 Purines
"Purines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
| Descriptor ID |
D011687
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| MeSH Number(s) |
D03.633.100.759
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Purines".
Below are MeSH descriptors whose meaning is more specific than "Purines".
This graph shows the total number of publications written about "Purines" by people in this website by year, and whether "Purines" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 0 | 2 | 2 | | 2004 | 2 | 1 | 3 | | 2005 | 2 | 3 | 5 | | 2006 | 6 | 1 | 7 | | 2007 | 3 | 5 | 8 | | 2008 | 4 | 8 | 12 | | 2009 | 2 | 2 | 4 | | 2010 | 1 | 2 | 3 | | 2011 | 3 | 5 | 8 | | 2012 | 2 | 5 | 7 | | 2013 | 1 | 5 | 6 | | 2014 | 4 | 2 | 6 | | 2015 | 1 | 2 | 3 | | 2016 | 2 | 1 | 3 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 4 | 5 | | 2019 | 1 | 2 | 3 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Purines" by people in Profiles.
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Li BX, Zhang H, Liu Y, Li Y, Zheng JJ, Li WX, Feng K, Sun M, Dai SX. Novel pathways of HIV latency reactivation revealed by integrated analysis of transcriptome and target profile of bryostatin. Sci Rep. 2020 02 26; 10(1):3511.
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Matyjasik MM, Batey RT. Structural basis for 2'-deoxyguanosine recognition by the 2'-dG-II class of riboswitches. Nucleic Acids Res. 2019 11 18; 47(20):10931-10941.
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Gehrke S, Shah N, Gamboni F, Kamyszek R, Srinivasan AJ, Gray A, Landrigan M, Welsby I, D'Alessandro A. Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients. Transfusion. 2019 10; 59(10):3102-3112.
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Sharman JP, Coutre SE, Furman RR, Cheson BD, Pagel JM, Hillmen P, Barrientos JC, Zelenetz AD, Kipps TJ, Flinn IW, Ghia P, Eradat H, Ervin T, Lamanna N, Coiffier B, Pettitt AR, Ma S, Tausch E, Cramer P, Huang J, Mitra S, Hallek M, O'Brien SM, Stilgenbauer S. Final Results of a Randomized, Phase III Study of Rituximab With or Without Idelalisib Followed by Open-Label Idelalisib in Patients With Relapsed Chronic Lymphocytic Leukemia. J Clin Oncol. 2019 06 01; 37(16):1391-1402.
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Weiss J, Afghahi A, Shagisultanova E, Diamond JR. Approaching Use of CDK4/6 Inhibitors in Metastatic HR+, HER2- Breast Cancer. Oncology (Williston Park). 2018 Oct 15; 32(10):513-5.
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Vladar EK, Stratton MB, Saal ML, Salazar-De Simone G, Wang X, Wolgemuth D, Stearns T, Axelrod JD. Cyclin-dependent kinase control of motile ciliogenesis. Elife. 2018 08 28; 7.
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Haines NR, Manoharan N, Olson JL, D'Alessandro A, Reisz JA. Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal Detachment. J Proteome Res. 2018 07 06; 17(7):2421-2427.
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D'Alessandro A, Reisz JA, Culp-Hill R, Korsten H, van Bruggen R, de Korte D. Metabolic effect of alkaline additives and guanosine/gluconate in storage solutions for red blood cells. Transfusion. 2018 08; 58(8):1992-2002.
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Sherlock ME, Sudarsan N, Stav S, Breaker RR. Tandem riboswitches form a natural Boolean logic gate to control purine metabolism in bacteria. Elife. 2018 03 05; 7.
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Galbraith MD, Andrysik Z, Pandey A, Hoh M, Bonner EA, Hill AA, Sullivan KD, Espinosa JM. CDK8 Kinase Activity Promotes Glycolysis. Cell Rep. 2017 Nov 07; 21(6):1495-1506.
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