 beta-Lactamases
"beta-Lactamases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
| Descriptor ID |
D001618
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| MeSH Number(s) |
D08.811.277.087.180
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "beta-Lactamases".
Below are MeSH descriptors whose meaning is more specific than "beta-Lactamases".
This graph shows the total number of publications written about "beta-Lactamases" by people in this website by year, and whether "beta-Lactamases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 3 | 0 | 3 | | 2016 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "beta-Lactamases" by people in Profiles.
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Snyder BM, Montague BT, Anandan S, Madabhushi AG, Pragasam AK, Verghese VP, Balaji V, Simões EAF. Risk factors and epidemiologic predictors of blood stream infections with New Delhi Metallo-b-lactamase (NDM-1) producing Enterobacteriaceae. Epidemiol Infect. 2019 01; 147:e137.
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Young HL, Croyle C, Janelle SJ, Knepper BC, Kurtz J, Miller A, Reese SM, Schutz K, Bamberg WM. Collaboration for containment: Detection of OXA-23-like carbapenamase-producing Acinetobacter baumannii in Colorado. Infect Control Hosp Epidemiol. 2018 10; 39(10):1273-1274.
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Klesmith JR, Bacik JP, Wrenbeck EE, Michalczyk R, Whitehead TA. Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2265-2270.
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McCollister B, Kotter CV, Frank DN, Washburn T, Jobling MG. Whole-Genome Sequencing Identifies In Vivo Acquisition of a blaCTX-M-27-Carrying IncFII Transmissible Plasmid as the Cause of Ceftriaxone Treatment Failure for an Invasive Salmonella enterica Serovar Typhimurium Infection. Antimicrob Agents Chemother. 2016 12; 60(12):7224-7235.
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Yi H, Choi JM, Hwang J, Prati F, Cao TP, Lee SH, Kim HS. High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A ß-lactamase, PenL. Sci Rep. 2016 11 09; 6:36527.
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Wrenbeck EE, Klesmith JR, Stapleton JA, Adeniran A, Tyo KE, Whitehead TA. Plasmid-based one-pot saturation mutagenesis. Nat Methods. 2016 Nov; 13(11):928-930.
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Hwang J, Kim HS. Cell Wall Recycling-Linked Coregulation of AmpC and PenB ß-Lactamases through ampD Mutations in Burkholderia cenocepacia. Antimicrob Agents Chemother. 2015 Dec; 59(12):7602-10.
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Drobnak I, Braselmann E, Clark PL. Multiple driving forces required for efficient secretion of autotransporter virulence proteins. J Biol Chem. 2015 Apr 17; 290(16):10104-16.
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Yi H, Song H, Hwang J, Kim K, Nierman WC, Kim HS. The tandem repeats enabling reversible switching between the two phases of ß-lactamase substrate spectrum. PLoS Genet. 2014 Sep; 10(9):e1004640.
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Hwang J, Cho KH, Song H, Yi H, Kim HS. Deletion mutations conferring substrate spectrum extension in the class A ß-lactamase. Antimicrob Agents Chemother. 2014 Oct; 58(10):6265-9.
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