Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Steven F Maier

TitleDistinguished Professor
InstitutionUniversity of Colorado Boulder
DepartmentPsych-Psychology
Phone303/492-6275

    Collapse Research 
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    T32MH014617     (MAIER, STEVEN F)Jul 1, 1976 - Aug 31, 1996
    NIH/NIMH
    EXPERIMENTAL PSYCHOLOGY
    Role: Principal Investigator

    K02MH000314     (MAIER, STEVEN F)Jul 1, 1986 - Jun 30, 1991
    NIH/NIMH
    STRESSOR CONTROLLABILITY: ITS NEUROBIOLOGY, PSYCHOLOGY
    Role: Principal Investigator

    K05MH000314     (MAIER, STEVEN F)Jul 1, 1986 - Apr 30, 2001
    NIH/NIMH
    STRESSOR CONTROLLABILITY--IMMUNOLOGY/PHYSIOLOGY/BEHAVIOR
    Role: Principal Investigator

    R01MH045045     (MAIER, STEVEN F)May 1, 1989 - Apr 30, 2002
    NIH/NIMH
    STRESS &IMMUNITY--BEHAVIORAL &PHYSIOLOGICAL MECHANISMS
    Role: Principal Investigator

    R37MH050479     (MAIER, STEVEN F)Apr 1, 1993 - May 31, 2007
    NIH/NIMH
    STRESSOR CONTROLLABILITY: ANXIETY AND SEROTONIN
    Role: Principal Investigator

    R01MH050479     (MAIER, STEVEN F)Apr 1, 1993 - Jul 31, 2017
    NIH/NIMH
    Stressor Controllability: The Role of the mPFC in Producing Resiliency
    Role: Principal Investigator

    R01DA013159     (MAIER, STEVEN F)Apr 1, 2000 - May 31, 2011
    NIH/NIDA
    Stressor Controllability, Drugs of Abuse, and Serotonin
    Role: Principal Investigator

    R01AG028271     (MAIER, STEVEN F)Apr 1, 2006 - Feb 28, 2017
    NIH/NIA
    Neuroinflammation, Inflammatory Challenge, and Memory
    Role: Principal Investigator

    RC1MH088046     (MAIER, STEVEN F)Sep 30, 2009 - Aug 31, 2012
    NIH/NIMH
    Behavioral Control, the Medial Prefrontal Cortex, and Resilience in the Face of C
    Role: Principal Investigator

    R01DE021966     (WATKINS, LINDA)Sep 1, 2011 - Aug 31, 2016
    NIH/NIDCR
    Preventing Transition of Acute-to-Chronic Neuropathic Pain: Models, Mechanisms &
    Role: Co-Principal Investigator

    R21MH096224     (MAIER, STEVEN F)Jan 15, 2012 - Dec 31, 2014
    NIH/NIMH
    Stress, Glucocorticoids and Neuroinflammatory Priming
    Role: Principal Investigator

    R21MH106817     (BARATTA, MICHAEL V)Sep 1, 2015 - Jun 30, 2017
    NIH/NIMH
    Embedded Prefrontal Circuits in Stress Resilience
    Role: Co-Principal Investigator

    R01MH108523     (MAIER, STEVEN F)Jun 16, 2016 - Mar 31, 2021
    NIH/NIMH
    Stress-induced neuroinflammatory priming: Glucocorticoids, inflammasomes, alarmins
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lewis SS, Grace PM, Hutchinson MR, Maier SF, Watkins LR. Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia. Brain Behav Immun. 2016 Dec 18. PMID: 27993689.
      View in: PubMed
    2. Barrientos RM, Kitt MM, D'Angelo HM, Watkins LR, Rudy JW, Maier SF. Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol. Learn Mem. 2016 Dec; 23(12):699-702. PMID: 27918274.
      View in: PubMed
    3. Grace PM, Gaudet AD, Staikopoulos V, Maier SF, Hutchinson MR, Salvemini D, Watkins LR. Nitroxidative Signaling Mechanisms in Pathological Pain. Trends Neurosci. 2016 Dec; 39(12):862-879. PMID: 27842920.
      View in: PubMed
    4. Dolzani SD, Baratta MV, Amat J, Agster KL, Saddoris MP, Watkins LR, Maier SF. Activation of a Habenulo-Raphe Circuit Is Critical for the Behavioral and Neurochemical Consequences of Uncontrollable Stress in the Male Rat. eNeuro. 2016 Sep-Oct; 3(5). PMID: 27785462.
      View in: PubMed
    5. Sørensen AT, Cooper YA, Baratta MV, Weng FJ, Zhang Y, Ramamoorthi K, Fropf R, LaVerriere E, Xue J, Young A, Schneider C, Gøtzsche CR, Hemberg M, Yin JC, Maier SF, Lin Y. A robust activity marking system for exploring active neuronal ensembles. Elife. 2016 Sep 23; 5. PMID: 27661450.
      View in: PubMed
    6. Grace PM, Fabisiak TJ, Green-Fulgham SM, Anderson ND, Strand KA, Kwilasz AJ, Galer EL, Walker FR, Greenwood BN, Maier SF, Fleshner M, Watkins LR. Prior voluntary wheel running attenuates neuropathic pain. Pain. 2016 09; 157(9):2012-23. PMID: 27355182.
      View in: PubMed
    7. Sobesky JL, D'Angelo HM, Weber MD, Anderson ND, Frank MG, Watkins LR, Maier SF, Barrientos RM. Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1. eNeuro. 2016 Jul-Aug; 3(4). PMID: 27595136.
      View in: PubMed
    8. Ellis A, Grace PM, Wieseler J, Favret J, Springer K, Skarda B, Ayala M, Hutchinson MR, Falci S, Rice KC, Maier SF, Watkins LR. Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury. Brain Behav Immun. 2016 Nov; 58:348-356. PMID: 27519154.
      View in: PubMed
    9. Fonken LK, Kitt MM, Gaudet AD, Barrientos RM, Watkins LR, Maier SF. Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization. Neurobiol Aging. 2016 Nov; 47:102-112. PMID: 27568094.
      View in: PubMed
    10. Fonken LK, Frank MG, Kitt MM, D'Angelo HM, Norden DM, Weber MD, Barrientos RM, Godbout JP, Watkins LR, Maier SF. The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming. J Neurosci. 2016 Jul 27; 36(30):7946-56. PMID: 27466339.
      View in: PubMed
    11. Fleshner M, Frank M, Maier SF. Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders. Neuropsychopharmacology. 2017 Jan; 42(1):36-45. PMID: 27412959.
      View in: PubMed
    12. Maier SF, Seligman ME. Learned helplessness at fifty: Insights from neuroscience. Psychol Rev. 2016 Jul; 123(4):349-67. PMID: 27337390.
      View in: PubMed
    13. Grace PM, Strand KA, Galer EL, Urban DJ, Wang X, Baratta MV, Fabisiak TJ, Anderson ND, Cheng K, Greene LI, Berkelhammer D, Zhang Y, Ellis AL, Yin HH, Campeau S, Rice KC, Roth BL, Maier SF, Watkins LR. Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proc Natl Acad Sci U S A. 2016 06 14; 113(24):E3441-50. PMID: 27247388.
      View in: PubMed
    14. Grace PM, Loram LC, Christianson JP, Strand KA, Flyer-Adams JG, Penzkover KR, Forsayeth JR, van Dam AM, Mahoney MJ, Maier SF, Chavez RA, Watkins LR. Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy. Brain Behav Immun. 2017 Jan; 59:49-54. PMID: 27189037.
      View in: PubMed
    15. Grace P, Strand K, Galer E, Anderson N, Fabisiak T, Fulgham S, Greenwood B, Fleshner M, Maier S, Watkins L. (464) Prior voluntary wheel running is protective for neuropathic-like pain. J Pain. 2016 Apr; 17(4S):S90. PMID: 28162718.
      View in: PubMed
    16. Fonken LK, Weber MD, Daut RA, Kitt MM, Frank MG, Watkins LR, Maier SF. Stress-induced neuroinflammatory priming is time of day dependent. Psychoneuroendocrinology. 2016 Apr; 66:82-90. PMID: 26799851.
      View in: PubMed
    17. Frank MG, Weber MD, Watkins LR, Maier SF. Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders. Neurobiol Stress. 2016 Oct; 4:62-70. PMID: 27981190.
      View in: PubMed
    18. Clark PJ, Amat J, McConnell SO, Ghasem PR, Greenwood BN, Maier SF, Fleshner M. Running Reduces Uncontrollable Stress-Evoked Serotonin and Potentiates Stress-Evoked Dopamine Concentrations in the Rat Dorsal Striatum. PLoS One. 2015; 10(11):e0141898. PMID: 26555633.
      View in: PubMed
    19. Frank MG, Weber MD, Fonken LK, Hershman SA, Watkins LR, Maier SF. The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome. Brain Behav Immun. 2016 Jul; 55:215-24. PMID: 26482581.
      View in: PubMed
    20. Frank MG, Adhikary S, Sobesky JL, Weber MD, Watkins LR, Maier SF. The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine. Brain Behav Immun. 2016 Jan; 51:99-108. PMID: 26254235.
      View in: PubMed
    21. Frank MG, Watkins LR, Maier SF. The permissive role of glucocorticoids in neuroinflammatory priming: mechanisms and insights. Curr Opin Endocrinol Diabetes Obes. 2015 Aug; 22(4):300-5. PMID: 26087336.
      View in: PubMed
    22. Grace PM, Maier SF, Watkins LR. Opioid-induced central immune signaling: implications for opioid analgesia. Headache. 2015 Apr; 55(4):475-89. PMID: 25833219.
      View in: PubMed
    23. Frank MG, Weber MD, Watkins LR, Maier SF. Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming. Brain Behav Immun. 2015 Aug; 48:1-7. PMID: 25816800.
      View in: PubMed
    24. Barrientos RM, Kitt MM, Watkins LR, Maier SF. Neuroinflammation in the normal aging hippocampus. Neuroscience. 2015 Nov 19; 309:84-99. PMID: 25772789.
      View in: PubMed
    25. Northcutt AL, Hutchinson MR, Wang X, Baratta MV, Hiranita T, Cochran TA, Pomrenze MB, Galer EL, Kopajtic TA, Li CM, Amat J, Larson G, Cooper DC, Huang Y, O'Neill CE, Yin H, Zahniser NR, Katz JL, Rice KC, Maier SF, Bachtell RK, Watkins LR. DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Mol Psychiatry. 2015 Dec; 20(12):1525-37. PMID: 25644383.
      View in: PubMed
    26. Loram LC, Strand KA, Taylor FR, Sloane E, Van Dam AM, Rieger J, Maier SF, Watkins LR. Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats. Brain Behav Immun. 2015 May; 46:50-4. PMID: 25653191.
      View in: PubMed
    27. Weber MD, Frank MG, Tracey KJ, Watkins LR, Maier SF. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. J Neurosci. 2015 Jan 07; 35(1):316-24. PMID: 25568124.
      View in: PubMed
    28. Bachtell R, Hutchinson MR, Wang X, Rice KC, Maier SF, Watkins LR. Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4. CNS Neurol Disord Drug Targets. 2015; 14(6):692-9. PMID: 26022268.
      View in: PubMed
    29. Maier SF. Behavioral control blunts reactions to contemporaneous and future adverse events: medial prefrontal cortex plasticity and a corticostriatal network. Neurobiol Stress. 2015 Jan 01; 1:12-22. PMID: 25506602.
      View in: PubMed
    30. Barrientos RM, Thompson VM, Kitt MM, Amat J, Hale MW, Frank MG, Crysdale NY, Stamper CE, Hennessey PA, Watkins LR, Spencer RL, Lowry CA, Maier SF. Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. Neurobiol Aging. 2015 Mar; 36(3):1483-95. PMID: 25559333.
      View in: PubMed
    31. van Elst LT, Maier S, Fangmeier T, Endres D, Mueller GT, Nickel K, Ebert D, Lange T, Hennig J, Biscaldi M, Riedel A, Perlov E. Magnetic resonance spectroscopy comparing adults with high functioning autism and above average IQ. Mol Psychiatry. 2014 Dec; 19(12):1251. PMID: 25407610.
      View in: PubMed
    32. Fonken LK, Frank MG, Kitt MM, Barrientos RM, Watkins LR, Maier SF. Microglia inflammatory responses are controlled by an intrinsic circadian clock. Brain Behav Immun. 2015 Mar; 45:171-9. PMID: 25433170.
      View in: PubMed
    33. Kwilasz AJ, Grace PM, Serbedzija P, Maier SF, Watkins LR. The therapeutic potential of interleukin-10 in neuroimmune diseases. Neuropharmacology. 2015 Sep; 96(Pt A):55-69. PMID: 25446571.
      View in: PubMed
    34. O'Neill CE, Levis SC, Schreiner DC, Amat J, Maier SF, Bachtell RK. Effects of adolescent caffeine consumption on cocaine sensitivity. Neuropsychopharmacology. 2015 Mar; 40(4):813-21. PMID: 25328052.
      View in: PubMed
    35. Christianson JP, Flyer-Adams JG, Drugan RC, Amat J, Daut RA, Foilb AR, Watkins LR, Maier SF. Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex. Front Behav Neurosci. 2014; 8:348. PMID: 25324750.
      View in: PubMed
    36. Grace PM, Ramos KM, Rodgers KM, Wang X, Hutchinson MR, Lewis MT, Morgan KN, Kroll JL, Taylor FR, Strand KA, Zhang Y, Berkelhammer D, Huey MG, Greene LI, Cochran TA, Yin H, Barth DS, Johnson KW, Rice KC, Maier SF, Watkins LR. Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience. 2014 Nov 07; 280:299-317. PMID: 25241065.
      View in: PubMed
    37. Lewis SS, Hutchinson MR, Frick MM, Zhang Y, Maier SF, Sammakia T, Rice KC, Watkins LR. Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain. Brain Behav Immun. 2015 Feb; 44:128-36. PMID: 25218902.
      View in: PubMed
    38. Tebartz van Elst L, Maier S, Fangmeier T, Endres D, Mueller GT, Nickel K, Ebert D, Lange T, Hennig J, Biscaldi M, Riedel A, Perlov E. Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance hypothesis. Mol Psychiatry. 2014 Dec; 19(12):1314-25. PMID: 25048006.
      View in: PubMed
    39. Barrientos RM, Thompson VM, Arnold TH, Frank MG, Watkins LR, Maier SF. The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats. Brain Behav Immun. 2015 Jan; 43:60-7. PMID: 25043992.
      View in: PubMed
    40. Sobesky JL, Barrientos RM, De May HS, Thompson BM, Weber MD, Watkins LR, Maier SF. High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1ß, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism. Brain Behav Immun. 2014 Nov; 42:22-32. PMID: 24998196.
      View in: PubMed
    41. Amat J, Christianson JP, Aleksejev RM, Kim J, Richeson KR, Watkins LR, Maier SF. Control over a stressor involves the posterior dorsal striatum and the act/outcome circuit. Eur J Neurosci. 2014 Jul; 40(2):2352-8. PMID: 24862585.
      View in: PubMed
    42. Grace PM, Hutchinson MR, Maier SF, Watkins LR. Pathological pain and the neuroimmune interface. Nat Rev Immunol. 2014 Apr; 14(4):217-31. PMID: 24577438.
      View in: PubMed
    43. Ellis A, Wieseler J, Favret J, Johnson KW, Rice KC, Maier SF, Falci S, Watkins LR. Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain. J Pain. 2014 Apr; 15(4):407-21. PMID: 24412802.
      View in: PubMed
    44. Kreisel T, Frank MG, Licht T, Reshef R, Ben-Menachem-Zidon O, Baratta MV, Maier SF, Yirmiya R. Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol Psychiatry. 2014 Jun; 19(6):699-709. PMID: 24342992.
      View in: PubMed
    45. Frank MG, Hershman SA, Weber MD, Watkins LR, Maier SF. Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus. Psychoneuroendocrinology. 2014 Feb; 40:191-200. PMID: 24485491.
      View in: PubMed
    46. Baratta MV, Rozeske RR, Maier SF. Understanding stress resilience. Front Behav Neurosci. 2013; 7:158. PMID: 24265608.
      View in: PubMed
    47. Grace PM, Strand KA, Maier SF, Watkins LR. Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain. J Pain. 2014 Feb; 15(2):121-8. PMID: 24287315.
      View in: PubMed
    48. Loram LC, Taylor FR, Strand KA, Harrison JA, Rzasalynn R, Sholar P, Rieger J, Maier SF, Watkins LR. Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling. Brain Behav Immun. 2013 Oct; 33:112-22. PMID: 23811314.
      View in: PubMed
    49. Bastos LF, Godin AM, Zhang Y, Jarussophon S, Ferreira BC, Machado RR, Maier SF, Konishi Y, de Freitas RP, Fiebich BL, Watkins LR, Coelho MM, Moraes MF. A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4. Neurosci Lett. 2013 May 24; 543:157-62. PMID: 23523650.
      View in: PubMed
    50. Weber MD, Frank MG, Sobesky JL, Watkins LR, Maier SF. Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge. Brain Behav Immun. 2013 Aug; 32:112-21. PMID: 23500798.
      View in: PubMed
    51. Frank MG, Watkins LR, Maier SF. Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger. Brain Behav Immun. 2013 Oct; 33:1-6. PMID: 23459026.
      View in: PubMed
    52. Christianson JP, Drugan RC, Flyer JG, Watkins LR, Maier SF. Anxiogenic effects of brief swim stress are sensitive to stress history. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 01; 44:17-22. PMID: 23357538.
      View in: PubMed
    53. Lewis SS, Hutchinson MR, Zhang Y, Hund DK, Maier SF, Rice KC, Watkins LR. Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain Behav Immun. 2013 May; 30:24-32. PMID: 23348028.
      View in: PubMed
    54. Loram LC, Taylor FR, Strand KA, Maier SF, Speake JD, Jordan KG, James JW, Wene SP, Pritchard RC, Green H, Van Dyke K, Mazarov A, Letchworth SR, Watkins LR. Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats. J Pain. 2012 Dec; 13(12):1162-71. PMID: 23182225.
      View in: PubMed
    55. Barrientos RM, Hein AM, Frank MG, Watkins LR, Maier SF. Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. J Neurosci. 2012 Oct 17; 32(42):14641-8. PMID: 23077050.
      View in: PubMed
    56. Varela JA, Wang J, Christianson JP, Maier SF, Cooper DC. Control over stress, but not stress per se increases prefrontal cortical pyramidal neuron excitability. J Neurosci. 2012 Sep 12; 32(37):12848-53. PMID: 22973008.
      View in: PubMed
    57. Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, Maslanik T, Chapman TR, Strand KA, Fleshner M, Bachtell RK, Somogyi AA, Yin H, Katz JL, Rice KC, Maier SF, Watkins LR. Opioid activation of toll-like receptor 4 contributes to drug reinforcement. J Neurosci. 2012 Aug 15; 32(33):11187-200. PMID: 22895704.
      View in: PubMed
    58. Loram LC, Grace PM, Strand KA, Taylor FR, Ellis A, Berkelhammer D, Bowlin M, Skarda B, Maier SF, Watkins LR. Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy. Brain Behav Immun. 2012 Nov; 26(8):1256-64. PMID: 22902523.
      View in: PubMed
    59. Frank MG, Barrientos RM, Thompson BM, Weber MD, Watkins LR, Maier SF. IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses. J Neuroimmunol. 2012 Nov 15; 252(1-2):33-9. PMID: 22871632.
      View in: PubMed
    60. Kubala KH, Christianson JP, Kaufman RD, Watkins LR, Maier SF. Short- and long-term consequences of stressor controllability in adolescent rats. Behav Brain Res. 2012 Oct 01; 234(2):278-84. PMID: 22771417.
      View in: PubMed
    61. Helmreich DL, Tylee D, Christianson JP, Kubala KH, Govindarajan ST, O'Neill WE, Becoats K, Watkins L, Maier SF. Active behavioral coping alters the behavioral but not the endocrine response to stress. Psychoneuroendocrinology. 2012 Dec; 37(12):1941-8. PMID: 22578266.
      View in: PubMed
    62. Lewis SS, Loram LC, Hutchinson MR, Li CM, Zhang Y, Maier SF, Huang Y, Rice KC, Watkins LR. (+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. J Pain. 2012 May; 13(5):498-506. PMID: 22520687.
      View in: PubMed
    63. Loram LC, Sholar PW, Taylor FR, Wiesler JL, Babb JA, Strand KA, Berkelhammer D, Day HE, Maier SF, Watkins LR. Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats. Psychoneuroendocrinology. 2012 Oct; 37(10):1688-99. PMID: 22497984.
      View in: PubMed
    64. Barrientos RM, Frank MG, Watkins LR, Maier SF. Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition. Horm Behav. 2012 Aug; 62(3):219-27. PMID: 22370243.
      View in: PubMed
    65. Wieseler J, Sprunger D, Ellis A, Maier SF, Watkins LR. Indwelling supradural catheters for induction of facial allodynia: surgical procedures, application of inflammatory stimuli, and behavioral testing. Methods Mol Biol. 2012; 851:99-107. PMID: 22351084.
      View in: PubMed
    66. Wieseler J, Ellis A, Maier SF, Watkins LR, Falci S. Unilateral T13 and L1 dorsal root avulsion: methods for a novel model of central neuropathic pain. Methods Mol Biol. 2012; 851:171-83. PMID: 22351090.
      View in: PubMed
    67. Forgeard MJ, Haigh EA, Beck AT, Davidson RJ, Henn FA, Maier SF, Mayberg HS, Seligman ME. Beyond Depression: Towards a Process-Based Approach to Research, Diagnosis, and Treatment. Clin Psychol (New York). 2011 Dec; 18(4):275-299. PMID: 22509072.
      View in: PubMed
    68. Rozeske RR, Der-Avakian A, Watkins LR, Maier SF. Activation of the medial prefrontal cortex by escapable stress is necessary for protection against subsequent inescapable stress-induced potentiation of morphine conditioned place preference. Eur J Neurosci. 2012 Jan; 35(1):160-5. PMID: 22118376.
      View in: PubMed
    69. Frank MG, Thompson BM, Watkins LR, Maier SF. Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses. Brain Behav Immun. 2012 Feb; 26(2):337-45. PMID: 22041296.
      View in: PubMed
    70. Rozeske RR, Evans AK, Frank MG, Watkins LR, Lowry CA, Maier SF. Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus. J Neurosci. 2011 Oct 05; 31(40):14107-15. PMID: 21976495.
      View in: PubMed
    71. Strong PV, Christianson JP, Loughridge AB, Amat J, Maier SF, Fleshner M, Greenwood BN. 5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-induced interference with negatively reinforced instrumental escape behavior. Neuroscience. 2011 Dec 01; 197:132-44. PMID: 21958863.
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    72. Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR. Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol. 2011 Oct 28; 239(1-2):53-60. PMID: 21907418.
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    73. Chapman TR, Barrientos RM, Ahrendsen JT, Hoover JM, Maier SF, Patterson SL. Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus. Neurobiol Aging. 2012 Apr; 33(4):832.e1-14. PMID: 21907460.
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    74. Johnston IN, Maier SF, Rudy JW, Watkins LR. Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat. Behav Brain Res. 2012 Jan 15; 226(2):361-8. PMID: 21920390.
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    75. Christianson JP, Jennings JH, Ragole T, Flyer JG, Benison AM, Barth DS, Watkins LR, Maier SF. Safety signals mitigate the consequences of uncontrollable stress via a circuit involving the sensory insular cortex and bed nucleus of the stria terminalis. Biol Psychiatry. 2011 Sep 01; 70(5):458-64. PMID: 21684526.
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    76. Barrientos RM, Frank MG, Crysdale NY, Chapman TR, Ahrendsen JT, Day HE, Campeau S, Watkins LR, Patterson SL, Maier SF. Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes. J Neurosci. 2011 Aug 10; 31(32):11578-86. PMID: 21832188.
      View in: PubMed
    77. Fleshner M, Maier SF, Lyons DM, Raskind MA. The neurobiology of the stress-resistant brain. Stress. 2011 Sep; 14(5):498-502. PMID: 21790482.
      View in: PubMed
    78. Hutchinson MR, Shavit Y, Grace PM, Rice KC, Maier SF, Watkins LR. Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev. 2011 Sep; 63(3):772-810. PMID: 21752874.
      View in: PubMed
    79. Benison AM, Chumachenko S, Harrison JA, Maier SF, Falci SP, Watkins LR, Barth DS. Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy. J Neurosci. 2011 Apr 27; 31(17):6317-28. PMID: 21525272.
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    80. Loram LC, Taylor FR, Strand KA, Frank MG, Sholar P, Harrison JA, Maier SF, Watkins LR. Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation. Brain Behav Immun. 2011 Oct; 25(7):1408-15. PMID: 21536123.
      View in: PubMed
    81. Cortese GP, Barrientos RM, Maier SF, Patterson SL. Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes. J Neurosci. 2011 Mar 16; 31(11):4274-9. PMID: 21411668.
      View in: PubMed
    82. Rozeske RR, Greenwood BN, Fleshner M, Watkins LR, Maier SF. Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference. Behav Brain Res. 2011 Jun 01; 219(2):378-81. PMID: 21262267.
      View in: PubMed
    83. Frank MG, Watkins LR, Maier SF. Stress- and glucocorticoid-induced priming of neuroinflammatory responses: potential mechanisms of stress-induced vulnerability to drugs of abuse. Brain Behav Immun. 2011 Jun; 25 Suppl 1:S21-8. PMID: 21256955.
      View in: PubMed
    84. Thompson BM, Baratta MV, Biedenkapp JC, Rudy JW, Watkins LR, Maier SF. Activation of the infralimbic cortex in a fear context enhances extinction learning. Learn Mem. 2010 Nov; 17(11):591-9. PMID: 21041382.
      View in: PubMed
    85. Koerner P, Traeger T, Mehmcke H, Cziupka K, Kessler W, Busemann A, Diedrich S, Hartmann G, Heidecke CD, Maier S. Stimulation of TLR7 prior to polymicrobial sepsis improves the immune control of the inflammatory response in adult mice. Inflamm Res. 2011 Mar; 60(3):271-9. PMID: 20953969.
      View in: PubMed
    86. Hains LE, Loram LC, Weiseler JL, Frank MG, Bloss EB, Sholar P, Taylor FR, Harrison JA, Martin TJ, Eisenach JC, Maier SF, Watkins LR. Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain. 2010 Oct; 11(10):1004-14. PMID: 20434956.
      View in: PubMed
    87. Wieseler J, Ellis AL, McFadden A, Brown K, Starnes C, Maier SF, Watkins LR, Falci S. Below level central pain induced by discrete dorsal spinal cord injury. J Neurotrauma. 2010 Sep; 27(9):1697-707. PMID: 20649467.
      View in: PubMed
    88. Maier SF, Watkins LR. Role of the medial prefrontal cortex in coping and resilience. Brain Res. 2010 Oct 08; 1355:52-60. PMID: 20727864.
      View in: PubMed
    89. Weinberg MS, Grissom N, Paul E, Bhatnagar S, Maier SF, Spencer RL. Inescapable but not escapable stress leads to increased struggling behavior and basolateral amygdala c-fos gene expression in response to subsequent novel stress challenge. Neuroscience. 2010 Sep 29; 170(1):138-48. PMID: 20600641.
      View in: PubMed
    90. Ramos KM, Lewis MT, Morgan KN, Crysdale NY, Kroll JL, Taylor FR, Harrison JA, Sloane EM, Maier SF, Watkins LR. Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders. Neuroscience. 2010 Sep 15; 169(4):1888-900. PMID: 20547213.
      View in: PubMed
    91. Chapman TR, Barrientos RM, Ahrendsen JT, Maier SF, Patterson SL. Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1. J Neurosci. 2010 Jun 02; 30(22):7598-603. PMID: 20519534.
      View in: PubMed
    92. Frank MG, Barrientos RM, Watkins LR, Maier SF. Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo. J Neuroimmunol. 2010 Sep 14; 226(1-2):181-4. PMID: 20537730.
      View in: PubMed
    93. Kozora E, West SG, Maier SF, Filley CM, Arciniegas DB, Brown M, Miller D, Grimm A, Zhang L. Antibodies against N-methyl-D-aspartate receptors in patients with systemic lupus erythematosus without major neuropsychiatric syndromes. J Neurol Sci. 2010 Aug 15; 295(1-2):87-91. PMID: 20546792.
      View in: PubMed
    94. Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR. Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience. 2010 Jun 30; 168(2):551-63. PMID: 20381591.
      View in: PubMed
    95. Loram LC, Harrison JA, Chao L, Taylor FR, Reddy A, Travis CL, Giffard R, Al-Abed Y, Tracey K, Maier SF, Watkins LR. Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats. Brain Behav Immun. 2010 Aug; 24(6):959-67. PMID: 20353818.
      View in: PubMed
    96. Bland ST, Beckley JT, Watkins LR, Maier SF, Bilbo SD. Neonatal Escherichia coli infection alters glial, cytokine, and neuronal gene expression in response to acute amphetamine in adolescent rats. Neurosci Lett. 2010 Apr 19; 474(1):52-7. PMID: 20223277.
      View in: PubMed
    97. Hutchinson MR, Lewis SS, Coats BD, Rezvani N, Zhang Y, Wieseler JL, Somogyi AA, Yin H, Maier SF, Rice KC, Watkins LR. Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience. 2010 May 19; 167(3):880-93. PMID: 20178837.
      View in: PubMed
    98. Lewis SS, Hutchinson MR, Rezvani N, Loram LC, Zhang Y, Maier SF, Rice KC, Watkins LR. Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta. Neuroscience. 2010 Jan 20; 165(2):569-83. PMID: 19833175.
      View in: PubMed
    99. Barrientos RM, Frank MG, Watkins LR, Maier SF. Memory impairments in healthy aging: Role of aging-induced microglial sensitization. Aging Dis. 2010 Jan 01; 1(3):212-231. PMID: 21132050.
      View in: PubMed
    100. Christianson JP, Ragole T, Amat J, Greenwood BN, Strong PV, Paul ED, Fleshner M, Watkins LR, Maier SF. 5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress. Biol Psychiatry. 2010 Feb 15; 67(4):339-45. PMID: 19914601.
      View in: PubMed
    101. Amat J, Aleksejev RM, Paul E, Watkins LR, Maier SF. Behavioral control over shock blocks behavioral and neurochemical effects of later social defeat. Neuroscience. 2010 Feb 17; 165(4):1031-8. PMID: 19909791.
      View in: PubMed
    102. Loram LC, Harrison JA, Sloane EM, Hutchinson MR, Sholar P, Taylor FR, Berkelhammer D, Coats BD, Poole S, Milligan ED, Maier SF, Rieger J, Watkins LR. Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain. J Neurosci. 2009 Nov 04; 29(44):14015-25. PMID: 19890011.
      View in: PubMed
    103. Wieseler J, Ellis A, Sprunger D, Brown K, McFadden A, Mahoney J, Rezvani N, Maier SF, Watkins LR. A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats. J Neurosci Methods. 2010 Jan 15; 185(2):236-45. PMID: 19837113.
      View in: PubMed
    104. Hein AM, Stasko MR, Matousek SB, Scott-McKean JJ, Maier SF, Olschowka JA, Costa AC, O'Banion MK. Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav Immun. 2010 Feb; 24(2):243-53. PMID: 19825412.
      View in: PubMed
    105. Frank MG, Barrientos RM, Hein AM, Biedenkapp JC, Watkins LR, Maier SF. IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats. Brain Behav Immun. 2010 Feb; 24(2):254-62. PMID: 19822205.
      View in: PubMed
    106. Hutchinson MR, Ramos KM, Loram LC, Wieseler J, Sholar PW, Kearney JJ, Lewis MT, Crysdale NY, Zhang Y, Harrison JA, Maier SF, Rice KC, Watkins LR. Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats. Neuroscience. 2009 Dec 29; 164(4):1821-32. PMID: 19788917.
      View in: PubMed
    107. Bland ST, Beckley JT, Young S, Tsang V, Watkins LR, Maier SF, Bilbo SD. Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain. Brain Behav Immun. 2010 Mar; 24(3):329-38. PMID: 19782746.
      View in: PubMed
    108. Watkins LR, Hutchinson MR, Rice KC, Maier SF. The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci. 2009 Nov; 30(11):581-91. PMID: 19762094.
      View in: PubMed
    109. Christianson JP, Thompson BM, Watkins LR, Maier SF. Medial prefrontal cortical activation modulates the impact of controllable and uncontrollable stressor exposure on a social exploration test of anxiety in the rat. Stress. 2009 Sep; 12(5):445-50. PMID: 19051125.
      View in: PubMed
    110. Bilbo SD, Wieseler JL, Barrientos RM, Tsang V, Watkins LR, Maier SF. Neonatal bacterial infection alters fever to live and simulated infections in adulthood. Psychoneuroendocrinology. 2010 Apr; 35(3):369-81. PMID: 19682802.
      View in: PubMed
    111. Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, Falke JJ, Leinwand LA, Maier SF, Yin H, Rice KC, Watkins LR. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun. 2010 Jan; 24(1):83-95. PMID: 19679181.
      View in: PubMed
    112. Baratta MV, Zarza CM, Gomez DM, Campeau S, Watkins LR, Maier SF. Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress. Eur J Neurosci. 2009 Sep; 30(6):1111-6. PMID: 19686468.
      View in: PubMed
    113. Frank MG, Miguel ZD, Watkins LR, Maier SF. Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide. Brain Behav Immun. 2010 Jan; 24(1):19-30. PMID: 19647070.
      View in: PubMed
    114. Sloane E, Langer S, Jekich B, Mahoney J, Hughes T, Frank M, Seibert W, Huberty G, Coats B, Harrison J, Klinman D, Poole S, Maier S, Johnson K, Chavez R, Watkins LR, Leinwand L, Milligan E. Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain. Gene Ther. 2009 Oct; 16(10):1210-22. PMID: 19571887.
      View in: PubMed
    115. Rodgers KM, Hutchinson MR, Northcutt A, Maier SF, Watkins LR, Barth DS. The cortical innate immune response increases local neuronal excitability leading to seizures. Brain. 2009 Sep; 132(Pt 9):2478-86. PMID: 19567702.
      View in: PubMed
    116. McDevitt RA, Szot P, Baratta MV, Bland ST, White SS, Maier SF, Neumaier JF. Stress-induced activity in the locus coeruleus is not sensitive to stressor controllability. Brain Res. 2009 Aug 18; 1285:109-18. PMID: 19524553.
      View in: PubMed
    117. Sloane EM, Soderquist RG, Maier SF, Mahoney MJ, Watkins LR, Milligan ED. Long-term control of neuropathic pain in a non-viral gene therapy paradigm. Gene Ther. 2009 Apr; 16(4):470-5. PMID: 19262611.
      View in: PubMed
    118. Barrientos RM, Watkins LR, Rudy JW, Maier SF. Characterization of the sickness response in young and aging rats following E. coli infection. Brain Behav Immun. 2009 May; 23(4):450-4. PMID: 19486645.
      View in: PubMed
    119. Bland ST, Hutchinson MR, Maier SF, Watkins LR, Johnson KW. The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain Behav Immun. 2009 May; 23(4):492-7. PMID: 19486648.
      View in: PubMed
    120. Christianson JP, Benison AM, Jennings J, Sandsmark EK, Amat J, Kaufman RD, Baratta MV, Paul ED, Campeau S, Watkins LR, Barth DS, Maier SF. The sensory insular cortex mediates the stress-buffering effects of safety signals but not behavioral control. J Neurosci. 2008 Dec 10; 28(50):13703-11. PMID: 19074043.
      View in: PubMed
    121. Hutchinson MR, Lewis SS, Coats BD, Skyba DA, Crysdale NY, Berkelhammer DL, Brzeski A, Northcutt A, Vietz CM, Judd CM, Maier SF, Watkins LR, Johnson KW. Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain Behav Immun. 2009 Feb; 23(2):240-50. PMID: 18938237.
      View in: PubMed
    122. Sloane E, Ledeboer A, Seibert W, Coats B, van Strien M, Maier SF, Johnson KW, Chavez R, Watkins LR, Leinwand L, Milligan ED, Van Dam AM. Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy. Brain Behav Immun. 2009 Jan; 23(1):92-100. PMID: 18835435.
      View in: PubMed
    123. Hutchinson MR, Northcutt AL, Chao LW, Kearney JJ, Zhang Y, Berkelhammer DL, Loram LC, Rozeske RR, Bland ST, Maier SF, Gleeson TT, Watkins LR. Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behav Immun. 2008 Nov; 22(8):1248-56. PMID: 18706994.
      View in: PubMed
    124. Barrientos RM, Frank MG, Hein AM, Higgins EA, Watkins LR, Rudy JW, Maier SF. Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun. 2009 Jan; 23(1):46-54. PMID: 18664380.
      View in: PubMed
    125. Hutchinson MR, Coats BD, Lewis SS, Zhang Y, Sprunger DB, Rezvani N, Baker EM, Jekich BM, Wieseler JL, Somogyi AA, Martin D, Poole S, Judd CM, Maier SF, Watkins LR. Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun. 2008 Nov; 22(8):1178-89. PMID: 18599265.
      View in: PubMed
    126. Hutchinson MR, Zhang Y, Brown K, Coats BD, Shridhar M, Sholar PW, Patel SJ, Crysdale NY, Harrison JA, Maier SF, Rice KC, Watkins LR. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci. 2008 Jul; 28(1):20-9. PMID: 18662331.
      View in: PubMed
    127. Christianson JP, Paul ED, Irani M, Thompson BM, Kubala KH, Yirmiya R, Watkins LR, Maier SF. The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration. Behav Brain Res. 2008 Nov 03; 193(1):87-93. PMID: 18554730.
      View in: PubMed
    128. Amat J, Paul E, Watkins LR, Maier SF. Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control. Neuroscience. 2008 Jul 17; 154(4):1178-86. PMID: 18515010.
      View in: PubMed
    129. Bilbo SD, Yirmiya R, Amat J, Paul ED, Watkins LR, Maier SF. Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats. Psychoneuroendocrinology. 2008 Apr; 33(3):261-9. PMID: 18164556.
      View in: PubMed
    130. Rozeske RR, Der-Avakian A, Bland ST, Beckley JT, Watkins LR, Maier SF. The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress. Neuropsychopharmacology. 2009 Mar; 34(4):834-43. PMID: 18368036.
      View in: PubMed
    131. Maier S, Reiterer V, Ruggiero AM, Rothstein JD, Thomas S, Dahm R, Sitte HH, Farhan H. GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation. J Cell Mol Med. 2009 Jan; 13(1):114-24. PMID: 18363836.
      View in: PubMed
    132. Baratta MV, Lucero TR, Amat J, Watkins LR, Maier SF. Role of the ventral medial prefrontal cortex in mediating behavioral control-induced reduction of later conditioned fear. Learn Mem. 2008 Feb; 15(2):84-7. PMID: 18235108.
      View in: PubMed
    133. Bilbo SD, Barrientos RM, Eads AS, Northcutt A, Watkins LR, Rudy JW, Maier SF. Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood. Brain Behav Immun. 2008 May; 22(4):451-5. PMID: 17997277.
      View in: PubMed
    134. Hutchinson MR, Bland ST, Johnson KW, Rice KC, Maier SF, Watkins LR. Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal. 2007 Nov 02; 7:98-111. PMID: 17982582.
      View in: PubMed
    135. Hein AM, Stutzman DL, Bland ST, Barrientos RM, Watkins LR, Rudy JW, Maier SF. Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus. Neuroscience. 2007 Dec 19; 150(4):754-63. PMID: 18035502.
      View in: PubMed
    136. Watkins LR, Hutchinson MR, Milligan ED, Maier SF. "Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev. 2007 Nov; 56(1):148-69. PMID: 17706291.
      View in: PubMed
    137. Baratta MV, Christianson JP, Gomez DM, Zarza CM, Amat J, Masini CV, Watkins LR, Maier SF. Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear. Neuroscience. 2007 Jun 08; 146(4):1495-503. PMID: 17478046.
      View in: PubMed
    138. Kleibeuker W, Ledeboer A, Eijkelkamp N, Watkins LR, Maier SF, Zijlstra J, Heijnen CJ, Kavelaars A. A role for G protein-coupled receptor kinase 2 in mechanical allodynia. Eur J Neurosci. 2007 Mar; 25(6):1696-704. PMID: 17408432.
      View in: PubMed
    139. Frank MG, Der-Avakian A, Bland ST, Watkins LR, Maier SF. Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression. Psychoneuroendocrinology. 2007 May; 32(4):376-84. PMID: 17383826.
      View in: PubMed
    140. Holguin A, Frank MG, Biedenkapp JC, Nelson K, Lippert D, Watkins LR, Rudy JW, Maier SF. Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1beta. J Neurosci Methods. 2007 Apr 15; 161(2):265-72. PMID: 17241670.
      View in: PubMed
    141. Der-Avakian A, Bland ST, Rozeske RR, Tamblyn JP, Hutchinson MR, Watkins LR, Maier SF. The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats. Psychopharmacology (Berl). 2007 May; 191(4):909-17. PMID: 17211647.
      View in: PubMed
    142. Der-Avakian A, Rozeske RR, Bland ST, Watkins LR, Maier SF. The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats. Psychopharmacology (Berl). 2007 May; 191(4):899-907. PMID: 17211648.
      View in: PubMed
    143. Schoeniger-Skinner DK, Ledeboer A, Frank MG, Milligan ED, Poole S, Martin D, Maier SF, Watkins LR. Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120. Brain Behav Immun. 2007 Jul; 21(5):660-7. PMID: 17204394.
      View in: PubMed
    144. Bland ST, Tamlyn JP, Barrientos RM, Greenwood BN, Watkins LR, Campeau S, Day HE, Maier SF. Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress. Neuroscience. 2007 Feb 23; 144(4):1219-28. PMID: 17197100.
      View in: PubMed
    145. Amat J, Paul E, Zarza C, Watkins LR, Maier SF. Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex. J Neurosci. 2006 Dec 20; 26(51):13264-72. PMID: 17182776.
      View in: PubMed
    146. Watkins LR, Hutchinson MR, Ledeboer A, Wieseler-Frank J, Milligan ED, Maier SF. Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun. 2007 Feb; 21(2):131-46. PMID: 17175134.
      View in: PubMed
    147. Ledeboer A, Jekich BM, Sloane EM, Mahoney JH, Langer SJ, Milligan ED, Martin D, Maier SF, Johnson KW, Leinwand LA, Chavez RA, Watkins LR. Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun. 2007 Jul; 21(5):686-98. PMID: 17174526.
      View in: PubMed
    148. Bilbo SD, Newsum NJ, Sprunger DB, Watkins LR, Rudy JW, Maier SF. Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood. Brain Behav Immun. 2007 Mar; 21(3):332-42. PMID: 17126527.
      View in: PubMed
    149. Milligan ED, Soderquist RG, Malone SM, Mahoney JH, Hughes TS, Langer SJ, Sloane EM, Maier SF, Leinwand LA, Watkins LR, Mahoney MJ. Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. Neuron Glia Biol. 2006 Nov; 2(4):293-308. PMID: 18079973.
      View in: PubMed
    150. Ledeboer A, Mahoney JH, Milligan ED, Martin D, Maier SF, Watkins LR. Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats. J Pain. 2006 Oct; 7(10):757-67. PMID: 17018336.
      View in: PubMed
    151. Wieseler-Frank J, Jekich BM, Mahoney JH, Bland ST, Maier SF, Watkins LR. A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus. Brain Behav Immun. 2007 Jul; 21(5):711-8. PMID: 16989980.
      View in: PubMed
    152. Milligan ED, Sloane EM, Langer SJ, Hughes TS, Jekich BM, Frank MG, Mahoney JH, Levkoff LH, Maier SF, Cruz PE, Flotte TR, Johnson KW, Mahoney MM, Chavez RA, Leinwand LA, Watkins LR. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain. 2006 Dec 15; 126(1-3):294-308. PMID: 16949747.
      View in: PubMed
    153. Frank MG, Baratta MV, Sprunger DB, Watkins LR, Maier SF. Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun. 2007 Jan; 21(1):47-59. PMID: 16647243.
      View in: PubMed
    154. Frank MG, Barrientos RM, Biedenkapp JC, Rudy JW, Watkins LR, Maier SF. mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Neurobiol Aging. 2006 May; 27(5):717-22. PMID: 15890435.
      View in: PubMed
    155. Barrientos RM, Higgins EA, Biedenkapp JC, Sprunger DB, Wright-Hardesty KJ, Watkins LR, Rudy JW, Maier SF. Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiol Aging. 2006 May; 27(5):723-32. PMID: 15893410.
      View in: PubMed
    156. Bland ST, Schmid MJ, Greenwood BN, Watkins LR, Maier SF. Behavioral control of the stressor modulates stress-induced changes in neurogenesis and fibroblast growth factor-2. Neuroreport. 2006 Apr 24; 17(6):593-7. PMID: 16603918.
      View in: PubMed
    157. Der-Avakian A, Bland ST, Schmid MJ, Watkins LR, Spencer RL, Maier SF. The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine. Psychoneuroendocrinology. 2006 Jun; 31(5):653-63. PMID: 16584846.
      View in: PubMed
    158. Pan ZJ, Davis K, Maier S, Bachmann MP, Kim-Howard XR, Keech C, Gordon TP, McCluskey J, Farris AD. Neo-epitopes are required for immunogenicity of the La/SS-B nuclear antigen in the context of late apoptotic cells. Clin Exp Immunol. 2006 Feb; 143(2):237-48. PMID: 16412047.
      View in: PubMed
    159. Bilbo SD, Rudy JW, Watkins LR, Maier SF. A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats. Behav Brain Res. 2006 Apr 25; 169(1):39-47. PMID: 16413067.
      View in: PubMed
    160. Watkins LR, Wieseler-Frank J, Milligan ED, Johnston I, Maier SF. Chapter 22 Contribution of glia to pain processing in health and disease. Handb Clin Neurol. 2006; 81:309-23. PMID: 18808844.
      View in: PubMed
    161. Maier SF, Amat J, Baratta MV, Paul E, Watkins LR. Behavioral control, the medial prefrontal cortex, and resilience. Dialogues Clin Neurosci. 2006; 8(4):397-406. PMID: 17290798.
      View in: PubMed
    162. Milligan E, Zapata V, Schoeniger D, Chacur M, Green P, Poole S, Martin D, Maier SF, Watkins LR. An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine. Eur J Neurosci. 2005 Dec; 22(11):2775-82. PMID: 16324111.
      View in: PubMed
    163. Watkins LR, Hutchinson MR, Johnston IN, Maier SF. Glia: novel counter-regulators of opioid analgesia. Trends Neurosci. 2005 Dec; 28(12):661-9. PMID: 16246435.
      View in: PubMed
    164. Ledeboer A, Gamanos M, Lai W, Martin D, Maier SF, Watkins LR, Quan N. Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation. Eur J Neurosci. 2005 Oct; 22(8):1977-86. PMID: 16262636.
      View in: PubMed
    165. Bilbo SD, Biedenkapp JC, Der-Avakian A, Watkins LR, Rudy JW, Maier SF. Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. J Neurosci. 2005 Aug 31; 25(35):8000-9. PMID: 16135757.
      View in: PubMed
    166. Frank MG, Wieseler-Frank JL, Watkins LR, Maier SF. Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. J Neurosci Methods. 2006 Mar 15; 151(2):121-30. PMID: 16125247.
      View in: PubMed
    167. Takase LF, Nogueira MI, Bland ST, Baratta M, Watkins LR, Maier SF, Fornal CA, Jacobs BL. Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat. Behav Brain Res. 2005 Jul 30; 162(2):299-306. PMID: 15913803.
      View in: PubMed
    168. Bland ST, Schmid MJ, Der-Avakian A, Watkins LR, Spencer RL, Maier SF. Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress. Brain Res. 2005 Jul 27; 1051(1-2):90-9. PMID: 15993862.
      View in: PubMed
    169. Ledeboer A, Sloane EM, Milligan ED, Frank MG, Mahony JH, Maier SF, Watkins LR. Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain. 2005 May; 115(1-2):71-83. PMID: 15836971.
      View in: PubMed
    170. Milligan ED, Langer SJ, Sloane EM, He L, Wieseler-Frank J, O'Connor K, Martin D, Forsayeth JR, Maier SF, Johnson K, Chavez RA, Leinwand LA, Watkins LR. Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. Eur J Neurosci. 2005 Apr; 21(8):2136-48. PMID: 15869510.
      View in: PubMed
    171. Wieseler-Frank J, Maier SF, Watkins LR. Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences. Brain Behav Immun. 2005 Mar; 19(2):104-11. PMID: 15664782.
      View in: PubMed
    172. Twining CM, Sloane EM, Schoeniger DK, Milligan ED, Martin D, Marsh H, Maier SF, Watkins LR. Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization. J Pain. 2005 Mar; 6(3):174-83. PMID: 15772911.
      View in: PubMed
    173. Milligan ED, Sloane EM, Langer SJ, Cruz PE, Chacur M, Spataro L, Wieseler-Frank J, Hammack SE, Maier SF, Flotte TR, Forsayeth JR, Leinwand LA, Chavez R, Watkins LR. Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Mol Pain. 2005 Feb 25; 1:9. PMID: 15813997.
      View in: PubMed
    174. Greenwood BN, Foley TE, Burhans D, Maier SF, Fleshner M. The consequences of uncontrollable stress are sensitive to duration of prior wheel running. Brain Res. 2005 Feb 08; 1033(2):164-78. PMID: 15694921.
      View in: PubMed
    175. Amat J, Baratta MV, Paul E, Bland ST, Watkins LR, Maier SF. Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nat Neurosci. 2005 Mar; 8(3):365-71. PMID: 15696163.
      View in: PubMed
    176. Watkins LR, Maier SF. Immune regulation of central nervous system functions: from sickness responses to pathological pain. J Intern Med. 2005 Feb; 257(2):139-55. PMID: 15656873.
      View in: PubMed
    177. Bilbo SD, Levkoff LH, Mahoney JH, Watkins LR, Rudy JW, Maier SF. Neonatal infection induces memory impairments following an immune challenge in adulthood. Behav Neurosci. 2005 Feb; 119(1):293-301. PMID: 15727533.
      View in: PubMed
    178. Maier SF, Watkins LR. Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev. 2005; 29(4-5):829-41. PMID: 15893820.
      View in: PubMed
    179. Wieseler-Frank J, Maier SF, Watkins LR. Central proinflammatory cytokines and pain enhancement. Neurosignals. 2005; 14(4):166-74. PMID: 16215299.
      View in: PubMed
    180. O'Connor KA, Ginsberg AB, Maksimova E, Wieseler Frank JL, Johnson JD, Spencer RL, Campeau S, Watkins LR, Maier SF. Stress-induced sensitization of the hypothalamic-pituitary adrenal axis is associated with alterations of hypothalamic and pituitary gene expression. Neuroendocrinology. 2004; 80(4):252-63. PMID: 15627803.
      View in: PubMed
    181. Bland ST, Schmid MJ, Watkins LR, Maier SF. Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine. Neuroreport. 2004 Dec 03; 15(17):2637-41. PMID: 15570168.
      View in: PubMed
    182. Der-Avakian A, Will MJ, Bland ST, Deak T, Nguyen KT, Schmid MJ, Spencer RL, Watkins LR, Maier SF. Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats. Psychopharmacology (Berl). 2005 May; 179(2):409-17. PMID: 15821955.
      View in: PubMed
    183. Milligan ED, Zapata V, Chacur M, Schoeniger D, Biedenkapp J, O'Connor KA, Verge GM, Chapman G, Green P, Foster AC, Naeve GS, Maier SF, Watkins LR. Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats. Eur J Neurosci. 2004 Nov; 20(9):2294-302. PMID: 15525271.
      View in: PubMed
    184. Barrientos RM, Sprunger DB, Campeau S, Watkins LR, Rudy JW, Maier SF. BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration. J Neuroimmunol. 2004 Oct; 155(1-2):119-26. PMID: 15342202.
      View in: PubMed
    185. Spataro LE, Sloane EM, Milligan ED, Wieseler-Frank J, Schoeniger D, Jekich BM, Barrientos RM, Maier SF, Watkins LR. Spinal gap junctions: potential involvement in pain facilitation. J Pain. 2004 Sep; 5(7):392-405. PMID: 15501197.
      View in: PubMed
    186. Verge GM, Milligan ED, Maier SF, Watkins LR, Naeve GS, Foster AC. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci. 2004 Sep; 20(5):1150-60. PMID: 15341587.
      View in: PubMed
    187. Chacur M, Gutiérrez JM, Milligan ED, Wieseler-Frank J, Britto LR, Maier SF, Watkins LR, Cury Y. Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators. Pain. 2004 Sep; 111(1-2):65-76. PMID: 15327810.
      View in: PubMed
    188. Johnston IN, Milligan ED, Wieseler-Frank J, Frank MG, Zapata V, Campisi J, Langer S, Martin D, Green P, Fleshner M, Leinwand L, Maier SF, Watkins LR. A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci. 2004 Aug 18; 24(33):7353-65. PMID: 15317861.
      View in: PubMed
    189. Takase LF, Nogueira MI, Baratta M, Bland ST, Watkins LR, Maier SF, Fornal CA, Jacobs BL. Inescapable shock activates serotonergic neurons in all raphe nuclei of rat. Behav Brain Res. 2004 Aug 12; 153(1):233-9. PMID: 15219724.
      View in: PubMed
    190. Holguin A, O'Connor KA, Biedenkapp J, Campisi J, Wieseler-Frank J, Milligan ED, Hansen MK, Spataro L, Maksimova E, Bravmann C, Martin D, Fleshner M, Maier SF, Watkins LR. HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS). Pain. 2004 Aug; 110(3):517-30. PMID: 15288392.
      View in: PubMed
    191. Wieseler-Frank J, Maier SF, Watkins LR. Glial activation and pathological pain. Neurochem Int. 2004 Jul-Aug; 45(2-3):389-95. PMID: 15145553.
      View in: PubMed
    192. Twining CM, Sloane EM, Milligan ED, Chacur M, Martin D, Poole S, Marsh H, Maier SF, Watkins LR. Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats. Pain. 2004 Jul; 110(1-2):299-309. PMID: 15275780.
      View in: PubMed
    193. Day HE, Greenwood BN, Hammack SE, Watkins LR, Fleshner M, Maier SF, Campeau S. Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. J Comp Neurol. 2004 Jun 28; 474(3):364-78. PMID: 15174080.
      View in: PubMed
    194. O'Connor KA, Holguin A, Hansen MK, Maier SF, Watkins LR. A method for measuring multiple cytokines from small samples. Brain Behav Immun. 2004 May; 18(3):274-80. PMID: 15050654.
      View in: PubMed
    195. Hammack SE, Richey KJ, Watkins LR, Maier SF. Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress. Behav Neurosci. 2004 Apr; 118(2):443-8. PMID: 15113272.
      View in: PubMed
    196. Chacur M, Milligan ED, Sloan EM, Wieseler-Frank J, Barrientos RM, Martin D, Poole S, Lomonte B, Gutiérrez JM, Maier SF, Cury Y, Watkins LR. Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide. Pain. 2004 Mar; 108(1-2):180-91. PMID: 15109522.
      View in: PubMed
    197. Amat J, Tamblyn JP, Paul ED, Bland ST, Amat P, Foster AC, Watkins LR, Maier SF. Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala. Neuroscience. 2004; 129(3):509-19. PMID: 15541873.
      View in: PubMed
    198. Johnson JD, O'Connor KA, Watkins LR, Maier SF. The role of IL-1beta in stress-induced sensitization of proinflammatory cytokine and corticosterone responses. Neuroscience. 2004; 127(3):569-77. PMID: 15283957.
      View in: PubMed
    199. Milligan ED, Maier SF, Watkins LR. Sciatic inflammatory neuropathy in the rat: surgical procedures, induction of inflammation, and behavioral testing. Methods Mol Med. 2004; 99:67-89. PMID: 15131330.
      View in: PubMed
    200. Bland ST, Twining C, Schmid MJ, Der-Avakian A, Watkins LR, Maier SF. Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus. Neuroscience. 2004; 126(3):705-15. PMID: 15183519.
      View in: PubMed
    201. O'Connor KA, Hansen MK, Rachal Pugh C, Deak MM, Biedenkapp JC, Milligan ED, Johnson JD, Wang H, Maier SF, Tracey KJ, Watkins LR. Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects. Cytokine. 2003 Dec 21; 24(6):254-65. PMID: 14609567.
      View in: PubMed
    202. Hammack SE, Pepin JL, DesMarteau JS, Watkins LR, Maier SF. Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress. Behav Brain Res. 2003 Dec 17; 147(1-2):55-64. PMID: 14659570.
      View in: PubMed
    203. Gazda LS, Smith T, Watkins LR, Maier SF, Fleshner M. Stressor exposure produces long-term reductions in antigen-specific T and B cell responses. Stress. 2003 Dec; 6(4):259-67. PMID: 14660058.
      View in: PubMed
    204. Watkins LR, Maier SF. Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov. 2003 Dec; 2(12):973-85. PMID: 14654796.
      View in: PubMed
    205. O'Connor KA, Johnson JD, Hansen MK, Wieseler Frank JL, Maksimova E, Watkins LR, Maier SF. Peripheral and central proinflammatory cytokine response to a severe acute stressor. Brain Res. 2003 Nov 21; 991(1-2):123-32. PMID: 14575884.
      View in: PubMed
    206. Bonaccorso S, Maier SF, Meltzer HY, Maes M. Behavioral changes in rats after acute, chronic and repeated administration of interleukin-1beta: relevance for affective disorders. J Affect Disord. 2003 Nov; 77(2):143-8. PMID: 14607391.
      View in: PubMed
    207. McDaniel MA, Maier SF, Einstein GO. "Brain-specific" nutrients: a memory cure? Nutrition. 2003 Nov-Dec; 19(11-12):957-75. PMID: 14624946.
      View in: PubMed
    208. Will MJ, Der-Avakian A, Bland ST, Grahn RE, Hammack SE, Sparks PD, Pepin JL, Watkins LR, Maier SF. Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats. Psychopharmacology (Berl). 2004 Jan; 171(2):191-8. PMID: 13680080.
      View in: PubMed
    209. Brennan FX, Grahn RE, Watkins LR, Maier SF. Serum cholesterol levels and stressor controllability in rats. Physiol Behav. 2003 Sep; 79(4-5):757-60. PMID: 12954419.
      View in: PubMed
    210. Bland ST, Twining C, Watkins LR, Maier SF. Stressor controllability modulates stress-induced serotonin but not dopamine efflux in the nucleus accumbens shell. Synapse. 2003 Sep 01; 49(3):206-8. PMID: 12774305.
      View in: PubMed
    211. Campisi J, Hansen MK, O'Connor KA, Biedenkapp JC, Watkins LR, Maier SF, Fleshner M. Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge. J Appl Physiol (1985). 2003 Nov; 95(5):1873-82. PMID: 12871965.
      View in: PubMed
    212. Bland ST, Hargrave D, Pepin JL, Amat J, Watkins LR, Maier SF. Stressor controllability modulates stress-induced dopamine and serotonin efflux and morphine-induced serotonin efflux in the medial prefrontal cortex. Neuropsychopharmacology. 2003 Sep; 28(9):1589-96. PMID: 12784102.
      View in: PubMed
    213. O'Connor KA, Johnson JD, Hammack SE, Brooks LM, Spencer RL, Watkins LR, Maier SF. Inescapable shock induces resistance to the effects of dexamethasone. Psychoneuroendocrinology. 2003 May; 28(4):481-500. PMID: 12689607.
      View in: PubMed
    214. Maier SF. Bi-directional immune-brain communication: Implications for understanding stress, pain, and cognition. Brain Behav Immun. 2003 Apr; 17(2):69-85. PMID: 12676570.
      View in: PubMed
    215. Greenwood BN, Foley TE, Day HE, Campisi J, Hammack SH, Campeau S, Maier SF, Fleshner M. Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J Neurosci. 2003 Apr 01; 23(7):2889-98. PMID: 12684476.
      View in: PubMed
    216. Maier SF, Watkins LR. Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment. Brain Behav Immun. 2003 Feb; 17 Suppl 1:S125-31. PMID: 12615198.
      View in: PubMed
    217. Milligan ED, Twining C, Chacur M, Biedenkapp J, O'Connor K, Poole S, Tracey K, Martin D, Maier SF, Watkins LR. Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci. 2003 Feb 01; 23(3):1026-40. PMID: 12574433.
      View in: PubMed
    218. Hammack SE, Schmid MJ, LoPresti ML, Der-Avakian A, Pellymounter MA, Foster AC, Watkins LR, Maier SF. Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. J Neurosci. 2003 Feb 01; 23(3):1019-25. PMID: 12574432.
      View in: PubMed
    219. Barrientos RM, Sprunger DB, Campeau S, Higgins EA, Watkins LR, Rudy JW, Maier SF. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist. Neuroscience. 2003; 121(4):847-53. PMID: 14580934.
      View in: PubMed
    220. Watkins LR, Milligan ED, Maier SF. Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol. 2003; 521:1-21. PMID: 12617561.
      View in: PubMed
    221. Johnson JD, O'Connor KA, Hansen MK, Watkins LR, Maier SF. Effects of prior stress on LPS-induced cytokine and sickness responses. Am J Physiol Regul Integr Comp Physiol. 2003 Feb; 284(2):R422-32. PMID: 12399247.
      View in: PubMed
    222. Watkins LR, Maier SF. Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev. 2002 Oct; 82(4):981-1011. PMID: 12270950.
      View in: PubMed
    223. Barrientos RM, Higgins EA, Sprunger DB, Watkins LR, Rudy JW, Maier SF. Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus. Behav Brain Res. 2002 Aug 21; 134(1-2):291-8. PMID: 12191816.
      View in: PubMed
    224. Grahn RE, Hammack SE, Will MJ, O'Connor KA, Deak T, Sparks PD, Watkins LR, Maier SF. Blockade of alpha1 adrenoreceptors in the dorsal raphe nucleus prevents enhanced conditioned fear and impaired escape performance following uncontrollable stressor exposure in rats. Behav Brain Res. 2002 Aug 21; 134(1-2):387-92. PMID: 12191825.
      View in: PubMed
    225. Johnson JD, O'Connor KA, Deak T, Stark M, Watkins LR, Maier SF. Prior stressor exposure sensitizes LPS-induced cytokine production. Brain Behav Immun. 2002 Aug; 16(4):461-76. PMID: 12096891.
      View in: PubMed
    226. Moraska A, Campisi J, Nguyen KT, Maier SF, Watkins LR, Fleshner M. Elevated IL-1beta contributes to antibody suppression produced by stress. J Appl Physiol (1985). 2002 Jul; 93(1):207-15. PMID: 12070207.
      View in: PubMed
    227. McDaniel MA, Maier SF, Einstein GO. "Brain-Specific" Nutrients: A Memory Cure? Psychol Sci Public Interest. 2002 May; 3(1):12-38. PMID: 26151475.
      View in: PubMed
    228. Johnson JD, O'Connor KA, Deak T, Spencer RL, Watkins LR, Maier SF. Prior stressor exposure primes the HPA axis. Psychoneuroendocrinology. 2002 Apr; 27(3):353-65. PMID: 11818171.
      View in: PubMed
    229. Hammack SE, Richey KJ, Schmid MJ, LoPresti ML, Watkins LR, Maier SF. The role of corticotropin-releasing hormone in the dorsal raphe nucleus in mediating the behavioral consequences of uncontrollable stress. J Neurosci. 2002 Feb 01; 22(3):1020-6. PMID: 11826130.
      View in: PubMed
    230. Will MJ, Der-Avakian A, Pepin JL, Durkan BT, Watkins LR, Maier SF. Modulation of the locomotor properties of morphine and amphetamine by uncontrollable stress. Pharmacol Biochem Behav. 2002 Jan-Feb; 71(1-2):345-51. PMID: 11812543.
      View in: PubMed
    231. Chacur M, Milligan ED, Gazda LS, Armstrong C, Wang H, Tracey KJ, Maier SF, Watkins LR. A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats. Pain. 2001 Dec; 94(3):231-44. PMID: 11731060.
      View in: PubMed
    232. Milligan ED, O'Connor KA, Armstrong CB, Hansen MK, Martin D, Tracey KJ, Maier SF, Watkins LR. Systemic administration of CNI-1493, a p38 mitogen-activated protein kinase inhibitor, blocks intrathecal human immunodeficiency virus-1 gp120-induced enhanced pain states in rats. J Pain. 2001 Dec; 2(6):326-33. PMID: 14622812.
      View in: PubMed
    233. Amat J, Sparks PD, Matus-Amat P, Griggs J, Watkins LR, Maier SF. The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress. Brain Res. 2001 Oct 26; 917(1):118-26. PMID: 11602236.
      View in: PubMed
    234. Emmanuilidis K, Weighardt H, Maier S, Gerauer K, Fleischmann T, Zheng XX, Hancock WW, Holzmann B, Heidecke CD. Critical role of Kupffer cell-derived IL-10 for host defense in septic peritonitis. J Immunol. 2001 Oct 01; 167(7):3919-27. PMID: 11564810.
      View in: PubMed
    235. Gazda LS, Milligan ED, Hansen MK, Twining CM, Poulos NM, Chacur M, O'Connor KA, Armstrong C, Maier SF, Watkins LR, Myers RR. Sciatic inflammatory neuritis (SIN): behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production. J Peripher Nerv Syst. 2001 Sep; 6(3):111-29. PMID: 11817330.
      View in: PubMed
    236. Watkins LR, Milligan ED, Maier SF. Spinal cord glia: new players in pain. Pain. 2001 Sep; 93(3):201-5. PMID: 11514078.
      View in: PubMed
    237. Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends Neurosci. 2001 Aug; 24(8):450-5. PMID: 11476884.
      View in: PubMed
    238. Goehler LE, Gaykema RP, Hansen MK, Kleiner JL, Maier SF, Watkins LR. Staphylococcal enterotoxin B induces fever, brain c-Fos expression, and serum corticosterone in rats. Am J Physiol Regul Integr Comp Physiol. 2001 May; 280(5):R1434-9. PMID: 11294765.
      View in: PubMed
    239. Maier SF. Exposure to the stressor environment prevents the temporal dissipation of behavioral depression/learned helplessness. Biol Psychiatry. 2001 May 01; 49(9):763-73. PMID: 11331084.
      View in: PubMed
    240. Milligan ED, O'Connor KA, Nguyen KT, Armstrong CB, Twining C, Gaykema RP, Holguin A, Martin D, Maier SF, Watkins LR. Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines. J Neurosci. 2001 Apr 15; 21(8):2808-19. PMID: 11306633.
      View in: PubMed
    241. Hansen MK, O'Connor KA, Goehler LE, Watkins LR, Maier SF. The contribution of the vagus nerve in interleukin-1beta-induced fever is dependent on dose. Am J Physiol Regul Integr Comp Physiol. 2001 Apr; 280(4):R929-34. PMID: 11247812.
      View in: PubMed
    242. Fleshner M, Deak T, Nguyen KT, Watkins LR, Maier SF. Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response. J Immunol. 2001 Mar 15; 166(6):3813-9. PMID: 11238624.
      View in: PubMed
    243. Rachal Pugh C, Fleshner M, Watkins LR, Maier SF, Rudy JW. The immune system and memory consolidation: a role for the cytokine IL-1beta. Neurosci Biobehav Rev. 2001 Jan; 25(1):29-41. PMID: 11166076.
      View in: PubMed
    244. Gaykema RP, Goehler LE, Hansen MK, Maier SF, Watkins LR. Subdiaphragmatic vagotomy blocks interleukin-1beta-induced fever but does not reduce IL-1beta levels in the circulation. Auton Neurosci. 2000 Dec 20; 85(1-3):72-7. PMID: 11189029.
      View in: PubMed
    245. Hansen MK, Nguyen KT, Goehler LE, Gaykema RP, Fleshner M, Maier SF, Watkins LR. Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats. Auton Neurosci. 2000 Dec 20; 85(1-3):119-26. PMID: 11189018.
      View in: PubMed
    246. Goehler LE, Gaykema RP, Hansen MK, Anderson K, Maier SF, Watkins LR. Vagal immune-to-brain communication: a visceral chemosensory pathway. Auton Neurosci. 2000 Dec 20; 85(1-3):49-59. PMID: 11189026.
      View in: PubMed
    247. Hansen MK, Daniels S, Goehler LE, Gaykema RP, Maier SF, Watkins LR. Subdiaphragmatic vagotomy does not block intraperitoneal lipopolysaccharide-induced fever. Auton Neurosci. 2000 Dec 20; 85(1-3):83-7. PMID: 11189031.
      View in: PubMed
    248. Grahn RE, Watkins LR, Maier SF. Impaired escape performance and enhanced conditioned fear in rats following exposure to an uncontrollable stressor are mediated by glutamate and nitric oxide in the dorsal raphe nucleus. Behav Brain Res. 2000 Jul; 112(1-2):33-41. PMID: 10862933.
      View in: PubMed
    249. Van Dam AM, Bol JG, Gaykema RP, Goehler LE, Maier SF, Watkins LR, Tilders FJ. Vagotomy does not inhibit high dose lipopolysaccharide-induced interleukin-1beta immunoreactivity in rat brain and pituitary gland. Neurosci Lett. 2000 May 19; 285(3):169-72. PMID: 10806313.
      View in: PubMed
    250. Pugh CR, Johnson JD, Martin D, Rudy JW, Maier SF, Watkins LR. Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments. Brain Res. 2000 Apr 07; 861(1):8-15. PMID: 10751560.
      View in: PubMed
    251. Milligan ED, Mehmert KK, Hinde JL, Harvey LO, Martin D, Tracey KJ, Maier SF, Watkins LR. Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Brain Res. 2000 Apr 07; 861(1):105-16. PMID: 10751570.
      View in: PubMed
    252. Nguyen KT, Deak T, Will MJ, Hansen MK, Hunsaker BN, Fleshner M, Watkins LR, Maier SF. Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress. Brain Res. 2000 Mar 24; 859(2):193-201. PMID: 10719064.
      View in: PubMed
    253. Weighardt H, Heidecke CD, Emmanuilidis K, Maier S, Bartels H, Siewert JR, Holzmann B. Sepsis after major visceral surgery is associated with sustained and interferon-gamma-resistant defects of monocyte cytokine production. Surgery. 2000 Mar; 127(3):309-15. PMID: 10715987.
      View in: PubMed
    254. Hansen MK, Nguyen KT, Fleshner M, Goehler LE, Gaykema RP, Maier SF, Watkins LR. Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide. Am J Physiol Regul Integr Comp Physiol. 2000 Feb; 278(2):R331-6. PMID: 10666132.
      View in: PubMed
    255. Watkins LR, Maier SF. The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol. 2000; 51:29-57. PMID: 10751964.
      View in: PubMed
    256. Pugh CR, Nguyen KT, Gonyea JL, Fleshner M, Wakins LR, Maier SF, Rudy JW. Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation. Behav Brain Res. 1999 Dec; 106(1-2):109-18. PMID: 10595426.
      View in: PubMed
    257. Deak T, Nguyen KT, Cotter CS, Fleshner M, Watkins LR, Maier SF, Spencer RL. Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor. Brain Res. 1999 Nov 20; 847(2):211-20. PMID: 10575090.
      View in: PubMed
    258. Karges W, Maier S, Wissmann A, Dralle H, Dosch HM, Boehm BO. Primary structure, gene expression and chromosomal mapping of rodent homologs of the MEN1 tumor suppressor gene. Biochim Biophys Acta. 1999 Sep 03; 1446(3):286-94. PMID: 10524203.
      View in: PubMed
    259. Deak T, Nguyen KT, Fleshner M, Watkins LR, Maier SF. Acute stress may facilitate recovery from a subcutaneous bacterial challenge. Neuroimmunomodulation. 1999 Sep-Oct; 6(5):344-54. PMID: 10474053.
      View in: PubMed
    260. Milligan ED, Hinde JL, Mehmert KK, Maier SF, Watkins LR. A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats. J Neurosci Methods. 1999 Aug 01; 90(1):81-6. PMID: 10517276.
      View in: PubMed
    261. Hammack SE, Hartley CE, Lea SE, Maier SF, Watkins LR, Sutton LC. Inescapable shock-induced potentiation of morphine analgesia in rats: sites of action. Behav Neurosci. 1999 Aug; 113(4):795-803. PMID: 10495087.
      View in: PubMed
    262. Watkins LR, Maier SF. Implications of immune-to-brain communication for sickness and pain. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):7710-3. PMID: 10393885.
      View in: PubMed
    263. Grahn RE, Will MJ, Hammack SE, Maswood S, McQueen MB, Watkins LR, Maier SF. Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor. Brain Res. 1999 Apr 24; 826(1):35-43. PMID: 10216194.
      View in: PubMed
    264. Goehler LE, Gaykema RP, Nguyen KT, Lee JE, Tilders FJ, Maier SF, Watkins LR. Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems? J Neurosci. 1999 Apr 01; 19(7):2799-806. PMID: 10087091.
      View in: PubMed
    265. Grahn RE, Maswood S, McQueen MB, Watkins LR, Maier SF. Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus. Behav Brain Res. 1999 Mar; 99(2):153-67. PMID: 10512582.
      View in: PubMed
    266. Helmreich DL, Watkins LR, Deak T, Maier SF, Akil H, Watson SJ. The effect of stressor controllability on stress-induced neuropeptide mRNA expression within the paraventricular nucleus of the hypothalamus. J Neuroendocrinol. 1999 Feb; 11(2):121-8. PMID: 10048467.
      View in: PubMed
    267. Watkins LR, Nguyen KT, Lee JE, Maier SF. Dynamic regulation of proinflammatory cytokines. Adv Exp Med Biol. 1999; 461:153-78. PMID: 10442173.
      View in: PubMed
    268. Maier SF, Nguyen KT, Deak T, Milligan ED, Watkins LR. Stress, learned helplessness, and brain interleukin-1 beta. Adv Exp Med Biol. 1999; 461:235-49. PMID: 10442176.
      View in: PubMed
    269. Deak T, Nguyen KT, Ehrlich AL, Watkins LR, Spencer RL, Maier SF, Licinio J, Wong ML, Chrousos GP, Webster E, Gold PW. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. Endocrinology. 1999 Jan; 140(1):79-86. PMID: 9886810.
      View in: PubMed
    270. Watkins LR, Hansen MK, Nguyen KT, Lee JE, Maier SF. Dynamic regulation of the proinflammatory cytokine, interleukin-1beta: molecular biology for non-molecular biologists. Life Sci. 1999; 65(5):449-81. PMID: 10462074.
      View in: PubMed
    271. Deak T, Nguyen KT, Ehrlich AL, Watkins LR, Spencer RL, Maier SF, Licinio J, Wong ML, Chrousos GP, Webster E, Gold PW. The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress* *This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder. Endocrinology. 1999 Jan 01; 140(1):79-86. PMID: 28200658.
      View in: PubMed
    272. Amat J, Matus-Amat P, Watkins LR, Maier SF. Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat. Brain Res. 1998 Nov 23; 812(1-2):113-20. PMID: 9813270.
      View in: PubMed
    273. Milligan ED, Nguyen KT, Deak T, Hinde JL, Fleshner M, Watkins LR, Maier SF. The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone. Brain Res. 1998 Nov 09; 810(1-2):48-58. PMID: 9813238.
      View in: PubMed
    274. Goehler LE, Gaykema RP, Hammack SE, Maier SF, Watkins LR. Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve. Brain Res. 1998 Sep 07; 804(2):306-10. PMID: 9757071.
      View in: PubMed
    275. Fleshner M, Nguyen KT, Cotter CS, Watkins LR, Maier SF. Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity. Am J Physiol. 1998 Sep; 275(3 Pt 2):R870-8. PMID: 9728086.
      View in: PubMed
    276. Gaykema RP, Goehler LE, Tilders FJ, Bol JG, McGorry M, Fleshner M, Maier SF, Watkins LR. Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve. Neuroimmunomodulation. 1998 Sep-Oct; 5(5):234-40. PMID: 9730691.
      View in: PubMed
    277. Pugh CR, Kumagawa K, Fleshner M, Watkins LR, Maier SF, Rudy JW. Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning. Brain Behav Immun. 1998 Sep; 12(3):212-29. PMID: 9769157.
      View in: PubMed
    278. Will MJ, Watkins LR, Maier SF. Uncontrollable stress potentiates morphine's rewarding properties. Pharmacol Biochem Behav. 1998 Jul; 60(3):655-64. PMID: 9678649.
      View in: PubMed
    279. Amat J, Matus-Amat P, Watkins LR, Maier SF. Escapable and inescapable stress differentially and selectively alter extracellular levels of 5-HT in the ventral hippocampus and dorsal periaqueductal gray of the rat. Brain Res. 1998 Jun 22; 797(1):12-22. PMID: 9630480.
      View in: PubMed
    280. Fleshner M, Goehler LE, Schwartz BA, McGorry M, Martin D, Maier SF, Watkins LR. Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy. J Neuroimmunol. 1998 Jun 15; 86(2):134-41. PMID: 9663558.
      View in: PubMed
    281. Maier SF, Goehler LE, Fleshner M, Watkins LR. The role of the vagus nerve in cytokine-to-brain communication. Ann N Y Acad Sci. 1998 May 01; 840:289-300. PMID: 9629257.
      View in: PubMed
    282. Watkins LR, Wiertelak EP, McGorry M, Martinez J, Schwartz B, Sisk D, Maier SF. Neurocircuitry of conditioned inhibition of analgesia: effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat. Behav Neurosci. 1998 Apr; 112(2):360-78. PMID: 9588483.
      View in: PubMed
    283. Nguyen KT, Deak T, Owens SM, Kohno T, Fleshner M, Watkins LR, Maier SF. Exposure to acute stress induces brain interleukin-1beta protein in the rat. J Neurosci. 1998 Mar 15; 18(6):2239-46. PMID: 9482808.
      View in: PubMed
    284. Maswood S, Barter JE, Watkins LR, Maier SF. Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat. Brain Res. 1998 Feb 02; 783(1):115-20. PMID: 9479059.
      View in: PubMed
    285. Maier SF, Watkins LR. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev. 1998 Jan; 105(1):83-107. PMID: 9450372.
      View in: PubMed
    286. Deak T, Meriwether JL, Fleshner M, Spencer RL, Abouhamze A, Moldawer LL, Grahn RE, Watkins LR, Maier SF. Evidence that brief stress may induce the acute phase response in rats. Am J Physiol. 1997 Dec; 273(6 Pt 2):R1998-2004. PMID: 9435654.
      View in: PubMed
    287. Sutton LC, Lea SE, Will MJ, Schwartz BA, Hartley CE, Poole JC, Watkins LR, Maier SF. Inescapable shock-induced potentiation of morphine analgesia. Behav Neurosci. 1997 Oct; 111(5):1105-13. PMID: 9383528.
      View in: PubMed
    288. Milligan ED, McGorry MM, Fleshner M, Gaykema RP, Goehler LE, Watkins LR, Maier SF. Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E2: further evidence for the importance of vagal afferents in immune-to-brain communication. Brain Res. 1997 Aug 22; 766(1-2):240-3. PMID: 9359608.
      View in: PubMed
    289. Sutton LC, Grahn RE, Wiertelak EP, Watkins LR, Maier SF. Inescapable shock-induced potentiation of morphine analgesia in rats: involvement of opioid, GABAergic, and serotonergic mechanisms in the dorsal raphe nucleus. Behav Neurosci. 1997 Aug; 111(4):816-24. PMID: 9267659.
      View in: PubMed
    290. Watkins LR, Martin D, Ulrich P, Tracey KJ, Maier SF. Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. Pain. 1997 Jul; 71(3):225-35. PMID: 9231865.
      View in: PubMed
    291. Watkins LR, McGorry M, Schwartz B, Sisk D, Wiertelak EP, Maier SF. Reversal of spinal cord non-opiate analgesia by conditioned anti-analgesia in the rat. Pain. 1997 Jul; 71(3):237-47. PMID: 9231866.
      View in: PubMed
    292. Weisbrod M, Winkler S, Maier S, Hill H, Thomas C, Spitzer M. Left lateralized P300 amplitude deficit in schizophrenic patients depends on pitch disparity. Biol Psychiatry. 1997 Mar 01; 41(5):541-9. PMID: 9046986.
      View in: PubMed
    293. Spitzer M, Weisbrod M, Winkler S, Maier S. [Event-related potentials in semantic speech processing by schizophrenic patients]. Nervenarzt. 1997 Mar; 68(3):212-25. PMID: 9198781.
      View in: PubMed
    294. Wiertelak EP, Roemer B, Maier SF, Watkins LR. Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias. Brain Res. 1997 Feb 14; 748(1-2):143-50. PMID: 9067455.
      View in: PubMed
    295. Fleshner M, Silbert L, Deak T, Goehler LE, Martin D, Watkins LR, Maier SF. TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated. Brain Res Bull. 1997; 44(6):701-6. PMID: 9421133.
      View in: PubMed
    296. Goehler LE, Relton JK, Dripps D, Kiechle R, Tartaglia N, Maier SF, Watkins LR. Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication. Brain Res Bull. 1997; 43(3):357-64. PMID: 9227848.
      View in: PubMed
    297. Grisel JE, Watkins LR, Maier SF. Associative and non-associative mechanisms of morphine analgesic tolerance are neurochemically distinct in the rat spinal cord. Psychopharmacology (Berl). 1996 Dec; 128(3):248-55. PMID: 8972544.
      View in: PubMed
    298. Fleshner M, Brennan FX, Nguyen K, Watkins LR, Maier SF. RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response. Am J Physiol. 1996 Nov; 271(5 Pt 2):R1344-52. PMID: 8945973.
      View in: PubMed
    299. Brennan FX, Cobb CL, Silbert LH, Watkins LR, Maier SF. Peripheral beta-adrenoreceptors and stress-induced hypercholesterolemia in rats. Physiol Behav. 1996 Nov; 60(5):1307-10. PMID: 8916186.
      View in: PubMed
    300. Lockwood LL, Silbert LH, Fleshner MR, McNeal C, Watkins LR, Laudenslager ML, Rice KC, Weber RJ, Maier SF. Morphine-induced alterations in antibody levels: receptor and immune mechanisms. J Pharmacol Exp Ther. 1996 Aug; 278(2):689-96. PMID: 8768720.
      View in: PubMed
    301. Heidecke CD, Zantl N, Maier S, Varzaru A, Hager B, Kupiec-Weglinski J, Hancock WW. Induction of long-term rat renal allograft survival by pretransplant T cell receptor-alpha/beta-targeted therapy. Transplantation. 1996 Jan 27; 61(2):336-9. PMID: 8600649.
      View in: PubMed
    302. Brennan FX, Fleshner M, Watkins LR, Maier SF. Macrophage stimulation reduces the cholesterol levels of stressed and unstressed rats. Life Sci. 1996; 58(20):1771-6. PMID: 8637401.
      View in: PubMed
    303. Watkins LR, Maier SF, Goehler LE. Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain. 1995 Dec; 63(3):289-302. PMID: 8719529.
      View in: PubMed
    304. Fleshner M, Deak T, Spencer RL, Laudenslager ML, Watkins LR, Maier SF. A long-term increase in basal levels of corticosterone and a decrease in corticosteroid-binding globulin after acute stressor exposure. Endocrinology. 1995 Dec; 136(12):5336-42. PMID: 7588279.
      View in: PubMed
    305. Grahn RE, Kalman BA, Brennan FX, Watkins LR, Maier SF. The elevated plus-maze is not sensitive to the effect of stressor controllability in rats. Pharmacol Biochem Behav. 1995 Nov; 52(3):565-70. PMID: 8545475.
      View in: PubMed
    306. Maier SF, Watkins LR. Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock. Brain Res. 1995 Oct 16; 695(2):279-82. PMID: 8556346.
      View in: PubMed
    307. Watkins LR, Goehler LE, Relton J, Brewer MT, Maier SF. Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia. Brain Res. 1995 Sep 18; 692(1-2):244-50. PMID: 8548310.
      View in: PubMed
    308. Maier SF, Grahn RE, Maswood S, Watkins LR. The benzodiazepine receptor antagonists flumazenil and CGS8216 block the enhancement of fear conditioning and interference with escape behavior produced by inescapable shock. Psychopharmacology (Berl). 1995 Sep; 121(2):250-8. PMID: 8545531.
      View in: PubMed
    309. Maier SF, Busch CR, Maswood S, Grahn RE, Watkins LR. The dorsal raphe nucleus is a site of action mediating the behavioral effects of the benzodiazepine receptor inverse agonist DMCM. Behav Neurosci. 1995 Aug; 109(4):759-66. PMID: 7576219.
      View in: PubMed
    310. Fleshner M, Hermann J, Lockwood LL, Laudenslager ML, Watkins LR, Maier SF. Stressed rats fail to expand the CD45RC+CD4+ (Th1-like) T cell subset in response to KLH: possible involvement of IFN-gamma. Brain Behav Immun. 1995 Jun; 9(2):101-12. PMID: 7549034.
      View in: PubMed
    311. Maier SF, Grahn RE, Watkins LR. 8-OH-DPAT microinjected in the region of the dorsal raphe nucleus blocks and reverses the enhancement of fear conditioning and interference with escape produced by exposure to inescapable shock. Behav Neurosci. 1995 Jun; 109(3):404-12. PMID: 7662151.
      View in: PubMed
    312. Goehler LE, Busch CR, Tartaglia N, Relton J, Sisk D, Maier SF, Watkins LR. Blockade of cytokine induced conditioned taste aversion by subdiaphragmatic vagotomy: further evidence for vagal mediation of immune-brain communication. Neurosci Lett. 1995 Feb 13; 185(3):163-6. PMID: 7753482.
      View in: PubMed
    313. Watkins LR, Goehler LE, Relton JK, Tartaglia N, Silbert L, Martin D, Maier SF. Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci Lett. 1995 Jan 02; 183(1-2):27-31. PMID: 7746479.
      View in: PubMed
    314. Fleshner M, Goehler LE, Hermann J, Relton JK, Maier SF, Watkins LR. Interleukin-1 beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated. Brain Res Bull. 1995; 37(6):605-10. PMID: 7670884.
      View in: PubMed
    315. Fleshner M, Bellgrau D, Watkins LR, Laudenslager ML, Maier SF. Stress-induced reduction in the rat mixed lymphocyte reaction is due to macrophages and not to changes in T cell phenotypes. J Neuroimmunol. 1995 Jan; 56(1):45-52. PMID: 7822481.
      View in: PubMed
    316. Watkins LR, Maier SF, Goehler LE. Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sci. 1995; 57(11):1011-26. PMID: 7658909.
      View in: PubMed
    317. Maier SF, Watkins LR, Fleshner M. Psychoneuroimmunology. The interface between behavior, brain, and immunity. Am Psychol. 1994 Dec; 49(12):1004-17. PMID: 7818221.
      View in: PubMed
    318. Grisel JE, Wiertelak EP, Watkins LR, Maier SF. Route of morphine administration modulates conditioned analgesic tolerance and hyperalgesia. Pharmacol Biochem Behav. 1994 Dec; 49(4):1029-35. PMID: 7886072.
      View in: PubMed
    319. Wiertelak EP, Furness LE, Watkins LR, Maier SF. Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade. Brain Res. 1994 Nov 21; 664(1-2):9-16. PMID: 7895051.
      View in: PubMed
    320. Watkins LR, Wiertelak EP, Furness LE, Maier SF. Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids. Brain Res. 1994 Nov 21; 664(1-2):17-24. PMID: 7534600.
      View in: PubMed
    321. Sutton LC, Fleshner M, Mazzeo R, Maier SF, Watkins LR. A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release. Brain Res. 1994 Nov 07; 663(1):19-29. PMID: 7850467.
      View in: PubMed
    322. Watkins LR, Wiertelak EP, Goehler LE, Smith KP, Martin D, Maier SF. Characterization of cytokine-induced hyperalgesia. Brain Res. 1994 Aug 15; 654(1):15-26. PMID: 7982088.
      View in: PubMed
    323. Wiertelak EP, Furness LE, Horan R, Martinez J, Maier SF, Watkins LR. Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade. Brain Res. 1994 Jun 27; 649(1-2):19-26. PMID: 7953632.
      View in: PubMed
    324. Watkins LR, Wiertelak EP, Goehler LE, Mooney-Heiberger K, Martinez J, Furness L, Smith KP, Maier SF. Neurocircuitry of illness-induced hyperalgesia. Brain Res. 1994 Mar 14; 639(2):283-99. PMID: 8205482.
      View in: PubMed
    325. Lockwood LL, Silbert LH, Fleshner M, Laudenslager ML, Watkins LR, Maier SF. Morphine-induced decreases in in vivo antibody responses. Brain Behav Immun. 1994 Mar; 8(1):24-36. PMID: 8003769.
      View in: PubMed
    326. Maier SF, Kalman BA, Grahn RE. Chlordiazepoxide microinjected into the region of the dorsal raphe nucleus eliminates the interference with escape responding produced by inescapable shock whether administered before inescapable shock or escape testing. Behav Neurosci. 1994 Feb; 108(1):121-30. PMID: 8192838.
      View in: PubMed
    327. Wiertelak EP, Smith KP, Furness L, Mooney-Heiberger K, Mayr T, Maier SF, Watkins LR. Acute and conditioned hyperalgesic responses to illness. Pain. 1994 Feb; 56(2):227-34. PMID: 8008412.
      View in: PubMed
    328. Wiertelak EP, Yang HY, Mooney-Heiberger K, Maier SF, Watkins LR. The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry. Brain Res. 1994 Jan 21; 634(2):214-26. PMID: 8131071.
      View in: PubMed
    329. Spitzer M, Braun U, Hermle L, Maier S. Associative semantic network dysfunction in thought-disordered schizophrenic patients: direct evidence from indirect semantic priming. Biol Psychiatry. 1993 Dec 15; 34(12):864-77. PMID: 8110913.
      View in: PubMed
    330. Fleshner M, Brohm MM, Laudenslager ML, Watkins LR, Maier SF. Modulation of the in vivo antibody response by a benzodiazepine inverse agonist (DMCM) administered centrally or peripherally. Physiol Behav. 1993 Dec; 54(6):1149-54. PMID: 8295955.
      View in: PubMed
    331. Spitzer M, Braun U, Maier S, Hermle L, Maher BA. Indirect semantic priming in schizophrenic patients. Schizophr Res. 1993 Dec; 11(1):71-80. PMID: 8297807.
      View in: PubMed
    332. Lockwood LL, Silbert LH, Laudenslager ML, Watkins LR, Maier SF. Anesthesia-induced modulation of in vivo antibody levels: a study of pentobarbital, chloral hydrate, methoxyflurane, halothane, and ketamine/xylazine. Anesth Analg. 1993 Oct; 77(4):769-74. PMID: 8214663.
      View in: PubMed
    333. Maier SF, Wiertelak EP, Martin D, Watkins LR. Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin. Brain Res. 1993 Oct 01; 623(2):321-4. PMID: 8221116.
      View in: PubMed
    334. Short KR, Maier SF. Stressor controllability, social interaction, and benzodiazepine systems. Pharmacol Biochem Behav. 1993 Aug; 45(4):827-35. PMID: 8415822.
      View in: PubMed
    335. Woodmansee WW, Silbert LH, Maier SF. Factors that modulate inescapable shock-induced reductions in daily activity in the rat. Pharmacol Biochem Behav. 1993 Jul; 45(3):553-9. PMID: 8392730.
      View in: PubMed
    336. Grisel JE, Fleshner M, Watkins LR, Maier SF. Opioid and nonopioid interactions in two forms of stress-induced analgesia. Pharmacol Biochem Behav. 1993 May; 45(1):161-72. PMID: 8516354.
      View in: PubMed
    337. Maier SF, Grahn RE, Kalman BA, Sutton LC, Wiertelak EP, Watkins LR. The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock. Behav Neurosci. 1993 Apr; 107(2):377-88. PMID: 8484901.
      View in: PubMed
    338. Watkins LR, Wiertelak EP, Maier SF. The amygdala is necessary for the expression of conditioned but not unconditioned analgesia. Behav Neurosci. 1993 Apr; 107(2):402-5. PMID: 8484903.
      View in: PubMed
    339. Maier SF, Minor TR. Dissociation of interference with the speed and accuracy of escape produced by inescapable shock. Behav Neurosci. 1993 Feb; 107(1):139-46. PMID: 8383499.
      View in: PubMed
    340. Spitzer M, Weisker I, Winter M, Maier S. [Semantic activation phenomena in healthy probands and in schizophrenic patients. Analysis on the level of word pairs]. Z Klin Psychol Psychopathol Psychother. 1993; 41(4):343-57. PMID: 8212775.
      View in: PubMed
    341. Fleshner M, Watkins LR, Lockwood LL, Grahn RE, Gerhardt G, Meaney MJ, Laudenslager ML, Maier SF. Blockade of the hypothalamic-pituitary-adrenal response to stress by intraventricular injection of dexamethasone: a method for studying the stress-induced peripheral effects of glucocorticoids. Psychoneuroendocrinology. 1993; 18(4):251-63. PMID: 8391148.
      View in: PubMed
    342. Fleshner M, Watkins LR, Lockwood LL, Bellgrau D, Laudenslager ML, Maier SF. Specific changes in lymphocyte subpopulations: a potential mechanism for stress-induced immunomodulation. J Neuroimmunol. 1992 Dec; 41(2):131-42. PMID: 1469075.
      View in: PubMed
    343. Parker LA, Maier S, Rennie M, Crebolder J. Morphine- and naltrexone-induced modification of palatability: analysis by the taste reactivity test. Behav Neurosci. 1992 Dec; 106(6):999-1010. PMID: 1335271.
      View in: PubMed
    344. Watkins LR, Wiertelak EP, Grisel JE, Silbert LH, Maier SF. Parallel activation of multiple spinal opiate systems appears to mediate 'non-opiate' stress-induced analgesias. Brain Res. 1992 Oct 23; 594(1):99-108. PMID: 1334766.
      View in: PubMed
    345. Watkins LR, Wiertelak EP, Maier SF. Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels. Brain Res. 1992 Jun 05; 582(1):1-9. PMID: 1354010.
      View in: PubMed
    346. Watkins LR, Wiertelak EP, Maier SF. Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels. Brain Res. 1992 Jun 05; 582(1):10-21. PMID: 1323369.
      View in: PubMed
    347. Wiertelak EP, Maier SF, Watkins LR. Cholecystokinin antianalgesia: safety cues abolish morphine analgesia. Science. 1992 May 08; 256(5058):830-3. PMID: 1589765.
      View in: PubMed
    348. Brennan FX, Job RF, Watkins LR, Maier SF. Total plasma cholesterol levels of rats are increased following only three sessions of tailshock. Life Sci. 1992; 50(13):945-50. PMID: 1548978.
      View in: PubMed
    349. Barnes CA, Forster MJ, Fleshner M, Ahanotu EN, Laudenslager ML, Mazzeo RS, Maier SF, Lal H. Exercise does not modify spatial memory, brain autoimmunity, or antibody response in aged F-344 rats. Neurobiol Aging. 1991 Jan-Feb; 12(1):47-53. PMID: 2002883.
      View in: PubMed
    350. Maier SF, Silbert LH, Woodmansee WW, Desan PH. Adinazolam both prevents and reverses the long-term reduction of daily activity produced by inescapable shock. Pharmacol Biochem Behav. 1990 Aug; 36(4):767-73. PMID: 2217504.
      View in: PubMed
    351. Maier SF. Diazepam modulation of stress-induced analgesia depends on the type of analgesia. Behav Neurosci. 1990 Apr; 104(2):339-47. PMID: 2346627.
      View in: PubMed
    352. Maier SF. Role of fear in mediating shuttle escape learning deficit produced by inescapable shock. J Exp Psychol Anim Behav Process. 1990 Apr; 16(2):137-49. PMID: 2335769.
      View in: PubMed
    353. Fleshner M, Laudenslager ML, Simons L, Maier SF. Reduced serum antibodies associated with social defeat in rats. Physiol Behav. 1989 Jun; 45(6):1183-7. PMID: 2813542.
      View in: PubMed
    354. Maier SF. Determinants of the nature of environmentally induced hypoalgesia. Behav Neurosci. 1989 Feb; 103(1):131-43. PMID: 2923666.
      View in: PubMed
    355. MacLennan AJ, Pelleymounter MA, Atmadja S, Jakubovic A, Maier SF, Fibiger HC. D2 dopamine receptors in the rat prefrontal cortex: characterization and alteration by stress. Brain Res. 1989 Jan 16; 477(1-2):300-7. PMID: 2522809.
      View in: PubMed
    356. Lee RK, Maier SF. Inescapable shock and attention to internal versus external cues in a water discrimination escape task. J Exp Psychol Anim Behav Process. 1988 Jul; 14(3):302-10. PMID: 3404084.
      View in: PubMed
    357. Desan PH, Woodmansee WW, Ryan SM, Smock TK, Maier SF. Monoamine neurotransmitters and metabolites during the estrous cycle, pregnancy, and the postpartum period. Pharmacol Biochem Behav. 1988 Jul; 30(3):563-8. PMID: 3211964.
      View in: PubMed
    358. Maier SF, Laudenslager ML. Inescapable shock, shock controllability, and mitogen stimulated lymphocyte proliferation. Brain Behav Immun. 1988 Jun; 2(2):87-91. PMID: 3233360.
      View in: PubMed
    359. Ryan SM, Maier SF. The estrous cycle and estrogen modulate stress-induced analgesia. Behav Neurosci. 1988 Jun; 102(3):371-80. PMID: 2840093.
      View in: PubMed
    360. Laudenslager ML, Fleshner M, Hofstadter P, Held PE, Simons L, Maier SF. Suppression of specific antibody production by inescapable shock: stability under varying conditions. Brain Behav Immun. 1988 Jun; 2(2):92-101. PMID: 3148338.
      View in: PubMed
    361. Desan PH, Silbert LH, Maier SF. Long-term effects of inescapable stress on daily running activity and antagonism by desipramine. Pharmacol Biochem Behav. 1988 May; 30(1):21-9. PMID: 3174746.
      View in: PubMed
    362. Maier SF, Keith JR. Shock signals and the development of stress-induced analgesia. J Exp Psychol Anim Behav Process. 1987 Jul; 13(3):226-38. PMID: 3039035.
      View in: PubMed
    363. Maier SF, Ryan SM, Barksdale CM, Kalin NH. Stressor controllability and the pituitary-adrenal system. Behav Neurosci. 1986 Oct; 100(5):669-74. PMID: 3022767.
      View in: PubMed
    364. Maier SF. Stressor controllability and stress-induced analgesia. Ann N Y Acad Sci. 1986; 467:55-72. PMID: 3524388.
      View in: PubMed
    365. Drugan RC, Maier SF. Control vs. lack of control over aversive stimuli: nonopioid-opioid analgesic consequences. NIDA Res Monogr. 1986; 74:71-89. PMID: 3122055.
      View in: PubMed
    366. Drugan RC, Ader DN, Maier SF. Shock controllability and the nature of stress-induced analgesia. Behav Neurosci. 1985 Oct; 99(5):791-801. PMID: 3843301.
      View in: PubMed
    367. Drugan RC, McIntyre TD, Alpern HP, Maier SF. Coping and seizure susceptibility: control over shock protects against bicuculline-induced seizures. Brain Res. 1985 Sep 02; 342(1):9-17. PMID: 4041819.
      View in: PubMed
    368. Drugan RC, Maier SF, Skolnick P, Paul SM, Crawley JN. An anxiogenic benzodiazepine receptor ligand induces learned helplessness. Eur J Pharmacol. 1985 Jul 31; 113(3):453-7. PMID: 2995072.
      View in: PubMed
    369. Ryan SM, Watkins LR, Mayer DJ, Maier SF. Spinal pain suppression mechanisms may differ for phasic and tonic pain. Brain Res. 1985 May 13; 334(1):172-5. PMID: 3995310.
      View in: PubMed
    370. Drugan RC, Ryan SM, Minor TR, Maier SF. Librium prevents the analgesia and shuttlebox escape deficit typically observed following inescapable shock. Pharmacol Biochem Behav. 1984 Nov; 21(5):749-54. PMID: 6542677.
      View in: PubMed
    371. Williams JL, Drugan RC, Maier SF. Exposure to uncontrollable stress alters withdrawal from morphine. Behav Neurosci. 1984 Oct; 98(5):836-46. PMID: 6541499.
      View in: PubMed
    372. Minor TR, Jackson RL, Maier SF. Effects of task-irrelevant cues and reinforcement delay on choice-escape learning following inescapable shock: evidence for a deficit in selective attention. J Exp Psychol Anim Behav Process. 1984 Oct; 10(4):543-56. PMID: 6491612.
      View in: PubMed
    373. Maier SF, Ryan SM, Kurtz R. The formalin test and the opioid nature of stress-induced analgesia. Behav Neural Biol. 1984 May; 41(1):54-62. PMID: 6087789.
      View in: PubMed
    374. Watkins LR, Drugan R, Hyson RL, Moye TB, Ryan SM, Mayer DJ, Maier SF. Opiate and non-opiate analgesia induced by inescapable tail-shock: effects of dorsolateral funiculus lesions and decerebration. Brain Res. 1984 Jan 23; 291(2):325-36. PMID: 6697193.
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    375. Maier SF. Learned helplessness and animal models of depression. Prog Neuropsychopharmacol Biol Psychiatry. 1984; 8(3):435-46. PMID: 6385140.
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    376. Laudenslager ML, Ryan SM, Drugan RC, Hyson RL, Maier SF. Coping and immunosuppression: inescapable but not escapable shock suppresses lymphocyte proliferation. Science. 1983 Aug 05; 221(4610):568-70. PMID: 6603018.
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    377. MacLennan AJ, Maier SF. Coping and the stress-induced potentiation of stimulant stereotypy in the rat. Science. 1983 Mar 04; 219(4588):1091-3. PMID: 6681679.
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    378. MacLennan AJ, Drugan RC, Maier SF. Long-term stress-induced analgesia blocked by scopolamine. Psychopharmacology (Berl). 1983; 80(3):267-8. PMID: 6412272.
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    379. Maier SF, Sherman JE, Lewis JW, Terman GW, Liebeskind JC. The opioid/nonopioid nature of stress-induced analgesia and learned helplessness. J Exp Psychol Anim Behav Process. 1983 Jan; 9(1):80-90. PMID: 6682435.
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    380. MacLennan AJ, Drugan RC, Hyson RL, Maier SF, Madden J, Barchas JD. Dissociation of long-term analgesia and the shuttle box escape deficit caused by inescapable shock. J Comp Physiol Psychol. 1982 Dec; 96(6):904-12. PMID: 7153387.
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    381. Hyson RL, Ashcraft LJ, Drugan RC, Grau JW, Maier SF. Extent and control of shock affects naltrexone sensitivity of stress-induced analgesia and reactivity to morphine. Pharmacol Biochem Behav. 1982 Nov; 17(5):1019-25. PMID: 6294682.
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    382. Drugan RC, Moye TB, Maier SF. Opioid and nonopioid forms of stress-induced analgesia: some environmental determinants and characteristics. Behav Neural Biol. 1982 Jul; 35(3):251-64. PMID: 6295357.
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    383. MacLennan AJ, Drugan RC, Hyson RL, Maier SF, Madden J, Barchas JD. Corticosterone: a critical factor in an opioid form of stress-induced analgesia. Science. 1982 Mar 19; 215(4539):1530-2. PMID: 7063862.
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    384. Maier SF, Drugan RC, Grau JW. Controllability, coping behavior, and stress-induced analgesia in the rat. Pain. 1982 Jan; 12(1):47-56. PMID: 7199129.
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    385. Grau JW, Hyson RL, Maier SF, Madden J, Barchas JD. Long-term stress-induced analgesia and activation of the opiate system. Science. 1981 Sep 18; 213(4514):1409-11. PMID: 7268445.
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    386. Drugan RC, Grau JW, Maier SF, Madden J, Barchas JD. Cross tolerance between morphine and the long-term analgesic reaction to inescapable shock. Pharmacol Biochem Behav. 1981 May; 14(5):677-82. PMID: 7243845.
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    387. Maier SF, Davies S, Grau JW, Jackson RL, Morrison DH, Moye T, Madden J, Barchas JD. Opiate antagonists and long-term analgesic reaction induced by inescapable shock in rats. J Comp Physiol Psychol. 1980 Dec; 94(6):1172-83. PMID: 6259220.
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    388. Jackson RL, Alexander JH, Maier SF. Learned helplessness, inactivity, and associative deficits: effects of inescapable shock on response choice escape learning. J Exp Psychol Anim Behav Process. 1980 Jan; 6(1):1-20. PMID: 7373224.
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    389. Jackson RL, Maier SF, Coon DJ. Long-term analgesic effects of inescapable shock and learned helplessness. Science. 1979 Oct 05; 206(4414):91-3. PMID: 573496.
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    390. Maier SF, Rapaport P, Wheatley KL. Conditioned inhibition and the UCS-CS interval. Anim Learn Behav. 1976 May; 4(2):217-20. PMID: 964450.
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    391. Zahorik DM, Maier SF, Pies RW. Preferences for tastes paired with recovery from thiamine deficiency in rats: appetitive conditioning or learned safety? J Comp Physiol Psychol. 1974 Dec; 87(6):1083-91. PMID: 4443451.
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    392. Greenough WT, Maier SF. Molecular changes during learning: behavioral strategy--a comment on Gaito and Bonnet. Psychol Bull. 1972 Dec; 78(6):480-2. PMID: 4645475.
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    393. Maier SF, Anderson C, Lieberman DA. Influence of control of shock on subsequent shock-elicited aggression. J Comp Physiol Psychol. 1972 Oct; 81(1):94-100. PMID: 4672574.
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    394. Seligman ME, Maier SF, Geer JH. Alleviation of learned helplessness in the dog. J Abnorm Psychol. 1968 Jun; 73(3):256-62. PMID: 5658526.
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    395. Seligman ME, Maier SF. Failure to escape traumatic shock. J Exp Psychol. 1967 May; 74(1):1-9. PMID: 6032570.
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