 Dextromethorphan
"Dextromethorphan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
| Descriptor ID |
D003915
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| MeSH Number(s) |
D03.132.577.249.200 D03.605.497.212 D03.633.400.686.212 D04.615.723.795.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dextromethorphan".
Below are MeSH descriptors whose meaning is more specific than "Dextromethorphan".
This graph shows the total number of publications written about "Dextromethorphan" by people in this website by year, and whether "Dextromethorphan" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2016 | 2 | 1 | 3 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 1 | 2 | | 2020 | 0 | 3 | 3 | | 2021 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dextromethorphan" by people in Profiles.
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Song R, Zhang J, Perszyk RE, Camp CR, Tang W, Kannan V, Li J, Xu Y, Chen J, Li Y, Liang SH, Traynelis SF, Yuan H. Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors. J Neurochem. 2024 Dec; 168(12):3936-3949.
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Halmo LS, Wang GS, Reynolds KM, Delva-Clark H, Rapp-Olsson M, Banner W, Bond GR, Kauffman RE, Palmer RB, Paul IM, Green JL, Dart RC. Pediatric Fatalities Associated With Over-the-Counter Cough and Cold Medications. Pediatrics. 2021 11; 148(5).
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Wang GS, Green JL, Reynolds KM, Banner W, Bond GR, Kauffman RE, Palmer RB, Paul IM, Rapp-Olsson M, Dart RC. Trends in adverse events and related health-care facility utilization from cough and cold medication exposures in children. Clin Toxicol (Phila). 2021 Apr; 59(4):351-354.
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Amador A, Bostick CD, Olson H, Peters J, Camp CR, Krizay D, Chen W, Han W, Tang W, Kanber A, Kim S, Teoh J, Sah M, Petri S, Paek H, Kim A, Lutz CM, Yang M, Myers SJ, Bhattacharya S, Yuan H, Goldstein DB, Poduri A, Boland MJ, Traynelis SF, Frankel WN. Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice. Brain. 2020 07 01; 143(7):2039-2057.
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Campos-Ma?as MC, Cuevas SM, Ferrer I, Thurman EM, S?nchez-P?rez JA, Ag?era A. Determination of dextromethorphan and dextrorphan solar photo-transformation products by LC/Q-TOF-MS: Laboratory scale experiments and real water samples analysis. Environ Pollut. 2020 Oct; 265(Pt A):114722.
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Dalton R, Lee SB, Claw KG, Prasad B, Phillips BR, Shen DD, Wong LH, Fade M, McDonald MG, Dunham MJ, Fowler DM, Rettie AE, Schuetz E, Thornton TA, Nickerson DA, Gaedigk A, Thummel KE, Woodahl EL. Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity. Clin Transl Sci. 2020 01; 13(1):147-156.
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Wang GS, Reynolds KM, Banner W, Bond GR, Kauffman RE, Palmer RB, Paul IM, Rapp-Olsson M, Green JL, Dart RC. Medication Errors From Over-the-Counter Cough and Cold Medications in Children. Acad Pediatr. 2020 04; 20(3):327-332.
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Monte AA, West K, McDaniel KT, Flaten HK, Saben J, Shelton S, Abdelmawla F, Bushman LR, Williamson K, Abbott D, Anderson PL. CYP2D6 Genotype Phenotype Discordance Due to Drug-Drug Interaction. Clin Pharmacol Ther. 2018 11; 104(5):933-939.
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Maddry JK, Ng PC, Sessions D, Bebarta VS. A Prospective Observation Study of Medical Toxicology Consultation in a U.S. Combat Theater. Mil Med. 2016 11; 181(11):e1666-e1668.
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Okland T, Shirazi M, Rylander M, Holland J. A Case of Aggressive Psychosis in the Setting of Regular Dextromethorphan Abuse. Psychosomatics. 2016 Nov - Dec; 57(6):655-656.
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