 Methotrexate
"Methotrexate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
| Descriptor ID |
D008727
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| MeSH Number(s) |
D03.633.100.733.631.192.500
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| Concept/Terms |
Methotrexate Sodium- Methotrexate Sodium
- Sodium, Methotrexate
- Methotrexate, Sodium Salt
- Methotrexate, Disodium Salt
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Below are MeSH descriptors whose meaning is more general than "Methotrexate".
Below are MeSH descriptors whose meaning is more specific than "Methotrexate".
This graph shows the total number of publications written about "Methotrexate" by people in this website by year, and whether "Methotrexate" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 5 | 3 | 8 | | 1992 | 5 | 4 | 9 | | 1993 | 3 | 2 | 5 | | 1994 | 1 | 1 | 2 | | 1995 | 5 | 2 | 7 | | 1996 | 3 | 3 | 6 | | 1997 | 2 | 2 | 4 | | 1998 | 2 | 4 | 6 | | 1999 | 4 | 1 | 5 | | 2000 | 2 | 4 | 6 | | 2001 | 1 | 2 | 3 | | 2002 | 3 | 4 | 7 | | 2003 | 3 | 1 | 4 | | 2004 | 4 | 4 | 8 | | 2005 | 1 | 3 | 4 | | 2006 | 4 | 8 | 12 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 2 | 3 | | 2009 | 2 | 3 | 5 | | 2010 | 3 | 4 | 7 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 6 | 7 | | 2013 | 7 | 3 | 10 | | 2014 | 3 | 7 | 10 | | 2015 | 1 | 4 | 5 | | 2016 | 7 | 7 | 14 | | 2017 | 8 | 2 | 10 | | 2018 | 2 | 4 | 6 | | 2019 | 5 | 0 | 5 | | 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Methotrexate" by people in Profiles.
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Hayashi RJ, Winter SS, Dunsmore KP, Devidas M, Chen Z, Wood BL, Hermiston ML, Teachey DT, Perkins SL, Miles RR, Raetz EA, Loh ML, Winick NJ, Carroll WL, Hunger SP, Lim MS, Gross TG, Bollard CM. Successful Outcomes of Newly Diagnosed T Lymphoblastic Lymphoma: Results From Children's Oncology Group AALL0434. J Clin Oncol. 2020 09 10; 38(26):3062-3070.
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Salzer WL, Burke MJ, Devidas M, Dai Y, Hardy KK, Kairalla JA, Gore L, Hilden JM, Larsen E, Rabin KR, Zweidler-McKay PA, Borowitz MJ, Wood B, Heerema NA, Carroll AJ, Winick N, Carroll WL, Raetz EA, Loh ML, Hunger SP. Impact of Intrathecal Triple Therapy Versus Intrathecal Methotrexate on Disease-Free Survival for High-Risk B-Lymphoblastic Leukemia: Children's Oncology Group Study AALL1131. J Clin Oncol. 2020 08 10; 38(23):2628-2638.
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Erhardt DP, Cannon GW, Teng CC, Mikuls TR, Curtis JR, Sauer BC. Low Persistence Rates in Patients With Rheumatoid Arthritis Treated With Triple Therapy and Adverse Drug Events Associated With Sulfasalazine. Arthritis Care Res (Hoboken). 2019 10; 71(10):1326-1335.
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Li SC, Fuhlbrigge RC, Laxer RM, Pope E, Ibarra MF, Stewart K, Mason T, Becker ML, Hong S, Dedeoglu F, Torok KS, Rabinovich CE, Ferguson PJ, Punaro M, Feldman BM, Andrews T, Higgins GC. Developing comparative effectiveness studies for a rare, understudied pediatric disease: lessons learned from the CARRA juvenile localized scleroderma consensus treatment plan pilot study. Pediatr Rheumatol Online J. 2019 Jul 15; 17(1):43.
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Gilbert SB, Alvero RJ, Roth L, Polotsky AJ. Direct Methotrexate Injection into the Gestational Sac for Nontubal Ectopic Pregnancy: A Review of Efficacy and Outcomes from a Single Institution. J Minim Invasive Gynecol. 2020 01; 27(1):166-172.
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Amaral JK, Taylor PC, Teixeira MM, Morrison TET, Schoen RT. The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis. Viruses. 2019 03 22; 11(3).
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Alur-Gupta S, Cooney LG, Senapati S, Sammel MD, Barnhart KT. Two-dose versus single-dose methotrexate for treatment of ectopic pregnancy: a meta-analysis. Am J Obstet Gynecol. 2019 08; 221(2):95-108.e2.
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McCulley CB, Barton JL, Cannon GW, Sauer BC, Teng CC, George MD, Caplan L, England BR, Mikuls TR, Baker JF. Body mass index and persistence of conventional DMARDs and TNF inhibitors in rheumatoid arthritis. Clin Exp Rheumatol. 2019 May-Jun; 37(3):422-428.
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England BR, Sayles H, Michaud K, Thiele GM, Poole JA, Caplan L, Sauer BC, Cannon GW, Reimold A, Kerr GS, Baker JF, Mikuls TR. Chronic lung disease in U.S. Veterans with rheumatoid arthritis and the impact on survival. Clin Rheumatol. 2018 Nov; 37(11):2907-2915.
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George MD, Sauer BC, Teng CC, Cannon GW, England BR, Kerr GS, Mikuls TR, Baker JF. Biologic and Glucocorticoid Use after Methotrexate Initiation in Patients with Rheumatoid Arthritis. J Rheumatol. 2019 04; 46(4):343-350.
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