 GTP-Binding Protein alpha Subunits
"GTP-Binding Protein alpha Subunits" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The GTPase-containing subunits of heterotrimeric GTP-binding proteins. When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. Hydrolysis of GTP by the inherent GTPase activity of the subunit causes it to revert to its inactive (heterotrimeric) form. The GTP-Binding protein alpha subunits are grouped into families according to the type of action they have on second messenger systems.
| Descriptor ID |
D044385
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| MeSH Number(s) |
D08.811.277.040.330.300.200.100 D12.644.360.360.100 D12.776.157.325.332.100 D12.776.476.375.100 D12.776.543.325.100
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| Concept/Terms |
GTP-Binding Protein alpha Subunits- GTP-Binding Protein alpha Subunits
- GTP Binding Protein alpha Subunits
- G-Protein alpha Subunit
- G Protein alpha Subunit
- alpha Subunit, G-Protein
- GTP-Binding Protein alpha Subunit
- GTP Binding Protein alpha Subunit
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Below are MeSH descriptors whose meaning is more general than "GTP-Binding Protein alpha Subunits".
Below are MeSH descriptors whose meaning is more specific than "GTP-Binding Protein alpha Subunits".
This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2007 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 | | 2013 | 0 | 1 | 1 | | 2016 | 1 | 1 | 2 | | 2017 | 0 | 1 | 1 | | 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "GTP-Binding Protein alpha Subunits" by people in Profiles.
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Onken MD, Makepeace CM, Kaltenbronn KM, Kanai SM, Todd TD, Wang S, Broekelmann TJ, Rao PK, Cooper JA, Blumer KJ. Targeting nucleotide exchange to inhibit constitutively active G protein a subunits in cancer cells. Sci Signal. 2018 09 04; 11(546).
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Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 05 18; 9(1):1996.
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Paudyal P, Xie Q, Vaddi PK, Henry MD, Chen S. Inhibiting G protein ?? signaling blocks prostate cancer progression and enhances the efficacy of paclitaxel. Oncotarget. 2017 May 30; 8(22):36067-36081.
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Funk T, Lim Y, Kulungowski AM, Prok L, Crombleholme TM, Choate K, Bruckner AL. Symptomatic Congenital Hemangioma and Congenital Hemangiomatosis Associated With a Somatic Activating Mutation in GNA11. JAMA Dermatol. 2016 09 01; 152(9):1015-20.
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Lim YH, Bacchiocchi A, Qiu J, Straub R, Bruckner A, Bercovitch L, Narayan D, McNiff J, Ko C, Robinson-Bostom L, Antaya R, Halaban R, Choate KA. GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation. Am J Hum Genet. 2016 Aug 04; 99(2):443-50.
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Du J, Rountree A, Cleghorn WM, Contreras L, Lindsay KJ, Sadilek M, Gu H, Djukovic D, Raftery D, Satr?stegui J, Kanow M, Chan L, Tsang SH, Sweet IR, Hurley JB. Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina. J Biol Chem. 2016 Feb 26; 291(9):4698-710.
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Li F, Ponissery-Saidu S, Yee KK, Wang H, Chen ML, Iguchi N, Zhang G, Jiang P, Reisert J, Huang L. Heterotrimeric G protein subunit G?13 is critical to olfaction. J Neurosci. 2013 May 01; 33(18):7975-84.
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Khan SY, McLaughlin NJ, Kelher MR, Eckels P, Gamboni-Robertson F, Banerjee A, Silliman CC. Lysophosphatidylcholines activate G2A inducing G(ai)?1-/G(aq/)11- Ca?(+) flux, G(??)-Hck activation and clathrin/?-arrestin-1/GRK6 recruitment in PMNs. Biochem J. 2010 Nov 15; 432(1):35-45.
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Naarendorp F, Esdaille TM, Banden SM, Andrews-Labenski J, Gross OP, Pugh EN. Dark light, rod saturation, and the absolute and incremental sensitivity of mouse cone vision. J Neurosci. 2010 Sep 15; 30(37):12495-507.
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Zhao A, Ohara-Imaizumi M, Brissova M, Benninger RK, Xu Y, Hao Y, Abramowitz J, Boulay G, Powers AC, Piston D, Jiang M, Nagamatsu S, Birnbaumer L, Gu G. Gao represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. Diabetes. 2010 Oct; 59(10):2522-9.
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