 Lactase
"Lactase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme which catalyzes the hydrolysis of LACTOSE to D-GALACTOSE and D-GLUCOSE. Defects in the enzyme cause LACTOSE INTOLERANCE.
| Descriptor ID |
D043322
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| MeSH Number(s) |
D08.811.277.450.410.100.500
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| Concept/Terms |
Lactase- Lactase
- Lactose Galactohydrolase
- Galactohydrolase, Lactose
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Below are MeSH descriptors whose meaning is more general than "Lactase".
Below are MeSH descriptors whose meaning is more specific than "Lactase".
This graph shows the total number of publications written about "Lactase" by people in this website by year, and whether "Lactase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 0 | 2 | 2 | | 1992 | 0 | 4 | 4 | | 1995 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lactase" by people in Profiles.
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Baffour-Awuah NY, Fleet S, Montgomery RK, Baker SS, Butler JL, Campbell C, Tischfield S, Mitchell PD, Allende-Richter S, Moon JE, Fishman L, Bousvaros A, Fox V, Kuokkanen M, Grand RJ, Hirschhorn JN. Functional significance of single nucleotide polymorphisms in the lactase gene in diverse US patients and evidence for a novel lactase persistence allele at -13909 in those of European ancestry. J Pediatr Gastroenterol Nutr. 2015 Feb; 60(2):182-91.
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Montgomery RK, Krasinski SD, Hirschhorn JN, Grand RJ. Lactose and lactase--who is lactose intolerant and why? J Pediatr Gastroenterol Nutr. 2007 Dec; 45 Suppl 2:S131-7.
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Grand RJ, Montgomery RK, Chitkara DK, Hirschhorn JN. Changing genes; losing lactase. Gut. 2003 May; 52(5):617-9.
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Lee SY, Madan A, Furuta GT, Colgan SP, Sibley E. Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells. Mol Genet Metab. 2002 Jan; 75(1):65-9.
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Neele AM, Einerhand AW, Dekker J, Büller HA, Freund JN, Verhave M, Grand RJ, Montgomery RK. Verification of the lactase site of rat lactase-phlorizin hydrolase by site-directed mutagenesis. Gastroenterology. 1995 Oct; 109(4):1234-40.
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Rings EH, de Boer PA, Moorman AF, van Beers EH, Dekker J, Montgomery RK, Grand RJ, Büller HA. Lactase gene expression during early development of rat small intestine. Gastroenterology. 1992 Oct; 103(4):1154-61.
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Montgomery RK, Grand RJ. Developmental regulation of the brush border hydrolase lactase. J Pediatr Gastroenterol Nutr. 1992 Aug; 15(2):215-7.
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Rings EH, Büller HA, de Boer PA, Grand RJ, Montgomery RK, Lamers WH, Charles R, Moorman AF. Messenger RNA sorting in enterocytes. Co-localization with encoded proteins. FEBS Lett. 1992 Mar 30; 300(2):183-7.
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Escher JC, de Koning ND, van Engen CG, Arora S, Büller HA, Montgomery RK, Grand RJ. Molecular basis of lactase levels in adult humans. J Clin Invest. 1992 Feb; 89(2):480-3.
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Yeh KY, Yeh M, Montgomery RK, Grand RJ, Holt PR. Cortisone and thyroxine modulate intestinal lactase and sucrase mRNA levels and activities in the suckling rat. Biochem Biophys Res Commun. 1991 Oct 15; 180(1):174-80.
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