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Sherry S Leonard

TitleElectronic Research Admin
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PSYCH

    Collapse Research 
    Collapse research activities and funding
    I01BX001035     (LEONARD, SHERRY)Jan 1, 2011 - Dec 31, 2014
    NIH
    Expression and Function of the Alpha 7 Nicotinic Receptor in Schizophrenia
    Role: Principal Investigator
    R01MH081177     (LEONARD, SHERRY)Jun 14, 2007 - Jun 30, 2012
    NIH
    Regulation of the Human a7 Nicotinic Receptor Gene in Schizophrenia
    Role: Principal Investigator
    R01DA012281     (LEONARD, SHERRY)Sep 30, 1998 - Aug 31, 2002
    NIH
    NICOTINIC RECEPTORS AND SMOKING CESSATION
    Role: Principal Investigator
    R01DA009457     (LEONARD, SHERRY)Jul 1, 1995 - Jun 30, 2012
    NIH
    Regulation of Alpha 7 Nicotinic Receptor Assembly in Human Smokers
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Freund RK, Graw S, Choo KS, Stevens KE, Leonard S, Dell'Acqua ML. Genetic knockout of the a7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner. Neurosci Lett. 2016 08 03; 627:1-6. PMID: 27233215.
      View in: PubMed
    2. Ross RG, Hunter SK, Hoffman MC, McCarthy L, Chambers BM, Law AJ, Leonard S, Zerbe GO, Freedman R. Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation. Am J Psychiatry. 2016 05 01; 173(5):509-16. PMID: 26651393.
      View in: PubMed
    3. Sinkus ML, Graw S, Freedman R, Ross RG, Lester HA, Leonard S. The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function. Neuropharmacology. 2015 Sep; 96(Pt B):274-88. PMID: 25701707.
      View in: PubMed
    4. Schulz KM, Pearson JN, Gasparrini ME, Brooks KF, Drake-Frazier C, Zajkowski ME, Kreisler AD, Adams CE, Leonard S, Stevens KE. Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors. Behav Brain Res. 2014 Jul 15; 268:104-10. PMID: 24675162.
      View in: PubMed
    5. Ross RG, Hunter SK, McCarthy L, Beuler J, Hutchison AK, Wagner BD, Leonard S, Stevens KE, Freedman R. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013 Mar; 170(3):290-8. PMID: 23318559.
      View in: PubMed
    6. Sinkus ML, Adams CE, Logel J, Freedman R, Leonard S. Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia. Brain Behav Immun. 2013 Aug; 32:51-62. PMID: 23395714.
      View in: PubMed
    7. Stephens SH, Franks A, Berger R, Palionyte M, Fingerlin TE, Wagner B, Logel J, Olincy A, Ross RG, Freedman R, Leonard S. Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. Psychiatr Genet. 2012 Feb; 22(1):1-14. PMID: 21970977.
      View in: PubMed
    8. Graw SL, Swisshelm K, Floyd K, Carstens BJ, Wamboldt MZ, Ross RG, Leonard S. Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. Mol Cytogenet. 2012 Jan 03; 5(1):2. PMID: 22214315.
      View in: PubMed
    9. Canastar A, Logel J, Graw S, Finlay-Schultz J, Osborne C, Palionyte M, Drebing C, Plehaty M, Wilson L, Eyeson R, Leonard S. Promoter methylation and tissue-specific transcription of the a7 nicotinic receptor gene, CHRNA7. J Mol Neurosci. 2012 Jun; 47(2):389-400. PMID: 22052086.
      View in: PubMed
    10. Finlay-Schultz J, Canastar A, Short M, El Gazzar M, Coughlan C, Leonard S. Transcriptional repression of the a7 nicotinic acetylcholine receptor subunit gene (CHRNA7) by activating protein-2a (AP-2a). J Biol Chem. 2011 Dec 09; 286(49):42123-42132. PMID: 21979958.
      View in: PubMed
    11. Neeley EW, Berger R, Koenig JI, Leonard S. Strain dependent effects of prenatal stress on gene expression in the rat hippocampus. Physiol Behav. 2011 Aug 03; 104(2):334-9. PMID: 21382392.
      View in: PubMed
    12. Schulz KM, Pearson JN, Neeley EW, Berger R, Leonard S, Adams CE, Stevens KE. Maternal stress during pregnancy causes sex-specific alterations in offspring memory performance, social interactions, indices of anxiety, and body mass. Physiol Behav. 2011 Aug 03; 104(2):340-7. PMID: 21334352.
      View in: PubMed
    13. Sinkus ML, Wamboldt MZ, Barton A, Fingerlin TE, Laudenslager ML, Leonard S. The a7 nicotinic acetylcholine receptor and the acute stress response: maternal genotype determines offspring phenotype. Physiol Behav. 2011 Aug 03; 104(2):321-6. PMID: 21073885.
      View in: PubMed
    14. Tregellas JR, Tanabe J, Rojas DC, Shatti S, Olincy A, Johnson L, Martin LF, Soti F, Kem WR, Leonard S, Freedman R. Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia. Biol Psychiatry. 2011 Jan 01; 69(1):7-11. PMID: 20728875.
      View in: PubMed
    15. Ross RG, Stevens KE, Proctor WR, Leonard S, Kisley MA, Hunter SK, Freedman R, Adams CE. Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia. J Child Psychol Psychiatry. 2010 May; 51(5):535-49. PMID: 19925602.
      View in: PubMed
    16. Sinkus ML, Lee MJ, Gault J, Logel J, Short M, Freedman R, Christian SL, Lyon J, Leonard S. A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia. Brain Res. 2009 Sep 29; 1291:1-11. PMID: 19631623.
      View in: PubMed
    17. Stephens SH, Logel J, Barton A, Franks A, Schultz J, Short M, Dickenson J, James B, Fingerlin TE, Wagner B, Hodgkinson C, Graw S, Ross RG, Freedman R, Leonard S. Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. Schizophr Res. 2009 Apr; 109(1-3):102-12. PMID: 19181484.
      View in: PubMed
    18. Wagner BD, Zerbe GO, Mexal S, Leonard SS. Permutation-based adjustments for the significance of partial regression coefficients in microarray data analysis. Genet Epidemiol. 2008 Jan; 32(1):1-8. PMID: 17630650.
      View in: PubMed
    19. Leonard S, Mexal S, Freedman R. Smoking, Genetics and Schizophrenia: Evidence for Self Medication. J Dual Diagn. 2007 Nov 01; 3(3-4):43-59. PMID: 19122786.
      View in: PubMed
    20. Leonard S, Freedman R. Genetics of chromosome 15q13-q14 in schizophrenia. Biol Psychiatry. 2006 Jul 15; 60(2):115-22. PMID: 16843094.
      View in: PubMed
    21. Freedman R, Ross R, Leonard S, Myles-Worsley M, Adams CE, Waldo M, Tregellas J, Martin L, Olincy A, Tanabe J, Kisley MA, Hunter S, Stevens KE. Early biomarkers of psychosis. Dialogues Clin Neurosci. 2005; 7(1):17-29. PMID: 16060593.
      View in: PubMed
    22. Gault J, Hopkins J, Berger R, Drebing C, Logel J, Walton C, Short M, Vianzon R, Olincy A, Ross RG, Adler LE, Freedman R, Leonard S. Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects. Am J Med Genet B Neuropsychiatr Genet. 2003 Nov 15; 123B(1):39-49. PMID: 14582144.
      View in: PubMed
    23. Freedman R, Olincy A, Ross RG, Waldo MC, Stevens KE, Adler LE, Leonard S. The genetics of sensory gating deficits in schizophrenia. Curr Psychiatry Rep. 2003 Jun; 5(2):155-61. PMID: 12685995.
      View in: PubMed
    24. Leonard S, Gault J, Hopkins J, Logel J, Vianzon R, Short M, Drebing C, Berger R, Venn D, Sirota P, Zerbe G, Olincy A, Ross RG, Adler LE, Freedman R. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch Gen Psychiatry. 2002 Dec; 59(12):1085-96. PMID: 12470124.
      View in: PubMed
    25. Freedman R, Adler LE, Olincy A, Waldo MC, Ross RG, Stevens KE, Leonard S. Input dysfunction, schizotypy, and genetic models of schizophrenia. Schizophr Res. 2002 Mar 01; 54(1-2):25-32. PMID: 11853975.
      View in: PubMed
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