Furin
"Furin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.
Descriptor ID |
D045683
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MeSH Number(s) |
D08.811.277.656.300.760.353 D08.811.277.656.837.249 D08.811.277.656.959.350.353
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Concept/Terms |
Furin- Furin
- Dibasic Processing Enzyme
- Processing Enzyme, Dibasic
- Furin Protein
- SPC1 Proteinase
- Paired Basic Amino Acid Cleaving Enzyme
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Below are MeSH descriptors whose meaning is more general than "Furin".
Below are MeSH descriptors whose meaning is more specific than "Furin".
This graph shows the total number of publications written about "Furin" by people in this website by year, and whether "Furin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2002 | 0 | 1 | 1 | 2006 | 1 | 0 | 1 | 2007 | 1 | 0 | 1 | 2019 | 0 | 1 | 1 | 2021 | 1 | 1 | 2 | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Furin" by people in Profiles.
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Pacheco A, Issaian A, Davis J, Anderson N, Nemkov T, Paukovich N, Henen MA, V?geli B, Sikela JM, Hansen K. Proteolytic activation of human-specific Olduvai domains by the furin protease. Int J Biol Macromol. 2023 Apr 15; 234:123041.
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Showers WM, Leach SM, Kechris K, Strong M. Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations. Infect Genet Evol. 2022 01; 97:105153.
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Ouyang Y, Bagalkot T, Fitzgerald W, Sadovsky E, Chu T, Mart?nez-Marchal A, Brie?o-Enr?quez M, Su EJ, Margolis L, Sorkin A, Sadovsky Y. Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin. mSphere. 2021 04 14; 6(2).
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Buck JM, O'Neill HC, Stitzel JA. Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice. Biochem Pharmacol. 2019 10; 168:438-451.
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Ornatowski W, Poschet JF, Perkett E, Taylor-Cousar JL, Deretic V. Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity. J Clin Invest. 2007 Nov; 117(11):3489-97.
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Walker MB, Miller CT, Coffin Talbot J, Stock DW, Kimmel CB. Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning. Dev Biol. 2006 Jul 01; 295(1):194-205.
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Bowler RP, Nicks M, Olsen DA, Th?gersen IB, Valnickova Z, H?jrup P, Franzusoff A, Enghild JJ, Crapo JD. Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase. J Biol Chem. 2002 May 10; 277(19):16505-11.
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Bosshart H, Humphrey J, Deignan E, Davidson J, Drazba J, Yuan L, Oorschot V, Peters PJ, Bonifacino JS. The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system. J Cell Biol. 1994 Sep; 126(5):1157-72.
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