Ronald K Freund
Title | Instructor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-PHARM General Operations |
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Phone | 303/724-3641 |
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Bibliographic
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Tullis JE, Larsen ME, Rumian NL, Freund RK, Boxer EE, Brown CN, Coultrap SJ, Schulman H, Aoto J, Dell'Acqua ML, Bayer KU. LTP induction by structural rather than enzymatic functions of CaMKII. Nature. 2023 Sep; 621(7977):146-153. PMID: 37648853.
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Rumian NL, Freund RK, Dell'Acqua ML, Coultrap SJ, Bayer KU. Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice. Sci Signal. 2023 07 25; 16(795):eade5892. PMID: 37490545.
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Lucero EM, Freund RK, Smith A, Johnson NR, Dooling B, Sullivan E, Prikhodko O, Ahmed MM, Bennett DA, Hohman TJ, Dell'Acqua ML, Chial HJ, Potter H. Increased KIF11/kinesin-5 expression offsets Alzheimer A?-mediated toxicity and cognitive dysfunction. iScience. 2022 Nov 18; 25(11):105288. PMID: 36304124.
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Sanderson JL, Freund RK, Castano AM, Benke TA, Dell'Acqua ML. The CaV1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca2+ channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome. Neuropharmacology. 2022 Dec 01; 220:109271. PMID: 36162529.
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Sanderson JL, Freund RK, Gorski JA, Dell'Acqua ML. ?-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca2+-permeable AMPA receptors. Cell Rep. 2021 10 05; 37(1):109786. PMID: 34610314.
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Freund RK, Graw S, Choo KS, Stevens KE, Leonard S, Dell'Acqua ML. Genetic knockout of the a7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner. Neurosci Lett. 2016 08 03; 627:1-6. PMID: 27233215.
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Freund RK, Gibson ES, Potter H, Dell'Acqua ML. Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid ?-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss. Mol Pharmacol. 2016 May; 89(5):552-9. PMID: 26957206.
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Corser-Jensen CE, Goodell DJ, Freund RK, Serbedzija P, Murphy RC, Farias SE, Dell'Acqua ML, Frey LC, Serkova N, Heidenreich KA. Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits. Exp Neurol. 2014 Jun; 256:7-16. PMID: 24681156.
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Coultrap SJ, Freund RK, O'Leary H, Sanderson JL, Roche KW, Dell'Acqua ML, Bayer KU. Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection. Cell Rep. 2014 Feb 13; 6(3):431-7. PMID: 24485660.
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Sanderson JL, Gorski JA, Gibson ES, Lam P, Freund RK, Chick WS, Dell'Acqua ML. AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors. J Neurosci. 2012 Oct 24; 32(43):15036-52. PMID: 23100425.
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Freund RK. Commentary: How ethanol short-circuits the cerebellum-actions on Golgi cells in freely-moving animals. Alcohol Clin Exp Res. 2012 Nov; 36(11):1837-9. PMID: 23013287.
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Hicklin TR, Wu PH, Radcliffe RA, Freund RK, Goebel-Goody SM, Correa PR, Proctor WR, Lombroso PJ, Browning MD. Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6650-5. PMID: 21464302.
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Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU. CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci. 2010 Jun 16; 30(24):8214-20. PMID: 20554872.
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Goebel-Goody SM, Davies KD, Alvestad Linger RM, Freund RK, Browning MD. Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices. Neuroscience. 2009 Feb 18; 158(4):1446-59. PMID: 19041929.
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Proctor WR, Diao L, Freund RK, Browning MD, Wu PH. Synaptic GABAergic and glutamatergic mechanisms underlying alcohol sensitivity in mouse hippocampal neurons. J Physiol. 2006 Aug 15; 575(Pt 1):145-59. PMID: 16762999.
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Freund RK, Gerhardt GA, Marshall KE, Palmer MR. Differences in norepinephrine clearance in cerebellar slices from low-alcohol-sensitive and high-alcohol-sensitive rats. Alcohol. 2003 May; 30(1):9-18. PMID: 12878270.
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Palmer MR, Granholm AC, van Horne CG, Giardina KE, Freund RK, Moorhead JW, Gerhardt GA. Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats. Brain Res. 2001 Jan 26; 890(1):86-99. PMID: 11164771.
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Wang Y, Freund RK, Palmer MR. Potentiation of ethanol effects in cerebellum by activation of endogenous noradrenergic inputs. J Pharmacol Exp Ther. 1999 Jan; 288(1):211-20. PMID: 9862773.
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Trok K, Palmer MR, Freund RK, Olson L. Functional interactions between spinal cord grafts suggest asymmetries dictated by graft maturity. Exp Neurol. 1997 May; 145(1):268-77. PMID: 9184129.
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Craparo A, Freund R, Gustafson TA. 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner. J Biol Chem. 1997 Apr 25; 272(17):11663-9. PMID: 9111084.
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Freund RK, Palmer MR. Beta adrenergic sensitization of gamma-aminobutyric acid receptors to ethanol involves a cyclic AMP/protein kinase A second-messenger mechanism. J Pharmacol Exp Ther. 1997 Mar; 280(3):1192-200. PMID: 9067303.
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Pearson BJ, Donatelli DP, Freund RK, Palmer MR. Differential development and characterization of rapid acute neuronal tolerance to the depressant effects of ethanol on cerebellar Purkinje neurons of low-alcohol-sensitive and high-alcohol-sensitive rats. J Pharmacol Exp Ther. 1997 Feb; 280(2):739-46. PMID: 9023286.
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Freund RK, Palmer MR. Ethanol depression of cerebellar Purkinje neuron firing involves nicotinic acetylcholine receptors. Exp Neurol. 1997 Feb; 143(2):319-22. PMID: 9056394.
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Freund RK, Palmer MR. 8-Bromo-cAMP mimics beta-adrenergic sensitization of GABA responses to ethanol in cerebellar Purkinje neurons in vivo. Alcohol Clin Exp Res. 1996 Apr; 20(2):408-12. PMID: 8730238.
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Lin AM, Freund RK, Hoffer BJ, Palmer MR. Ethanol-induced depressions of cerebellar Purkinje neurons are potentiated by beta-adrenergic mechanisms in rat brain. J Pharmacol Exp Ther. 1994 Dec; 271(3):1175-80. PMID: 7996423.
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Trok K, Freund RK, Palmer MR, Olson L. Spinal cord-skeletal muscle cografts: trophic and functional interactions. Brain Res. 1994 Oct 03; 659(1-2):138-46. PMID: 7820655.
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Freund RK, Wang Y, Palmer MR. Differential effects of ethanol on the firing rates of Golgi-like neurons and Purkinje neurons in cerebellar slices in vitro. Neurosci Lett. 1993 Dec 24; 164(1-2):9-12. PMID: 8152623.
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Freund RK, van Horne CG, Harlan T, Palmer MR. Electrophysiological interactions of ethanol with GABAergic mechanisms in the rat cerebellum in vivo. Alcohol Clin Exp Res. 1993 Apr; 17(2):321-8. PMID: 8387727.
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Lin AM, Freund RK, Palmer MR. Sensitization of gamma-aminobutyric acid-induced depressions of cerebellar Purkinje neurons to the potentiative effects of ethanol by beta adrenergic mechanisms in rat brain. J Pharmacol Exp Ther. 1993 Apr; 265(1):426-32. PMID: 8386243.
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Lin AM, Freund RK, Palmer MR. Ethanol potentiation of GABA-induced electrophysiological responses in cerebellum: requirement for catecholamine modulation. Neurosci Lett. 1991 Jan 28; 122(2):154-8. PMID: 2027515.
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Freund RK, Luntz-Leybman V, Collins AC. Nicotine interferes with GABA-mediated inhibitory processes in mouse hippocampus. Brain Res. 1990 Sep 17; 527(2):286-91. PMID: 2253036.
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Luntz-Leybman V, Freund RK, Collins AC. 5 alpha-Pregnan-3 alpha-ol-20-one blocks nicotine-induced seizures and enhances paired-pulse inhibition. Eur J Pharmacol. 1990 Aug 28; 185(2-3):239-42. PMID: 2253697.
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Freund RK, Jungschaffer DA, Collins AC. Nicotine effects in mouse hippocampus are blocked by mecamylamine, but not other nicotinic antagonists. Brain Res. 1990 Mar 19; 511(2):187-91. PMID: 2334841.
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Marley RJ, Freund RK, Wehner JM. Differential response to flurazepam in long-sleep and short-sleep mice. Pharmacol Biochem Behav. 1988 Oct; 31(2):453-8. PMID: 3244720.
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Freund RK, Martin BJ, Jungschaffer DA, Ullman EA, Collins AC. Genetic differences in plasma corticosterone levels in response to nicotine injection. Pharmacol Biochem Behav. 1988 Aug; 30(4):1059-64. PMID: 3227029.
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Freund RK, Jungschaffer DA, Collins AC, Wehner JM. Evidence for modulation of GABAergic neurotransmission by nicotine. Brain Res. 1988 Jun 21; 453(1-2):215-20. PMID: 2841012.
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Freund RK, Marley RJ, Wehner JM. Differential sensitivity to bicuculline in three inbred mouse strains. Brain Res Bull. 1987 May; 18(5):657-62. PMID: 3607531.
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Freund RK, Wehner JM. Strain-selective effects of nicotine on electrophysiological responses evoked in hippocampus from DBA/2Ibg and C3H/2Ibg mice. J Neurogenet. 1987 Apr; 4(2-3):75-86. PMID: 3598770.
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Crooks SL, Freund RK, Halsrud DA, Koerner JF, Johnson RL. Antagonist activity of methyl-substituted analogues of 2-amino-4-phosphonobutanoic acid in the hippocampal slice. Brain Res. 1985 Mar 11; 329(1-2):346-9. PMID: 2983843.
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Freund RK, Crooks SL, Koerner JF, Johnson RL. Antagonist activity of phosphorus-containing glutamate analogues in the perforant path. Brain Res. 1984 Jan 16; 291(1):150-3. PMID: 6141836.
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Koerner JF, Johnson RL, Freund RK, Robinson MB, Crooks SL. Structure - function relationships for gamma-substituted glutamate analogues on dentate granule cells. Brain Res. 1983 Aug 08; 272(2):299-309. PMID: 6412962.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1994 | 2 | 1996 | 1 | 1997 | 5 | 1999 | 1 | 2001 | 1 | 2003 | 1 | 2006 | 1 | 2008 | 1 | 2010 | 1 | 2011 | 1 | 2012 | 2 | 2014 | 2 | 2016 | 2 | 2021 | 1 | 2022 | 2 | 2023 | 2 |
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