 Troponin I
"Troponin I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TROPONIN complex subunit that inhibits ACTOMYOSIN ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three troponin I subtypes: troponin I1, I2 and I3. Troponin I3 is cardiac-specific whereas troponin I1 and I2 are skeletal subtypes. Troponin I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
| Descriptor ID |
D019210
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| MeSH Number(s) |
D05.500.945.925 D05.750.078.730.825.925 D12.776.210.500.910.925 D12.776.220.525.825.925
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Troponin I".
Below are MeSH descriptors whose meaning is more specific than "Troponin I".
This graph shows the total number of publications written about "Troponin I" by people in this website by year, and whether "Troponin I" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1993 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1997 | 2 | 0 | 2 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 1 | 1 | 2 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2004 | 3 | 0 | 3 | | 2005 | 1 | 0 | 1 | | 2006 | 2 | 1 | 3 | | 2007 | 0 | 2 | 2 | | 2008 | 1 | 2 | 3 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 2 | 3 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 1 | 2 | | 2013 | 5 | 1 | 6 | | 2014 | 2 | 0 | 2 | | 2015 | 1 | 2 | 3 | | 2016 | 2 | 1 | 3 | | 2017 | 2 | 3 | 5 | | 2018 | 2 | 0 | 2 | | 2019 | 2 | 0 | 2 | | 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Troponin I" by people in Profiles.
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Kavsak PA, Cerasuolo JO, Ko DT, Ma J, Sherbino J, Mondoux SE, Clayton N, Hill SA, McQueen M, Griffith LE, Mehta SR, Perez R, Seow H, Devereaux PJ, Worster A. Using the clinical chemistry score in the emergency department to detect adverse cardiac events: a diagnostic accuracy study. CMAJ Open. 2020 Oct-Dec; 8(4):E676-E684.
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Lin YH, Schmidt W, Fritz KS, Jeong MY, Cammarato A, Foster DB, Biesiadecki BJ, McKinsey TA, Woulfe KC. Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity. J Mol Cell Cardiol. 2020 02; 139:135-147.
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Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 12 01; 317(6):H1221-H1230.
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Wanamaker BL, Seth MM, Sukul D, Dixon SR, Bhatt DL, Madder RD, Rumsfeld JS, Gurm HS. Relationship Between Troponin on Presentation and In-Hospital Mortality in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. J Am Heart Assoc. 2019 10; 8(19):e013551.
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Kavsak PA, Neumann JT, Cullen L, Than M, Shortt C, Greenslade JH, Pickering JW, Ojeda F, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Westermann D, Sörensen NA, Parsonage WA, Griffith L, Mehta SR, Devereaux PJ, Richards M, Troughton R, Pemberton C, Aldous S, Blankenberg S, Worster A. Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department. CMAJ. 2018 08 20; 190(33):E974-E984.
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Mandell MS, Kay J. High-Sensitivity Troponins in Liver Transplantation: How Will They Change Our Practice? Transplantation. 2018 05; 102(5):716-717.
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Bonaca MP. Time for a New Strategy for High-Sensitivity Troponin in the Emergency Department. J Am Coll Cardiol. 2017 10 31; 70(18):2237-2239.
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Mauro AG, Mezzaroma E, Marchetti C, Narayan P, Del Buono MG, Capuano M, Prestamburgo A, Catapano S, Salloum FN, Abbate A, Toldo S. A Preclinical Translational Study of the Cardioprotective Effects of Plasma-Derived Alpha-1 Anti-trypsin in Acute Myocardial Infarction. J Cardiovasc Pharmacol. 2017 May; 69(5):273-278.
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Bodor GS. Cardiac Troponins: Molecules of Many Surprises. Clin Chem. 2017 06; 63(6):1059-1060.
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Farber AJ, Suarez K, Slicker K, Patel CD, Pope B, Kowal R, Michel JB. Frequency of Troponin Testing in Inpatient Versus Outpatient Settings. Am J Cardiol. 2017 04 15; 119(8):1153-1155.
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