 Mechlorethamine
"Mechlorethamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
| Descriptor ID |
D008466
|
| MeSH Number(s) |
D02.455.526.728.650.529
|
| Concept/Terms |
Mechlorethamine- Mechlorethamine
- Chlormethine
- Bis(2-chloroethyl)methylamine
- Mustine
- Nitrogen Mustard
- Chlorethazine
- Methylchlorethamine
Mechlorethamine Hydrochloride N-Oxide- Mechlorethamine Hydrochloride N-Oxide
- Hydrochloride N-Oxide, Mechlorethamine
- Mechlorethamine Hydrochloride N Oxide
- N-Oxide, Mechlorethamine Hydrochloride
Mechlorethamine N-Oxide- Mechlorethamine N-Oxide
- Mechlorethamine N Oxide
- Nitrogen Mustard N-Oxide
- N-Oxide, Nitrogen Mustard
- Nitrogen Mustard N Oxide
|
Below are MeSH descriptors whose meaning is more general than "Mechlorethamine".
Below are MeSH descriptors whose meaning is more specific than "Mechlorethamine".
This graph shows the total number of publications written about "Mechlorethamine" by people in this website by year, and whether "Mechlorethamine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 3 | 0 | 3 | | 2014 | 4 | 0 | 4 | | 2015 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 2 | 0 | 2 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 | | 2022 | 1 | 1 | 2 | | 2024 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Mechlorethamine" by people in Profiles.
-
Mishra N, Kant R, Kandhari K, Ammar DA, Tewari-Singh N, Pantcheva MB, Petrash JM, Agarwal C, Agarwal R. Nitrogen Mustard-Induced Ex Vivo Human Cornea Injury Model and Therapeutic Intervention by Dexamethasone. J Pharmacol Exp Ther. 2024 01 17; 388(2):484-494.
-
Basu SK, Prislovsky A, Lenchik N, Stephenson DJ, Agarwal R, Chalfant CE, Mandal N. Mouse Model of Nitrogen Mustard Ocular Surface Injury Characterization and Sphingolipid Signaling. Int J Mol Sci. 2024 Jan 06; 25(2).
-
Mishra N, Agarwal R. Research models of sulfur mustard- and nitrogen mustard-induced ocular injuries and potential therapeutics. Exp Eye Res. 2022 10; 223:109209.
-
Goswami DG, Mishra N, Kant R, Agarwal C, Ammar DA, Petrash JM, Tewari-Singh N, Agarwal R. Effect of dexamethasone treatment at variable therapeutic windows in reversing nitrogen mustard-induced corneal injuries in rabbit ocular in vivo model. Toxicol Appl Pharmacol. 2022 02 15; 437:115904.
-
Cruz-Hernandez A, Mendoza RP, Nguyen K, Harder A, Evans CM, Bauer AK, Tewari-Singh N, Brown JM. Mast Cells Promote Nitrogen Mustard-Mediated Toxicity in the Lung Associated With Proinflammatory Cytokine and Bioactive Lipid Mediator Production. Toxicol Sci. 2021 10 27; 184(1):127-141.
-
McGraw MD, Kim SY, White CW, Veress LA. Acute cytotoxicity and increased vascular endothelial growth factor after in vitro nitrogen mustard vapor exposure. Ann N Y Acad Sci. 2020 11; 1479(1):223-233.
-
Goswami DG, Kant R, Ammar DA, Kumar D, Enzenauer RW, Petrash JM, Tewari-Singh N, Agarwal R. Acute corneal injury in rabbits following nitrogen mustard ocular exposure. Exp Mol Pathol. 2019 10; 110:104275.
-
Goswami DG, Kant R, Tewari-Singh N, Agarwal R. Efficacy of anti-inflammatory, antibiotic and pleiotropic agents in reversing nitrogen mustard-induced injury in ex vivo cultured rabbit cornea. Toxicol Lett. 2018 Sep 01; 293:127-132.
-
Charkoftaki G, Jester JV, Thompson DC, Vasiliou V. Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway. Ocul Surf. 2018 01; 16(1):154-162.
-
Goswami DG, Tewari-Singh N, Dhar D, Kumar D, Agarwal C, Ammar DA, Kant R, Enzenauer RW, Petrash JM, Agarwal R. Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization. Cornea. 2016 Feb; 35(2):257-66.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|