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Benjamin L Barthel

TitleResearch Associate
InstitutionUniversity of Colorado Boulder
DepartmentChemical & Biological Engin

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ganesh AN, Logie J, McLaughlin CK, Barthel BL, Koch TH, Shoichet BK, Shoichet MS. Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations. Mol Pharm. 2017 Jun 05; 14(6):1852-1860. PMID: 28502177.
      View in: PubMed
    2. Barthel BL, Mooz EL, Wiener LE, Koch GG, Koch TH. Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde. J Med Chem. 2016 Mar 10; 59(5):2205-21. PMID: 26881291.
      View in: PubMed
    3. Xiao D, Shi D, Yang D, Barthel B, Koch TH, Yan B. Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs. Biochem Pharmacol. 2013 Feb 01; 85(3):439-47. PMID: 23228697; PMCID: PMC4102434.
    4. Barthel BL, Rudnicki DL, Kirby TP, Colvin SM, Burkhart DJ, Koch TH. Synthesis and biological characterization of protease-activated prodrugs of doxazolidine. J Med Chem. 2012 Jul 26; 55(14):6595-607. PMID: 22742660; PMCID: PMC3433255.
    5. Barthel BL, Zhang Z, Rudnicki DL, Coldren CD, Polinkovsky M, Sun H, Koch GG, Chan DC, Koch TH. Preclinical efficacy of a carboxylesterase 2-activated prodrug of doxazolidine. J Med Chem. 2009 Dec 10; 52(23):7678-88. PMID: 19634903; PMCID: PMC2788667.
    6. Barthel BL, Torres RC, Hyatt JL, Edwards CC, Hatfield MJ, Potter PM, Koch TH. Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug. J Med Chem. 2008 Jan 24; 51(2):298-304. PMID: 18173233.
      View in: PubMed
    7. Koch TH, Barthel BL, Kalet BT, Rudnicki DL, Post GC, Burkhart DJ. Anthracycline-formaldehyde conjugates and their targeted prodrugs. Top Curr Chem. 2008; 283:141-70. PMID: 23605631.
      View in: PubMed
    8. Burkhart DJ, Barthel BL, Post GC, Kalet BT, Nafie JW, Shoemaker RK, Koch TH. Design, synthesis, and preliminary evaluation of doxazolidine carbamates as prodrugs activated by carboxylesterases. J Med Chem. 2006 Nov 30; 49(24):7002-12. PMID: 17125253; PMCID: PMC2569826.
    9. Post GC, Barthel BL, Burkhart DJ, Hagadorn JR, Koch TH. Doxazolidine, a proposed active metabolite of doxorubicin that cross-links DNA. J Med Chem. 2005 Dec 01; 48(24):7648-57. PMID: 16302805.
      View in: PubMed
    10. Kisley LR, Barrett BS, Bauer AK, Dwyer-Nield LD, Barthel B, Meyer AM, Thompson DC, Malkinson AM. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Res. 2002 Dec 01; 62(23):6850-6. PMID: 12460898.
      View in: PubMed
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