 Primary Graft Dysfunction
"Primary Graft Dysfunction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
| Descriptor ID |
D055031
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| MeSH Number(s) |
C14.907.725.675 C23.550.767.877.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Primary Graft Dysfunction".
Below are MeSH descriptors whose meaning is more specific than "Primary Graft Dysfunction".
This graph shows the total number of publications written about "Primary Graft Dysfunction" by people in this website by year, and whether "Primary Graft Dysfunction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 | | 2014 | 2 | 0 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 2 | 1 | 3 | | 2018 | 2 | 0 | 2 | | 2019 | 5 | 0 | 5 |
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Below are the most recent publications written about "Primary Graft Dysfunction" by people in Profiles.
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Wilkey BJ, Abrams BA. Mitigation of Primary Graft Dysfunction in Lung Transplantation: Current Understanding and Hopes for the Future. Semin Cardiothorac Vasc Anesth. 2020 Mar; 24(1):54-66.
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Smirnova NF, Eickelberg O. Three Is Better than One: An Improved Multiple-Hit Model of Primary Graft Dysfunction. Am J Respir Cell Mol Biol. 2019 Aug; 61(2):141-142.
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Rehm SRT, Smirnova NF, Morrone C, Götzfried J, Feuchtinger A, Pedersen J, Korkmaz B, Yildirim AÖ, Jenne DE. Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation. Sci Rep. 2019 07 09; 9(1):9925.
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Stone ML, Everitt MD. Primary graft dysfunction: Worry less about organ quality and do more to improve candidate condition. J Heart Lung Transplant. 2019 06; 38(6):609-610.
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Mowers KL, Simpson KE, Gazit AZ, Eghtesady P, Canter CE, Castleberry CD. Moderate-severe primary graft dysfunction after pediatric heart transplantation. Pediatr Transplant. 2019 03; 23(2):e13340.
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Chan C, Schiano T, Agudelo E, Paul Haydek J, Hoteit M, Laurito MP, Norvell JP, Terrault N, Verna EC, Yang A, Levitsky J. Immune-mediated graft dysfunction in liver transplant recipients with hepatitis C virus treated with direct-acting antiviral therapy. Am J Transplant. 2018 10; 18(10):2506-2512.
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Götzfried J, Smirnova NF, Morrone C, Korkmaz B, Yildirim AÖ, Eickelberg O, Jenne DE. Preservation with a1-antitrypsin improves primary graft function of murine lung transplants. J Heart Lung Transplant. 2018 08; 37(8):1021-1028.
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Tan YB, Mulekar S, Gorodnya O, Weyant MJ, Zamora MR, Simmons JD, Machuka T, Gillespie MN. Pharmacologic Protection of Mitochondrial DNA Integrity May Afford a New Strategy for Suppressing Lung Ischemia-Reperfusion Injury. Ann Am Thorac Soc. 2017 Sep; 14(Supplement_3):S210-S215.
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Kneidinger N, Milger K, Janitza S, Ceelen F, Leuschner G, Dinkel J, Königshoff M, Weig T, Schramm R, Winter H, Behr J, Neurohr C. Lung volumes predict survival in patients with chronic lung allograft dysfunction. Eur Respir J. 2017 04; 49(4).
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Moniodis A, Townsend K, Rabin A, Aloum O, Stempel J, Burkett P, Camp P, Divo M, El-Chemaly S, Mallidi H, Rosas I, Fuhlbrigge A, Koo S, Goldberg HJ. Comparison of extracorporeal photopheresis and alemtuzumab for the treatment of chronic lung allograft dysfunction. J Heart Lung Transplant. 2018 03; 37(3):340-348.
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