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Ronald K Freund

TitleInstructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM - Pharmacology
Phone303/724-3641

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Freund RK, Graw S, Choo KS, Stevens KE, Leonard S, Dell'Acqua ML. Genetic knockout of the a7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner. Neurosci Lett. 2016 Aug 03; 627:1-6.
      View in: PubMed
    2. Freund RK, Gibson ES, Potter H, Dell'Acqua ML. Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid ß-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss. Mol Pharmacol. 2016 May; 89(5):552-9.
      View in: PubMed
    3. Corser-Jensen CE, Goodell DJ, Freund RK, Serbedzija P, Murphy RC, Farias SE, Dell'Acqua ML, Frey LC, Serkova N, Heidenreich KA. Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits. Exp Neurol. 2014 Jun; 256:7-16.
      View in: PubMed
    4. Coultrap SJ, Freund RK, O'Leary H, Sanderson JL, Roche KW, Dell'Acqua ML, Bayer KU. Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection. Cell Rep. 2014 Feb 13; 6(3):431-7.
      View in: PubMed
    5. Sanderson JL, Gorski JA, Gibson ES, Lam P, Freund RK, Chick WS, Dell'Acqua ML. AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors. J Neurosci. 2012 Oct 24; 32(43):15036-52.
      View in: PubMed
    6. Freund RK. Commentary: How ethanol short-circuits the cerebellum-actions on Golgi cells in freely-moving animals. Alcohol Clin Exp Res. 2012 Nov; 36(11):1837-9.
      View in: PubMed
    7. Hicklin TR, Wu PH, Radcliffe RA, Freund RK, Goebel-Goody SM, Correa PR, Proctor WR, Lombroso PJ, Browning MD. Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6650-5.
      View in: PubMed
    8. Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU. CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci. 2010 Jun 16; 30(24):8214-20.
      View in: PubMed
    9. Goebel-Goody SM, Davies KD, Alvestad Linger RM, Freund RK, Browning MD. Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices. Neuroscience. 2009 Feb 18; 158(4):1446-59.
      View in: PubMed
    10. Proctor WR, Diao L, Freund RK, Browning MD, Wu PH. Synaptic GABAergic and glutamatergic mechanisms underlying alcohol sensitivity in mouse hippocampal neurons. J Physiol. 2006 Aug 15; 575(Pt 1):145-59.
      View in: PubMed
    11. Freund RK, Gerhardt GA, Marshall KE, Palmer MR. Differences in norepinephrine clearance in cerebellar slices from low-alcohol-sensitive and high-alcohol-sensitive rats. Alcohol. 2003 May; 30(1):9-18.
      View in: PubMed
    12. Palmer MR, Granholm AC, van Horne CG, Giardina KE, Freund RK, Moorhead JW, Gerhardt GA. Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats. Brain Res. 2001 Jan 26; 890(1):86-99.
      View in: PubMed
    13. Wang Y, Freund RK, Palmer MR. Potentiation of ethanol effects in cerebellum by activation of endogenous noradrenergic inputs. J Pharmacol Exp Ther. 1999 Jan; 288(1):211-20.
      View in: PubMed
    14. Trok K, Palmer MR, Freund RK, Olson L. Functional interactions between spinal cord grafts suggest asymmetries dictated by graft maturity. Exp Neurol. 1997 May; 145(1):268-77.
      View in: PubMed
    15. Craparo A, Freund R, Gustafson TA. 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner. J Biol Chem. 1997 Apr 25; 272(17):11663-9.
      View in: PubMed
    16. Freund RK, Palmer MR. Beta adrenergic sensitization of gamma-aminobutyric acid receptors to ethanol involves a cyclic AMP/protein kinase A second-messenger mechanism. J Pharmacol Exp Ther. 1997 Mar; 280(3):1192-200.
      View in: PubMed
    17. Freund RK, Palmer MR. Ethanol depression of cerebellar Purkinje neuron firing involves nicotinic acetylcholine receptors. Exp Neurol. 1997 Feb; 143(2):319-22.
      View in: PubMed
    18. Pearson BJ, Donatelli DP, Freund RK, Palmer MR. Differential development and characterization of rapid acute neuronal tolerance to the depressant effects of ethanol on cerebellar Purkinje neurons of low-alcohol-sensitive and high-alcohol-sensitive rats. J Pharmacol Exp Ther. 1997 Feb; 280(2):739-46.
      View in: PubMed
    19. Freund RK, Palmer MR. 8-Bromo-cAMP mimics beta-adrenergic sensitization of GABA responses to ethanol in cerebellar Purkinje neurons in vivo. Alcohol Clin Exp Res. 1996 Apr; 20(2):408-12.
      View in: PubMed
    20. Lin AM, Freund RK, Hoffer BJ, Palmer MR. Ethanol-induced depressions of cerebellar Purkinje neurons are potentiated by beta-adrenergic mechanisms in rat brain. J Pharmacol Exp Ther. 1994 Dec; 271(3):1175-80.
      View in: PubMed
    21. Trok K, Freund RK, Palmer MR, Olson L. Spinal cord-skeletal muscle cografts: trophic and functional interactions. Brain Res. 1994 Oct 03; 659(1-2):138-46.
      View in: PubMed
    22. Freund RK, Wang Y, Palmer MR. Differential effects of ethanol on the firing rates of Golgi-like neurons and Purkinje neurons in cerebellar slices in vitro. Neurosci Lett. 1993 Dec 24; 164(1-2):9-12.
      View in: PubMed
    23. Freund RK, van Horne CG, Harlan T, Palmer MR. Electrophysiological interactions of ethanol with GABAergic mechanisms in the rat cerebellum in vivo. Alcohol Clin Exp Res. 1993 Apr; 17(2):321-8.
      View in: PubMed
    24. Lin AM, Freund RK, Palmer MR. Sensitization of gamma-aminobutyric acid-induced depressions of cerebellar Purkinje neurons to the potentiative effects of ethanol by beta adrenergic mechanisms in rat brain. J Pharmacol Exp Ther. 1993 Apr; 265(1):426-32.
      View in: PubMed
    25. Lin AM, Freund RK, Palmer MR. Ethanol potentiation of GABA-induced electrophysiological responses in cerebellum: requirement for catecholamine modulation. Neurosci Lett. 1991 Jan 28; 122(2):154-8.
      View in: PubMed
    26. Freund RK, Luntz-Leybman V, Collins AC. Nicotine interferes with GABA-mediated inhibitory processes in mouse hippocampus. Brain Res. 1990 Sep 17; 527(2):286-91.
      View in: PubMed
    27. Luntz-Leybman V, Freund RK, Collins AC. 5 alpha-Pregnan-3 alpha-ol-20-one blocks nicotine-induced seizures and enhances paired-pulse inhibition. Eur J Pharmacol. 1990 Aug 28; 185(2-3):239-42.
      View in: PubMed
    28. Freund RK, Jungschaffer DA, Collins AC. Nicotine effects in mouse hippocampus are blocked by mecamylamine, but not other nicotinic antagonists. Brain Res. 1990 Mar 19; 511(2):187-91.
      View in: PubMed
    29. Marley RJ, Freund RK, Wehner JM. Differential response to flurazepam in long-sleep and short-sleep mice. Pharmacol Biochem Behav. 1988 Oct; 31(2):453-8.
      View in: PubMed
    30. Freund RK, Martin BJ, Jungschaffer DA, Ullman EA, Collins AC. Genetic differences in plasma corticosterone levels in response to nicotine injection. Pharmacol Biochem Behav. 1988 Aug; 30(4):1059-64.
      View in: PubMed
    31. Freund RK, Jungschaffer DA, Collins AC, Wehner JM. Evidence for modulation of GABAergic neurotransmission by nicotine. Brain Res. 1988 Jun 21; 453(1-2):215-20.
      View in: PubMed
    32. Freund RK, Marley RJ, Wehner JM. Differential sensitivity to bicuculline in three inbred mouse strains. Brain Res Bull. 1987 May; 18(5):657-62.
      View in: PubMed
    33. Freund RK, Wehner JM. Strain-selective effects of nicotine on electrophysiological responses evoked in hippocampus from DBA/2Ibg and C3H/2Ibg mice. J Neurogenet. 1987 Apr; 4(2-3):75-86.
      View in: PubMed
    34. Crooks SL, Freund RK, Halsrud DA, Koerner JF, Johnson RL. Antagonist activity of methyl-substituted analogues of 2-amino-4-phosphonobutanoic acid in the hippocampal slice. Brain Res. 1985 Mar 11; 329(1-2):346-9.
      View in: PubMed
    35. Freund RK, Crooks SL, Koerner JF, Johnson RL. Antagonist activity of phosphorus-containing glutamate analogues in the perforant path. Brain Res. 1984 Jan 16; 291(1):150-3.
      View in: PubMed
    36. Koerner JF, Johnson RL, Freund RK, Robinson MB, Crooks SL. Structure - function relationships for gamma-substituted glutamate analogues on dentate granule cells. Brain Res. 1983 Aug 08; 272(2):299-309.
      View in: PubMed
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