 Receptors, TNF-Related Apoptosis-Inducing Ligand
"Receptors, TNF-Related Apoptosis-Inducing Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved DEATH DOMAINS that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
| Descriptor ID |
D053220
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| MeSH Number(s) |
D12.776.543.750.690.600 D12.776.543.750.705.852.760.396
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| Concept/Terms |
Receptors, TNF-Related Apoptosis-Inducing Ligand- Receptors, TNF-Related Apoptosis-Inducing Ligand
- Receptors, TNF Related Apoptosis Inducing Ligand
- Tumor Necrosis Factor Receptor Superfamily, Member 10
- TRAIL Receptors
- Receptors, TRAIL
- Receptors, Tumor Necrosis Factor, Member 10
- TNF-Related Apoptosis-Inducing Ligand Receptors
- TNF Related Apoptosis Inducing Ligand Receptors
Receptors, Tumor Necrosis Factor, Member 10d- Receptors, Tumor Necrosis Factor, Member 10d
- Decoy Receptor 2, Tumor Necrosis Factor
- Receptor, TRAIL-4
- Receptor, TRAIL 4
- TRAIL-4 Receptor
- DCR2 Receptor
- Receptor, DCR2
- CD264 Antigen
- Antigen, CD264
- TRAIL Receptor 4
- Receptor 4, TRAIL
Receptors, Tumor Necrosis Factor, Member 10a- Receptors, Tumor Necrosis Factor, Member 10a
- Tumor Necrosis Factor Receptor Superfamily, Member 10a
- APO2 Receptor
- Receptor, APO2
- Receptor, TRAIL-1
- Receptor, TRAIL 1
- TRAIL-1 Receptor
- TRAIL Receptor 1
- DR4 Receptor
- Receptor, DR4
- CD261 Antigen
- Antigen, CD261
- Death Receptor-4
- Death Receptor 4
- Receptor-4, Death
Receptors, Tumor Necrosis Factor, Member 10b- Receptors, Tumor Necrosis Factor, Member 10b
- TRAIL Receptor 2
- Receptor, TRAIL-2
- Receptor, TRAIL 2
- TRAIL-2 Receptor
- DR5 Receptor
- Receptor, DR5
- Tumor Necrosis Factor Receptor Superfamily, Member 10b
- TNF-Related Apoptosis-Inducing Ligand Receptor 2
- TNF Related Apoptosis Inducing Ligand Receptor 2
- CD262 Antigen
- Antigen, CD262
- Death Receptor-5
- Death Receptor 5
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Below are MeSH descriptors whose meaning is more general than "Receptors, TNF-Related Apoptosis-Inducing Ligand".
Below are MeSH descriptors whose meaning is more specific than "Receptors, TNF-Related Apoptosis-Inducing Ligand".
This graph shows the total number of publications written about "Receptors, TNF-Related Apoptosis-Inducing Ligand" by people in this website by year, and whether "Receptors, TNF-Related Apoptosis-Inducing Ligand" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 1 | 1 | 2 | | 2011 | 2 | 0 | 2 | | 2012 | 2 | 0 | 2 | | 2013 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptors, TNF-Related Apoptosis-Inducing Ligand" by people in Profiles.
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Subbiah V, Chawla SP, Conley AP, Wilky BA, Tolcher A, Lakhani NJ, Berz D, Andrianov V, Crago W, Holcomb M, Hussain A, Veldstra C, Kalabus J, O'Neill B, Senne L, Rowell E, Heidt AB, Willis KM, Eckelman BP. Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma. Clin Cancer Res. 2023 08 15; 29(16):2988-3003.
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Dimberg LY, Towers CG, Behbakht K, Hotz TJ, Kim J, Fosmire S, Porter CC, Tan AC, Thorburn A, Ford HL. A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance. Mol Cancer Res. 2017 04; 15(4):382-394.
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von Pawel J, Harvey JH, Spigel DR, Dediu M, Reck M, Cebotaru CL, Humphreys RC, Gribbin MJ, Fox NL, Camidge DR. Phase II trial of mapatumumab, a fully human agonist monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), in combination with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer. Clin Lung Cancer. 2014 May; 15(3):188-196.e2.
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Derry M, Raina K, Agarwal R, Agarwal C. Differential effects of grape seed extract against human colorectal cancer cell lines: the intricate role of death receptors and mitochondria. Cancer Lett. 2013 Jun 28; 334(1):69-78.
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Henry RE, Andrysik Z, Par?s R, Galbraith MD, Espinosa JM. A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. EMBO J. 2012 Mar 07; 31(5):1266-78.
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Menke C, Bin L, Thorburn J, Behbakht K, Ford HL, Thorburn A. Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. Cancer Res. 2011 Mar 01; 71(5):1883-92.
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Menke C, Goncharov T, Qamar L, Korch C, Ford HL, Behbakht K, Thorburn A. TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro. PLoS One. 2011 Jan 14; 6(1):e14527.
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Deep G, Gangar SC, Oberlies NH, Kroll DJ, Agarwal R. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-?B, and androgen receptor signaling. Mol Carcinog. 2010 Oct; 49(10):902-12.
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Camidge DR, Herbst RS, Gordon MS, Eckhardt SG, Kurzrock R, Durbin B, Ing J, Tohnya TM, Sager J, Ashkenazi A, Bray G, Mendelson D. A phase I safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignancies. Clin Cancer Res. 2010 Feb 15; 16(4):1256-63.
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Leong S, Cohen RB, Gustafson DL, Langer CJ, Camidge DR, Padavic K, Gore L, Smith M, Chow LQ, von Mehren M, O'Bryant C, Hariharan S, Diab S, Fox NL, Miceli R, Eckhardt SG. Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and pharmacokinetic study. J Clin Oncol. 2009 Sep 10; 27(26):4413-21.
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