MicroRNAs
"MicroRNAs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Descriptor ID |
D035683
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MeSH Number(s) |
D13.150.650.319 D13.444.735.150.319 D13.444.735.790.552.500
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Concept/Terms |
MicroRNAs- MicroRNAs
- MicroRNA
- miRNAs
- Micro RNA
- RNA, Micro
- miRNA
Primary MicroRNA- Primary MicroRNA
- MicroRNA, Primary
- Primary miRNA
- miRNA, Primary
- pri-miRNA
- pri miRNA
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Below are MeSH descriptors whose meaning is more general than "MicroRNAs".
Below are MeSH descriptors whose meaning is more specific than "MicroRNAs".
This graph shows the total number of publications written about "MicroRNAs" by people in this website by year, and whether "MicroRNAs" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2005 | 2 | 0 | 2 | 2006 | 0 | 2 | 2 | 2007 | 4 | 0 | 4 | 2008 | 6 | 2 | 8 | 2009 | 7 | 0 | 7 | 2010 | 18 | 5 | 23 | 2011 | 18 | 8 | 26 | 2012 | 25 | 7 | 32 | 2013 | 22 | 7 | 29 | 2014 | 30 | 11 | 41 | 2015 | 25 | 9 | 34 | 2016 | 17 | 7 | 24 | 2017 | 29 | 6 | 35 | 2018 | 23 | 4 | 27 | 2019 | 18 | 3 | 21 | 2020 | 21 | 6 | 27 | 2021 | 12 | 5 | 17 | 2022 | 11 | 0 | 11 |
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Below are the most recent publications written about "MicroRNAs" by people in Profiles.
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Keller DM, Perez IG. Dual regulation of miR-375 and CREM genes in pancreatic beta cells. Islets. 2022 12 31; 14(1):139-148.
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Galkin A, Sitapara R, Clemons B, Garcia E, Kennedy M, Guimond D, Carter LL, Douthitt A, Osterhout R, Gandjeva A, Slee D, Salter-Cid L, Tuder RM, Zisman LS. Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension. Eur Respir J. 2022 12; 60(6).
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Herrera JA, Schwartz MA. MicroRNAs in Mechanical Homeostasis. Cold Spring Harb Perspect Med. 2022 08 15; 12(8).
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Franzin R, Stasi A, Sallustio F, Bruno S, Merlotti G, Quaglia M, Grandaliano G, Pontrelli P, Thurman JM, Camussi G, Stallone G, Cantaluppi V, Gesualdo L, Castellano G. Extracellular vesicles derived from patients with antibody-mediated rejection induce tubular senescence and endothelial to mesenchymal transition in renal cells. Am J Transplant. 2022 09; 22(9):2139-2157.
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Crawford J, Christensen BC, Chikina M, Greene CS. Widespread redundancy in -omics profiles of cancer mutation states. Genome Biol. 2022 06 27; 23(1):137.
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McCollum CR, Courtney CM, O'Connor NJ, Aunins TR, Ding Y, Jordan TX, Rogers KL, Brindley S, Brown JM, Nagpal P, Chatterjee A. Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice. ACS Biomater Sci Eng. 2022 07 11; 8(7):3087-3106.
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Elliott CI, Stotesbury TE, Shafer ABA. Using total RNA quality metrics for time since deposition estimates in degrading bloodstains. J Forensic Sci. 2022 Sep; 67(5):1776-1785.
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Veitch S, Njock MS, Chandy M, Siraj MA, Chi L, Mak H, Yu K, Rathnakumar K, Perez-Romero CA, Chen Z, Alibhai FJ, Gustafson D, Raju S, Wu R, Zarrin Khat D, Wang Y, Caballero A, Meagher P, Lau E, Pepic L, Cheng HS, Galant NJ, Howe KL, Li RK, Connelly KA, Husain M, Delgado-Olguin P, Fish JE. MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes. Cardiovasc Diabetol. 2022 02 24; 21(1):31.
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Xu J, Hu J, Idlett-Ali S, Zhang L, Caples K, Peddibhotla S, Reeves M, Zgheib C, Malany S, Liechty KW. Discovery of Small Molecule Activators of Chemokine Receptor CXCR4 That Improve Diabetic Wound Healing. Int J Mol Sci. 2022 Feb 16; 23(4).
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Smith AJ, Do P, Sompel K, Elango A, Tennis MA. miR-520a-5p regulates Frizzled 9 expression and mediates effects of cigarette smoke and iloprost chemoprevention. Sci Rep. 2022 02 11; 12(1):2388.
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