798510.
    60. Deane KD, West SG. Antiphospholipid antibodies as a cause of pulmonary capillaritis and diffuse alveolar hemorrhage: a case series and literature review. Semin Arthritis Rheum. 2005 Dec; 35(3):154-65. PMID: 16325656.
      View in: PubMed
    61. Ferucci ED, Majka DS, Parrish LA, Moroldo MB, Ryan M, Passo M, Thompson SD, Deane KD, Rewers M, Arend WP, Glass DN, Norris JM, Holers VM. Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum. 2005 Jan; 52(1):239-46. PMID: 15641089.
      View in: PubMed
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