 Leukocyte Elastase
"Leukocyte Elastase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.
| Descriptor ID |
D019272
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| MeSH Number(s) |
D08.811.277.656.300.760.560.500 D08.811.277.656.959.350.560.500
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| Concept/Terms |
Leukocyte Elastase- Leukocyte Elastase
- Elastase, Leukocyte
- Polymorphonuclear Leukocyte Elastase
- Elastase, Polymorphonuclear Leukocyte
- Leukocyte Elastase, Polymorphonuclear
- Neutrophil Elastase
- Elastase, Neutrophil
- PMN Elastase
- Elastase, PMN
- Granulocyte Elastase
- Elastase, Granulocyte
- Lysosomal Elastase
- Elastase, Lysosomal
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Below are MeSH descriptors whose meaning is more general than "Leukocyte Elastase".
Below are MeSH descriptors whose meaning is more specific than "Leukocyte Elastase".
This graph shows the total number of publications written about "Leukocyte Elastase" by people in this website by year, and whether "Leukocyte Elastase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 0 | 1 | 1 | | 1993 | 0 | 1 | 1 | | 1995 | 1 | 1 | 2 | | 1996 | 1 | 2 | 3 | | 1997 | 4 | 1 | 5 | | 1998 | 1 | 1 | 2 | | 1999 | 0 | 2 | 2 | | 2000 | 1 | 0 | 1 | | 2001 | 0 | 2 | 2 | | 2002 | 3 | 3 | 6 | | 2003 | 1 | 1 | 2 | | 2004 | 1 | 0 | 1 | | 2005 | 1 | 1 | 2 | | 2007 | 1 | 2 | 3 | | 2008 | 0 | 2 | 2 | | 2009 | 2 | 5 | 7 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 2 | 2 | | 2013 | 4 | 1 | 5 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 0 | 3 | 3 | | 2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "Leukocyte Elastase" by people in Profiles.
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Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB. Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin. J Trauma Acute Care Surg. 2017 12; 83(6):1053-1061.
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Ni K, Umair Mukhtar Mian M, Meador C, Gill A, Barwinska D, Cao D, Justice MJ, Jiang D, Schaefer N, Schweitzer KS, Chu HW, March KL, Petrache I. Oncostatin M and TNF-a Induce Alpha-1 Antitrypsin Production in Undifferentiated Adipose Stromal Cells. Stem Cells Dev. 2017 10 15; 26(20):1468-1476.
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Di Francesco A, Di Germanio C, Panda AC, Huynh P, Peaden R, Navas-Enamorado I, Bastian P, Lehrmann E, Diaz-Ruiz A, Ross D, Siegel D, Martindale JL, Bernier M, Gorospe M, Abdelmohsen K, de Cabo R. Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation. Free Radic Biol Med. 2016 10; 99:225-233.
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Toldo S, Mauro AG, Marchetti C, Rose SW, Mezzaroma E, Van Tassell BW, Kim S, Dinarello CA, Abbate A. Recombinant Human Alpha-1 Antitrypsin-Fc Fusion Protein Reduces Mouse Myocardial Inflammatory Injury After Ischemia-Reperfusion Independent of Elastase Inhibition. J Cardiovasc Pharmacol. 2016 Jul; 68(1):27-32.
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Toonen EJ, Mirea AM, Tack CJ, Stienstra R, Ballak DB, van Diepen JA, Hijmans A, Chavakis T, Dokter WH, Pham CT, Netea MG, Dinarello CA, Joosten LA. Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance. Mol Med. 2016 05 24; 22.
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Dau T, Sarker RS, Yildirim AO, Eickelberg O, Jenne DE. Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors. Nat Commun. 2015 Apr 10; 6:6722.
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Taylor-Cousar JL, Wiley C, Felton LA, St Clair C, Jones M, Curran-Everett D, Poch K, Nichols DP, Solomon GM, Saavedra MT, Accurso FJ, Nick JA. Pharmacokinetics and tolerability of oral sildenafil in adults with cystic fibrosis lung disease. J Cyst Fibros. 2015 Mar; 14(2):228-36.
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Porsbjerg CM, Gibson PG, Pretto JJ, Salome CM, Brown NJ, Berend N, King GG. Relationship between airway pathophysiology and airway inflammation in older asthmatics. Respirology. 2013 Oct; 18(7):1128-34.
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Jonigk D, Al-Omari M, Maegel L, Müller M, Izykowski N, Hong J, Hong K, Kim SH, Dorsch M, Mahadeva R, Laenger F, Kreipe H, Braun A, Shahaf G, Lewis EC, Welte T, Dinarello CA, Janciauskiene S. Anti-inflammatory and immunomodulatory properties of a1-antitrypsin without inhibition of elastase. Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):15007-12.
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Jiang D, Wenzel SE, Wu Q, Bowler RP, Schnell C, Chu HW. Human neutrophil elastase degrades SPLUNC1 and impairs airway epithelial defense against bacteria. PLoS One. 2013; 8(5):e64689.
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