 Protein Footprinting
"Protein Footprinting" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A method for determining points of contact between interacting proteins or binding sites of proteins to nucleic acids. Protein footprinting utilizes a protein cutting reagent or protease. Protein cleavage is inhibited where the proteins, or nucleic acids and protein, contact each other. After completion of the cutting reaction, the remaining peptide fragments are analyzed by electrophoresis.
| Descriptor ID |
D023302
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| MeSH Number(s) |
E05.196.700.690 E05.393.760.705.685.690
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| Concept/Terms |
Protein Footprints- Protein Footprints
- Footprint, Protein
- Protein Footprint
- Footprints, Protein
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Below are MeSH descriptors whose meaning is more general than "Protein Footprinting".
Below are MeSH descriptors whose meaning is more specific than "Protein Footprinting".
This graph shows the total number of publications written about "Protein Footprinting" by people in this website by year, and whether "Protein Footprinting" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 2 | 2 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Footprinting" by people in Profiles.
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Silverman IM, Li F, Alexander A, Goff L, Trapnell C, Rinn JL, Gregory BD. RNase-mediated protein footprint sequencing reveals protein-binding sites throughout the human transcriptome. Genome Biol. 2014 Jan 07; 15(1):R3.
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Ditzler MA, Bose D, Shkriabai N, Marchand B, Sarafianos SG, Kvaratskhelia M, Burke DH. Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates. Nucleic Acids Res. 2011 Oct; 39(18):8237-47.
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Chen X, Hoffman MM, Bilmes JA, Hesselberth JR, Noble WS. A dynamic Bayesian network for identifying protein-binding footprints from single molecule-based sequencing data. Bioinformatics. 2010 Jun 15; 26(12):i334-42.
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Fowler JD, Brown JA, Kvaratskhelia M, Suo Z. Probing conformational changes of human DNA polymerase lambda using mass spectrometry-based protein footprinting. J Mol Biol. 2009 Jul 17; 390(3):368-79.
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Kvaratskhelia M, Grice SF. Structural analysis of protein-RNA interactions with mass spectrometry. Methods Mol Biol. 2008; 488:213-9.
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Connaghan-Jones KD, Moody AD, Bain DL. Quantitative DNase footprint titration: a tool for analyzing the energetics of protein-DNA interactions. Nat Protoc. 2008; 3(5):900-14.
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Datta SA, Zhao Z, Clark PK, Tarasov S, Alexandratos JN, Campbell SJ, Kvaratskhelia M, Lebowitz J, Rein A. Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch. J Mol Biol. 2007 Jan 19; 365(3):799-811.
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Shkriabai N, Datta SA, Zhao Z, Hess S, Rein A, Kvaratskhelia M. Interactions of HIV-1 Gag with assembly cofactors. Biochemistry. 2006 Apr 04; 45(13):4077-83.
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