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James McManaman

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OB/GYN BRS
Phone303/724-3500

    Collapse Research 
    Collapse research activities and funding
    R01NS023058     (MCMANAMAN, JAMES LEWIS)Dec 1, 1985 - Nov 30, 1991
    NIH/NINDS
    ACTION OF MUSCLE TROPHIC FACTORS ON SPINAL MOTOR NEURONS
    Role: Principal Investigator

    R01HD045965     (MCMANAMAN, JAMES LEWIS)Dec 1, 2003 - Jul 31, 2014
    NIH/NICHD
    Mechanisms of milk lipid secretion
    Role: Principal Investigator

    R21HD050863     (MCMANAMAN, JAMES LEWIS)Jul 1, 2007 - Jun 30, 2009
    NIH/NICHD
    LACTATIONAL EFFECTORS OF TRIACYLGLYCEROL MOBILIZATION
    Role: Principal Investigator

    R01HD075285     (MACLEAN, PAUL S.)Aug 1, 2013 - May 31, 2018
    NIH/NICHD
    Postnatal Actions of Maternal Obesity on Neonatal Metabolic Health
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hazegh KE, Nemkov T, D'Alessandro A, Diller JD, Monks J, McManaman JL, Jones KL, Hansen KC, Reis T. An autonomous metabolic role for Spen. PLoS Genet. 2017 Jun; 13(6):e1006859. PMID: 28640815.
      View in: PubMed
    2. Monks J, Dzieciatkowska M, Bales ES, Orlicky DJ, Wright RM, McManaman JL. Xanthine oxidoreductase mediates membrane docking of milk-fat droplets but is not essential for apocrine lipid secretion. J Physiol. 2016 Oct 15; 594(20):5899-5921. PMID: 27357166.
      View in: PubMed
    3. Skaznik-Wikiel ME, Swindle DC, Allshouse AA, Polotsky AJ, McManaman JL. High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice. Biol Reprod. 2016 May; 94(5):108. PMID: 27030045; PMCID: PMC4939738 [Available on 05/01/17].
    4. Frank DN, Bales ES, Monks J, Jackman MJ, MacLean PS, Ir D, Robertson CE, Orlicky DJ, McManaman JL. Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine. PLoS One. 2015; 10(7):e0131944. PMID: 26147095; PMCID: PMC4493139.
    5. Saben JL, Bales ES, Jackman MR, Orlicky D, MacLean PS, McManaman JL. Maternal obesity reduces milk lipid production in lactating mice by inhibiting acetyl-CoA carboxylase and impairing fatty acid synthesis. PLoS One. 2014; 9(5):e98066. PMID: 24849657; PMCID: PMC4029960.
    6. McManaman JL. Lipid transport in the lactating mammary gland. J Mammary Gland Biol Neoplasia. 2014 Mar; 19(1):35-42. PMID: 24567110; PMCID: PMC4413448.
    7. Crunk AE, Monks J, Murakami A, Jackman M, Maclean PS, Ladinsky M, Bales ES, Cain S, Orlicky DJ, McManaman JL. Dynamic regulation of hepatic lipid droplet properties by diet. PLoS One. 2013; 8(7):e67631. PMID: 23874434; PMCID: PMC3708958.
    8. Orlicky DJ, Monks J, Stefanski AL, McManaman JL. Dynamics and molecular determinants of cytoplasmic lipid droplet clustering and dispersion. PLoS One. 2013; 8(6):e66837. PMID: 23825572; PMCID: PMC3692517.
    9. McManaman JL, Bales ES, Orlicky DJ, Jackman M, MacLean PS, Cain S, Crunk AE, Mansur A, Graham CE, Bowman TA, Greenberg AS. Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease. J Lipid Res. 2013 May; 54(5):1346-59. PMID: 23402988; PMCID: PMC3622329.
    10. Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Ruzicky P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013; 4:2434. PMID: 24022321; PMCID: PMC3833672.
    11. McManaman JL. Milk lipid secretion: recent biomolecular aspects. Biomol Concepts. 2012 Dec 01; 3(6):581-591. PMID: 24605173.
      View in: PubMed
    12. Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and neonatal nutrition: defining and refining the critical questions. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):167-88. PMID: 22752723; PMCID: PMC3428522.
    13. Gracie S, Pennell C, Ekman-Ordeberg G, Lye S, McManaman J, Williams S, Palmer L, Kelley M, Menon R, Gravett M. An integrated systems biology approach to the study of preterm birth using "-omic" technology--a guideline for research. BMC Pregnancy Childbirth. 2011 Oct 12; 11:71. PMID: 21992798; PMCID: PMC3205030.
    14. Russell TD, Schaack J, Orlicky DJ, Palmer C, Chang BH, Chan L, McManaman JL. Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands. J Cell Sci. 2011 Oct 01; 124(Pt 19):3247-53. PMID: 21878492; PMCID: PMC3178452.
    15. Wahlig JL, Bales ES, Jackman MR, Johnson GC, McManaman JL, Maclean PS. Impact of high-fat diet and obesity on energy balance and fuel utilization during the metabolic challenge of lactation. Obesity (Silver Spring). 2012 Jan; 20(1):65-75. PMID: 21720435; PMCID: PMC4109263.
    16. Greenberg AS, Coleman RA, Kraemer FB, McManaman JL, Obin MS, Puri V, Yan QW, Miyoshi H, Mashek DG. The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest. 2011 Jun; 121(6):2102-10. PMID: 21633178; PMCID: PMC3104768.
    17. Chong BM, Reigan P, Mayle-Combs KD, Orlicky DJ, McManaman JL. Determinants of adipophilin function in milk lipid formation and secretion. Trends Endocrinol Metab. 2011 Jun; 22(6):211-7. PMID: 21592818; PMCID: PMC3118920.
    18. Orlicky DJ, Roede JR, Bales E, Greenwood C, Greenberg A, Petersen D, McManaman JL. Chronic ethanol consumption in mice alters hepatocyte lipid droplet properties. Alcohol Clin Exp Res. 2011 Jun; 35(6):1020-33. PMID: 21535024; PMCID: PMC4158406.
    19. Chong BM, Russell TD, Schaack J, Orlicky DJ, Reigan P, Ladinsky M, McManaman JL. The adipophilin C terminus is a self-folding membrane-binding domain that is important for milk lipid secretion. J Biol Chem. 2011 Jul 01; 286(26):23254-65. PMID: 21383012; PMCID: PMC3123092.
    20. Schaack J, Bennett ML, Shapiro GS, DeGregori J, McManaman JL, Moorhead JW. Strong foreign promoters contribute to innate inflammatory responses induced by adenovirus transducing vectors. Virology. 2011 Mar 30; 412(1):28-35. PMID: 21255815; PMCID: PMC4419336.
    21. Huang X, Gao L, Wang S, McManaman JL, Thor AD, Yang X, Esteva FJ, Liu B. Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin. Cancer Res. 2010 Feb 01; 70(3):1204-14. PMID: 20103628.
      View in: PubMed
    22. Coletta RD, McCoy EL, Burns V, Kawakami K, McManaman JL, Wysolmerski JJ, Ford HL. Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis. BMC Dev Biol. 2010 Jan 14; 10:4. PMID: 20074369; PMCID: PMC2823684.
    23. McManaman JL. Formation of milk lipids: a molecular perspective. Clin Lipidol. 2009; 4(3):391-401. PMID: 26084294.
      View in: PubMed
    24. Orlicky DJ, Degala G, Greenwood C, Bales ES, Russell TD, McManaman JL. Multiple functions encoded by the N-terminal PAT domain of adipophilin. J Cell Sci. 2008 Sep 01; 121(Pt 17):2921-9. PMID: 18697835; PMCID: PMC3139108.
    25. Klein LL, Jonscher KR, Heerwagen MJ, Gibbs RS, McManaman JL. Shotgun proteomic analysis of vaginal fluid from women in late pregnancy. Reprod Sci. 2008 Apr; 15(3):263-73. PMID: 18421021.
      View in: PubMed
    26. Harvell DM, Spoelstra NS, Singh M, McManaman JL, Finlayson C, Phang T, Trapp S, Hunter L, Dye WW, Borges VF, Elias A, Horwitz KB, Richer JK. Molecular signatures of neoadjuvant endocrine therapy for breast cancer: characteristics of response or intrinsic resistance. Breast Cancer Res Treat. 2008 Dec; 112(3):475-88. PMID: 18327671.
      View in: PubMed
    27. McManaman JL, Russell TD, Schaack J, Orlicky DJ, Robenek H. Molecular determinants of milk lipid secretion. J Mammary Gland Biol Neoplasia. 2007 Dec; 12(4):259-68. PMID: 17999166.
      View in: PubMed
    28. Russell TD, Palmer CA, Orlicky DJ, Bales ES, Chang BH, Chan L, McManaman JL. Mammary glands of adipophilin-null mice produce an amino-terminally truncated form of adipophilin that mediates milk lipid droplet formation and secretion. J Lipid Res. 2008 Jan; 49(1):206-16. PMID: 17921437.
      View in: PubMed
    29. Russell TD, Palmer CA, Orlicky DJ, Fischer A, Rudolph MC, Neville MC, McManaman JL. Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolism. J Lipid Res. 2007 Jul; 48(7):1463-75. PMID: 17452747.
      View in: PubMed
    30. Schroeder-Gloeckler JM, Rahman SM, Janssen RC, Qiao L, Shao J, Roper M, Fischer SJ, Lowe E, Orlicky DJ, McManaman JL, Palmer C, Gitomer WL, Huang W, O'Doherty RM, Becker TC, Klemm DJ, Jensen DR, Pulawa LK, Eckel RH, Friedman JE. CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. J Biol Chem. 2007 May 25; 282(21):15717-29. PMID: 17387171; PMCID: PMC4109269.
    31. Anderson SM, Rudolph MC, McManaman JL, Neville MC. Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis! Breast Cancer Res. 2007; 9(1):204. PMID: 17338830; PMCID: PMC1851396.
    32. Rudolph MC, McManaman JL, Phang T, Russell T, Kominsky DJ, Serkova NJ, Stein T, Anderson SM, Neville MC. Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine. Physiol Genomics. 2007 Feb 12; 28(3):323-36. PMID: 17105756.
      View in: PubMed
    33. Palmer CA, Neville MC, Anderson SM, McManaman JL. Analysis of lactation defects in transgenic mice. J Mammary Gland Biol Neoplasia. 2006 Oct; 11(3-4):269-82. PMID: 17136614.
      View in: PubMed
    34. McManaman JL, Reyland ME, Thrower EC. Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland. J Mammary Gland Biol Neoplasia. 2006 Oct; 11(3-4):249-68. PMID: 17136613.
      View in: PubMed
    35. Wang Z, Jiang T, Li J, Proctor G, McManaman JL, Lucia S, Chua S, Levi M. Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes. 2005 Aug; 54(8):2328-35. PMID: 16046298.
      View in: PubMed
    36. McManaman JL, Palmer CA, Anderson S, Schwertfeger K, Neville MC. Regulation of milk lipid formation and secretion in the mouse mammary gland. Adv Exp Med Biol. 2004; 554:263-79. PMID: 15384582.
      View in: PubMed
    37. Wright RM, Ginger LA, Kosila N, Elkins ND, Essary B, McManaman JL, Repine JE. Mononuclear phagocyte xanthine oxidoreductase contributes to cytokine-induced acute lung injury. Am J Respir Cell Mol Biol. 2004 Apr; 30(4):479-90. PMID: 14512376.
      View in: PubMed
    38. Rudolph MC, McManaman JL, Hunter L, Phang T, Neville MC. Functional development of the mammary gland: use of expression profiling and trajectory clustering to reveal changes in gene expression during pregnancy, lactation, and involution. J Mammary Gland Biol Neoplasia. 2003 Jul; 8(3):287-307. PMID: 14973374.
      View in: PubMed
    39. Palmer CA, Lubon H, McManaman JL. Transgenic mice expressing recombinant human protein C exhibit defects in lactation and impaired mammary gland development. Transgenic Res. 2003 Jun; 12(3):283-92. PMID: 12779117.
      View in: PubMed
    40. McManaman JL, Neville MC. Mammary physiology and milk secretion. Adv Drug Deliv Rev. 2003 Apr 29; 55(5):629-41. PMID: 12706546.
      View in: PubMed
    41. Schwertfeger KL, McManaman JL, Palmer CA, Neville MC, Anderson SM. Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation. J Lipid Res. 2003 Jun; 44(6):1100-12. PMID: 12700340.
      View in: PubMed
    42. McManaman JL, Zabaronick W, Schaack J, Orlicky DJ. Lipid droplet targeting domains of adipophilin. J Lipid Res. 2003 Apr; 44(4):668-73. PMID: 12562852.
      View in: PubMed
    43. McManaman JL, Palmer CA, Wright RM, Neville MC. Functional regulation of xanthine oxidoreductase expression and localization in the mouse mammary gland: evidence of a role in lipid secretion. J Physiol. 2002 Dec 01; 545(Pt 2):567-79. PMID: 12456835; PMCID: PMC2290700.
    44. McManaman JL, Bain DL. Structural and conformational analysis of the oxidase to dehydrogenase conversion of xanthine oxidoreductase. J Biol Chem. 2002 Jun 14; 277(24):21261-8. PMID: 11914370.
      View in: PubMed
    45. Bain DL, Franden MA, McManaman JL, Takimoto GS, Horwitz KB. The N-terminal region of human progesterone B-receptors: biophysical and biochemical comparison to A-receptors. J Biol Chem. 2001 Jun 29; 276(26):23825-31. PMID: 11328821.
      View in: PubMed
    46. Wu CC, Howell KE, Neville MC, Yates JR, McManaman JL. Proteomics reveal a link between the endoplasmic reticulum and lipid secretory mechanisms in mammary epithelial cells. Electrophoresis. 2000 Oct; 21(16):3470-82. PMID: 11079566.
      View in: PubMed
    47. Wright RM, Riley MG, Weigel LK, Ginger LA, Costantino DA, McManaman JL. Activation of the human aldehyde oxidase (hAOX1) promoter by tandem cooperative Sp1/Sp3 binding sites: identification of complex architecture in the hAOX upstream DNA that includes a proximal promoter, distal activation sites, and a silencer element. DNA Cell Biol. 2000 Aug; 19(8):459-74. PMID: 10975464.
      View in: PubMed
    48. Bergman B, McManaman JL, Haskins K. Biochemical characterization of a beta cell membrane fraction antigenic for autoreactive T cell clones. J Autoimmun. 2000 Jun; 14(4):343-51. PMID: 10882061.
      View in: PubMed
    49. Bain DL, Franden MA, McManaman JL, Takimoto GS, Horwitz KB. The N-terminal region of the human progesterone A-receptor. Structural analysis and the influence of the DNA binding domain. J Biol Chem. 2000 Mar 10; 275(10):7313-20. PMID: 10702302.
      View in: PubMed
    50. McManaman JL, Hanson L, Neville MC, Wright RM. Lactogenic hormones regulate xanthine oxidoreductase and beta-casein levels in mammary epithelial cells by distinct mechanisms. Arch Biochem Biophys. 2000 Jan 15; 373(2):318-27. PMID: 10620355.
      View in: PubMed
    51. McManaman JL, Neville MC, Wright RM. Mouse mammary gland xanthine oxidoreductase: purification, characterization, and regulation. Arch Biochem Biophys. 1999 Nov 15; 371(2):308-16. PMID: 10545219.
      View in: PubMed
    52. Wright RM, Clayton DA, Riley MG, McManaman JL, Repine JE. cDNA cloning, sequencing, and characterization of male and female rat liver aldehyde oxidase (rAOX1). Differences in redox status may distinguish male and female forms of hepatic APX. J Biol Chem. 1999 Feb 05; 274(6):3878-86. PMID: 9920943.
      View in: PubMed
    53. Wright RM, McManaman JL, Repine JE. Alcohol-induced breast cancer: a proposed mechanism. Free Radic Biol Med. 1999 Feb; 26(3-4):348-54. PMID: 9895226.
      View in: PubMed
    54. Terada LS, Piermattei D, Shibao GN, McManaman JL, Wright RM. Hypoxia regulates xanthine dehydrogenase activity at pre- and posttranslational levels. Arch Biochem Biophys. 1997 Dec 01; 348(1):163-8. PMID: 9390187.
      View in: PubMed
    55. Martin D, Merkel E, Tucker KK, McManaman JL, Albert D, Relton J, Russell DA. Cachectic effect of ciliary neurotrophic factor on innervated skeletal muscle. Am J Physiol. 1996 Nov; 271(5 Pt 2):R1422-8. PMID: 8945982.
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    56. McManaman JL, Shellman V, Wright RM, Repine JE. Purification of rat liver xanthine oxidase and xanthine dehydrogenase by affinity chromatography on benzamidine-sepharose. Arch Biochem Biophys. 1996 Aug 01; 332(1):135-41. PMID: 8806718.
      View in: PubMed
    57. Wright RM, Vaitaitis GM, Weigel LK, Repine TB, McManaman JL, Repine JE. Identification of the candidate ALS2 gene at chromosome 2q33 as a human aldehyde oxidase gene. Redox Rep. 1995 Nov; 1(5):313-21. PMID: 27405828.
      View in: PubMed
    58. Valenzuela CF, Machu TK, McKernan RM, Whiting P, VanRenterghem BB, McManaman JL, Brozowski SJ, Smith GB, Olsen RW, Harris RA. Tyrosine kinase phosphorylation of GABAA receptors. Brain Res Mol Brain Res. 1995 Jul; 31(1-2):165-72. PMID: 7476025.
      View in: PubMed
    59. Rabinovsky ED, Browder DP, McManaman JL. Preparation and affinity purification of a novel, biologically active, CNTF fusion protein. J Neurosci Res. 1994 Jun 01; 38(2):127-33. PMID: 8078097.
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    60. Rabinovsky ED, Smith GM, Browder DP, Shine HD, McManaman JL. Peripheral nerve injury down-regulates CNTF expression in adult rat sciatic nerves. J Neurosci Res. 1992 Jan; 31(1):188-92. PMID: 1319503.
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    61. Marchetti D, Haverkamp LJ, Clark RC, McManaman JL. Ontogeny of high- and low-affinity nerve growth factor receptors in the lumbar spinal cord of the developing chick embryo. Dev Biol. 1991 Nov; 148(1):306-13. PMID: 1657663.
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    62. McManaman JL, Smith RG, Appel SH. Low-molecular-weight peptide stimulates cholinergic development in ventral spinal cord cultures. Dev Biol. 1985 Nov; 112(1):248-52. PMID: 3902537.
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    63. Cocivera M, McManaman J, Wilson IB. Formation of active isozymes I and III by reassociation of separated subunits of isozyme I of alkaline phosphatase. Arch Biochem Biophys. 1980 Apr 01; 200(2):396-400. PMID: 7002043.
      View in: PubMed
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