 Receptors, Neurokinin-1
"Receptors, Neurokinin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of cell surface receptors for TACHYKININS with a preference for SUBSTANCE P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.
| Descriptor ID |
D018040
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| MeSH Number(s) |
D12.776.543.750.695.862.500 D12.776.543.750.720.600.830.500 D12.776.543.750.750.555.830.500
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| Concept/Terms |
Receptors, Neurokinin-1- Receptors, Neurokinin-1
- Receptors, Neurokinin 1
- Substance P Receptors
- Receptors, Substance P
- P Receptors, Substance
- NK-1 Receptor
- NK 1 Receptor
- Receptor, NK-1
- Receptors, NK-1
- Receptors, NK 1
- NK-1 Receptors
- NK 1 Receptors
- Tachykinin Receptor 1
- Neurokinin-1 Receptors
- Neurokinin 1 Receptors
- Receptors, SP-P
- Receptors, SP P
- SP-P Receptor
- Receptor, SP-P
- SP P Receptor
- SP-P Receptors
- SP P Receptors
- Substance-P Receptor
- Receptor, Substance-P
- Substance P Receptor
- P Receptor, Substance
- Receptor, Substance P
- Neurokinin-1 Receptor
- Neurokinin 1 Receptor
- Receptor, Neurokinin-1
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Below are MeSH descriptors whose meaning is more general than "Receptors, Neurokinin-1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Tachykinin [D12.776.543.750.695.862]
- Receptors, Neurokinin-1 [D12.776.543.750.695.862.500]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Neuropeptide [D12.776.543.750.720.600]
- Receptors, Tachykinin [D12.776.543.750.720.600.830]
- Receptors, Neurokinin-1 [D12.776.543.750.720.600.830.500]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Neuropeptide [D12.776.543.750.750.555]
- Receptors, Tachykinin [D12.776.543.750.750.555.830]
- Receptors, Neurokinin-1 [D12.776.543.750.750.555.830.500]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Neurokinin-1".
This graph shows the total number of publications written about "Receptors, Neurokinin-1" by people in this website by year, and whether "Receptors, Neurokinin-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 | | 2009 | 2 | 0 | 2 | | 2010 | 0 | 1 | 1 | | 2012 | 2 | 0 | 2 | | 2013 | 2 | 0 | 2 | | 2014 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptors, Neurokinin-1" by people in Profiles.
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Bubak AN, Como CN, Blackmon AM, Frietze S, Mescher T, Jones D, Cohrs RJ, Paucek P, Baird NL, Nagel MA. Varicella Zoster Virus Induces Nuclear Translocation of the Neurokinin-1 Receptor, Promoting Lamellipodia Formation and Viral Spread in Spinal Astrocytes. J Infect Dis. 2018 09 08; 218(8):1324-1335.
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Saunders CJ, Christensen M, Finger TE, Tizzano M. Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):6075-80.
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Spitsin S, Tuluc F, Meshki J, Ping Lai J, Tustin Iii R, Douglas SD. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. Neuroimmunomodulation. 2013; 20(5):247-55.
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Schwartz L, Spitsin SV, Meshki J, Tuluc F, Douglas SD, Wolfe JH. Substance P enhances HIV-1 infection in human fetal brain cell cultures expressing full-length neurokinin-1 receptor. J Neurovirol. 2013 Jun; 19(3):219-27.
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Blaine S, Claus E, Harlaar N, Hutchison K. TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence. Alcohol Clin Exp Res. 2013 Jan; 37 Suppl 1:E125-30.
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Chen P, Douglas SD, Meshki J, Tuluc F. Neurokinin 1 receptor mediates membrane blebbing and sheer stress-induced microparticle formation in HEK293 cells. PLoS One. 2012; 7(9):e45322.
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Manak MM, Moshkoff DA, Nguyen LT, Meshki J, Tebas P, Tuluc F, Douglas SD. Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals. AIDS. 2010 Nov 27; 24(18):2789-96.
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Ablin JN, Bar-Shira A, Yaron M, Orr-Urtreger A. Candidate-gene approach in fibromyalgia syndrome: association analysis of the genes encoding substance P receptor, dopamine transporter and alpha1-antitrypsin. Clin Exp Rheumatol. 2009 Sep-Oct; 27(5 Suppl 56):S33-8.
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Meshki J, Douglas SD, Lai JP, Schwartz L, Kilpatrick LE, Tuluc F. Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinase-dependent mechanism. J Biol Chem. 2009 Apr 03; 284(14):9280-9.
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Meza U, Thapliyal A, Bannister RA, Adams BA. Neurokinin 1 receptors trigger overlapping stimulation and inhibition of CaV2.3 (R-type) calcium channels. Mol Pharmacol. 2007 Jan; 71(1):284-93.
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