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Sherry S Leonard

TitleElectronic Research Admin
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
    Collapse research activities and funding
    R01DA009457     (LEONARD, SHERRY)Jul 1, 1995 - Jun 30, 2012
    Regulation of Alpha 7 Nicotinic Receptor Assembly in Human Smokers
    Role: Principal Investigator

    R01DA012281     (LEONARD, SHERRY)Sep 30, 1998 - Aug 31, 2002
    Role: Principal Investigator

    R01MH081177     (LEONARD, SHERRY)Jun 14, 2007 - Jun 30, 2012
    Regulation of the Human a7 Nicotinic Receptor Gene in Schizophrenia
    Role: Principal Investigator

    I01BX001035     (LEONARD, SHERRY)Jan 1, 2011 - Dec 31, 2014
    Expression and Function of the Alpha 7 Nicotinic Receptor in Schizophrenia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Freund RK, Graw S, Choo KS, Stevens KE, Leonard S, Dell'Acqua ML. Genetic knockout of the a7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner. Neurosci Lett. 2016 08 03; 627:1-6. PMID: 27233215.
      View in: PubMed
    2. Ross RG, Hunter SK, Hoffman MC, McCarthy L, Chambers BM, Law AJ, Leonard S, Zerbe GO, Freedman R. Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation. Am J Psychiatry. 2016 05 01; 173(5):509-16. PMID: 26651393.
      View in: PubMed
    3. Sinkus ML, Graw S, Freedman R, Ross RG, Lester HA, Leonard S. The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function. Neuropharmacology. 2015 Sep; 96(Pt B):274-88. PMID: 25701707; PMCID: PMC4486515.
    4. Schulz KM, Pearson JN, Gasparrini ME, Brooks KF, Drake-Frazier C, Zajkowski ME, Kreisler AD, Adams CE, Leonard S, Stevens KE. Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors. Behav Brain Res. 2014 Jul 15; 268:104-10. PMID: 24675162; PMCID: PMC4144861.
    5. Ross RG, Hunter SK, McCarthy L, Beuler J, Hutchison AK, Wagner BD, Leonard S, Stevens KE, Freedman R. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013 Mar; 170(3):290-8. PMID: 23318559; PMCID: PMC3640283.
    6. Sinkus ML, Adams CE, Logel J, Freedman R, Leonard S. Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia. Brain Behav Immun. 2013 Aug; 32:51-62. PMID: 23395714; PMCID: PMC3686871.
    7. Stephens SH, Franks A, Berger R, Palionyte M, Fingerlin TE, Wagner B, Logel J, Olincy A, Ross RG, Freedman R, Leonard S. Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. Psychiatr Genet. 2012 Feb; 22(1):1-14. PMID: 21970977.
      View in: PubMed
    8. Graw SL, Swisshelm K, Floyd K, Carstens BJ, Wamboldt MZ, Ross RG, Leonard S. Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. Mol Cytogenet. 2012 Jan 03; 5(1):2. PMID: 22214315; PMCID: PMC3274485.
    9. Canastar A, Logel J, Graw S, Finlay-Schultz J, Osborne C, Palionyte M, Drebing C, Plehaty M, Wilson L, Eyeson R, Leonard S. Promoter methylation and tissue-specific transcription of the a7 nicotinic receptor gene, CHRNA7. J Mol Neurosci. 2012 Jun; 47(2):389-400. PMID: 22052086.
      View in: PubMed
    10. Finlay-Schultz J, Canastar A, Short M, El Gazzar M, Coughlan C, Leonard S. Transcriptional repression of the a7 nicotinic acetylcholine receptor subunit gene (CHRNA7) by activating protein-2a (AP-2a). J Biol Chem. 2011 Dec 09; 286(49):42123-32. PMID: 21979958; PMCID: PMC3234925.
    11. Araud T, Graw S, Berger R, Lee M, Neveu E, Bertrand D, Leonard S. The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of a7*nAChR function. Biochem Pharmacol. 2011 Oct 15; 82(8):904-14. PMID: 21718690; PMCID: PMC3162115.
    12. Neeley EW, Berger R, Koenig JI, Leonard S. Strain dependent effects of prenatal stress on gene expression in the rat hippocampus. Physiol Behav. 2011 Aug 03; 104(2):334-9. PMID: 21382392; PMCID: PMC3118943.
    13. Schulz KM, Pearson JN, Neeley EW, Berger R, Leonard S, Adams CE, Stevens KE. Maternal stress during pregnancy causes sex-specific alterations in offspring memory performance, social interactions, indices of anxiety, and body mass. Physiol Behav. 2011 Aug 03; 104(2):340-7. PMID: 21334352; PMCID: PMC4420621.
    14. Sinkus ML, Wamboldt MZ, Barton A, Fingerlin TE, Laudenslager ML, Leonard S. The a7 nicotinic acetylcholine receptor and the acute stress response: maternal genotype determines offspring phenotype. Physiol Behav. 2011 Aug 03; 104(2):321-6. PMID: 21073885; PMCID: PMC3094732.
    15. Tregellas JR, Tanabe J, Rojas DC, Shatti S, Olincy A, Johnson L, Martin LF, Soti F, Kem WR, Leonard S, Freedman R. Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia. Biol Psychiatry. 2011 Jan 01; 69(1):7-11. PMID: 20728875; PMCID: PMC3005969.
    16. Ross RG, Stevens KE, Proctor WR, Leonard S, Kisley MA, Hunter SK, Freedman R, Adams CE. Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia. J Child Psychol Psychiatry. 2010 May; 51(5):535-49. PMID: 19925602.
      View in: PubMed
    17. Sinkus ML, Lee MJ, Gault J, Logel J, Short M, Freedman R, Christian SL, Lyon J, Leonard S. A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia. Brain Res. 2009 Sep 29; 1291:1-11. PMID: 19631623; PMCID: PMC2747474.
    18. Stephens SH, Logel J, Barton A, Franks A, Schultz J, Short M, Dickenson J, James B, Fingerlin TE, Wagner B, Hodgkinson C, Graw S, Ross RG, Freedman R, Leonard S. Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. Schizophr Res. 2009 Apr; 109(1-3):102-12. PMID: 19181484; PMCID: PMC2748327.
    19. Wagner BD, Zerbe GO, Mexal S, Leonard SS. Permutation-based adjustments for the significance of partial regression coefficients in microarray data analysis. Genet Epidemiol. 2008 Jan; 32(1):1-8. PMID: 17630650; PMCID: PMC2592303.
    20. Leonard S, Mexal S, Freedman R. Smoking, Genetics and Schizophrenia: Evidence for Self Medication. J Dual Diagn. 2007 Nov 01; 3(3-4):43-59. PMID: 19122786.
      View in: PubMed
    21. Leonard S, Freedman R. Genetics of chromosome 15q13-q14 in schizophrenia. Biol Psychiatry. 2006 Jul 15; 60(2):115-22. PMID: 16843094.
      View in: PubMed
    22. Freedman R, Ross R, Leonard S, Myles-Worsley M, Adams CE, Waldo M, Tregellas J, Martin L, Olincy A, Tanabe J, Kisley MA, Hunter S, Stevens KE. Early biomarkers of psychosis. Dialogues Clin Neurosci. 2005; 7(1):17-29. PMID: 16060593; PMCID: PMC3181722.
    23. Gault J, Hopkins J, Berger R, Drebing C, Logel J, Walton C, Short M, Vianzon R, Olincy A, Ross RG, Adler LE, Freedman R, Leonard S. Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects. Am J Med Genet B Neuropsychiatr Genet. 2003 Nov 15; 123B(1):39-49. PMID: 14582144.
      View in: PubMed
    24. Freedman R, Olincy A, Ross RG, Waldo MC, Stevens KE, Adler LE, Leonard S. The genetics of sensory gating deficits in schizophrenia. Curr Psychiatry Rep. 2003 Jun; 5(2):155-61. PMID: 12685995.
      View in: PubMed
    25. Leonard S, Gault J, Hopkins J, Logel J, Vianzon R, Short M, Drebing C, Berger R, Venn D, Sirota P, Zerbe G, Olincy A, Ross RG, Adler LE, Freedman R. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch Gen Psychiatry. 2002 Dec; 59(12):1085-96. PMID: 12470124.
      View in: PubMed
    26. Freedman R, Adler LE, Olincy A, Waldo MC, Ross RG, Stevens KE, Leonard S. Input dysfunction, schizotypy, and genetic models of schizophrenia. Schizophr Res. 2002 Mar 01; 54(1-2):25-32. PMID: 11853975.
      View in: PubMed
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